{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:39:35Z","timestamp":1791085175670,"version":"4.1.0"},"reference-count":272,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101021"],"award-info":[{"award-number":["82101021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mtbio.2025.101863","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T02:48:21Z","timestamp":1747277301000},"page":"101863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Regulating periodontal disease with smart stimuli-responsive systems: Antimicrobial activity, immunomodulation, periodontium regeneration"],"prefix":"10.1016","volume":"32","author":[{"given":"Guang-Liang","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ze","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4329-1736","authenticated-orcid":false,"given":"Tian","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-5291","authenticated-orcid":false,"given":"Yu-Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.101863_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.ebd.6401287","article-title":"Periodontal disease has an impact on patients' quality of life","volume":"19","author":"Reynolds","year":"2018","journal-title":"Evid Based Dent"},{"key":"10.1016\/j.mtbio.2025.101863_bib3","article-title":"Relationship between periodontitis and systemic diseases: a bibliometric and visual study","volume":"2000","author":"Isola","year":"2025","journal-title":"Periodontol"},{"key":"10.1016\/j.mtbio.2025.101863_bib4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1600-051X.2009.01396.x","article-title":"Polymicrobial infections, biofilms, and beyond","volume":"36","author":"Kinane","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/clr.14405","article-title":"Effect of nonsurgical mechanical debridement with or without chlorhexidine formulations in the treatment of peri-implant mucositis. A randomized placebo-controlled clinical trial","author":"Isola","year":"2025","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/prd.12294","article-title":"Periodontal disease and adverse pregnancy outcomes","volume":"83","author":"Bobetsis","year":"2020","journal-title":"Periodontol"},{"key":"10.1016\/j.mtbio.2025.101863_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/prd.12271","article-title":"Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol"},{"key":"10.1016\/j.mtbio.2025.101863_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.mtbio.2025.101863_bib10","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/jcpe.13468","article-title":"Prevalence and antibiotic susceptibility trends of periodontal pathogens in the subgingival microbiota of German periodontitis patients: a retrospective surveillance study","volume":"48","author":"Jepsen","year":"2021","journal-title":"J. Clin. Periodontol."},{"issue":"Suppl 22","key":"10.1016\/j.mtbio.2025.101863_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib13","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3109\/07388551.2015.1035693","article-title":"Advanced biomaterials and their potential applications in the treatment of periodontal disease","volume":"36","author":"Chen","year":"2016","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.101863_bib14","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1177\/154405910608501002","article-title":"The role of sucrose in cariogenic dental biofilm formation\u2014new insight","volume":"85","author":"Leme","year":"2006","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/cre2.907","article-title":"The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis-A systematic review and meta-analysis","volume":"10","author":"Mohideen","year":"2024","journal-title":"Clin. Exp. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib16","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1128\/IAI.00873-08","article-title":"Local and systemic responses in matrix metalloproteinase 8-deficient mice during -induced periodontitis","volume":"77","author":"Kuula","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mtbio.2025.101863_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-bioeng-071811-150114","article-title":"Regulation of cell behavior and tissue patterning by bioelectrical signals: challenges and opportunities for biomedical engineering","volume":"14","author":"Levin","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2025.101863_bib18","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3389\/fphys.2017.00910","article-title":"Oxidative stress and antioxidant system in periodontitis","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mtbio.2025.101863_bib19","article-title":"pH\u2010sensitive polymers: classification and some fine potential applications","author":"Fabrice","year":"2021","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.mtbio.2025.101863_bib20","doi-asserted-by":"crossref","first-page":"13573","DOI":"10.1021\/acsami.3c19621","article-title":"Multifunctional metal-phenolic composites promote efficient periodontitis treatment via antibacterial and osteogenic properties","volume":"16","author":"Mei","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101863_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12951-024-02555-9","article-title":"Dynamic hydrogel-metal-organic framework system promotes bone regeneration in periodontitis through controlled drug delivery","volume":"22","author":"Luo","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.101863_bib22","doi-asserted-by":"crossref","first-page":"68794","DOI":"10.1021\/acsami.4c10912","article-title":"Dual-functionalized injectable pH-responsive hydrogels loaded with magnesium peroxide for the treatment of implant-associated infection","volume":"16","author":"Peng","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101863_bib23","article-title":"pH-responsive polyglycerol nanogels for periodontitis treatment through antibacterial and pro-angiogenesis action","volume":"64","author":"Ma","year":"2025","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.mtbio.2025.101863_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12951-021-00992-4","article-title":"An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration","volume":"19","author":"Ding","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.mtbio.2025.101863_bib25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/0022034514538283","article-title":"Filifactor alocis: the newly discovered kid on the block with special talents","volume":"93","author":"Aruni","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jdent.2004.10.009","article-title":"Health benefits of saliva: a review","volume":"33","author":"Dodds","year":"2005","journal-title":"J. Dent."},{"key":"10.1016\/j.mtbio.2025.101863_bib27","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3390\/dj12100312","article-title":"Updates on caries risk assessment-A literature review","volume":"12","author":"Ng","year":"2024","journal-title":"Dent J-Basel"},{"key":"10.1016\/j.mtbio.2025.101863_bib28","article-title":"Phenylboronic acid-based glucose-responsive polymeric nanoparticles: synthesis and applications in drug delivery","author":"Rujiang","year":"2014","journal-title":"Polym. Chem."},{"key":"10.1016\/j.mtbio.2025.101863_bib29","article-title":"Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy","volume":"20","author":"Tang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.101863_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143292","article-title":"Ultra-small Au\/Pt NCs@GOX clusterzyme for enhancing cascade catalytic antibiofilm effect against F. nucleatum-induced periodontitis","volume":"466","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2025.101863_bib31","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1039\/D3TB02898D","article-title":"A whole-course-repair system based on ROS\/glucose stimuli-responsive EGCG release and tunable mechanical property for efficient treatment of chronic periodontitis in diabetic rats","volume":"12","author":"Feng","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2025.101863_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add3197","article-title":"Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs","volume":"8","author":"Yang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2025.101863_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/prd.12270","article-title":"Diabetes as a potential risk for periodontitis: association studies","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol"},{"key":"10.1016\/j.mtbio.2025.101863_bib34","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Cascade reactions catalyzed by gold hybrid nanoparticles generate CO gas against periodontitis in diabetes","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib35","doi-asserted-by":"crossref","first-page":"7633","DOI":"10.1039\/C6CC02202B","article-title":"Glucose-sensitive polymer nanoparticles for self-regulated drug delivery","volume":"52","author":"Zhao","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.mtbio.2025.101863_bib36","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jdent.2018.08.010","article-title":"The role of natural salivary defences in maintaining a healthy oral microbiota","volume":"80","author":"Lynge Pedersen","year":"2019","journal-title":"J. Dent."},{"key":"10.1016\/j.mtbio.2025.101863_bib37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1039\/C2BM00041E","article-title":"Enzyme responsive materials: design strategies and future developments","volume":"1","author":"Zelzer","year":"2013","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib38","doi-asserted-by":"crossref","first-page":"36880","DOI":"10.1021\/acsami.1c08855","article-title":"Gingipain-responsive thermosensitive hydrogel loaded with SDF-1 facilitates periodontal tissue regeneration","volume":"13","author":"Liu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101863_bib39","doi-asserted-by":"crossref","first-page":"18732","DOI":"10.1021\/acsnano.3c01940","article-title":"Microenvironment-responsive metal-phenolic nanozyme release platform with antibacterial, ROS scavenging, and osteogenesis for periodontitis","volume":"17","author":"Xu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101863_bib40","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.7150\/thno.91165","article-title":"Activatable prodrug for controlled release of an antimicrobial peptide via the proteases overexpressed in Candida albicans and Porphyromonas gingivalis","volume":"14","author":"Amer","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.101863_bib41","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/s12951-024-02751-7","article-title":"Alkaline phosphatase-activated prodrug system based on a bifunctional CuO NP tandem nanoenzyme for on-demand bacterial inactivation and wound disinfection","volume":"22","author":"Zhuang","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.mtbio.2025.101863_bib42","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1177\/0022034511416240","article-title":"Metabolomics reveals elevated macromolecular degradation in periodontal disease","volume":"90","author":"Barnes","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib43","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1177\/0022034520943187","article-title":"Porphyromonas gingivalis outer membrane vesicles increase vascular permeability","volume":"99","author":"Farrugia","year":"2020","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031806","article-title":"The role of matrix metalloproteinases (MMP-8, MMP-9, MMP-13) in periodontal and peri-implant pathological processes","volume":"23","author":"Luchian","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib45","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v6.24800","article-title":"Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases","volume":"6","author":"Olsen","year":"2014","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.mtbio.2025.101863_bib46","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4103\/0970-9290.74209","article-title":"Alkaline phosphatase as a periodontal disease marker","volume":"21","author":"Malhotra","year":"2010","journal-title":"Indian J. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib47","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.joen.2021.04.005","article-title":"Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases during apical periodontitis development","volume":"47","author":"Wan","year":"2021","journal-title":"J. Endod."},{"key":"10.1016\/j.mtbio.2025.101863_bib48","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.polymdegradstab.2010.05.008","article-title":"Storage stability study of salicylate-based poly(anhydride-esters)","volume":"95","author":"Deronde","year":"2010","journal-title":"Polym. Degrad. Stab."},{"key":"10.1016\/j.mtbio.2025.101863_bib49","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.addr.2006.09.017","article-title":"Freeze-drying of nanoparticles: formulation, process and storage considerations","volume":"58","author":"Abdelwahed","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.101863_bib50","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10541-005-0161-9","article-title":"Reactive oxygen species and human inflammatory periodontal diseases","volume":"70","author":"Canak\u00e7i","year":"2005","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.mtbio.2025.101863_bib51","article-title":"NADPH-dependent ROS accumulation contributes to the impaired osteogenic differentiation of periodontal ligament stem cells under high glucose conditions","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mtbio.2025.101863_bib52","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-051X.2009.01504.x","article-title":"Crevicular fluid glutathione levels in periodontitis and the effect of non-surgical therapy","volume":"37","author":"Grant","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib53","article-title":"Mitochondrial glutathione in cellular redox homeostasis and disease manifestation","volume":"25","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib54","doi-asserted-by":"crossref","first-page":"119","DOI":"10.34133\/research.0119","article-title":"Bee sting-inspired inflammation-responsive microneedles for periodontal disease treatment","volume":"6","author":"Song","year":"2023","journal-title":"Research"},{"key":"10.1016\/j.mtbio.2025.101863_bib55","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.actbio.2021.08.009","article-title":"Remodeling the periodontitis microenvironment for osteogenesis by using a reactive oxygen species-cleavable nanoplatform","volume":"135","author":"Qiu","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101863_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121683","article-title":"ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation","volume":"287","author":"Li","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101863_bib57","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jcis.2022.01.091","article-title":"A glutathione-responsive silica-based nanosystem capped with in-situ polymerized cell-penetrating poly(disulfide)s for precisely modulating immuno-inflammatory responses","volume":"614","author":"Li","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib58","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jmst.2020.10.027","article-title":"Stimuli responsive co-delivery of celecoxib and BMP2 from micro-scaffold for periodontal disease treatment","volume":"75","author":"Hao","year":"2021","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.mtbio.2025.101863_bib59","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2165\/11208240-000000000-00000","article-title":"Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis","volume":"71","author":"McCormack","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.mtbio.2025.101863_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121387","article-title":"Injectable hydrogels with high drug loading through B-N coordination and ROS-triggered drug release for efficient treatment of chronic periodontitis in diabetic rats","volume":"282","author":"Zhao","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101863_bib61","first-page":"1","article-title":"Mass spectrometry imaging reveals the redox and metabolic heterogeneity","volume":"0","author":"Han","year":"2024","journal-title":"CCS Chem."},{"key":"10.1016\/j.mtbio.2025.101863_bib62","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1902\/jop.2011.100757","article-title":"Responses of human neutrophils to nicotine and\/or Porphyromonas gingivalis","volume":"82","author":"Al-Shibani","year":"2011","journal-title":"J. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib63","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tcb.2007.04.007","article-title":"Large-scale biophysics: ion flows and regeneration","volume":"17","author":"Levin","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mtbio.2025.101863_bib64","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.6740320","article-title":"Endogenous ionic currents traverse intact and damaged bone","volume":"225","author":"Borgens","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2025.101863_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201703771","article-title":"Built\u2010in electric fields dramatically induce enhancement of osseointegration","volume":"27","author":"Liu","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib66","first-page":"213","article-title":"Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes","volume":"18","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib67","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1038\/s41467-024-53290-6","article-title":"Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes","volume":"15","author":"Fang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.101863_bib68","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/j.actbio.2014.02.015","article-title":"Conductive polymers: towards a smart biomaterial for tissue engineering","volume":"10","author":"Balint","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101863_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202400256","article-title":"Effects of electric field\u2010modulated conductive hydrogel on osseoperception and osseointegration of dental implants","volume":"34","author":"Qin","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fenrg.2021.806595","article-title":"The influence of humidity on electron transport parameters and insulation performance of air","volume":"9","author":"An","year":"2022","journal-title":"Front. Energy Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib71","article-title":"Study on temperature and electric field dependence of conductivity in polyimide","volume":"65","author":"Wang","year":"2016","journal-title":"Acta Phys. Sin."},{"key":"10.1016\/j.mtbio.2025.101863_bib72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1600-0765.2012.01518.x","article-title":"Effects of electrical stimulation on periodontal tissue remodeling in rats","volume":"48","author":"Tomofuji","year":"2012","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib73","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2504\/kds.36.64_1","article-title":"Effect of electrical currents on alveolar bony defects","volume":"36","author":"Kubota","year":"1982","journal-title":"J. Kyushu Dent. Soc."},{"key":"10.1016\/j.mtbio.2025.101863_bib74","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.1039\/D1TB01310F","article-title":"Near infrared photothermal conversion materials: mechanism, preparation, and photothermal cancer therapy applications","volume":"9","author":"Li","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2025.101863_bib75","article-title":"Carbon-based materials for photodynamic therapy: a mini-review","author":"Di","year":"2019","journal-title":"Front. Chem. Sci. Eng."},{"key":"10.1016\/j.mtbio.2025.101863_bib76","article-title":"Improvement of performance of traditional photocatalysis and development of new photocatalysis materials and technologies","author":"Wei","year":"2014","journal-title":"Appl. Mech. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib77","article-title":"Stimuli\u2010responsive AIEgens","volume":"33","author":"Zhang","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib78","article-title":"Design and applications of photoresponsive hydrogels","volume":"31","author":"Li","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.125194","article-title":"Rapid bacteria trapping and killing of metal-organic frameworks strengthened photo-responsive hydrogel for rapid tissue repair of bacterial infected wounds","volume":"396","author":"Han","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2025.101863_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2022.111401","article-title":"Branched AuAg nanoparticles coated by metal\u2013phenolic networks for treating bacteria-induced periodontitis via photothermal antibacterial and immunotherapy","volume":"224","author":"Wang","year":"2022","journal-title":"Mater. Des."},{"key":"10.1016\/j.mtbio.2025.101863_bib81","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1038\/s41467-019-12429-6","article-title":"Zinc-doped Prussian blue enhances photothermal clearance of and promotes tissue repair in infected wounds","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.101863_bib82","article-title":"Engineering mild-photothermal responsive and NO donor prussian blue nanozymes using mild synthesis for inflammation regulation and bacterial eradication in periodontal disease","volume":"37","author":"Li","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114168","article-title":"Enhanced antimicrobial activity through the combination of antimicrobial photodynamic therapy and low-frequency ultrasonic irradiation","volume":"183","author":"Wang","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.101863_bib84","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1039\/b311904c","article-title":"Photosensitized inactivation of microorganisms","volume":"3","author":"Jori","year":"2004","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib85","doi-asserted-by":"crossref","first-page":"21077","DOI":"10.1021\/acsnano.4c02316","article-title":"Erythrocyte-mimicking nanovesicle targeting Porphyromonas gingivalis for periodontitis","volume":"18","author":"Tang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101863_bib86","article-title":"Activating MoO3 nanobelts via aqueous intercalation as a near\u2010infrared type I photosensitizer for photodynamic periodontitis treatment","author":"Bohua","year":"2023","journal-title":"SmartMat"},{"key":"10.1016\/j.mtbio.2025.101863_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202302547","article-title":"A novel Z-scheme heterostructured Bi(2) S(3)\/Cu-TCPP nanocomposite with synergistically enhanced therapeutics against bacterial biofilm infections in periodontitis","volume":"19","author":"Kong","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.101863_bib88","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55060-w","article-title":"Photocatalytic therapy via photoinduced redox imbalance in biological system","volume":"15","author":"Zhou","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.101863_bib89","first-page":"215","article-title":"[Progress on photodynamic therapy in oral diseases]","volume":"39","author":"Li","year":"2021","journal-title":"Hua xi kou qiang yi xue za zhi"},{"key":"10.1016\/j.mtbio.2025.101863_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114688","article-title":"Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment","volume":"162","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2025.101863_bib91","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/adhm.201300627","article-title":"Biodegradable thermogelling polymers: working towards clinical applications","volume":"3","author":"Dou","year":"2014","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib92","first-page":"1113","article-title":"Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism","volume":"5","author":"Shen","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/S0144-8617(00)00281-2","article-title":"Rheological characterisation of thermogelling chitosan\/glycerol-phosphate solutions","author":"Chenite","year":"2001","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101863_bib94","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jobcr.2019.04.001","article-title":"Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: in-vitro drug release study and antibacterial activity","volume":"9","author":"Swain","year":"2019","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116585","article-title":"Construction of functional curdlan hydrogels with bio-inspired polydopamine for synergistic periodontal antibacterial therapeutics","volume":"245","author":"Tong","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101863_bib96","doi-asserted-by":"crossref","DOI":"10.1007\/BF01644264","article-title":"Chlorhexidine: antibacterial action and bacterial resistance","author":"Russell","year":"1986","journal-title":"Infection"},{"key":"10.1016\/j.mtbio.2025.101863_bib97","series-title":"Ions in Solution and Their Solvation","author":"Marcus","year":"2015"},{"key":"10.1016\/j.mtbio.2025.101863_bib98","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1600-051X.1998.tb02371.x","article-title":"Subgingival temperature and microbiota in initial periodontitis","volume":"25","author":"Maiden","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib99","article-title":"Preparation and application of magnetic responsive materials in bone tissue engineering","author":"Song","year":"2020","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2025.101863_bib100","first-page":"704","article-title":"Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application","volume":"16","author":"Kush","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib101","series-title":"A Modern Course in Statistical Physics","author":"Reichl","year":"2016"},{"key":"10.1016\/j.mtbio.2025.101863_bib102","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.2147\/IJN.S402410","article-title":"Combined ferromagnetic nanoparticles for effective periodontal biofilm eradication in rat model","volume":"18","author":"Tong","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.101863_bib103","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jgar.2020.01.022","article-title":"Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: back to the future","volume":"22","author":"Asadi","year":"2020","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.mtbio.2025.101863_bib104","article-title":"Magnetic microspheres mimicking certain functions of macrophages: towards precise antibacterial potency for bone defect healing","volume":"20","author":"Zhou","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.101863_bib105","doi-asserted-by":"crossref","first-page":"8694","DOI":"10.1021\/acsnano.2c02516","article-title":"Swarming magnetic photoactive microrobots for dental implant biofilm eradication","volume":"16","author":"Mayorga-Martinez","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101863_bib106","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1021\/acs.chemrev.1c00860","article-title":"Magnetic nanoparticles: synthesis, anisotropy, and applications","volume":"123","author":"Ma","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.mtbio.2025.101863_bib107","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/ab84a3","article-title":"Enhancing the magnetic and inductive heating properties of Fe(3)O(4) nanoparticles via morphology control","volume":"31","author":"Mohapatra","year":"2020","journal-title":"Nanotechnology"},{"key":"10.1016\/j.mtbio.2025.101863_bib108","article-title":"Magnetic fluid hyperthermia based on magnetic nanoparticles: physical characteristics, historical perspective, clinical trials, technological challenges, and recent advances","author":"Hossein","year":"2020","journal-title":"Adv. Therapeut."},{"key":"10.1016\/j.mtbio.2025.101863_bib109","article-title":"A review of ceramic, polymer and composite piezoelectric materials","author":"Mahpara","year":"2022","journal-title":"J. Phys. D Appl. Phys."},{"key":"10.1016\/j.mtbio.2025.101863_bib110","article-title":"Piezocatalytic medicine: an emerging frontier using piezoelectric materials for biomedical applications","volume":"35","author":"Chen","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib111","article-title":"Piezotronic effect enhanced catalytic sterilization: mechanisms and practical applications","author":"Xiaoyu","year":"2024","journal-title":"Nano Energy"},{"key":"10.1016\/j.mtbio.2025.101863_bib112","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206401","article-title":"A comprehensive review on barium titanate nanoparticles as a persuasive piezoelectric material for biomedical applications: prospects and challenges","volume":"19","author":"Sood","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.101863_bib113","doi-asserted-by":"crossref","first-page":"43441","DOI":"10.1021\/acsami.3c08336","article-title":"A novel injectable piezoelectric hydrogel for periodontal disease treatment","volume":"15","author":"Roldan","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101863_bib114","first-page":"346","article-title":"Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation","volume":"35","author":"Liu","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib115","article-title":"Dual templating fabrication of hierarchical porous three-dimensional ZnO\/carbon nanocomposites for enhanced photocatalytic and photoelectrochemical activity","author":"He","year":"2018","journal-title":"Appl. Catal. B Environ."},{"key":"10.1016\/j.mtbio.2025.101863_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104915","article-title":"NaNbO3\/ZnO piezocatalyst for non-destructive tooth cleaning and antibacterial activity","volume":"25","author":"Sharma","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.mtbio.2025.101863_bib117","first-page":"71","article-title":"Engineered Bdellovibrio bacteriovorus: a countermeasure for biofilm-induced periodontitis, Mater","volume":"53","author":"Tang","year":"2022","journal-title":"Today Off."},{"key":"10.1016\/j.mtbio.2025.101863_bib118","article-title":"Self-assembled NaNbO3-Nb2O5 (ferroelectric-semiconductor) heterostructures grown on LaAlO3 substrates","author":"Zhiguang","year":"2012","journal-title":"Appl. Phys. Lett."},{"key":"10.1016\/j.mtbio.2025.101863_bib119","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.abi7687","article-title":"Ultrahigh energy storage in superparaelectric relaxor ferroelectrics","volume":"374","author":"Pan","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2025.101863_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2016.e00177","article-title":"Reducing ZnO nanoparticles toxicity through silica coating","volume":"2","author":"Chia","year":"2016","journal-title":"Heliyon"},{"key":"10.1016\/j.mtbio.2025.101863_bib121","doi-asserted-by":"crossref","first-page":"43868","DOI":"10.1021\/acsami.1c06331","article-title":"Multifunctional dental composite with piezoelectric nanofillers for combined antibacterial and mineralization effects","volume":"13","author":"Montoya","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101863_bib122","first-page":"1","article-title":"Smart dental materials for antimicrobial applications","volume":"24","author":"Montoya","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib123","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1021\/acs.chemrev.1c00622","article-title":"Ultrasound-responsive systems as components for smart materials","volume":"122","author":"Athanassiadis","year":"2022","journal-title":"Chem. Rev."},{"key":"10.1016\/j.mtbio.2025.101863_bib124","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1088\/0370-1301\/63\/9\/305","article-title":"Cavitation produced by ultrasonics","volume":"63","author":"Noltingk","year":"1950","journal-title":"Proc. Phys. Soc. B"},{"key":"10.1016\/j.mtbio.2025.101863_bib125","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1121\/10.0003813","article-title":"Acoustic radiation torque on a compressible spheroid","volume":"149","author":"Jerome","year":"2021","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.mtbio.2025.101863_bib126","article-title":"Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery","volume":"80","author":"Low","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.mtbio.2025.101863_bib127","first-page":"42","article-title":"Efficacy of Chlorin e6-Mediated Sono-Photodynamic Therapy on 4T1 Cells","volume":"29","author":"Li","year":"2014","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.mtbio.2025.101863_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138782","article-title":"A robust ROS generation nanoplatform combating periodontitis via sonodynamic\/chemodynamic combination therapy","volume":"451","author":"Xin","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2025.101863_bib129","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jconrel.2023.02.040","article-title":"Reactive oxygen species-powered cancer immunotherapy: current status and challenges","volume":"356","author":"He","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.mtbio.2025.101863_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122407","article-title":"A telluroviologen-anchored tetraphenylporphyrin as sonosensitizer for periodontitis sonodynamic therapy","volume":"304","author":"Sun","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101863_bib131","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/jre.12119","article-title":"Gene delivery to periodontal tissue using Bubble liposomes and ultrasound","volume":"49","author":"Sugano","year":"2014","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib132","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1039\/D3TB00284E","article-title":"Engineering ultrasound-activated piezoelectric hydrogels with antibacterial activity to promote wound healing","volume":"11","author":"Xu","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2025.101863_bib133","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.actbio.2023.10.006","article-title":"Heterostructured piezocatalytic nanoparticles with enhanced ultrasound response for efficient repair of infectious bone defects","volume":"172","author":"Lei","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101863_bib134","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ijos.2017.10","article-title":"A new approach to transfect NF-\u03baB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method","volume":"9","author":"Yamaguchi","year":"2017","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib135","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/acsbiomaterials.3c01357","article-title":"A biomimetic nanogenerator to enhance bone regeneration by restoring electric microenvironments","volume":"10","author":"Chen","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.mtbio.2025.101863_bib136","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.addr.2014.03.004","article-title":"Ultrasound induced cancer immunotherapy","volume":"72","author":"Unga","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.101863_bib137","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.3390\/nu13103588","article-title":"Nutrition care practices of dietitians and oral health professionals for oral health conditions: a scoping review","volume":"13","author":"Lieffers","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.mtbio.2025.101863_bib138","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202300281","article-title":"Multifunctionalized and dual\u2010crosslinked hydrogel promotes inflammation resolution and bone regeneration via NLRP3 inhibition in periodontitis","volume":"5","author":"Liu","year":"2024","journal-title":"Small Struct."},{"key":"10.1016\/j.mtbio.2025.101863_bib139","article-title":"A microenvironment-responsive graphdiyne-iron nanozyme hydrogel with antibacterial and anti-inflammatory effect for periodontitis treatment","author":"Wu","year":"2024","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.mtbio.2025.101863_bib140","doi-asserted-by":"crossref","first-page":"18253","DOI":"10.1021\/acsnano.2c05923","article-title":"Penetrating macrophage-based nanoformulation for periodontitis treatment","volume":"16","author":"Yan","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.101863_bib141","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10717544.2019.1571121","article-title":"Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation","volume":"26","author":"Mou","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.mtbio.2025.101863_bib142","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actbio.2022.03.046","article-title":"ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis","volume":"146","author":"Liu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101863_bib143","doi-asserted-by":"crossref","first-page":"54497","DOI":"10.1021\/acsami.0c18070","article-title":"Jelly-Inspired injectable guided tissue regeneration strategy with shape auto-matched and dual-light-defined antibacterial\/osteogenic pattern switch properties","volume":"12","author":"Xu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101863_bib144","first-page":"2019","article-title":"Injectable hydrogels activated with copper sulfide nanoparticles for enhancing spatiotemporal sterilization and osteogenesis in periodontal therapy","volume":"15","author":"Yang","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib145","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41598-023-50929-0","article-title":"Fabrication and properties evaluation of chitosan\/BaTiO3 composite membranes for the periodontitis treatment","volume":"14","author":"Houshyar","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.101863_bib146","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1039\/D1NR06043K","article-title":"Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting the ROS\u2013NF\u03baB pathway","volume":"14","author":"Yu","year":"2022","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2025.101863_bib147","article-title":"Strontium-containing piezoelectric biofilm promotes dentin tissue regeneration","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib148","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.actbio.2023.09.014","article-title":"Amplification of oxidative damage using near-infrared II-mediated photothermal\/thermocatalytic effects for periodontitis treatment","volume":"171","author":"Dai","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101863_bib149","first-page":"428","article-title":"Photothermal therapy with regulated Nrf2\/NF-\u03baB signaling pathway for treating bacteria-induced periodontitis","volume":"9","author":"Tian","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101447","article-title":"NIR responsive nitric oxide nanogenerator for enhanced biofilm eradication and inflammation immunotherapy against periodontal diseases","volume":"43","author":"Qi","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.mtbio.2025.101863_bib151","article-title":"ROS-responsive sequential release systems with excellent biofilm permeability for enhanced antibacterial and regeneration-promoting therapy in periodontitis","author":"Zeng","year":"2022","journal-title":"Res. Square"},{"key":"10.1016\/j.mtbio.2025.101863_bib152","doi-asserted-by":"crossref","first-page":"17289","DOI":"10.1021\/acsami.1c01748","article-title":"Enhanced eradication of bacterial\/fungi biofilms by glucose oxidase-modified magnetic nanoparticles as a potential treatment for persistent endodontic infections","volume":"13","author":"Ji","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.101863_bib153","first-page":"324","article-title":"Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration","volume":"21","author":"Wang","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib154","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1208\/s12249-019-1613-7","article-title":"Stimuli responsive gelling systems loaded with PLGA nanoparticles of moxifloxacin hydrochloride for effective treatment of periodontitis","volume":"21","author":"Beg","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.mtbio.2025.101863_bib155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijbiomac.2018.09.202","article-title":"Glucose-sensitive delivery of metronidazole by using a photo-crosslinked chitosan hydrogel film to inhibit proliferation","volume":"122","author":"Liu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.101863_bib156","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4274\/tjps.galenos.2020.09623","article-title":"Development of metronidazole-loaded thermosensitive hydrogel for periodontitis treatment","volume":"18","author":"Pham","year":"2021","journal-title":"Turk. J. Pharm. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib157","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae058","article-title":"Polyphenols-based intelligent oral barrier membranes for periodontal bone defect reconstruction","volume":"11","author":"Chen","year":"2024","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.mtbio.2025.101863_bib158","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.ijbiomac.2018.09.057","article-title":"A novel pH-responsive quaternary ammonium chitosan-liposome nanoparticles for periodontal treatment","volume":"129","author":"Hu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.101863_bib159","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110454","article-title":"An enzyme-responsive membrane for antibiotic drug release and local periodontal treatment","volume":"183","author":"Li","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.mtbio.2025.101863_bib160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118659","article-title":"A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for localised treatment of periodontitis","volume":"570","author":"Aminu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2025.101863_bib161","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1007\/s10856-009-3729-x","article-title":"Injectable thermosensitive hydrogel based on chitosan and quaternized chitosan and the biomedical properties","volume":"20","author":"Ji","year":"2009","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.mtbio.2025.101863_bib162","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.msec.2019.02.024","article-title":"Injectable chitosan\/\u03b2-glycerophosphate hydrogels with sustained release of BMP-7 and ornidazole in periodontal wound healing of class III furcation defects","volume":"99","author":"Zang","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.mtbio.2025.101863_bib163","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1007\/s13577-023-00979-3","article-title":"Remodeling periodontal osteoimmune microenvironment through MAPK\/NF\u03baB phosphorylation pathway of macrophage via intelligent ROS scavenging","volume":"36","author":"Qiu","year":"2023","journal-title":"Hum. Cell"},{"key":"10.1016\/j.mtbio.2025.101863_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120293","article-title":"GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis","volume":"261","author":"Almoshari","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101863_bib165","first-page":"254","article-title":"pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats","volume":"18","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib166","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1902\/jop.2016.150542","article-title":"pH-responsive hydrogel with an anti-glycation agent for modulating experimental periodontitis","volume":"87","author":"Yu","year":"2016","journal-title":"J. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib167","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2019.01.001","article-title":"An injectable and thermosensitive hydrogel: promoting periodontal regeneration by controlled-release of aspirin and erythropoietin","volume":"86","author":"Xu","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.101863_bib168","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.carbpol.2010.06.045","article-title":"Biocompatibility of a chitosan-based injectable thermosensitive hydrogel and its effects on dog periodontal tissue regeneration","volume":"82","author":"Ji","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101863_bib169","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1039\/C9TB00613C","article-title":"Controlled delivery of recombinant human bone morphogenetic protein-2 by using glucose-sensitive core\u2013shell nanofibers to repair the mandible defects in diabetic rats","volume":"7","author":"Xiao","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2025.101863_bib170","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/php.13333","article-title":"Antibacterial photodynamic treatment of Porphyromonas gingivalis with toluidine blue O and a NonLaser red light source enhanced by dihydroartemisinin","volume":"97","author":"Ding","year":"2020","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mtbio.2025.101863_bib171","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jphotobiol.2017.06.019","article-title":"Optimization of hydrogel containing toluidine blue O for photodynamic therapy by response surface methodology","volume":"173","author":"Liang","year":"2017","journal-title":"J. Photochem. Photobiol., B"},{"key":"10.1016\/j.mtbio.2025.101863_bib172","article-title":"Oxygen\u2010free polycationic photosensitizers for treatment of periodontal inflammation","volume":"34","author":"Qian","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib173","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7156716","article-title":"Low-intensity ultrasound combined with hematoporphyrin monomethyl ether in the treatment of experimental periodontitis in rats","volume":"2016","author":"Zhuang","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.mtbio.2025.101863_bib174","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/10837450.2022.2161574","article-title":"Microemulsion-thermosensitive gel composites as in situ-forming drug reservoir for periodontitis tissue repair through alveolar bone and collagen regeneration strategy","volume":"28","author":"Ding","year":"2022","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.mtbio.2025.101863_bib175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111319","article-title":"Development and evaluation of thermosensitive hydrogels with binary mixture of extract and chitosan for periodontal diseases treatment","volume":"22","author":"Chanaj-Kaczmarek","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib176","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/pat.5874","article-title":"Thermosensitive acetylated carboxymethyl chitosan gel depot systems sustained release caffeic acid phenethyl ester for periodontitis treatment","volume":"34","author":"Peng","year":"2022","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.mtbio.2025.101863_bib177","first-page":"239","article-title":"A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: antibacterial, hemostasis, immune reprogramming, pro-osteo-\/angiogenesis and recruitment","volume":"41","author":"Yang","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2023.112314","article-title":"Simultaneously boosting inflammation resolution and osteogenic differentiation in periodontitis using folic acid-modified liposome-thermosensitive hydrogel composites","volume":"234","author":"Wang","year":"2023","journal-title":"Mater. Des."},{"key":"10.1016\/j.mtbio.2025.101863_bib179","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1080\/09205063.2022.2068948","article-title":"Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan hydrogel film for antibacterial and anti-inflammatory therapy","volume":"33","author":"Liu","year":"2022","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.mtbio.2025.101863_bib180","article-title":"Dually crosslinked copper-poly(tannic acid) nanoparticles with microenvironment-responsiveness for infected wound treatment","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib181","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10717544.2016.1233591","article-title":"Formulation, characterization and clinical evaluation of curcumin gel for treatment of periodontitis","volume":"24","author":"Nasra","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.mtbio.2025.101863_bib182","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1902\/jop.2016.160189","article-title":"Inhibition of periodontitis induction using a stimuli-responsive hydrogel carrying naringin","volume":"88","author":"Chang","year":"2017","journal-title":"J. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib183","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41586-023-05750-0","article-title":"Coordination of bacterial cell wall and outer membrane biosynthesis","volume":"615","author":"Hummels","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.101863_bib184","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/1758-2229.12346","article-title":"Disturbance of the bacterial cell wall specifically interferes with biofilm formation","volume":"7","author":"Bucher","year":"2015","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.mtbio.2025.101863_bib185","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.2147\/IJN.S165125","article-title":"Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies","volume":"13","author":"Qing","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.101863_bib186","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0169-4332(03)00836-5","article-title":"Characteristics of the silver-doped TiO2 nanoparticles","volume":"220","author":"Liu","year":"2003","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib187","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.archoralbio.2011.02.005","article-title":"Synergistic effect between clove oil and its major compounds and antibiotics against oral bacteria","volume":"56","author":"Moon","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.mtbio.2025.101863_bib188","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.582113","article-title":"Bacterial chromosome replication and DNA repair during the stringent response","volume":"11","author":"Sinha","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.mtbio.2025.101863_bib189","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1902\/jop.2008.070493","article-title":"Moxifloxacin as an adjunctive antibiotic in the treatment of severe chronic periodontitis","volume":"79","author":"Guentsch","year":"2008","journal-title":"J. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib190","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1080\/00958972.2014.910653","article-title":"Synthesis, characterization, crystal structures, enzyme inhibition, DNA binding, and electrochemical studies of zinc(II) complexes","volume":"67","author":"Ali","year":"2014","journal-title":"J. Coord. Chem."},{"key":"10.1016\/j.mtbio.2025.101863_bib191","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ijos.2017.31","article-title":"An early report: a modified porphyrin-linked metronidazole targeting intracellular Porphyromonas gingivalis in cultured oral epithelial cells","volume":"9","author":"Ye","year":"2017","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib192","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/1040841X.2021.1944054","article-title":"Bacterial adhesion to collagens: implications for biofilm formation and disease progression in the oral cavity","volume":"48","author":"\u00c1lvarez","year":"2021","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.mtbio.2025.101863_bib193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10266-021-00647-8","article-title":"Porphyromonas gingivalis outside the oral cavity","volume":"110","author":"Bregaint","year":"2021","journal-title":"Odontology"},{"key":"10.1016\/j.mtbio.2025.101863_bib194","article-title":"Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: current state and perspectives","author":"Jianhui","year":"2020","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.mtbio.2025.101863_bib195","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1902\/jop.1993.64.7.630","article-title":"Inhibitory effect of tea catechins on collagenase activity","volume":"64","author":"Makimura","year":"1993","journal-title":"J. Periodontol."},{"key":"10.1016\/j.mtbio.2025.101863_bib196","article-title":"Biodegradable piezoelectric janus membrane with enhanced antibacterial and osteoinductive properties for periodontitis therapy","author":"Cheng","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.mtbio.2025.101863_bib197","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2012.01102.x","article-title":"It takes two to tango: I\u03baBs, the multifunctional partners of NF\u2010\u03baB","volume":"246","author":"Hinz","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.mtbio.2025.101863_bib198","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-981-13-9367-9_10","article-title":"NF-\u03baB, I\u03baB, and IKK: integral components of immune system signaling","volume":"1172","author":"Mulero","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mtbio.2025.101863_bib199","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41368-019-0068-8","article-title":"Interleukin-1\u03b2 is a potential therapeutic target for periodontitis: a narrative review","volume":"12","author":"Cheng","year":"2020","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib200","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122741","article-title":"Immunomodulatory activity of red algal galactans and their partially depolymerized derivatives in RAW264.7 macrophages","volume":"347","author":"Humayun","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.101863_bib201","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.3945\/ajcn.2009.28836","article-title":"Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent","volume":"91","author":"Bao","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.mtbio.2025.101863_bib202","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112586","article-title":"Procyanidins inhibit fine particulate matter-induced vascular smooth muscle cells apoptosis via the activation of the Nrf2 signaling pathway","volume":"223","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.mtbio.2025.101863_bib203","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/138920009787048347","article-title":"The potential of p38 MAPK inhibitors to modulate periodontal infections","volume":"10","author":"Kirkwood","year":"2009","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.mtbio.2025.101863_bib204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/792639","article-title":"Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways?","volume":"2011","author":"Son","year":"2011","journal-title":"J. Signal Transduct."},{"key":"10.1016\/j.mtbio.2025.101863_bib205","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.mtbio.2025.101863_bib206","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1152\/physrev.00036.2016","article-title":"Osteoimmunology: the conceptual framework unifying the immune and skeletal systems","volume":"97","author":"Okamoto","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mtbio.2025.101863_bib207","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1177\/154405910708600903","article-title":"p38 MAPK signaling in oral-related diseases","volume":"86","author":"Patil","year":"2007","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib208","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","article-title":"Osteoimmunology: evolving concepts in bone-immune interactions in health and disease","volume":"19","author":"Tsukasaki","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2025.101863_bib209","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/0968051907079118","article-title":"Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase","volume":"13","author":"Rossa","year":"2007","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib210","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1124\/jpet.105.100362","article-title":"Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction","volume":"317","author":"Mbalaviele","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mtbio.2025.101863_bib211","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12906-021-03213-5","article-title":"Baicalein inhibits inflammatory response and promotes osteogenic activity in periodontal ligament cells challenged with lipopolysaccharides","volume":"21","author":"Ren","year":"2021","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.mtbio.2025.101863_bib212","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.mtbio.2025.101863_bib213","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.3390\/ijms22136995","article-title":"Macrophage polarization states in the tumor microenvironment","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib214","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763334","article-title":"Polarized macrophages in periodontitis: characteristics, function, and molecular signaling","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.101863_bib215","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1080\/10520295.2020.1718756","article-title":"A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis","volume":"95","author":"K\u0131z\u0131lda\u011f","year":"2020","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.mtbio.2025.101863_bib216","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/nu14010067","article-title":"Regulatory effects of quercetin on M1\/M2 macrophage polarization and oxidative\/antioxidative balance","volume":"14","author":"Tsai","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.mtbio.2025.101863_bib217","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.job.2020.02.002","article-title":"Osteoclastogenesis in periodontal diseases: possible mediators and mechanisms","volume":"62","author":"AlQranei","year":"2020","journal-title":"J. Oral Biosci."},{"key":"10.1016\/j.mtbio.2025.101863_bib218","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00774-024-01547-x","article-title":"Correction: crosstalk between bone and the immune system","volume":"42","author":"Okamoto","year":"2024","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.mtbio.2025.101863_bib219","article-title":"A biodegradable nano-drug delivery platform for Co-delivery of minocycline and chitosan to achieve efficient and safe non-surgical periodontitis therapy","author":"Yang","year":"2024","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.mtbio.2025.101863_bib220","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1016\/j.fct.2008.08.016","article-title":"Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis","volume":"46","author":"Kim","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.mtbio.2025.101863_bib221","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications","volume":"82","author":"Singh","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.101863_bib222","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4236\/jbise.2013.68A1004","article-title":"BMP signaling in mesenchymal stem cell differentiation and bone formation","volume":"6","author":"Beederman","year":"2013","journal-title":"J. Biomed. Sci. Eng."},{"key":"10.1016\/j.mtbio.2025.101863_bib223","doi-asserted-by":"crossref","first-page":"39401","DOI":"10.1074\/jbc.M110.103705","article-title":"Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways","volume":"285","author":"Lee","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2025.101863_bib224","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1002\/art.38181","article-title":"Role of interleukin-10 in endochondral bone formation in mice anabolic effect via the bone morphogenetic protein\/smad pathway","volume":"65","author":"Jung","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mtbio.2025.101863_bib225","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/dgd.12650","article-title":"H2O2 induces oxidative stress damage through the BMP\u20106\/SMAD\/hepcidin axis","volume":"62","author":"Chen","year":"2020","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.mtbio.2025.101863_bib226","article-title":"Topical metformin accelerates wound healing by promoting collagen synthesis and inhibiting apoptosis in a diabetic wound model","volume":"21","author":"Tombulturk","year":"2023","journal-title":"Int. Wound J."},{"key":"10.1016\/j.mtbio.2025.101863_bib227","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejmech.2017.09.001","article-title":"Anti-inflammatory effects of flavonoids in neurodegenerative disorders","volume":"153","author":"Spagnuolo","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.mtbio.2025.101863_bib228","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","article-title":"Targeting the Wnt\/\u03b2-catenin signaling pathway in cancer","volume":"13","author":"Zhang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.mtbio.2025.101863_bib229","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10059-010-0139-3","article-title":"Wnt\/\u03b2-Catenin signaling enhances osteoblastogenic differentiation from human periodontal ligament fibroblasts","volume":"30","author":"Heo","year":"2010","journal-title":"Mol. Cells"},{"key":"10.1016\/j.mtbio.2025.101863_bib230","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s10120-021-01180-x","article-title":"EPRS\/GluRS promotes gastric cancer development via WNT\/GSK-3\u03b2\/\u03b2-catenin signaling pathway","volume":"24","author":"Liu","year":"2021","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.mtbio.2025.101863_bib231","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4014\/jmb.2308.08013","article-title":"Low molecular weight collagen peptide (LMWCP) promotes hair growth by activating the Wnt\/GSK-3\u03b2\/\u03b2-catenin signaling pathway","volume":"34","author":"Kim","year":"2023","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.101863_bib232","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3389\/fimmu.2016.00378","article-title":"Crosstalk between Wnt\/\u03b2-catenin and NF-\u03baB signaling pathway during inflammation","volume":"7","author":"Ma","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.101863_bib233","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2021.105162","article-title":"The platelet derived growth factor BB promotes osteogenic differentiation of periodontal ligament stem cells via the Wnt\/\u03b2-catenin signaling pathway","volume":"129","author":"Deng","year":"2021","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.mtbio.2025.101863_bib234","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.ijbiomac.2021.05.122","article-title":"Insertion of gallic acid onto chitosan promotes the differentiation of osteoblasts from murine bone marrow-derived mesenchymal stem cells","volume":"183","author":"Oh","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.101863_bib235","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2174\/1574888X11666160921121555","article-title":"Bone tissue regeneration - application of mesenchymal stem cells and cellular and molecular mechanisms","volume":"12","author":"Zhang","year":"2017","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2025.101863_bib236","doi-asserted-by":"crossref","first-page":"9759","DOI":"10.3390\/ijms21249759","article-title":"Clinical application of bone marrow mesenchymal stem\/stromal cells to repair skeletal tissue","volume":"21","author":"Arthur","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib237","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13287-020-1562-9","article-title":"Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion","volume":"11","author":"Zhang","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2025.101863_bib238","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1182\/blood.V87.5.1928.1928","article-title":"Transforming growth factor-beta1: differential effects on multiple myeloma versus normal B cells","volume":"87","author":"Urashima","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.mtbio.2025.101863_bib239","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1038\/sj.onc.1204623","article-title":"The role of tumor necrosis factor \u03b1 in the pathophysiology of human multiple myeloma:: therapeutic applications","volume":"20","author":"Hideshima","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.mtbio.2025.101863_bib240","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/1471-2474-14-216","article-title":"Effect of interleukin-1\u03b2 treatment on co-cultures of human meniscus cells and bone marrow mesenchymal stromal cells","volume":"14","author":"Chowdhury","year":"2013","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.mtbio.2025.101863_bib241","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.4049\/jimmunol.1202397","article-title":"MicroRNA-146a negatively regulates the immunoregulatory activity of bone marrow stem cells by targeting prostaglandin E2 synthase-2","volume":"190","author":"Matysiak","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.mtbio.2025.101863_bib242","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biomaterials.2014.12.022","article-title":"A dual function of copper in designing regenerative implants","volume":"44","author":"Burghardt","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.101863_bib243","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13287-020-01938-7","article-title":"Stem cell therapies for periodontal tissue regeneration: a network meta-analysis of preclinical studies","volume":"11","author":"Li","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2025.101863_bib244","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/0022034514566431","article-title":"Erythropoietin promotes bone formation through EphrinB2\/EphB4 signaling","volume":"94","author":"Li","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib245","doi-asserted-by":"crossref","first-page":"550","DOI":"10.14348\/molcells.2017.0019","article-title":"Effect of FGF-2, TGF-\u03b2-1, and BMPs on teno\/ligamentogenesis and osteo\/cementogenesis of human periodontal ligament stem cells","volume":"40","author":"Hyun","year":"2017","journal-title":"Mol. Cells"},{"key":"10.1016\/j.mtbio.2025.101863_bib246","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/cbin.11202","article-title":"Metformin facilitates the proliferation, migration, and osteogenic differentiation of periodontal ligament stem cells in vitro","volume":"44","author":"Zhang","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.mtbio.2025.101863_bib247","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3727\/096368912X662426","article-title":"Scaffold-free cell pellet transplantations can Be applied to periodontal regeneration","volume":"23","author":"Guo","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.mtbio.2025.101863_bib248","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.diff.2017.08.004","article-title":"Tumor necrosis factor-\u03b1 suppresses adipogenic and osteogenic differentiation of human periodontal ligament stem cell by inhibiting miR-21\/Spry1 functional axis","volume":"97","author":"Yang","year":"2017","journal-title":"Differentiation"},{"key":"10.1016\/j.mtbio.2025.101863_bib249","doi-asserted-by":"crossref","first-page":"e2296","DOI":"10.1038\/cddis.2016.204","article-title":"Double-edged-sword effect of IL-1\u03b2 on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-\u03baB, MAPK and BMP\/Smad signaling pathways","volume":"7","author":"Mao","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2025.101863_bib250","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/ijms18051076","article-title":"Nrf2 inhibits periodontal ligament stem cell apoptosis under excessive oxidative stress","volume":"18","author":"Liu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib251","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2989076","article-title":"Effects of oxidative stress on mesenchymal stem cell biology","volume":"2016","author":"Denu","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mtbio.2025.101863_bib252","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.msec.2015.04.002","article-title":"Local administration of stromal cell-derived factor-1 promotes stem cell recruitment and bone regeneration in a rat periodontal bone defect model","volume":"53","author":"Liu","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.mtbio.2025.101863_bib253","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.compositesb.2019.01.036","article-title":"Characterization of chicken bone waste-derived hydroxyapatite and its functionality on chitosan membrane for guided bone regeneration","volume":"163","author":"Bee","year":"2019","journal-title":"Compos. Part B-Eng."},{"key":"10.1016\/j.mtbio.2025.101863_bib254","article-title":"Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection","author":"Masae","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.mtbio.2025.101863_bib255","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3389\/fphys.2017.00439","article-title":"The role of reactive oxygen species and autophagy in periodontitis and their potential linkage","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mtbio.2025.101863_bib256","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.apcsb.2019.12.001","article-title":"Roles of Porphyromonas gingivalis and its virulence factors in periodontitis","volume":"120","author":"Xu","year":"2020","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.mtbio.2025.101863_bib257","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/jre.12481","article-title":"Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide","volume":"53","author":"Lin","year":"2018","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib258","article-title":"Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel with antibacterial and anti-inflammatory effects for periodontitis treatment","volume":"16","author":"Li","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.101863_bib259","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.polymer.2015.11.016","article-title":"Fabrication and characterization of a glucose-sensitive antibacterial chitosan-polyethylene oxide hydrogel","volume":"82","author":"Xiao","year":"2016","journal-title":"Polymer"},{"key":"10.1016\/j.mtbio.2025.101863_bib260","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/0022034519831931","article-title":"MMP-8-Responsive polyethylene glycol hydrogel for intraoral drug delivery","volume":"98","author":"Guo","year":"2019","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.mtbio.2025.101863_bib261","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jdent.2018.12.011","article-title":"Nanoparticles having amphiphilic silane containing Chlorin e6 with strong anti-biofilm activity against periodontitis-related pathogens","volume":"81","author":"Sun","year":"2019","journal-title":"J. Dent."},{"key":"10.1016\/j.mtbio.2025.101863_bib262","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.2147\/IJN.S248538","article-title":"Hybrid hydrogels for synergistic periodontal antibacterial treatment with sustained drug release and NIR-responsive photothermal effect","volume":"15","author":"Lin","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.101863_bib263","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104192","article-title":"Hematoporphyrin monomethyl ether mediated sonodynamic antimicrobial chemotherapy on","volume":"144","author":"Zhang","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.mtbio.2025.101863_bib264","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.120884","article-title":"Development of novel fluorescent probes to detect and quantify specific reactive oxygen species","volume":"369","author":"Szymaszek","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.mtbio.2025.101863_bib265","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1109\/JSEN.2017.2786279","article-title":"Fiber-optic biosensor to detect pH and glucose","volume":"18","author":"Khan","year":"2018","journal-title":"IEEE Sens. J."},{"key":"10.1016\/j.mtbio.2025.101863_bib266","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2024.103360","article-title":"The application of machine learning in 3D\/4D printed stimuli-responsive hydrogels","volume":"336","author":"Ejeromedoghene","year":"2025","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2025.101863_bib267","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202200908","article-title":"Studying complex evolution of hyperelastic materials under external field stimuli using artificial neural networks with spatiotemporal features in a small-scale dataset","volume":"34","author":"Yu","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.101863_bib268","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1199230","article-title":"Lung inflammation perturbation by engineered nanoparticles","volume":"11","author":"Zhou","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.101863_bib269","doi-asserted-by":"crossref","first-page":"6045","DOI":"10.2147\/IJN.S132304","article-title":"Silica nanoparticles induce liver fibrosis via TGF-\u03b2(1)\/Smad3 pathway in ICR mice","volume":"12","author":"Yu","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.mtbio.2025.101863_bib270","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00204-021-02992-7","article-title":"Nanoparticle-induced inflammation and fibrosis in ex vivo murine precision-cut liver slices and effects of nanoparticle exposure conditions","volume":"95","author":"Bartucci","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.mtbio.2025.101863_bib271","unstructured":"FDA, Drugs@FDA: FDA-Approved Drugs. https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfm?event=overview.process&ApplNo=216720,."},{"key":"10.1016\/j.mtbio.2025.101863_bib272","doi-asserted-by":"crossref","DOI":"10.1002\/celc.202400666","article-title":"Microfluidic technology: a new strategy for controllable synthesis of metal nanomaterials","volume":"12","author":"Zhang","year":"2025","journal-title":"Chemelectrochem"},{"key":"10.1016\/j.mtbio.2025.101863_bib273","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1021\/acs.est.7b04992","article-title":"Mutual dependence of nitrogen and phosphorus as key nutrient elements: one facilitates Dolichospermum flos-aquae to overcome the limitations of the other","volume":"52","author":"Wang","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.mtbio.2025.101863_bib274","doi-asserted-by":"crossref","DOI":"10.1109\/TIM.2022.3151142","article-title":"Online monitoring system for macro-fatigue characteristics of glass fiber composite materials based on machine vision","volume":"71","author":"Song","year":"2022","journal-title":"IEEE Trans. Instrum. Meas."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425004235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425004235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:20:09Z","timestamp":1762633209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425004235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":272,"alternative-id":["S2590006425004235"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101863","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulating periodontal disease with smart stimuli-responsive systems: Antimicrobial activity, immunomodulation, periodontium regeneration","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101863"}}