{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:48:16Z","timestamp":1784594896365,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.mtbio.2025.101956","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T11:16:50Z","timestamp":1749295010000},"page":"101956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Application of PVA hydrogel loaded with luteolin nanoparticles in anti EMT treatment after GBM"],"prefix":"10.1016","volume":"33","author":[{"given":"Long","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renfu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3594-2913","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.101956_bib1","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noad149","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2016-2020","volume":"25","author":"Ostrom","year":"2023","journal-title":"Neuro Oncol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101956_bib2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1056\/NEJMoa1716435","article-title":"Recurrent glioblastoma treated with recombinant poliovirus","volume":"379","author":"Desjardins","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.mtbio.2025.101956_bib3","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1200\/JCO.2017.73.0119","article-title":"Adult glioblastoma","volume":"35","author":"Alexander","year":"2017","journal-title":"J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101956_bib4","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.drudis.2019.03.008","article-title":"Therapy for glioblastoma: is it working?","volume":"24","author":"Zanders","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.mtbio.2025.101956_bib5","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.biopha.2017.05.125","article-title":"Current status and future therapeutic perspectives of glioblastoma multiforme (GBM) therapy: a review","volume":"92","author":"Anjum","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2025.101956_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neuroscience.2022.03.030","article-title":"Recent advances in the therapeutic strategies of glioblastoma multiforme","volume":"491","author":"Aldoghachi","year":"2022","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.mtbio.2025.101956_bib7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101956_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.4103\/jomfp.jomfp_308_22","article-title":"Epithelial-mesenchymal transition in cancer stem cells: therapeutic implications","volume":"27","author":"Varun","year":"2023","journal-title":"J. Oral Maxillofac. Pathol."},{"issue":"11","key":"10.1016\/j.mtbio.2025.101956_bib9","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/14737175.2016.1202761","article-title":"Blood-brain barrier, cytotoxic chemotherapies and glioblastoma","volume":"16","author":"Dr\u00e9an","year":"2016","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.mtbio.2025.101956_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116113","article-title":"Lipid-based nanoparticles to address the limitations of GBM therapy by overcoming the blood-brain barrier, targeting glioblastoma stem cells, and counteracting the immunosuppressive tumor microenvironment","volume":"171","author":"Zhao","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2025.101956_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2015.02.002","article-title":"Overcoming the blood-brain tumor barrier for effective glioblastoma treatment","volume":"19","author":"Gooijer","year":"2015","journal-title":"Drug Resist. Updates"},{"issue":"11","key":"10.1016\/j.mtbio.2025.101956_bib12","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.trecan.2020.06.005","article-title":"Targeting EMT in cancer with repurposed metabolic inhibitors","volume":"6","author":"Ramesh","year":"2020","journal-title":"Trends Cancer"},{"issue":"18","key":"10.1016\/j.mtbio.2025.101956_bib13","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108647","article-title":"Dynamic EMT: a multi-tool for tumor progression","volume":"40","author":"Brabletz","year":"2021","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101956_bib14","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3390\/ijms19041115","article-title":"Migration\/invasion of malignant gliomas and implications for therapeutic treatment","volume":"19","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt 2","key":"10.1016\/j.mtbio.2025.101956_bib15","first-page":"136","article-title":"TGF-\u03b2 in developmental and fibrogenic EMTs","volume":"86","author":"Lee","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-023-05099-7","article-title":"Wnt\/\u03b2-catenin-driven EMT regulation in human cancers","volume":"81","author":"Xue","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/1389200221666200122120625","article-title":"Prognostic role of hedgehog-GLI1 signaling pathway in aggressive and metastatic breast cancers","volume":"21","author":"Rokkam","year":"2020","journal-title":"Curr. Drug Metabol."},{"issue":"7\u20138","key":"10.1016\/j.mtbio.2025.101956_bib18","article-title":"ROS-Nrf2 pathway mediates the development of TGF-\u03b21-induced epithelial-mesenchymal transition through the activation of Notch signaling","volume":"100","author":"Yazaki","year":"2021","journal-title":"Eur. J. Cell Biol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13046-020-01690-z","article-title":"TM4SF1 promotes EMT and cancer stemness via the Wnt\/\u03b2-catenin\/SOX2 pathway in colorectal cancer","volume":"39","author":"Tang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13046-020-01808-3","article-title":"Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b\/\u03b2-catenin\/c-Myc signaling and reprogramming glycolysis","volume":"40","author":"Jiang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101956_bib21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1142\/S0192415X20500354","article-title":"Cinobufacini inhibits colon cancer invasion and metastasis via suppressing wnt\/\u03b2-catenin signaling pathway and EMT","volume":"48","author":"Wang","year":"2020","journal-title":"Am. J. Chin. Med."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101956_bib22","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1365-2559.2012.04326.x","article-title":"Cyclin D1, E-cadherin and beta-catenin expression in FIGO Stage IA cervical squamous carcinoma: diagnostic value and evidence for epithelial-mesenchymal transition","volume":"61","author":"Koay","year":"2012","journal-title":"Histopathology (Oxf.)"},{"issue":"7","key":"10.1016\/j.mtbio.2025.101956_bib23","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1002\/ptr.8217","article-title":"Luteolin: a promising multifunctional natural flavonoid for human diseases","volume":"38","author":"Zhu","year":"2024","journal-title":"Phytother Res."},{"issue":"7","key":"10.1016\/j.mtbio.2025.101956_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e28919","article-title":"A Chinese classical prescription Xuefu Zhuyu decoction in the treatment of coronary heart disease: an overview","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.mtbio.2025.101956_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/1541-4337.13307","article-title":"Flavonoids and phenolic acids from sugarcane: distribution in the plant, changes during processing, and potential benefits to industry and health","volume":"23","author":"Hewawansa","year":"2024","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/138955709787001712","article-title":"Distribution and biological activities of the flavonoid luteolin","volume":"9","author":"L\u00f3pez-L\u00e1zaro","year":"2009","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.mtbio.2025.101956_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1430564","article-title":"Antibacterial activity and mechanism of luteolin isolated from Lophatherum gracile Brongn. against multidrug-resistant Escherichia coli","volume":"15","author":"Ding","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13020-024-00888-z","article-title":"The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages","volume":"19","author":"Wu","year":"2024","journal-title":"Chin. Med. (Lond.)"},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40360-024-00764-4","article-title":"Effect of luteolin on oxidative stress and inflammation in the human osteoblast cell line hFOB1.19 in an inflammatory microenvironment","volume":"25","author":"Peng","year":"2024","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.mtbio.2025.101956_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3517020","article-title":"Luteolin inhibited the self-renewal and altered the polarization of primary alveolar macrophages","volume":"2022","author":"Geng","year":"2022","journal-title":"Contrast Media Mol. Imaging"},{"issue":"10","key":"10.1016\/j.mtbio.2025.101956_bib31","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.3390\/ijms24108824","article-title":"Multi-faceted role of luteolin in cancer metastasis: EMT, angiogenesis, ECM degradation and apoptosis","volume":"24","author":"Rocchetti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.mtbio.2025.101956_bib32","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ptr.8066","article-title":"Luteolin, a flavone ingredient: anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches","volume":"38","author":"Shi","year":"2024","journal-title":"Phytother Res."},{"issue":"5","key":"10.1016\/j.mtbio.2025.101956_bib33","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00280-017-3299-4","article-title":"Luteolin induces apoptosis by ROS\/ER stress and mitochondrial dysfunction in gliomablastoma","volume":"79","author":"Wang","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.101956_bib34","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/bcpt.13077","article-title":"Luteolin decreases epidermal growth factor receptor-mediated cell proliferation and induces apoptosis in glioblastoma cell lines","volume":"123","author":"Anson","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.101956_bib35","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/ptr.6273","article-title":"HIF-1\u03b1\/VEGF signaling-mediated epithelial-mesenchymal transition and angiogenesis is critically involved in anti-metastasis effect of luteolin in melanoma cells","volume":"33","author":"Li","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.mtbio.2025.101956_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110462","article-title":"Luteolin suppresses epithelial-mesenchymal transition and migration of triple-negative breast cancer cells by inhibiting YAP\/TAZ activity","volume":"129","author":"Cao","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2025.101956_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jprot.2017.04.005","article-title":"Luteolin inhibits colorectal cancer cell epithelial-to-mesenchymal transition by suppressing CREB1 expression revealed by comparative proteomics study","volume":"161","author":"Liu","year":"2017","journal-title":"J. Proteonomics"},{"issue":"39","key":"10.1016\/j.mtbio.2025.101956_bib38","doi-asserted-by":"crossref","first-page":"11676","DOI":"10.1021\/acs.jafc.1c02898","article-title":"Evaluation of blood-brain barrier permeability of polyphenols, anthocyanins, and their metabolites","volume":"69","author":"Shimazu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.mtbio.2025.101956_bib39","article-title":"Ursolic acid nanoparticles for glioblastoma therapy","volume":"50","author":"Li","year":"2023","journal-title":"Nanomedicine."},{"issue":"4","key":"10.1016\/j.mtbio.2025.101956_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14528","article-title":"Self-Assembled nanoparticles of natural bioactive molecules enhance the delivery and efficacy of paclitaxel in glioblastoma","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib41","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1186\/s12951-024-02866-x","article-title":"Brain-targeted ursolic acid nanoparticles for anti-ferroptosis therapy in subarachnoid hemorrhage","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.101956_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12951-022-01238-7","article-title":"Betulinic acid self-assembled nanoparticles for effective treatment of glioblastoma","volume":"20","author":"Li","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.101956_bib43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2016.09.034","article-title":"Anticancer drug-loaded hydrogels as drug delivery systems for the local treatment of glioblastoma","volume":"243","author":"Bastiancich","year":"2016","journal-title":"J. Contr. Release"},{"issue":"6","key":"10.1016\/j.mtbio.2025.101956_bib44","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3390\/gels10060404","article-title":"Advances in hydrogels of drug delivery systems for the local treatment of brain tumors","volume":"10","author":"Yang","year":"2024","journal-title":"Gels"},{"key":"10.1016\/j.mtbio.2025.101956_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2024.1376799","article-title":"Construction methods and biomedical applications of PVA-based hydrogels","volume":"12","author":"Zhong","year":"2024","journal-title":"Front. Chem."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425005265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425005265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:25:09Z","timestamp":1762633509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425005265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":45,"alternative-id":["S2590006425005265"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101956","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of PVA hydrogel loaded with luteolin nanoparticles in anti EMT treatment after GBM","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.101956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101956"}}