{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:38:04Z","timestamp":1780450684950,"version":"3.54.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060403"],"award-info":[{"award-number":["82060403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.mtbio.2025.102027","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T16:31:02Z","timestamp":1751387462000},"page":"102027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration"],"prefix":"10.1016","volume":"33","author":[{"given":"Jiangminghao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peichuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanfeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-1499","authenticated-orcid":false,"given":"Xigao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"S2","key":"10.1016\/j.mtbio.2025.102027_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00586-013-2781-x","article-title":"Prevalence of cervical spondylotic myelopathy","volume":"24","author":"Boogaarts","year":"2013","journal-title":"Eur. Spine J."},{"issue":"10137","key":"10.1016\/j.mtbio.2025.102027_bib2","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","article-title":"What low back pain is and why we need to pay attention","volume":"391","author":"Hartvigsen","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2025.102027_bib3","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.2147\/JPR.S180018","article-title":"Cervical disc degeneration and neck pain","volume":"11","author":"Peng","year":"2018","journal-title":"J. Pain Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of cytokines in intervertebral disc degeneration: pain and disc content","volume":"10","author":"Risbud","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A new immunometabolic perspective of intervertebral disc degeneration","volume":"18","author":"Francisco","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3S","key":"10.1016\/j.mtbio.2025.102027_bib6","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1093\/neuros\/nyw078","article-title":"Intervertebral disk degeneration and repair","volume":"80","author":"Dowdell","year":"2017","journal-title":"Neurosurgery"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-020-00125-x","article-title":"Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions","volume":"9","author":"Lyu","year":"2021","journal-title":"Bone Research"},{"issue":"23","key":"10.1016\/j.mtbio.2025.102027_bib8","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1097\/01.brs.0000146499.97948.52","article-title":"Nutrition of the intervertebral disc","volume":"29","author":"Urban","year":"2004","journal-title":"Spine"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102027_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s40610-018-0105-y","article-title":"Contribution of the endplates to disc degeneration","volume":"4","author":"Fields","year":"2018","journal-title":"Current Molecular Biology Reports"},{"issue":"9","key":"10.1016\/j.mtbio.2025.102027_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrrheum.2014.91","article-title":"Intervertebral disc regeneration: do nutrients lead the way?","volume":"10","author":"Huang","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"issue":"8","key":"10.1016\/j.mtbio.2025.102027_bib11","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/jbmr.4009","article-title":"Intervertebral disc degeneration is associated with aberrant endplate remodeling and reduced small molecule transport","volume":"35","author":"Ashinsky","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-023-00307-3","article-title":"A new perspective on intervertebral disc Calcification\u2014from bench to bedside","volume":"12","author":"Novais","year":"2024","journal-title":"Bone Research"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102027_bib13","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jbiomech.2016.01.007","article-title":"Human cartilage endplate permeability varies with degeneration and intervertebral disc site","volume":"49","author":"Delucca","year":"2016","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/geno.1996.0319","article-title":"A novel human CCAAT\/enhancer binding protein gene, C\/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha\/delta locus","volume":"35","author":"Antonson","year":"1996","journal-title":"Genomics"},{"issue":"10","key":"10.1016\/j.mtbio.2025.102027_bib15","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1182\/blood-2005-09-031963","article-title":"Modulation of DNA binding properties of CCAAT\/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway","volume":"109","author":"Chumakov","year":"2007","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102027_bib16","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1182\/blood-2013-08-523233","article-title":"miRNA-130a regulates C\/EBP-\u03b5 expression during granulopoiesis","volume":"123","author":"Larsen","year":"2014","journal-title":"Blood"},{"issue":"Pt 3","key":"10.1016\/j.mtbio.2025.102027_bib17","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj20020508","article-title":"CCAAT\/enhancer-binding proteins: structure, function and regulation","volume":"365","author":"Ramji","year":"2002","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102027_bib18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41584-022-00783-7","article-title":"Mechanisms and clinical implications of intervertebral disc calcification","volume":"18","author":"Zehra","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mtbio.2025.102027_bib19","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.2147\/JIR.S415527","article-title":"Amygdalin delays cartilage endplate degeneration and improves intervertebral disc degeneration by inhibiting NF-\u03baB signaling pathway and inflammatory response","volume":"16","author":"Zeng","year":"2023","journal-title":"J. Inflamm. Res."},{"issue":"11","key":"10.1016\/j.mtbio.2025.102027_bib20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-021-00283-5","article-title":"mRNA vaccines for infectious diseases: principles, delivery and clinical translation","volume":"20","author":"Chaudhary","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mtbio.2025.102027_bib21","article-title":"CircSNHG5 sponges Mir-495-3p and modulates CITED2 to protect cartilage endplate from degradation","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2025.102027_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.etap.2016.09.015","article-title":"The biological activity of cationic liposomes in drug delivery and toxicity test in animal models","volume":"47","author":"Qi","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"16","key":"10.1016\/j.mtbio.2025.102027_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202312559","article-title":"Injectable microgels with hybrid exosomes of chondrocyte\u2010targeted FGF18 gene\u2010editing and self\u2010renewable lubrication for osteoarthritis therapy","volume":"36","author":"Chen","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.102027_bib24","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ebiom.2019.10.006","article-title":"Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9","volume":"48","author":"Jiang","year":"2019","journal-title":"EBioMedicine"},{"issue":"8","key":"10.1016\/j.mtbio.2025.102027_bib25","doi-asserted-by":"crossref","first-page":"12695","DOI":"10.1021\/acsnano.2c04420","article-title":"Lipid nanoparticle delivery of fas plasmid restores fas expression to suppress melanoma growth in vivo","volume":"16","author":"AL Subeh","year":"2022","journal-title":"ACS Nano"},{"issue":"18","key":"10.1016\/j.mtbio.2025.102027_bib26","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1097\/BRS.0b013e31817c64a9","article-title":"A simple disc degeneration model induced by percutaneous needle puncture in the rat tail","volume":"33","author":"Han","year":"2008","journal-title":"Spine"},{"issue":"6","key":"10.1016\/j.mtbio.2025.102027_bib27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3892\/etm.2020.9390","article-title":"Comprehensive evaluation of differential long non-coding RNA and gene expression in patients with cartilaginous endplate degeneration of cervical vertebra","volume":"20","author":"Yuan","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"17","key":"10.1016\/j.mtbio.2025.102027_bib28","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1097\/BRS.0000000000000372","article-title":"Molecular interactions between human cartilaginous endplates and nucleus pulposus cells","volume":"39","author":"Neidlinger-Wilke","year":"2014","journal-title":"Spine"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102027_bib29","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/jcmm.13398","article-title":"Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK\u2010ERK signalling pathway in vivo and in vitro","volume":"22","author":"Han","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"19","key":"10.1016\/j.mtbio.2025.102027_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18267","article-title":"LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2\/STAT3 pathway","volume":"28","author":"Li","year":"2024","journal-title":"J. Cell Mol. Med."},{"issue":"11","key":"10.1016\/j.mtbio.2025.102027_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau6762","article-title":"Engineering human megakaryocytic microparticles for targeted delivery of nucleic acids to hematopoietic stem and progenitor cells","volume":"4","author":"Kao","year":"2018","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.mtbio.2025.102027_bib32","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nrg1066","article-title":"Progress and problems with the use of viral vectors for gene therapy","volume":"4","author":"Thomas","year":"2003","journal-title":"Nat. Rev. Genet."},{"issue":"8","key":"10.1016\/j.mtbio.2025.102027_bib33","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrg2141","article-title":"Engineering targeted viral vectors for gene therapy","volume":"8","author":"Waehler","year":"2007","journal-title":"Nat. Rev. Genet."},{"issue":"7","key":"10.1016\/j.mtbio.2025.102027_bib34","first-page":"5530","article-title":"Delivery of Interferon \u03b2-Encoding plasmid via lipid nanoparticle restores Interferon \u03b2 expression to enhance antitumor immunity in Colon cancer","volume":"18","author":"Yang","year":"2024","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102027_bib35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41584-018-0033-5","article-title":"Molecular transport in articular cartilage \u2014 what have we learned from the past 50 years?","volume":"14","author":"Didomenico","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13476-9","article-title":"Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice","volume":"10","author":"Ni","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-021-00155-z","article-title":"PGE2\/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib","volume":"9","author":"Xue","year":"2021","journal-title":"Bone Research"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-021-00163-z","article-title":"Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs","volume":"9","author":"Gan","year":"2021","journal-title":"Bone Research"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib39","article-title":"Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degeneration","volume":"14","author":"Shi","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102027_bib40","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1146\/annurev.bi.58.070189.004055","article-title":"Eukaryotic transcriptional regulatory proteins","volume":"58","author":"Johnson","year":"1989","journal-title":"Annu. Rev. Biochem."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102027_bib41","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/j.1460-2075.1990.tb08316.x","article-title":"A nuclear factor for IL-6 expression (NF-IL6) is a member of a C\/EBP family","volume":"9","author":"Akira","year":"1990","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102027_bib42","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0092-8674(90)90459-R","article-title":"IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C\/EBP","volume":"63","author":"Poli","year":"1990","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.mtbio.2025.102027_bib43","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1101\/gad.4.9.1541","article-title":"LAP, a novel member of the C\/EBP gene family, encodes a liver-enriched transcriptional activator protein","volume":"4","author":"Descombes","year":"1990","journal-title":"Genes Dev."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102027_bib44","first-page":"6642","article-title":"Molecular cloning of a transcription factor, AGP\/EBP, that belongs to members of the C\/EBP family","volume":"10","author":"Chang","year":"1990","journal-title":"Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.mtbio.2025.102027_bib45","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1101\/gad.4.8.1404","article-title":"Ig\/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C\/EBP and heterodimerizes with C\/EBP","volume":"4","author":"Roman","year":"1990","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102027_bib46","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1101\/gad.5.9.1538","article-title":"REGULATED EXPRESSION OF THREE C\/EBP ISOFORMS DURING ADIPOSE CONVERSION OF 3T3-L1 CELLS. Regulated expression of three C\/EBP isoforms during adipose conversion of 3T3-L1 cells","volume":"5","author":"Cao","year":"1991","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102027_bib47","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1101\/gad.5.9.1553","article-title":"A family of C\/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro","volume":"5","author":"Williams","year":"1991","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102027_bib48","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1101\/gad.6.3.439","article-title":"CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C\/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription","volume":"6","author":"Ron","year":"1992","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102027_bib49","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.smim.2012.02.001","article-title":"The many roles of IL-7 in B cell development; Mediator of survival, proliferation and differentiation","volume":"24","author":"Corfe","year":"2012","journal-title":"Semin. Immunol."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102027_bib50","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.celrep.2015.12.003","article-title":"MLL-rearranged acute lymphoblastic leukemias activate BCL-2 through H3K79 methylation and are sensitive to the BCL-2-Specific antagonist ABT-199","volume":"13","author":"Benito Juliana","year":"2015","journal-title":"Cell Rep."},{"issue":"19","key":"10.1016\/j.mtbio.2025.102027_bib51","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1182\/blood-2008-07-172106","article-title":"Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia","volume":"113","author":"French","year":"2009","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.mtbio.2025.102027_bib52","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1182\/blood-2008-07-170282","article-title":"The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells","volume":"114","author":"Oehler","year":"2009","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.mtbio.2025.102027_bib53","doi-asserted-by":"crossref","first-page":"E1075","DOI":"10.1097\/BRS.0b013e31829a6930","article-title":"Extracellular signal-regulated kinase inhibition modulates Rat Annulus fibrosus cell response to Interleukin-1","volume":"38","author":"Wei","year":"2013","journal-title":"Spine"},{"issue":"9","key":"10.1016\/j.mtbio.2025.102027_bib54","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1016\/j.ajpath.2014.06.006","article-title":"Tumor necrosis Factor-\u03b1\u2013 and Interleukin-1\u03b2\u2013Dependent matrix Metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein Kinase\u2013NF-\u03baB axis","volume":"184","author":"Wang","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"33","key":"10.1016\/j.mtbio.2025.102027_bib55","doi-asserted-by":"crossref","first-page":"12097","DOI":"10.1073\/pnas.1302703111","article-title":"Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation","volume":"111","author":"Yang","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102027_bib56","article-title":"Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice","volume":"10","author":"Warman","year":"2014","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102027_bib57","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.yexcr.2007.05.015","article-title":"Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria","volume":"313","author":"Mader","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102027_bib58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1139\/o01-239","article-title":"Cancer prevention by bovine lactoferrin and underlying mechanisms \u2014 a review of experimental and clinical studies","volume":"80","author":"Tsuda","year":"2002","journal-title":"Biochem. Cell. Biol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102027_bib59","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10534-010-9390-5","article-title":"Conformational study of bovine lactoferricin in membrane-micking conditions by molecular dynamics simulation and circular dichroism","volume":"24","author":"Daidone","year":"2010","journal-title":"Biometals"},{"issue":"22","key":"10.1016\/j.mtbio.2025.102027_bib60","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1007\/s00018-005-5373-z","article-title":"Lactoferricin","volume":"62","author":"Gifford","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102027_bib61","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/jcp.24350","article-title":"Lactoferricin mediates anti\u2010inflammatory and anti\u2010catabolic effects via inhibition of IL\u20101 and LPS activity in the intervertebral disc","volume":"228","author":"Kim","year":"2013","journal-title":"J. Cell. Physiol."},{"issue":"3\u20134","key":"10.1016\/j.mtbio.2025.102027_bib62","first-page":"191","article-title":"Role of JAK\/STAT in the neuroinflammation and its association with neurological disorders","volume":"28","author":"Jain","year":"2022","journal-title":"Ann. Neurosci."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102027_bib63","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1615\/CritRevImmunol.2016015517","article-title":"Opportunities for translation from the bench: therapeutic intervention of the JAK\/STAT pathway in neuroinflammatory diseases","volume":"35","author":"Liu","year":"2015","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2025.102027_bib64","article-title":"HSP90 inhibitor 17-AAG attenuates nucleus pulposus inflammation and catabolism induced by M1-Polarized macrophages","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2025.102027_bib65","first-page":"141","article-title":"Targeting STAT3 signaling pathway in the treatment of Alzheimer's disease with compounds from natural products","author":"Wen","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.mtbio.2025.102027_bib66","article-title":"Basic mechanisms of JAK inhibition","volume":"31","author":"Isaacs","year":"2020","journal-title":"Mediterranean Journal of Rheumatology"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102027_bib67","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/annrheumdis-2016-209757","article-title":"Systemic inhibition of IL-6\/Stat3 signalling protects against experimental osteoarthritis","volume":"76","author":"Latourte","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.mtbio.2025.102027_bib68","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.apsb.2019.01.015","article-title":"Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-\u03baB\/MAPK signaling and protecting chondrocytes","volume":"9","author":"Zhou","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2025.102027_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.669213","article-title":"Angelicin alleviates post-trauma osteoarthritis progression by regulating macrophage polarization via STAT3 signaling pathway","volume":"12","author":"Tian","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425005976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425005976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:32:37Z","timestamp":1778905957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425005976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":69,"alternative-id":["S2590006425005976"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102027","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102027"}}