{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:47:27Z","timestamp":1792813647041,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1\\u2013052"],"award-info":[{"award-number":["2021-I2M-1\\u2013052"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371796"],"award-info":[{"award-number":["82371796"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["3332024056"],"award-info":[{"award-number":["3332024056"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1107800"],"award-info":[{"award-number":["2024YFA1107800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008436","name":"National Foundation for Medical Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7244400"],"award-info":[{"award-number":["7244400"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.mtbio.2025.102105","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:43:13Z","timestamp":1752712993000},"page":"102105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Integrated bioprinting of trachea-like structures based on tissue-specific bioink"],"prefix":"10.1016","volume":"34","author":[{"given":"Tianfeng","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-372X","authenticated-orcid":false,"given":"Haiyue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4065-3060","authenticated-orcid":false,"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mtbio.2025.102105_bib1","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/S0003-4975(02)03564-6","article-title":"Tracheal replacement: a critical review","volume":"73","author":"Grillo","year":"2002","journal-title":"Ann. Thorac. Surg."},{"issue":"5","key":"10.1016\/j.mtbio.2025.102105_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/TP.0b013e3181cd4ad3","article-title":"Tissue-engineered tracheal transplantation","volume":"89","author":"Baiguera","year":"2010","journal-title":"Transplantation"},{"issue":"9846","key":"10.1016\/j.mtbio.2025.102105_bib3","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0140-6736(12)60737-5","article-title":"Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study","volume":"380","author":"Elliott","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.mtbio.2025.102105_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1053\/j.sempedsurg.2014.04.002","article-title":"Stem cell-based organ replacements-airway and lung tissue engineering","volume":"23","author":"Fishman","year":"2014","journal-title":"Semin. Pediatr. Surg."},{"issue":"21","key":"10.1016\/j.mtbio.2025.102105_bib5","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1056\/NEJMc1206319","article-title":"Bioresorbable airway splint created with a three-dimensional printer","volume":"368","author":"Zopf","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102105_bib6","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/sctm.16-0443","article-title":"Tracheal replacement therapy with a stem cell-seeded graft: lessons from compassionate use application of a GMP-compliant tissue-engineered medicine","volume":"6","author":"Elliott","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.mtbio.2025.102105_bib7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102105_bib8","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.3390\/ijms24043451","article-title":"Chondroitin sulfate-tyramine-based hydrogels for cartilage tissue repair","volume":"24","author":"Uzieliene","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.mtbio.2025.102105_bib9","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/nprot.2011.379","article-title":"Materials fabrication from Bombyx mori silk fibroin","volume":"6","author":"Rockwood","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mtbio.2025.102105_bib10","article-title":"Crosslinker-free silk\/decellularized extracellular matrix porous bioink for 3D bioprinting-based cartilage tissue engineering. Materials science & engineering","volume":"118","author":"Zhang","year":"2021","journal-title":"C, Materials for biological applications"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102105_bib11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12951-025-03328-8","article-title":"Decellularized extracellular matrix-loaded exosome hydrogel for cell-free tracheal scaffold in tracheal defect reconstruction and repair","volume":"23","author":"Shen","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"42","key":"10.1016\/j.mtbio.2025.102105_bib12","article-title":"Volumetric bioprinting of complex living-tissue constructs within seconds","volume":"31","author":"Bernal","year":"2019","journal-title":"Advanced materials (Deerfield Beach, Fla.)"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102105_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biomaterials.2013.09.078","article-title":"The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability","volume":"35","author":"Billiet","year":"2014","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.mtbio.2025.102105_bib14","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/jbm.a.34420","article-title":"3D bioprinting of heterogeneous aortic valve conduits with alginate\/gelatin hydrogels","volume":"101","author":"Duan","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102105_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70086-y","article-title":"3D bioprinting of cells, tissues and organs","volume":"10","author":"Dey","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102105_bib16","first-page":"267","article-title":"Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration","volume":"18","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102105_bib17","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1073\/pnas.1521342113","article-title":"Three-dimensional bioprinting of thick vascularized tissues","volume":"113","author":"Kolesky","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102105_bib18","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1021\/bm801463q","article-title":"Evaluation of photocrosslinked lutrol hydrogel for tissue printing applications","volume":"10","author":"Fedorovich","year":"2009","journal-title":"Biomacromolecules"},{"issue":"5","key":"10.1016\/j.mtbio.2025.102105_bib19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.drudis.2020.03.002","article-title":"Organotypic cancer tissue models for drug screening: 3D constructs, bioprinting and microfluidic chips","volume":"25","author":"Radhakrishnan","year":"2020","journal-title":"Drug Discov. Today"},{"issue":"2","key":"10.1016\/j.mtbio.2025.102105_bib20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/0115665232262167231012102837","article-title":"Applications of scaffolds in tissue engineering: current utilization and future prospective","volume":"24","author":"Yadav","year":"2024","journal-title":"Curr. Gene Ther."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102105_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12015-019-09935-x","article-title":"Advances in pluripotent stem cells: history, mechanisms, technologies, and applications","volume":"16","author":"Liu","year":"2020","journal-title":"Stem Cell Rev Rep"},{"issue":"46","key":"10.1016\/j.mtbio.2025.102105_bib22","doi-asserted-by":"crossref","first-page":"17266","DOI":"10.1073\/pnas.0608156103","article-title":"Self-renewal of embryonic stem cells by a small molecule","volume":"103","author":"Chen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mtbio.2025.102105_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119536","article-title":"Progress in 3D bioprinting technology for tissue\/organ regenerative engineering","volume":"226","author":"Matai","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102105_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ebiom.2018.01.011","article-title":"In vitro regeneration of patient-specific ear-shaped cartilage and its first clinical application for auricular reconstruction","volume":"28","author":"Zhou","year":"2018","journal-title":"EBioMedicine"},{"issue":"29","key":"10.1016\/j.mtbio.2025.102105_bib25","article-title":"Functional trachea reconstruction using 3D-Bioprinted native-like tissue architecture based on designable tissue-specific bioinks","volume":"9","author":"Huo","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2025.102105_bib26","first-page":"52","article-title":"Instant trachea reconstruction using 3D-bioprinted C-shape biomimetic trachea based on tissue-specific matrix hydrogels","volume":"32","author":"Sun","year":"2023","journal-title":"Bioact. Mater."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102105_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/gels9020103","article-title":"Nanocomposite bioprinting for tissue engineering applications","volume":"9","author":"Loukelis","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.mtbio.2025.102105_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/20417314241309183","article-title":"3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models","volume":"15","author":"Zhang","year":"2024","journal-title":"J. Tissue Eng."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102105_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201601451","article-title":"Extrusion bioprinting of shear-thinning gelatin methacryloyl bioinks","volume":"6","author":"Liu","year":"2017","journal-title":"Adv. Healthcare Mater."},{"issue":"15","key":"10.1016\/j.mtbio.2025.102105_bib30","article-title":"Spatial-selective volumetric 4D printing and single-photon grafting of biomolecules within centimeter-scale hydrogels via tomographic manufacturing","volume":"8","author":"Falandt","year":"2023","journal-title":"Adv Mater Technol"},{"key":"10.1016\/j.mtbio.2025.102105_bib31","article-title":"Precision repair of zone-specific meniscal injuries using a tunable extracellular matrix-based hydrogel system","volume":"2024","author":"Lee","year":"2024","journal-title":"Preprint. bioRxiv."},{"issue":"Pt 2","key":"10.1016\/j.mtbio.2025.102105_bib32","article-title":"Injectable and self-healing sulfated hyaluronic acid\/gelatin hydrogel as dual drug delivery system for circumferential tracheal repair","volume":"279","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102105_bib33","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ab8753","article-title":"Nanoclay-based 3D printed scaffolds promote vascular ingrowth ex vivo and generate bone mineral tissue in vitro and in vivo","volume":"12","author":"Cidonio","year":"2020","journal-title":"Biofabrication"},{"key":"10.1016\/j.mtbio.2025.102105_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1187500","article-title":"Development of tissue-engineered tracheal scaffold with refined mechanical properties and vascularisation for tracheal regeneration","volume":"11","author":"Khalid","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102105_bib35","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2217\/rme-2020-0091","article-title":"Vascularization strategies for tissue engineering for tracheal reconstruction","volume":"16","author":"Sun","year":"2021","journal-title":"Regen. Med."},{"key":"10.1016\/j.mtbio.2025.102105_bib36","first-page":"1170","article-title":"Advances in cartilage tissue regeneration: a review of stem cell therapies, tissue engineering, biomaterials, and clinical trials","volume":"23","author":"Skoracka","year":"2024","journal-title":"EXCLI J"},{"issue":"2","key":"10.1016\/j.mtbio.2025.102105_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3727\/096368912X653147","article-title":"Evaluation of the use of induced pluripotent stem cells (iPSCs) for the regeneration of tracheal cartilage","volume":"22","author":"Imaizumi","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.mtbio.2025.102105_bib38","article-title":"Genipin cross-linked decellularized tracheal tubular matrix for tracheal tissue engineering applications","volume":"6","author":"Sun","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.mtbio.2025.102105_bib39","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3390\/bioengineering11080832","article-title":"Long-term survival and regeneration following transplantation of 3D-Printed biodegradable PCL tracheal grafts in large-scale porcine models","volume":"11","author":"Shai","year":"2024","journal-title":"Bioengineering (Basel)"},{"issue":"5","key":"10.1016\/j.mtbio.2025.102105_bib40","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ab2a6c","article-title":"Development of a flexible 3D printed scaffold with a cell-adhesive surface for artificial trachea","volume":"14","author":"Ahn","year":"2019","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.mtbio.2025.102105_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.actbio.2021.01.044","article-title":"A flexible porous chiral auxetic tracheal stent with ciliated epithelium","volume":"124","author":"Liu","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102105_bib42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2022.11.015","article-title":"Multifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair","volume":"155","author":"Gao","year":"2023","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.mtbio.2025.102105_bib43","article-title":"Inflammation-controlled anti-inflammatory hydrogels","volume":"10","author":"Helmecke","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"43","key":"10.1016\/j.mtbio.2025.102105_bib44","article-title":"Digitally tunable microfluidic bioprinting of multilayered cannular tissues","volume":"30","author":"Pi","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.102105_bib45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijporl.2018.11.010","article-title":"A 3-dimensional bioprinted tracheal segment implant pilot study: rabbit tracheal resection with graft implantation","volume":"117","author":"Kaye","year":"2019","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102105_bib46","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.mtbio.2025.102105_bib47","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmat4051","article-title":"Interplay of matrix stiffness and protein tethering in stem cell differentiation","volume":"13","author":"Wen","year":"2014","journal-title":"Nat. Mater."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425006751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425006751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:37:10Z","timestamp":1772768230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425006751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":47,"alternative-id":["S2590006425006751"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102105","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated bioprinting of trachea-like structures based on tissue-specific bioink","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102105"}}