{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:20:31Z","timestamp":1788542431050,"version":"build-2803163510"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["PY2024011"],"award-info":[{"award-number":["PY2024011"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301029"],"award-info":[{"award-number":["82301029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011487"],"award-info":[{"award-number":["2024A1515011487"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110175"],"award-info":[{"award-number":["2022A1515110175"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["SL2023A04J02147"],"award-info":[{"award-number":["SL2023A04J02147"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2025GXNSFBA069474"],"award-info":[{"award-number":["2025GXNSFBA069474"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025T180493"],"award-info":[{"award-number":["2025T180493"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M761343"],"award-info":[{"award-number":["2024M761343"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.mtbio.2025.102160","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T15:15:19Z","timestamp":1753974919000},"page":"102160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Delivered baicalein immunomodulatory hydrogel with dual properties of pH-responsive and anti-infection orchestrates pro-regenerative response of macrophages for enhanced hypertrophic scars therapy"],"prefix":"10.1016","volume":"34","author":[{"given":"Fengqing","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-5752","authenticated-orcid":false,"given":"Yanling","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-3961","authenticated-orcid":false,"given":"Yinghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8742-4188","authenticated-orcid":false,"given":"Leiguo","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-5188","authenticated-orcid":false,"given":"Ronghua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.102160_bib1","article-title":"The role of macrophages in hypertrophic scarring: molecular to therapeutic insights","volume":"16","author":"Shen","year":"2025","journal-title":"Front. Immun."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41702-020-00063-8","article-title":"Hypertrophic scars and keloids: a review and current treatment modalities","volume":"4","author":"Tripathi","year":"2020","journal-title":"Biomed. Dermatol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102160_bib3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/ijms19030711","article-title":"Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102160_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/wound.2013.0485","article-title":"Extracellular matrix reorganization during wound healing and its impact on abnormal scarring","volume":"4","author":"Xue","year":"2015","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.mtbio.2025.102160_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110287","article-title":"Current potential therapeutic strategies targeting the TGF-\u03b2\/Smad signaling pathway to attenuate keloid and hypertrophic scar formation","volume":"129","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102160_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101530","article-title":"The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation","volume":"298","author":"Moretti","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"10052","key":"10.1016\/j.mtbio.2025.102160_bib7","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(16)31406-4","article-title":"Hypertrophic scarring: the greatest unmet challenge after burn injury","volume":"388","author":"Finnerty","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102160_bib8","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3390\/ijms18071545","article-title":"Macrophage phenotypes regulate scar formation and chronic wound healing","volume":"18","author":"Hesketh","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102160_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archfaci.10.2.93","article-title":"Epidemiology and risk factors for pathologic scarring after burn wounds","volume":"10","author":"Gangemi","year":"2008","journal-title":"Arch. Facial Plast. Surg."},{"key":"10.1016\/j.mtbio.2025.102160_bib10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.actbio.2018.12.027","article-title":"Tissue-derived microparticles reduce inflammation and fibrosis in cornea wounds","volume":"85","author":"Yin","year":"2019","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.mtbio.2025.102160_bib11","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4049\/jimmunol.0903356","article-title":"Differential roles of macrophages in diverse phases of skin repair","volume":"184","author":"Lucas","year":"2010","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102160_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/PAI.0b013e3181efa2ef","article-title":"Cell talk: a phenomenon observed in the keloid scar by immunohistochemical study","volume":"19","author":"Shaker","year":"2011","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"issue":"5","key":"10.1016\/j.mtbio.2025.102160_bib13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1365-2133.2012.11190.x","article-title":"Site-specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates","volume":"167","author":"Bagabir","year":"2012","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102160_bib14","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1189\/jlb.1012512","article-title":"Macrophage phenotypes during tissue repair","volume":"93","author":"Novak","year":"2013","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102160_bib15","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s12015-024-10806-3","article-title":"Therapeutic properties of M2 macrophages in chronic wounds: an innovative area of biomaterial-assisted M2 macrophage targeted therapy","volume":"21","author":"Nazari","year":"2024","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.mtbio.2025.102160_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.143173","article-title":"Immunoregulatory hydrogel decorated with tannic acid\/ferric ion accelerates diabetic wound healing via regulating macrophage polarization","volume":"466","author":"Xu","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2025.102160_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbac065","article-title":"Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior","volume":"9","author":"Sousa","year":"2022","journal-title":"Regen. Biomater."},{"issue":"Pt 4","key":"10.1016\/j.mtbio.2025.102160_bib18","article-title":"Injectable carboxymethyl chitosan\/konjac glucomannan\/catechin hydrogel with free radical-scavenging, antimicrobial, and pro-healing abilities for infected wound repair","volume":"308","author":"Yang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102160_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkac019","article-title":"Multifunctional chitosan\/gelatin@tannic acid cryogels decorated with in situ reduced silver nanoparticles for wound healing","volume":"10","author":"Xu","year":"2022","journal-title":"Burns Trauma"},{"issue":"8","key":"10.1016\/j.mtbio.2025.102160_bib20","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.1021\/acsnano.1c04206","article-title":"Functional hydrogels as wound dressing to enhance wound healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102160_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research","volume":"17","author":"Turner","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.mtbio.2025.102160_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/srep29707","article-title":"Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus","volume":"6","author":"Mohamed","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102160_bib23","first-page":"341","article-title":"Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing","volume":"8","author":"Yang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.102160_bib24","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jconrel.2024.03.024","article-title":"A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing","volume":"368","author":"Wang","year":"2024","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102160_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwae044","article-title":"Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing","volume":"11","author":"Yang","year":"2024","journal-title":"Natl. Sci. Rev."},{"issue":"52","key":"10.1016\/j.mtbio.2025.102160_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202412154","article-title":"LysSYL\u2010Loaded pH\u2010switchable self\u2010assembling peptide hydrogels promote Methicillin\u2010resistant Staphylococcus Aureus elimination and wound healing","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mat."},{"key":"10.1016\/j.mtbio.2025.102160_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113996","article-title":"Therapeutic applications of electrospun nanofibers impregnated with various biological macromolecules for effective wound healing strategy - a review","volume":"157","author":"Sethuram","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102160_bib28","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.3390\/molecules23092392","article-title":"Treatment strategies for infected wounds","volume":"23","author":"Negut","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.mtbio.2025.102160_bib29","doi-asserted-by":"crossref","DOI":"10.1177\/15347354251344953","article-title":"Research progress of traditional Chinese medicine monomer inhibiting metastatic colonization of ovarian cancer cells based on cell biology","volume":"24","author":"Wang","year":"2025","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.mtbio.2025.102160_bib30","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.2147\/DDDT.S514042","article-title":"Comprehensive treatment of functional dyspepsia using traditional Chinese medicine: a review based on pathophysiological perspectives","volume":"19","author":"Fan","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.mtbio.2025.102160_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104939","article-title":"Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)","volume":"158","author":"Huang","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"48","key":"10.1016\/j.mtbio.2025.102160_bib32","doi-asserted-by":"crossref","first-page":"56944","DOI":"10.1021\/acsami.1c17420","article-title":"Dual-targeted nanoplatform regulating the bone immune microenvironment enhances fracture healing","volume":"13","author":"Zhou","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.102160_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/09603271241249990","article-title":"Baicalein exerts beneficial effects in lipopolysaccharide-induced pulmonary inflammation by modulating macrophage polarization and inhibiting pyroptosis","volume":"43","author":"Kou","year":"2024","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.mtbio.2025.102160_bib34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3389\/fchem.2020.00787","article-title":"Deliver anti-inflammatory drug baicalein to macrophages by using a crystallization strategy","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Chem."},{"issue":"10","key":"10.1016\/j.mtbio.2025.102160_bib35","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1111\/cas.14577","article-title":"Baicalein inhibits non-small-cell lung cancer invasion and metastasis by reducing ezrin tension in inflammation microenvironment","volume":"111","author":"Zhang","year":"2020","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib36","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1080\/21691401.2019.1645150","article-title":"Baicalein inhibits proliferation and collagen synthesis of mice fibroblast cell line NIH\/3T3 by regulation of miR-9\/insulin-like growth factor-1 axis","volume":"47","author":"Yang","year":"2019","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/bjd.14108","article-title":"Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor-\u03b2\/Smad2\/3 signalling pathway","volume":"174","author":"Zhang","year":"2016","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib38","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41392-021-00830-x","article-title":"Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102160_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404274","article-title":"NIR-light activable 3D printed platform nanoarchitectured with electrospun plasmonic filaments for on demand treatment of infected wounds","volume":"14","author":"Rybak","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.mtbio.2025.102160_bib40","article-title":"Emerging trends in the application of hydrogel-based biomaterials for enhanced wound healing: a literature review","volume":"261","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/gels10010043","article-title":"Hydrogels and wound healing: current and future prospects","volume":"10","author":"Gounden","year":"2024","journal-title":"Gels"},{"issue":"6","key":"10.1016\/j.mtbio.2025.102160_bib42","first-page":"383","article-title":"Injectable biopolymer-based hydrogels: a next-generation platform for minimally invasive therapeutics","volume":"11","author":"Parvin","year":"2025","journal-title":"Gels (Basel, Switzerland)"},{"key":"10.1016\/j.mtbio.2025.102160_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113897","article-title":"Injectable hydrogel-based drug formulation for enhancing tertiary lymphoid structure formation and cancer immunotherapy efficacy","volume":"384","author":"Kuwentrai","year":"2025","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.mtbio.2025.102160_bib44","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1021\/acs.chemmater.2c00188","article-title":"Recent advances in hydrogels","volume":"34","author":"Yang","year":"2022","journal-title":"Chem. Mater."},{"key":"10.1016\/j.mtbio.2025.102160_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2024.113610","article-title":"Injectable hydrogel formulations: design, synthesis and applications for subcutaneous delivery -a comprehensive review","volume":"222","author":"Sarvepalli","year":"2025","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.mtbio.2025.102160_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2025.109588","article-title":"Biological effects of chitosan oligosaccharides on the skin and their clinical applicability","volume":"555","author":"Lee","year":"2025","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.mtbio.2025.102160_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121394","article-title":"Chitosan scaffolds: expanding horizons in biomedical applications","volume":"323","author":"Gholap","year":"2024","journal-title":"Carbohydr. Polym."},{"issue":"7","key":"10.1016\/j.mtbio.2025.102160_bib48","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/17425247.2017.1247803","article-title":"Controlled local drug delivery strategies from chitosan hydrogels for wound healing","volume":"14","author":"Elviri","year":"2017","journal-title":"Expert. Opin. Drug Delivery"},{"key":"10.1016\/j.mtbio.2025.102160_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125250","article-title":"Chitosan-based hydrogel wound dressing: from mechanism to applications, a review","volume":"244","author":"Zhao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102160_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122262","article-title":"Borate bonds-containing pH-responsive chitosan hydrogel for postoperative tumor recurrence and wound infection prevention","volume":"339","author":"Yu","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102160_bib51","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijbiomac.2021.08.006","article-title":"Dual antioxidant-photosensitizing hydrogel system: cross-linking of chitosan with tannic acid for enhanced photodynamic efficacy","volume":"188","author":"Azadikhah","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102160_bib52","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.actbio.2024.06.027","article-title":"A ROS-responsive and scavenging hydrogel for postoperative abdominal adhesion prevention","volume":"184","author":"Zhang","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102160_bib53","article-title":"Inflammatory microenvironment of skin wounds","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.102160_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120534","article-title":"Covalent grafting of hyperbranched poly-L-lysine on Ti-based implants achieves dual functions of antibacteria and promoted osteointegration in vivo","volume":"269","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102160_bib55","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1111\/j.1524-475X.2007.00224.x","article-title":"Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction","volume":"15","author":"Kloeters","year":"2007","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13287-020-02061-3","article-title":"Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2025.102160_bib57","first-page":"269","article-title":"A tough, antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds","volume":"34","author":"Liu","year":"2024","journal-title":"Bioact. Mater."},{"issue":"43","key":"10.1016\/j.mtbio.2025.102160_bib58","article-title":"A new strategy to inhibit scar formation by accelerating normal healing using silicate bioactive materials","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/archfaci.2011.62","article-title":"Comparison of effectiveness of silicone gel sheeting with microporous paper tape in the prevention of hypertrophic scarring in a rabbit model","volume":"14","author":"Tollefson","year":"2012","journal-title":"Arch. Facial Plast. Surg."},{"key":"10.1016\/j.mtbio.2025.102160_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.743837","article-title":"Baicalein potentiated M1 macrophage polarization in cancer through targeting PI3K\u03b3\/NF-\u03baB signaling","volume":"12","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib61","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1186\/s12903-024-04740-6","article-title":"Investigation of the mechanism of baicalein in the treatment of periodontitis based on network pharmacology, molecular docking and experimental validation","volume":"24","author":"Liu","year":"2024","journal-title":"BMC Oral Health"},{"issue":"11","key":"10.1016\/j.mtbio.2025.102160_bib62","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102160_bib63","first-page":"516","article-title":"Targeting dipeptidyl peptidase-8\/9 to combat inflammation-induced osteoclastogenesis in RAW264.7 macrophages and analysis of anti-osteoclastogenesis potential of chrysin, Iran","volume":"28","author":"Ahmad","year":"2025","journal-title":"J. Basic Med. Sci."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102160_bib64","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.7150\/thno.15156","article-title":"Phenylboronic acid-mediated tumor targeting of chitosan nanoparticles","volume":"6","author":"Wang","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.102160_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118642","article-title":"Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: an overview","volume":"570","author":"Zhao","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.mtbio.2025.102160_bib66","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/acs.biomac.9b01732","article-title":"Injectable antimicrobial conductive hydrogels for wound disinfection and infectious wound healing","volume":"21","author":"Liang","year":"2020","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.mtbio.2025.102160_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122232","article-title":"Functional hydrogel-based wound dressings: a review on biocompatibility and therapeutic efficacy","volume":"334","author":"Nasra","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.mtbio.2025.102160_bib68","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ijbiomac.2022.03.002","article-title":"Recent progress of collagen, chitosan, alginate and other hydrogels in skin repair and wound dressing applications","volume":"208","author":"Peng","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102160_bib69","article-title":"A tough synthetic hydrogel with excellent post-loading of drugs for promoting the healing of infected wounds in vivo, Biomater","volume":"134","author":"Deng","year":"2022","journal-title":"Adv"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib70","first-page":"72","article-title":"Current progress on biological evaluation for medical devices","volume":"45","author":"Liu","year":"2021","journal-title":"Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation"},{"key":"10.1016\/j.mtbio.2025.102160_bib71","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.2147\/CCID.S489625","article-title":"Effects of cell-free fat extract and platelet-rich fibrin on scar maturation in an experimental rabbit ear wound model","volume":"17","author":"Wei","year":"2024","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00006534-200207000-00029","article-title":"Effect of Mederma on hypertrophic scarring in the rabbit ear model","volume":"110","author":"Saulis","year":"2002","journal-title":"Plast. Reconstr. Surg."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102160_bib73","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00006534-199709000-00021","article-title":"Acute and chronic animal models for excessive dermal scarring: quantitative studies","volume":"100","author":"Morris","year":"1997","journal-title":"Plast. Reconstr. Surg."},{"issue":"13","key":"10.1016\/j.mtbio.2025.102160_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33802","article-title":"Isorhamnetin inhibits hypertrophic scar formation through TGF-\u03b21\/Smad and TGF-\u03b21\/CREB3L1 signaling pathways","volume":"10","author":"Wu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.mtbio.2025.102160_bib75","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.addr.2018.08.009","article-title":"Current and upcoming therapies to modulate skin scarring and fibrosis","volume":"146","author":"Coentro","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102160_bib76","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-Catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.mtbio.2025.102160_bib77","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.3892\/mmr.2017.6992","article-title":"ATF3 promotes migration and M1\/M2 polarization of macrophages by activating tenascin-C via Wnt\/\u03b2-catenin pathway","volume":"16","author":"Sha","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mtbio.2025.102160_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117925","article-title":"Zoledronic acid inhibits thyroid cancer stemness and metastasis by repressing M2-like tumor-associated macrophages induced Wnt\/\u03b2-catenin pathway","volume":"256","author":"Lv","year":"2020","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103639","article-title":"Therapeutic exosomal vaccine for enhanced cancer immunotherapy by mediating tumor microenvironment","volume":"25","author":"Lv","year":"2022","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102160_bib80","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1681\/ASN.2017040391","article-title":"Wnt\/\u03b2-Catenin-promoted macrophage alternative activation contributes to kidney fibrosis","volume":"29","author":"Feng","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"8","key":"10.1016\/j.mtbio.2025.102160_bib81","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41419-018-0818-0","article-title":"Crosstalk between hepatic tumor cells and macrophages via Wnt\/\u03b2-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425007306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425007306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:32:55Z","timestamp":1778905975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425007306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":81,"alternative-id":["S2590006425007306"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102160","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delivered baicalein immunomodulatory hydrogel with dual properties of pH-responsive and anti-infection orchestrates pro-regenerative response of macrophages for enhanced hypertrophic scars therapy","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102160"}}