{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:48:29Z","timestamp":1789192109581,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023B03J1240"],"award-info":[{"award-number":["2023B03J1240"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301129"],"award-info":[{"award-number":["32301129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82150410451"],"award-info":[{"award-number":["82150410451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202201020396"],"award-info":[{"award-number":["202201020396"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.mtbio.2025.102198","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T23:31:18Z","timestamp":1755041478000},"page":"102198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Neodymium-doped mesoporous silica nanoparticles promote bone regeneration via autophagy-mediated macrophage immunomodulation"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4272-0818","authenticated-orcid":false,"given":"Qing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-3101","authenticated-orcid":false,"given":"Duraipandy","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-3491","authenticated-orcid":false,"given":"Yin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-1223","authenticated-orcid":false,"given":"Marco N.","family":"Helder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-0952","authenticated-orcid":false,"given":"Richard T.","family":"Jaspers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janak Lal","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.102198_bib1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/978-3-319-73664-8_18","article-title":"Bone grafts and bone substitutes for bone defect management","author":"Wang","year":"2017","journal-title":"Orthopedic Biomaterials: Advances and Applications"},{"issue":"14","key":"10.1016\/j.mtbio.2025.102198_bib2","doi-asserted-by":"crossref","first-page":"8471","DOI":"10.3390\/app13148471","article-title":"Current options and future perspectives on bone graft and biomaterials substitutes for bone repair, from clinical needs to advanced biomaterials research","volume":"13","author":"Georgeanu","year":"2023","journal-title":"Appl. Sci."},{"issue":"10","key":"10.1016\/j.mtbio.2025.102198_bib3","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.3390\/molecules26103007","article-title":"Bone grafts and substitutes in dentistry: a review of current trends and developments","volume":"26","author":"Zhao","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.mtbio.2025.102198_bib4","article-title":"The Use of biomaterials in the treatment of fractures","author":"Monteiro","year":"2015","journal-title":"PQDT-Global"},{"key":"10.1016\/j.mtbio.2025.102198_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214236","article-title":"Rare earth-based materials for bone regeneration: breakthroughs and advantages","volume":"450","author":"Huang","year":"2022","journal-title":"Coord. Chem. Rev."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102198_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0301-4622(92)80017-Y","article-title":"Characterization of the five-fold Ca2+ binding site of satellite tobacco necrosis virus using Eu3+ luminescence spectroscopy: a marked size-selectivity among rare earth ions","volume":"42","author":"Burroughs","year":"1992","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.mtbio.2025.102198_bib7","first-page":"242","article-title":"Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering","volume":"7","author":"Ren","year":"2022","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10262","article-title":"Rare earth smart nanomaterials for bone tissue engineering and implantology: advances, challenges, and prospects","volume":"7","author":"Natarajan","year":"2022","journal-title":"Bioengineering & Translational Medicine"},{"issue":"7\u20138","key":"10.1016\/j.mtbio.2025.102198_bib9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0923-2494(99)80039-X","article-title":"The role of the macrophage in immune regulation","volume":"149","author":"Gordon","year":"1998","journal-title":"Res. Immunol."},{"key":"10.1016\/j.mtbio.2025.102198_bib10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.actbio.2021.04.052","article-title":"The multifaceted roles of macrophages in bone regeneration: a story of polarization, activation and time","volume":"133","author":"Schlundt","year":"2021","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102198_bib11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.mattod.2015.11.004","article-title":"Osteoimmunomodulation for the development of advanced bone biomaterials","volume":"19","author":"Chen","year":"2016","journal-title":"Mater. Today"},{"key":"10.1016\/j.mtbio.2025.102198_bib12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10456-013-9381-6","article-title":"Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo","volume":"17","author":"Jetten","year":"2014","journal-title":"Angiogenesis"},{"issue":"9","key":"10.1016\/j.mtbio.2025.102198_bib13","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.4161\/auto.29455","article-title":"Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes","volume":"10","author":"Sharma","year":"2014","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4161\/15548627.2014.984283","article-title":"SUMO1 promotes Abeta production via the modulation of autophagy","volume":"11","author":"Cho","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.mtbio.2025.102198_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121743","article-title":"Gold nanoparticles targeting the autophagy\u2013lysosome system to combat the inflammation-compromised osteogenic potential of periodontal ligament stem cells: from mechanism to therapy","author":"Yin","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102198_bib16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.apmt.2017.12.003","article-title":"Immunomodulatory effects of mesoporous silica nanoparticles on osteogenesis: from nanoimmunotoxicity to nanoimmunotherapy","volume":"10","author":"Chen","year":"2018","journal-title":"Appl. Mater. Today"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/cells9010070","article-title":"Autophagy and macrophage functions: inflammatory response and phagocytosis","volume":"9","author":"Wu","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2025.102198_bib18","article-title":"Macrophages at low-inflammatory status improved osteogenesis via autophagy regulation","author":"Yang","year":"2021","journal-title":"Tissue Eng."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbrc.2005.09.018","article-title":"Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells","volume":"337","author":"Chen","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mtbio.2025.102198_bib20","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.jcis.2023.09.186","article-title":"Neodymium and manganese ions co-doped whitlockite for temperature monitoring, photothermal therapy, and bone tissue repair in osteosarcoma","volume":"653","author":"Heng","year":"2024","journal-title":"J. Colloid Interface Sci."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102198_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00339-024-07603-7","article-title":"Neodymium (III)-containing poly (lactide-co-glycolide)-coated robocast bioactive glass scaffolds for photothermal therapy and bone regeneration","volume":"130","author":"Deliormanl\u0131","year":"2024","journal-title":"Appl. Phys. A"},{"issue":"32","key":"10.1016\/j.mtbio.2025.102198_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb1311","article-title":"Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair","volume":"6","author":"Ma","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2025.102198_bib23","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.colsurfb.2019.05.073","article-title":"Effects of structural distinction in neodymium nanoparticle for therapeutic application in aberrant angiogenesis","volume":"181","author":"Duraipandy","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"2","key":"10.1016\/j.mtbio.2025.102198_bib24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s13273-023-00347-0","article-title":"Long non-coding RNA NONHSAT217600. 1 is involved in the regulation of neodymium oxide-induced cytotoxicity in 16HBE cells","volume":"20","author":"Hong","year":"2024","journal-title":"Molecular & Cellular Toxicology"},{"issue":"12","key":"10.1016\/j.mtbio.2025.102198_bib25","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3390\/toxics11120952","article-title":"RNA-seq analysis of testes from mice exposed to neodymium oxide","volume":"11","author":"Wang","year":"2023","journal-title":"Toxics"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib26","first-page":"75","article-title":"Neodymium oxide induces cytotoxicity and activates NF-\u03baB and caspase-3 in NR8383 cells","volume":"30","author":"Huang","year":"2017","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.mtbio.2025.102198_bib27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.actbio.2015.11.033","article-title":"Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis","volume":"30","author":"Shi","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102198_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fmats.2021.692309","article-title":"Mesoporous silica based nanostructures for bone tissue regeneration","volume":"8","author":"Ghosh","year":"2021","journal-title":"Frontiers in Materials"},{"issue":"43","key":"10.1016\/j.mtbio.2025.102198_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201902652","article-title":"Metal species\u2013encapsulated mesoporous silica nanoparticles: current advancements and latest breakthroughs","volume":"29","author":"Kankala","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.102198_bib30","article-title":"Self-assembled degradable iron-doped mesoporous silica nanoparticles for the smart delivery of prochloraz to improve plant protection and reduce environmental impact","volume":"28","author":"Wu","year":"2022","journal-title":"Environ. Technol. Innovat."},{"issue":"11","key":"10.1016\/j.mtbio.2025.102198_bib31","doi-asserted-by":"crossref","DOI":"10.15541\/jim20220114","article-title":"Nd-Doped mesoporous borosilicate bioactive glass-ceramic bone cement","volume":"37","author":"Chen","year":"2022","journal-title":"J. Inorg. Mater."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nprot.2008.221","article-title":"A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow","volume":"4","author":"Soleimani","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mtbio.2025.102198_bib33","article-title":"Silica nanocarrier-mediated intracellular delivery of rapamycin promotes autophagy-mediated M2 macrophage polarization to regulate bone regeneration","volume":"20","author":"Zhang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.102198_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbab075","article-title":"Dicalcium silicate-induced mitochondrial dysfunction and autophagy-mediated macrophagic inflammation promotes osteogenic differentiation of BMSCs","volume":"9","author":"Luo","year":"2022","journal-title":"Regen. Biomater."},{"issue":"18","key":"10.1016\/j.mtbio.2025.102198_bib35","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.7150\/thno.33376","article-title":"Licorice isoliquiritigenin-encapsulated mesoporous silica nanoparticles for osteoclast inhibition and bone loss prevention","volume":"9","author":"Sun","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib36","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ymthe.2017.09.011","article-title":"Antimicrobial peptide combined with BMP2-modified mesenchymal stem cells promotes calvarial repair in an osteolytic model","volume":"26","author":"Liu","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.mtbio.2025.102198_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2017.07.003","article-title":"Psoralidin suppresses osteoclastogenesis in BMMs and attenuates LPS-mediated osteolysis by inhibiting inflammatory cytokines","volume":"51","author":"Kong","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mtbio.2025.102198_bib38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.colsurfb.2019.05.073","article-title":"Effects of structural distinction in neodymium nanoparticle for therapeutic application in aberrant angiogenesis","volume":"181","author":"Duraipandy","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"5","key":"10.1016\/j.mtbio.2025.102198_bib39","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3390\/biomedicines10051203","article-title":"Current development of nano-drug delivery to target macrophages","volume":"10","author":"Cai","year":"2022","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12885-016-2411-1","article-title":"Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells","volume":"16","author":"Yang","year":"2016","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102198_bib41","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1002\/pat.6053","article-title":"Strontium\u2010doped mesoporous silica nanoparticles incorporated in chitosan\/alginate biocomposite scaffolds for enhanced bone tissue regeneration","volume":"34","author":"Yousefiasl","year":"2023","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.mtbio.2025.102198_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.nano.2021.102496","article-title":"Strontium doped mesoporous silica nanoparticles accelerate osteogenesis and angiogenesis in distraction osteogenesis by activation of Wnt pathway","volume":"41","author":"Liu","year":"2022","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102198_bib43","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.dental.2020.03.026","article-title":"Preparation of Zn doped mesoporous silica nanoparticles (Zn-MSNs) for the improvement of mechanical and antibacterial properties of dental resin composites","volume":"36","author":"Bai","year":"2020","journal-title":"Dent. Mater."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102198_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202200113","article-title":"A 3D printed bone tissue engineering scaffold composed of alginate dialdehyde\u2010gelatine reinforced by lysozyme loaded cerium doped mesoporous silica\u2010calcia nanoparticles","volume":"22","author":"Monavari","year":"2022","journal-title":"Macromol. Biosci."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102198_bib45","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1021\/acsabm.9b01082","article-title":"Electrochemiluminescence biosensor for hyaluronidase based on the Ru (bpy) 32+ doped SiO2 nanoparticles embedded in the hydrogel fabricated by hyaluronic acid and polyethylenimine","volume":"3","author":"Li","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102198_bib46","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1021\/acs.chemrev.1c00644","article-title":"Rare-earth doping in nanostructured inorganic materials","volume":"122","author":"Zheng","year":"2022","journal-title":"Chem. Rev."},{"key":"10.1016\/j.mtbio.2025.102198_bib47","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jddst.2016.07.002","article-title":"Mesoporous silica nanoparticles as a potential vaccine adjuvant against Schistosoma mansoni","volume":"35","author":"de P\u00e1dua Oliveira","year":"2016","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.mtbio.2025.102198_bib48","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.actbio.2014.09.041","article-title":"Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium","volume":"11","author":"Willbold","year":"2015","journal-title":"Acta Biomater."},{"issue":"10","key":"10.1016\/j.mtbio.2025.102198_bib49","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.3390\/polym13101575","article-title":"Characterization of biocompatible hydrogel lenses using methacrylic acid with neodymium oxide nanoparticles","volume":"13","author":"Lee","year":"2021","journal-title":"Polymers"},{"issue":"9","key":"10.1016\/j.mtbio.2025.102198_bib50","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.3390\/ijms21093242","article-title":"Functional relationship between osteogenesis and angiogenesis in tissue regeneration","volume":"21","author":"Diomede","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102198_bib51","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/jcpe.13051","article-title":"The critical interplay between bone resorbing and bone forming cells","volume":"46","author":"Lerner","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.mtbio.2025.102198_bib52","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biomaterials.2014.10.017","article-title":"Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds","volume":"37","author":"Spiller","year":"2015","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102198_bib53","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201901024RR","article-title":"IL\u201010 promotes endothelial progenitor cell infiltration and wound healing via STAT3","volume":"36","author":"Short","year":"2022","journal-title":"FASEB J."},{"issue":"13","key":"10.1016\/j.mtbio.2025.102198_bib54","doi-asserted-by":"crossref","first-page":"6616","DOI":"10.7150\/thno.57701","article-title":"TGF-\u03b2 loaded exosome enhances ischemic wound healing in vitro and in vivo","volume":"11","author":"Shi","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.102198_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110353","article-title":"IL-10 inhibits osteoclast differentiation and osteolysis through MEG3\/IRF8 pathway","volume":"95","author":"Gao","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mtbio.2025.102198_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108784","article-title":"Interleukin 4 promotes anti-inflammatory macrophages that clear cartilage debris and inhibits osteoclast development to protect against osteoarthritis","volume":"229","author":"von Kaeppler","year":"2021","journal-title":"Clin. Immunol."},{"issue":"10","key":"10.1016\/j.mtbio.2025.102198_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0312169","article-title":"Orthosilicic acid inhibits human osteoclast differentiation and bone resorption","volume":"19","author":"Magnusson","year":"2024","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102198_bib58","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41598-017-00456-6","article-title":"Role of p62 in the suppression of inflammatory cytokine production by adiponectin in macrophages: involvement of autophagy and p21\/Nrf2 axis","volume":"7","author":"Tilija Pun","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102198_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-020-00634-1","article-title":"p62\/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-\u03baB activation","volume":"18","author":"Wu","year":"2020","journal-title":"J. Nanobiotechnol."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425007689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425007689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:35:12Z","timestamp":1772915712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425007689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":59,"alternative-id":["S2590006425007689"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102198","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neodymium-doped mesoporous silica nanoparticles promote bone regeneration via autophagy-mediated macrophage immunomodulation","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102198"}}