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Commun."},{"key":"10.1016\/j.mtbio.2025.102480_bib30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1021\/cr0404646","article-title":"NMR structures of damaged DNA","volume":"106","author":"Lukin","year":"2006","journal-title":"Chem Rev"},{"key":"10.1016\/j.mtbio.2025.102480_bib31","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.102480_bib32","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. 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Pathol."},{"key":"10.1016\/j.mtbio.2025.102480_bib36","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.aaa1356","article-title":"Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging","volume":"348","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2025.102480_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111451","article-title":"A stem cell aging framework, from mechanisms to interventions","volume":"41","author":"Liu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.mtbio.2025.102480_bib38","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s13238-020-00728-4","article-title":"SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer","volume":"11","author":"Bi","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.mtbio.2025.102480_bib39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41422-020-0385-7","article-title":"Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration","volume":"31","author":"Liang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.mtbio.2025.102480_bib40","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1038\/s41467-019-10831-8","article-title":"Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis","volume":"10","author":"Deng","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102480_bib41","first-page":"3323","article-title":"BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates","volume":"50","author":"Liang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mtbio.2025.102480_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.109681","article-title":"Self-calibrating probes constructed on a unique dual-emissive fluorescence platform for the precise tracking of cellular senescence","volume":"35","author":"Qu","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.mtbio.2025.102480_bib43","article-title":"Activatable photoacoustic bioprobe for visual detection of aging in vivo","volume":"35","author":"Li","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.mtbio.2025.102480_bib44","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1093\/nar\/gkab161","article-title":"SIRT3 consolidates heterochromatin and counteracts senescence","volume":"49","author":"Diao","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mtbio.2025.102480_bib45","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1038\/ncomms6011","article-title":"SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age","volume":"5","author":"Van Meter","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102480_bib46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41586-021-03210-1","article-title":"METTL3 regulates heterochromatin in mouse embryonic stem cells","volume":"591","author":"Xu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.102480_bib47","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.abe9582","article-title":"FTO mediates LINE1 m(6)A demethylation and chromatin regulation in mESCs and mouse development","volume":"376","author":"Wei","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2025.102480_bib48","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41586-021-03313-9","article-title":"The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity","volume":"591","author":"Liu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.102480_bib49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s43587-022-00186-z","article-title":"Destabilizing heterochromatin by APOE mediates senescence","volume":"2","author":"Zhao","year":"2022","journal-title":"Nat Aging"},{"key":"10.1016\/j.mtbio.2025.102480_bib50","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1128\/MCB.20.18.6741-6754.2000","article-title":"Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts","volume":"20","author":"Duli\u0107","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2025.102480_bib51","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging","volume":"132","author":"Miwa","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mtbio.2025.102480_bib52","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/1873-3468.13498","article-title":"Mitochondrial dysfunction and cell senescence: deciphering a complex relationship","volume":"593","author":"Chapman","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mtbio.2025.102480_bib53","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1096\/fj.14-268276","article-title":"Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease","volume":"29","author":"Ahmad","year":"2015","journal-title":"Faseb j"},{"key":"10.1016\/j.mtbio.2025.102480_bib54","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1038\/ncomms3308","article-title":"Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart","volume":"4","author":"Hoshino","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102480_bib55","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.arr.2018.08.003","article-title":"Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence","volume":"47","author":"Park","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mtbio.2025.102480_bib56","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1021\/cbmi.3c00070","article-title":"Advances in small-molecule fluorescent pH probes for monitoring mitophagy","volume":"2","author":"Liu","year":"2024","journal-title":"Chem Biomed Imaging"},{"key":"10.1016\/j.mtbio.2025.102480_bib57","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and age-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mtbio.2025.102480_bib58","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cmet.2015.11.011","article-title":"Mitochondrial dysfunction induces senescence with a distinct secretory phenotype","volume":"23","author":"Wiley","year":"2016","journal-title":"Cell metab"},{"key":"10.1016\/j.mtbio.2025.102480_bib59","doi-asserted-by":"crossref","first-page":"7378","DOI":"10.1038\/s41467-024-51363-0","article-title":"Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells","volume":"15","author":"L\u00f3pez-Polo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102480_bib60","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2025.102480_bib61","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nrm3479","article-title":"Mitochondria: master regulators of danger signalling","volume":"13","author":"Galluzzi","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2025.102480_bib62","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41580-022-00456-z","article-title":"Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology","volume":"23","author":"Sies","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2025.102480_bib63","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","author":"van Deursen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.102480_bib64","doi-asserted-by":"crossref","first-page":"17031","DOI":"10.1073\/pnas.0905299106","article-title":"Cell surface-bound IL-1\u03b1 is an upstream regulator of the senescence-associated IL-6\/IL-8 cytokine network","volume":"106","author":"Orjalo","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mtbio.2025.102480_bib65","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13365","article-title":"IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2","volume":"85","author":"Nakamura","year":"2021","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.mtbio.2025.102480_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-017-0172-3","article-title":"Senescence-associated IL-6 and IL-8 cytokines induce a self-and cross-reinforced senescence\/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line","volume":"15","author":"Ortiz-Montero","year":"2017","journal-title":"Cell Commun. 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Res."},{"key":"10.1016\/j.mtbio.2025.102480_bib70","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130056","article-title":"Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis","volume":"4","author":"Wiley","year":"2019","journal-title":"JCI insight"},{"key":"10.1016\/j.mtbio.2025.102480_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111263","article-title":"The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype","volume":"189","author":"Wallis","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mtbio.2025.102480_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310788","article-title":"Exploring the communication of the SASP: dynamic, interactive, and adaptive effects on the microenvironment","volume":"24","author":"Giroud","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102480_bib73","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mad.2017.04.003","article-title":"Alterations of the translation apparatus during aging and stress response","volume":"168","author":"Gonskikh","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mtbio.2025.102480_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1129281","article-title":"Protein translation paradox: implications in translational regulation of aging","volume":"11","author":"Kim","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2025.102480_bib75","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004440","article-title":"Aging as an event of proteostasis collapse","volume":"3","author":"Taylor","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.mtbio.2025.102480_bib76","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-biochem-060614-033955","article-title":"The biology of proteostasis in aging and disease","volume":"84","author":"Labbadia","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mtbio.2025.102480_bib77","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","article-title":"The proteostasis network and its decline in ageing","volume":"20","author":"Hipp","year":"2019","journal-title":"Nat. Rev. Mol. 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Icad 2014","volume":"6","author":"Stambler","year":"2015","journal-title":"Aging Dis"},{"key":"10.1016\/j.mtbio.2025.102480_bib84","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.18632\/oncotarget.28049","article-title":"Anti-aging: senolytics or gerostatics (unconventional view)","volume":"12","author":"Blagosklonny","year":"2021","journal-title":"Oncotarget"},{"key":"10.1016\/j.mtbio.2025.102480_bib85","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2021.05.003","article-title":"Senolytics and senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases","volume":"171","author":"Lagoumtzi","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2025.102480_bib86","article-title":"CD44-targeting and ZIF-8-gated gold nanocage for programmed breast cancer therapy through Pt-induced immunogenic cell death","author":"Li","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.mtbio.2025.102480_bib87","article-title":"Senolytics: eliminating senescent cells and alleviating intervertebral disc degeneration","volume":"10","author":"Wu","year":"2022","journal-title":"Front. Bioeng. 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Sci."},{"key":"10.1016\/j.mtbio.2025.102480_bib104","first-page":"6937","article-title":"High-dose vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-\u03baB and PI3K\/AKT\/mTOR signaling pathways in rats","volume":"16","author":"Cui","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mtbio.2025.102480_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114739","article-title":"Ginseng root extract attenuates inflammation by inhibiting the MAPK\/NF-\u03baB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo","volume":"283","author":"Yang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mtbio.2025.102480_bib107","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/geroni\/igad104.3459","article-title":"Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner","volume":"7","author":"Kane","year":"2024","journal-title":"Innov. 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Sci."},{"key":"10.1016\/j.mtbio.2025.102480_bib141","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.mtbio.2025.102480_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135098","article-title":"Synergistic anti-aging effect of Dendrobium officinale polysaccharide and spermidine: a metabolomics analysis focusing on the regulation of lipid, nucleotide and energy metabolism","volume":"278","author":"Duan","year":"2024","journal-title":"Int. J. Biol. 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Longev."},{"key":"10.1016\/j.mtbio.2025.102480_bib155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s43587-024-00747-4","article-title":"Generation of a selective senolytic platform using a micelle-encapsulated Sudan black B conjugated analog","volume":"5","author":"Magkouta","year":"2025","journal-title":"Nat Aging"},{"key":"10.1016\/j.mtbio.2025.102480_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113908","article-title":"Microneedle-mediated biomimetic nanoparticles for targeted antioxidant and anti-inflammatory therapy in age-related macular degeneration","volume":"384","author":"Liu","year":"2025","journal-title":"J Control Release"},{"key":"10.1016\/j.mtbio.2025.102480_bib157","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13287-025-04160-5","article-title":"Mesenchymal stem cell exosome therapy: current research status in the treatment of neurodegenerative diseases and the possibility of reversing normal brain aging","volume":"16","author":"Quan","year":"2025","journal-title":"Stem Cell Res. 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Nanotechnol."},{"key":"10.1016\/j.mtbio.2025.102480_bib161","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.032904","article-title":"Enhanced cardiomyocyte nlrp3 inflammasome-mediated pyroptosis promotes d-galactose-induced cardiac aging","volume":"13","author":"Liu","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.mtbio.2025.102480_bib162","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12072648","article-title":"Organic nanodelivery systems as a new platform in the management of breast cancer: a comprehensive review from preclinical to clinical studies","volume":"12","author":"Rafik","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mtbio.2025.102480_bib163","article-title":"Smart cargo delivery system based on mesoporous nanoparticles for bone disease diagnosis and treatment","volume":"8","author":"Pan","year":"2021","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2025.102480_bib164","doi-asserted-by":"crossref","first-page":"21991","DOI":"10.1021\/jacs.3c06898","article-title":"Supramolecular senolytics via intracellular oligomerization of peptides in response to elevated reactive oxygen species levels in aging cells","volume":"145","author":"Kim","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2025.102480_bib165","article-title":"A binary siRNA-Loaded tetrahedral DNA nanobox for synergetic anti-aging therapy","volume":"21","author":"Yue","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.102480_bib166","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.3390\/ijms10062510","article-title":"Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders","volume":"10","author":"Choonara","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102480_bib167","article-title":"Health economic considerations in neurodegenerative disorders","volume":"42","author":"Rapp","year":"2015","journal-title":"Imaging Neurodegener. Disord"},{"key":"10.1016\/j.mtbio.2025.102480_bib168","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41583-020-0325-z","article-title":"Cellular senescence and alzheimer disease: the egg and the chicken scenario","volume":"21","author":"Saez-Atienzar","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mtbio.2025.102480_bib169","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.102480_bib170","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mtbio.2025.102480_bib171","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s43587-021-00107-6","article-title":"An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo","volume":"1","author":"Wang","year":"2021","journal-title":"Nature aging"},{"key":"10.1016\/j.mtbio.2025.102480_bib172","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.mtbio.2025.102480_bib173","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in health and disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2025.102480_bib174","article-title":"SSK1\u2010loaded neurotransmitter\u2010derived nanoparticles for Alzheimer'S disease therapy via clearance of senescent cells","volume":"20","author":"Ji","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.102480_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101206","article-title":"Nrf2: a dark horse in alzheimer's disease treatment","volume":"64","author":"Osama","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mtbio.2025.102480_bib176","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc Nat Acad Sci"},{"key":"10.1016\/j.mtbio.2025.102480_bib179","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl\u20102 family of anti\u2010apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.mtbio.2025.102480_bib177","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/acel.12075","article-title":"Metformin inhibits the senescence\u2010associated secretory phenotype by interfering with IKK\/NF\u2010\u03ba B activation","volume":"12","author":"Moiseeva","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.mtbio.2025.102480_bib178","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.18632\/aging.103135","article-title":"Identification of SYK inhibitor, R406 as a novel senolytic agent","volume":"12","author":"Cho","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mtbio.2025.102480_bib180","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11190","article-title":"Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL","volume":"7","author":"Yosef","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102480_bib181","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41467-017-00314-z","article-title":"Identification of HSP90 inhibitors as a novel class of senolytics","volume":"8","author":"Fuhrmann-Stroissnigg","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102480_bib182","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1161\/ATVBAHA.110.210500","article-title":"Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the akt pathway","volume":"30","author":"Ota","year":"2010","journal-title":"Arterioscl Throm Vas"},{"key":"10.1016\/j.mtbio.2025.102480_bib183","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nchembio.2342","article-title":"Chemical screening identifies ATM as a target for alleviating senescence","volume":"13","author":"Kang","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.mtbio.2025.102480_bib184","article-title":"Biomimetic dendrimer\u2013peptide conjugates for early multi\u2010target therapy of alzheimer's disease by inflammatory microenvironment modulation","volume":"33","author":"Liu","year":"2021","journal-title":"Adv Mater"},{"key":"10.1016\/j.mtbio.2025.102480_bib185","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: from discovery to translation","volume":"288","author":"Kirkland","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.mtbio.2025.102480_bib186","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-3-030-30930-5_14","article-title":"Curcumin and its nanoformulations as therapeutic for Alzheimer's disease","author":"Kakkar","year":"2019","journal-title":"Nanobiotechnology in neurodegenerative diseases"},{"key":"10.1016\/j.mtbio.2025.102480_bib187","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11671-018-2759-z","article-title":"Curcumin-loaded chitosan\u2013bovine serum albumin nanoparticles potentially enhanced A\u03b2 42 phagocytosis and modulated macrophage polarization in Alzheimer's disease","volume":"13","author":"Yang","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.mtbio.2025.102480_bib188","article-title":"Positively correlated cd47 activation and autophagy in umbilical cord blood\u2010derived mesenchymal stem cells during senescence","volume":"2021","author":"Kim","year":"2021","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.mtbio.2025.102480_bib189","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.apsb.2024.01.008","article-title":"Macrophage senescence in health and diseases","volume":"14","author":"Wang","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2025.102480_bib190","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-0-387-85960-6_3","article-title":"Classification of cardiovascular diseases: epidemiology, diagnosis, and treatment","author":"Kapuku","year":"2022","journal-title":"Handbook of cardiovascular behavioral medicine"},{"key":"10.1016\/j.mtbio.2025.102480_bib191","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1038\/s41467-019-12888-x","article-title":"Identification and characterization of cardiac glycosides as senolytic compounds","volume":"10","author":"Triana-Mart\u00ednez","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102480_bib192","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s42255-019-0122-z","article-title":"Cardiac glycosides are broad-spectrum senolytics","volume":"1","author":"Guerrero","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.mtbio.2025.102480_bib193","first-page":"35","article-title":"The evolution of coronary stents: a brief review","volume":"30","author":"Simard","year":"2014","journal-title":"Can. J. 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