{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:19:42Z","timestamp":1792887582282,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Provincial Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["YDZJ202401155ZYTS"],"award-info":[{"award-number":["YDZJ202401155ZYTS"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","award":["2021-I2M-1-031"],"award-info":[{"award-number":["2021-I2M-1-031"]}],"id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","award":["2022-I2M-1\\u2013018"],"award-info":[{"award-number":["2022-I2M-1\\u2013018"]}],"id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","award":["2060302-2305-04"],"award-info":[{"award-number":["2060302-2305-04"]}],"id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mtbio.2025.102509","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T15:59:18Z","timestamp":1762617558000},"page":"102509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Preparation of hierarchically targetable Astragalus polysaccharide lipid nanoparticles and study on their therapeutic effect on orthotopic colon cancer"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-1561","authenticated-orcid":false,"given":"Yan","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4745-1709","authenticated-orcid":false,"given":"Xiaobo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5528-8253","authenticated-orcid":false,"given":"Zhengqi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mtbio.2025.102509_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"24","key":"10.1016\/j.mtbio.2025.102509_bib2","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1056\/NEJMoa2200075","article-title":"Circulating tumor DNA analysis guiding adjuvant therapy in stage II Colon cancer","volume":"386","author":"Tie","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.102509_bib3","article-title":"Multifunctional drug delivery nanoparticles for combined chemotherapy\/chemodynamic\/photothermal therapy against colorectal cancer through synergistic cuproptosis\/ferroptosis\/apoptosis","volume":"30","author":"Yan","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102509_bib4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/nano14070557","article-title":"Current advances of nanomaterial-based oral drug delivery for colorectal cancer treatment","volume":"14","author":"Wang","year":"2024","journal-title":"Nanomaterials"},{"issue":"44","key":"10.1016\/j.mtbio.2025.102509_bib5","article-title":"Overcoming biopotency barriers: advanced oral delivery strategies for enhancing the efficacy of bioactive food ingredients","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2025.102509_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117893","article-title":"Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: a smart pH-responsive and receptor-targeted system for colorectal cancer therapy","volume":"261","author":"Narayan","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102509_bib7","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.ijbiomac.2020.11.117","article-title":"Carboxymethyl chitosan micro\u2010spheres loaded hyaluronic acid\/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease","volume":"167","author":"Zhang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"20","key":"10.1016\/j.mtbio.2025.102509_bib8","article-title":"Microfluidized dextran microgels loaded with Cisplatin\/SPION lipid nanotherapeutics for local Colon cancer treatment via oral administration","volume":"11","author":"Lu","year":"2022","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.mtbio.2025.102509_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biomaterials.2019.01.019","article-title":"Hierarchically targetable polysaccharide-coated solid lipid nanoparticles as an oral chemo\/thermotherapy delivery system for local treatment of colon cancer","volume":"197","author":"Shen","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102509_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1021\/acsabm.9b00676","article-title":"Oral colon-targeted konjac glucomannan hydrogel constructed through noncovalent cross-linking by cucurbit 8 uril for ulcerative colitis therapy","volume":"3","author":"Ding","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.mtbio.2025.102509_bib11","article-title":"pH and reactive oxygen species\u2010sequential responsive nano\u2010in\u2010micro composite for targeted therapy of inflammatory bowel disease","volume":"28","author":"Bertoni","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.102509_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201900610","article-title":"A proresolving peptide nanotherapy for site-specific treatment of inflammatory bowel disease by regulating proinflammatory microenvironment and gut microbiota","volume":"6","author":"Li","year":"2019","journal-title":"Adv Sci"},{"key":"10.1016\/j.mtbio.2025.102509_bib13","doi-asserted-by":"crossref","first-page":"40378","DOI":"10.1021\/acsami.8b08254","article-title":"Inflammation-responsive drug-conjugated dextran nanoparticles enhance anti-inflammatory drug efficacy","volume":"10","author":"Lee","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.102509_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2020.125606","article-title":"Chitosan\/Heparin polyelectrolyte complexes as ion-paring approach to encapsulate heparin in orally administrable SLN: in vitro evaluation","volume":"608","author":"Maretti","year":"2021","journal-title":"Colloids Surf., A"},{"key":"10.1016\/j.mtbio.2025.102509_bib15","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1080\/10837450.2021.1873370","article-title":"Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible colon-targeted delivery","volume":"26","author":"Samprasit","year":"2021","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.mtbio.2025.102509_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119299","article-title":"Synthesis, molecular features and biological activities of modified plant polysaccharides","volume":"289","author":"Mukherjee","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102509_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154667","article-title":"Astragalus polysaccharide ameliorates vascular endothelial dysfunction by stimulating macrophage M2 polarization via potentiating Nrf2\/HO-1 signaling pathway","volume":"112","author":"Sha","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mtbio.2025.102509_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.123058","article-title":"Astragalus polysaccharide\/carboxymethyl chitosan\/sodium alginate based electroconductive hydrogels for diabetic wound healing and muscle function assessment","volume":"350","author":"Tang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102509_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123497","article-title":"Composite microneedles loaded with Astragalus membranaceus polysaccharide nanoparticles promote wound healing by curbing the ROS\/NF-\u03baB pathway to regulate macrophage polarization","volume":"357","author":"Liu","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102509_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116172","article-title":"Astragalus polysaccharide ameliorates CD8+ T cell dysfunction through STAT3\/Gal-3\/LAG3 pathway in inflammation-induced colorectal cancer","volume":"171","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102509_bib21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s11427-023-2465-x","article-title":"Self-adjuvant Astragalus polysaccharide-based nanovaccines for enhanced tumor immunotherapy: a novel delivery system candidate for tumor vaccines","volume":"67","author":"Li","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.mtbio.2025.102509_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118622","article-title":"The synergistic effect of Huangqi Gegen decoction on thrombosis relates to the astragalus polysaccharide-improved oral delivery of puerarin","volume":"335","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mtbio.2025.102509_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ijbiomac.2022.05.087","article-title":"A review on plant polysaccharide based on drug delivery system for construction and application, with emphasis on traditional Chinese medicine polysaccharide","volume":"211","author":"Gong","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102509_bib24","doi-asserted-by":"crossref","first-page":"6705","DOI":"10.2147\/IJN.S434196","article-title":"A multi-component nano-co-delivery system utilizing astragalus polysaccharides as carriers for improving biopharmaceutical properties of astragalus flavonoids","volume":"18","author":"Yang","year":"2023","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.mtbio.2025.102509_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119653","article-title":"A lymphatic route for a hyperbranched heteroglycan from Radix Astragali to trigger immune responses after oral dosing","volume":"292","author":"Zhang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102509_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126484","article-title":"Preclinical pharmacokinetics-related pharmacological effects of orally administered polysaccharides from traditional Chinese medicines: a review","volume":"252","author":"Ye","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102509_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155492","article-title":"Astragalus polysaccharides attenuate chemotherapy-induced immune injury by modulating gut microbiota and polyunsaturated fatty acid metabolism","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.mtbio.2025.102509_bib28","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1111\/cas.15078","article-title":"Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice","volume":"112","author":"Ding","year":"2021","journal-title":"Cancer Sci."},{"issue":"Pt A","key":"10.1016\/j.mtbio.2025.102509_bib29","article-title":"Astragalus polysaccharides alleviate DSS-induced ulcerative colitis in mice by restoring SCFA production and regulating Th17\/Treg cell homeostasis in a microbiota-dependent manner","volume":"349","author":"Zhang","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"11","key":"10.1016\/j.mtbio.2025.102509_bib30","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3390\/nu16111698","article-title":"Astragalus polysaccharide modulates the gut Microbiota and metabolites of patients with type 2 diabetes in an In Vitro fermentation model","volume":"16","author":"Zhang","year":"2024","journal-title":"Nutrients"},{"issue":"Pt 1","key":"10.1016\/j.mtbio.2025.102509_bib31","article-title":"Functional fractions of Astragalus polysaccharides as a potential prebiotic to alleviate ulcerative colitis","volume":"271","author":"Huo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"13","key":"10.1016\/j.mtbio.2025.102509_bib32","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.1039\/D2FO01009G","article-title":"Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats","volume":"13","author":"Zhong","year":"2022","journal-title":"Food Funct."},{"issue":"24","key":"10.1016\/j.mtbio.2025.102509_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202100478","article-title":"iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis","volume":"31","author":"Guan","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102509_bib34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12943-023-01849-0","article-title":"Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics","volume":"22","author":"Gajbhiye","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mtbio.2025.102509_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121440","article-title":"Targeted therapeutic effects of oral inulin-modified double-layered nanoparticles containing chemotherapeutics on orthotopic colon cancer","volume":"283","author":"Hou","year":"2022","journal-title":"Biomaterials"},{"issue":"Pt 2","key":"10.1016\/j.mtbio.2025.102509_bib36","article-title":"Exploring oral drug delivery: in vitro release and mathematical modeling of hydrophobic drug (Na-L-thyroxine) and its cyclodextrin inclusion complex in chitosan microparticles","volume":"265","author":"Lakkakula","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102509_bib37","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.apsb.2021.09.029","article-title":"The effect of drug loading and multiple administration on the protein corona formation and brain delivery property of PEG-PLA nanoparticles","volume":"12","author":"Tang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/j.mtbio.2025.102509_bib38","article-title":"Acidic\/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy","volume":"19","author":"Guo","year":"2024","journal-title":"Asian J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102509_bib39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12943-019-1114-z","article-title":"Chemotherapeutic drugs stimulate the release and recycling of extracellular vesicles to assist cancer cells in developing an urgent chemoresistance","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.mtbio.2025.102509_bib40","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1039\/c3nr00114h","article-title":"Microscopy and tunable resistive pulse sensing characterization of the swelling of pH-responsive, polymeric expansile nanoparticles","volume":"5","author":"Colby","year":"2013","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2025.102509_bib41","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ijbiomac.2020.02.132","article-title":"Oral delivery of pH-responsive alginate microbeads incorporating folic acid-grafted solid lipid nanoparticles exhibits enhanced targeting effect against colorectal cancer: a dual-targeted approach","volume":"151","author":"Rajpoot","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"16","key":"10.1016\/j.mtbio.2025.102509_bib42","article-title":"Novel strategy to drive the intracellular uptake of lipid nanoparticles for photodynamic therapy","volume":"62","author":"Ho","year":"2023","journal-title":"Angew Chem Int Ed Engl."},{"key":"10.1016\/j.mtbio.2025.102509_bib43","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jconrel.2024.05.015","article-title":"Ionizable lipid nanoparticles for RAS protease delivery to inhibit cancer cell proliferation","volume":"370","author":"Atsavapranee","year":"2024","journal-title":"J Control Release"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102509_bib44","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1186\/s12951-024-02967-7","article-title":"Dual targeting and bioresponsive nano-PROTAC induced precise and effective lung cancer therapy","volume":"22","author":"Guan","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.mtbio.2025.102509_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123387","article-title":"Tumor microenvironment responsive nano-PROTAC for BRD4 degradation enhanced cancer photo-immunotherapy","volume":"322","author":"Li","year":"2025","journal-title":"Biomaterials"},{"issue":"17","key":"10.1016\/j.mtbio.2025.102509_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800285","article-title":"Uniform core-shell nanoparticles with thiolated hyaluronic acid coating to enhance oral delivery of insulin","volume":"7","author":"Tian","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.mtbio.2025.102509_bib47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2015.12.008","article-title":"Efficient mucus permeation and tight junction opening by dissociable \"mucus-inert\" agent coated trimethyl chitosan nanoparticles for oral insulin delivery","volume":"222","author":"Liu","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.mtbio.2025.102509_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.121797","article-title":"Fabrication of hyaluronic acid-inulin coated Enterococcus faecium for colon-targeted delivery to fight Fusobacterium nucleatum","volume":"329","author":"Zhu","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102509_bib49","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.addr.2017.10.001","article-title":"Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties","volume":"124","author":"Wu","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.102509_bib50","article-title":"Multi-functionalized probiotics through layer-by-layer coating with tannic acid-Mg2+ and casein phosphopeptide complexes for preventing ulcerative colitis","volume":"31","author":"Qian","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.102509_bib51","article-title":"Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis","volume":"25","author":"Zhang","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102509_bib52","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1053\/j.gastro.2021.02.020","article-title":"Microbial community heterogeneity within Colorectal neoplasia and its correlation with colorectal carcinogenesis","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102509_bib53","doi-asserted-by":"crossref","first-page":"9092","DOI":"10.1038\/s41467-024-53347-6","article-title":"Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102509_bib54","first-page":"167","article-title":"Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease","volume":"35","author":"Shi","year":"2024","journal-title":"Bioact. Mater."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102509_bib55","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3390\/cancers15030866","article-title":"Gut microbiota in colorectal cancer: biological role and therapeutic opportunities","volume":"15","author":"Pandey","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"Suppl 4","key":"10.1016\/j.mtbio.2025.102509_bib56","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1186\/s12864-022-09008-3","article-title":"Gut microbiota profiling variated during colorectal cancer development in mouse","volume":"23","author":"Liu","year":"2022","journal-title":"BMC Genom."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102509_bib57","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/gutjnl-2024-333530","article-title":"Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer\/T-cell lymphoma by dampening the JAK-STAT pathway","volume":"74","author":"Shi","year":"2025","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102509_bib58","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4014\/jmb.2301.01031","article-title":"Anticancer effects of gut microbiota-derived short-chain fatty acids in cancers","volume":"33","author":"Son","year":"2023","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.102509_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107148","article-title":"The interactions between traditional Chinese medicine and gut microbiota in cancers: current status and future perspectives","volume":"203","author":"Wei","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102509_bib60","doi-asserted-by":"crossref","first-page":"6291","DOI":"10.1038\/s41598-023-33178-z","article-title":"A pathogenicity locus of Streptococcus gallolyticus subspecies gallolyticus","volume":"13","author":"Taylor","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102509_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114862","article-title":"Astragalus polysaccharide ameliorated complex factor-induced chronic fatigue syndrome by modulating the gut microbiota and metabolites in mice","volume":"163","author":"Wei","year":"2023","journal-title":"Biomed. Pharmacother."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425010804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425010804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:28:39Z","timestamp":1773332919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425010804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":61,"alternative-id":["S2590006425010804"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102509","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation of hierarchically targetable Astragalus polysaccharide lipid nanoparticles and study on their therapeutic effect on orthotopic colon cancer","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102509"}}