{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:19:19Z","timestamp":1793380759755,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20210942"],"award-info":[{"award-number":["Y20210942"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mtbio.2025.102519","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:00:36Z","timestamp":1762315236000},"page":"102519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["pH-responsive bilayer hydrogel with sequential release of morin-based nanoparticles and bFGF for the treatment of the \u201cice and fire\u201d wounds"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8648-4119","authenticated-orcid":false,"given":"Meilin","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-5792","authenticated-orcid":false,"given":"Wenzhang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunfu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wa","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-7769","authenticated-orcid":false,"given":"Xiang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.102519_bib1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/wrr.13154","article-title":"Development of pro\u2010angiogenic skin substitutes for wound healing","volume":"32","author":"Song","year":"2024","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.mtbio.2025.102519_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.burns.2022.02.011","article-title":"The effect of stromal vascular fraction in an experimental frostbite injury model","volume":"49","author":"\u00d6ner","year":"2023","journal-title":"Burns : journal of the International Society for Burn Injuries"},{"key":"10.1016\/j.mtbio.2025.102519_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.09.018","article-title":"Burn injury: challenges and advances in burn wound healing, infection, pain and scarring","volume":"123","author":"Wang","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.102519_bib4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1089\/sur.2020.102","article-title":"Burn infection and burn sepsis","volume":"22","author":"D'Abbondanza","year":"2021","journal-title":"Surg. Infect."},{"key":"10.1016\/j.mtbio.2025.102519_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00421-018-4012-y","article-title":"Relation between finger cold-induced vasodilation and rewarming speed after cold exposure","volume":"119","author":"Kingma","year":"2019","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.mtbio.2025.102519_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2020.102716","article-title":"Frostbite: current status and advancements in therapeutics","volume":"93","author":"Joshi","year":"2020","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.mtbio.2025.102519_bib7","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.reth.2024.10.008","article-title":"In situ forming Hydrogel with adding ZnO Nano-particle for effectively methicillin-resistant Staphylococcus aureus infected frostbite injury","volume":"26","author":"Xu","year":"2024","journal-title":"Regenerative therapy"},{"key":"10.1016\/j.mtbio.2025.102519_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102034","article-title":"Metal chelation attenuates oxidative stress, inflammation, and vertical burn progression in a porcine brass comb burn model","volume":"45","author":"El Ayadi","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.mtbio.2025.102519_bib9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/jbcr\/irz037","article-title":"The effects of two different burn dressings on Serum oxidative stress indicators in children with partial burn","volume":"40","author":"G\u00fcr\u00fcnl\u00fco\u011flu","year":"2019","journal-title":"J. Burn Care Res. : official publication of the American Burn Association"},{"key":"10.1016\/j.mtbio.2025.102519_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jss.2011.03.066","article-title":"Pathophysiologic difference between frostbite and burn injury and implications for therapy","volume":"174","author":"Nguyen","year":"2012","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.mtbio.2025.102519_bib11","doi-asserted-by":"crossref","first-page":"618","DOI":"10.18063\/ijb.v8i4.618","article-title":"3D-Printed gelatin-alginate Hydrogel dressings for burn wound healing: a comprehensive Study","volume":"8","author":"Fayyazbakhsh","year":"2022","journal-title":"International journal of bioprinting"},{"key":"10.1016\/j.mtbio.2025.102519_bib12","doi-asserted-by":"crossref","first-page":"e420","DOI":"10.1097\/CCM.0000000000000309","article-title":"Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin","volume":"42","author":"Plichta","year":"2014","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.mtbio.2025.102519_bib13","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1038\/s41598-020-63464-z","article-title":"Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing","volume":"10","author":"Zhang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102519_bib14","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.12968\/jowc.2023.32.Sup5.S11","article-title":"Burn wound conversion: clinical implications for the treatment of severe burns","volume":"32","author":"Asuku","year":"2023","journal-title":"J. Wound Care"},{"key":"10.1016\/j.mtbio.2025.102519_bib15","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1056\/NEJMra1800868","article-title":"Diagnosis and treatment of Frostbite","volume":"386","author":"Sheridan","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.102519_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129704","article-title":"Bilirubin\/morin self-assembled nanoparticle-engulfed collagen\/polyvinyl alcohol hydrogel accelerates chronic diabetic wound healing by modulating inflammation and ameliorating oxidative stress","volume":"261","author":"Zhao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102519_bib17","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3109\/10715761003610737","article-title":"Morin modulates the oxidative stress-induced NF-kappaB pathway through its anti-oxidant activity","volume":"44","author":"Kim","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.mtbio.2025.102519_bib18","volume":"203","author":"El-Tanbouly","year":"2025"},{"key":"10.1016\/j.mtbio.2025.102519_bib19","doi-asserted-by":"crossref","first-page":"21400","DOI":"10.1021\/acsami.3c17642","article-title":"Morin-based nanoparticles for regulation of blood glucose","volume":"16","author":"Hua","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.102519_bib20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biopha.2018.06.161","article-title":"Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis","volume":"106","author":"Kuzu","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.mtbio.2025.102519_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177807","article-title":"Morin ameliorates coronary artery relaxation by activating TRPV4-eNOS-NO signalling in high-salt diet-fed rats","volume":"1002","author":"Zhang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.102519_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fct.2019.01.038","article-title":"Development of morin\/hydroxypropyl-\u03b2-cyclodextrin inclusion complex: enhancement of bioavailability, antihyperalgesic and anti-inflammatory effects","volume":"126","author":"Lima","year":"2019","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.mtbio.2025.102519_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114495","article-title":"Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice","volume":"249","author":"Luo","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.mtbio.2025.102519_bib24","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jconrel.2012.03.017","article-title":"Chitosan-based drug nanocarriers: where do we stand?","volume":"161","author":"Garcia-Fuentes","year":"2012","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102519_bib25","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1039\/c3nr00338h","article-title":"Advances in chitosan-based drug delivery vehicles","volume":"5","author":"Hu","year":"2013","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2025.102519_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.colsurfb.2018.03.017","article-title":"Role of proton balance in formation of self-assembled chitosan nanoparticles","volume":"166","author":"Dey","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.mtbio.2025.102519_bib27","first-page":"15","article-title":"Comparative evaluation of the in vitro cytotoxicity of a series of chitosans and chitooligosaccharides water-soluble at physiological pH","author":"Dias","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.mtbio.2025.102519_bib28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijbiomac.2018.12.182","article-title":"Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin","volume":"126","author":"Tsai","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102519_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2014.07.016","article-title":"Chitosan\/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive compounds","volume":"115","author":"Pinheiro","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102519_bib30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijbiomac.2020.04.233","article-title":"Mucoadhesive and pH responsive fucoidan-chitosan nanoparticles for the oral delivery of methotrexate","volume":"158","author":"Coutinho","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102519_bib31","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1163\/092050611X581534","article-title":"Curcumin-loaded N,O-carboxymethyl chitosan nanoparticles for cancer drug delivery","volume":"23","author":"Anitha","year":"2012","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.mtbio.2025.102519_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.biomaterials.2017.06.043","article-title":"Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice","volume":"141","author":"Devalliere","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102519_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124205","article-title":"All-in-one hydrogel patches with sprayed bFGF-loaded GelMA microspheres for infected wound healing studies","volume":"658","author":"Jin","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2025.102519_bib34","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jconrel.2024.10.046","article-title":"Drug conjugates crosslinked bioresponsive hydrogel for combination therapy of diabetic wound","volume":"376","author":"Zheng","year":"2024","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102519_bib35","article-title":"Acceleration of burn wound healing by micronized amniotic membrane seeded with umbilical cord-derived mesenchymal stem cells","volume":"20","author":"Zhou","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.102519_bib36","article-title":"Dual drug delivery system based on pH-sensitive silk fibroin\/alginate nanoparticles entrapped in PNIPAM hydrogel for treating severe infected burn wound","volume":"13","author":"Rezaei","year":"2020","journal-title":"Biofabrication"},{"key":"10.1016\/j.mtbio.2025.102519_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132935","article-title":"Enhancing diabetic wound healing with a pH\/glucose dual-responsive hydrogel for ROS clearance and antibacterial activity","volume":"272","author":"Hao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102519_bib38","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4155\/tde-2019-0066","article-title":"Challenges and opportunities of pH in chronic wounds","volume":"10","author":"Wallace","year":"2019","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.mtbio.2025.102519_bib39","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/wound.2014.0538","article-title":"The effect of pH on the extracellular matrix and biofilms","volume":"4","author":"Jones","year":"2015","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.mtbio.2025.102519_bib40","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000094670","article-title":"The pH of the skin surface and its impact on the barrier function","volume":"19","author":"Schmid-Wendtner","year":"2006","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.mtbio.2025.102519_bib41","article-title":"A novel hydrogel loaded with plant exosomes and stem cell exosomes as a new strategy for treating diabetic wounds","volume":"32","author":"Weng","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.102519_bib42","article-title":"Advanced healing potential of simple natural hydrogel loaded with sildenafil in combating infectious wounds","volume":"9","author":"Lai","year":"2025","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.mtbio.2025.102519_bib43","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1016\/j.biomaterials.2005.04.012","article-title":"Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin","volume":"26","author":"Balakrishnan","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102519_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115803","article-title":"Fabrication of versatile dynamic hyaluronic acid-based hydrogels","volume":"233","author":"Shi","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102519_bib45","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jconrel.2024.11.001","article-title":"Injectable nanocomposite hydrogel with cascade drug release for treatment of uveal melanoma","volume":"376","author":"Guo","year":"2024","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102519_bib46","doi-asserted-by":"crossref","first-page":"28827","DOI":"10.1021\/acsomega.4c03240","article-title":"pH-Sensitive hydrogels fabricated with hyaluronic acid as a polymer for site-specific delivery of mesalamine","volume":"9","author":"Liaqat","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.mtbio.2025.102519_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133559","article-title":"The application of pH-responsive hyaluronic acid-based essential oils hydrogels with enhanced anti-biofilm and wound healing","volume":"275","author":"Qiu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2025.102519_bib48","article-title":"pH and reactive oxygen species\u2010sequential responsive nano\u2010in\u2010micro composite for targeted therapy of inflammatory bowel disease","volume":"28","author":"Bertoni","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.102519_bib49","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.carbpol.2017.12.021","article-title":"Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases","volume":"189","author":"Sun","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102519_bib50","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12951-021-01014-z","article-title":"Donut-like MOFs of copper\/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing","volume":"19","author":"Wang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.102519_bib51","article-title":"Platelet membrane-encapsulated poly(lactic-co-glycolic acid) nanoparticles loaded with Sildenafil for targeted therapy of vein graft intimal hyperplasia","volume":"8","author":"Yang","year":"2024","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.mtbio.2025.102519_bib52","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.1021\/acsnano.5c01134","article-title":"Hydrogel-based bioactive synthetic skin stimulates regenerative gas signaling and eliminates interfacial pathogens to promote burn wound healing","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.102519_bib53","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1007\/s12035-024-03949-4","article-title":"Dermorphin [D-Arg2, Lys4] (1-4) amide alleviates frostbite-induced pain by regulating TRP channel-mediated microglial activation and neuroinflammation","volume":"61","author":"Ummadisetty","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mtbio.2025.102519_bib54","article-title":"AP39, a novel mitochondria-targeted hydrogen sulfide donor, promotes cutaneous wound healing in an in vivo murine model of acute frostbite injury","volume":"183","author":"Dugbartey","year":"2025","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.mtbio.2025.102519_bib55","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jcis.2005.04.061","article-title":"The interaction between morin and CTAB aggregates","volume":"290","author":"Liu","year":"2005","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2025.102519_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/md17120654","article-title":"Marine polysaccharides in pharmaceutical applications: Fucoidan and Chitosan as key players in the drug delivery match field","volume":"17","author":"Barbosa","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.mtbio.2025.102519_bib57","first-page":"24","article-title":"Application of pH-Responsive fucoidan\/chitosan nanoparticles to improve oral Quercetin delivery","author":"Barbosa","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.mtbio.2025.102519_bib58","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s11814-013-0243-0","article-title":"Polyelectrolyte complexes of chitosan self-assembled with fucoidan: an optimum condition to prepare their nanoparticles and their characteristics","volume":"31","author":"Lee","year":"2014","journal-title":"Kor. J. Chem. Eng."},{"key":"10.1016\/j.mtbio.2025.102519_bib59","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.polymer.2016.07.086","article-title":"Role of the OH and NH vibrational groups in polysaccharide-nanocomposite interactions: a FTIR-ATR study on chitosan and chitosan\/clay films","volume":"99","author":"Branca","year":"2016","journal-title":"Polymer"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102519_bib60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jemt.24419","article-title":"Mass production of morin-stabilized silver nanoparticles: characterization, antioxidant, and antimicrobial activities","volume":"87","author":"Zayed","year":"2024","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.mtbio.2025.102519_bib61","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/jbm.a.37679","article-title":"Ultrasmall polyvinylpyrrolidone-modified iridium nanoparticles with antioxidant and anti-inflammatory activity for acute pancreatitis alleviation","volume":"112","author":"Jin","year":"2024","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"10.1016\/j.mtbio.2025.102519_bib62","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1472-6750-4-21","article-title":"A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods","volume":"4","author":"Yarrow","year":"2004","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.mtbio.2025.102519_bib63","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3109\/17435390.2010.541604","article-title":"Inflammatory responses of RAW 264.7 macrophages upon exposure to nanoparticles: role of ROS-NF\u03baB signaling pathway","volume":"5","author":"Nishanth","year":"2011","journal-title":"Nanotoxicology"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425010907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425010907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:05:30Z","timestamp":1773813930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425010907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":63,"alternative-id":["S2590006425010907"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102519","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"pH-responsive bilayer hydrogel with sequential release of morin-based nanoparticles and bFGF for the treatment of the \u201cice and fire\u201d wounds","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102519","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102519"}}