{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:21:51Z","timestamp":1786994511044,"version":"build-2736575974"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Shanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["202403021221346"],"award-info":[{"award-number":["202403021221346"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"UCL","doi-asserted-by":"publisher","award":["214046\/Z\/18\/Z"],"award-info":[{"award-number":["214046\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016694","name":"Science and Technology Development Plan of Shandong Province","doi-asserted-by":"publisher","award":["202204070744"],"award-info":[{"award-number":["202204070744"]}],"id":[{"id":"10.13039\/100016694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019447","name":"Applied Basic Research Project of Shanxi Province, China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mtbio.2025.102576","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:49:24Z","timestamp":1763772564000},"page":"102576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Engineering a targeted daphnetin delivery system to enhance spinal cord injury treatment effectiveness"],"prefix":"10.1016","volume":"35","author":[{"given":"Jun","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenye","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishuang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runtian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Ghorbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaozong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dachuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4840-4181","authenticated-orcid":false,"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.apmr.2020.04.001","volume":"102","author":"Lo","year":"2021","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1212\/CON.0000000000001392","article-title":"Traumatic spinal cord injury","volume":"30","author":"Izzy","year":"2024","journal-title":"Continuum (Minneap Minn)"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41392-022-00885-4","article-title":"Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"17","key":"10.1016\/j.mtbio.2025.102576_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cells11172692","article-title":"Inflammation: a target for treatment in spinal cord injury","volume":"11","author":"Freyermuth-Trujillo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2025.102576_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2014.12.045","article-title":"Macrophage activation and its role in repair and pathology after spinal cord injury","volume":"1619","author":"Gensel","year":"2015","journal-title":"Brain Res."},{"issue":"20","key":"10.1016\/j.mtbio.2025.102576_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207533","article-title":"Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms","volume":"21","author":"Anjum","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102576_bib7","doi-asserted-by":"crossref","first-page":"16786","DOI":"10.1007\/s11356-021-18391-5","article-title":"An update on pathophysiology and treatment of sports-mediated brain injury","volume":"29","author":"Kalra","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.mtbio.2025.102576_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.expneurol.2014.04.028","article-title":"Complement and spinal cord injury: traditional and non-traditional aspects of complement cascade function in the injured spinal cord microenvironment","volume":"258","author":"Peterson","year":"2014","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102576_bib9","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12974-020-01751-2","article-title":"Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-kappaB signaling pathway and pyroptosis after secondary spinal cord injury","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.mtbio.2025.102576_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119144","article-title":"Microglia and the blood-brain barrier: an external player in acute and chronic neuroinflammatory conditions","volume":"24","author":"Gullotta","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102576_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094925","article-title":"Polarization of microglia and its therapeutic potential in sepsis","volume":"23","author":"Castro","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102576_bib13","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.7150\/thno.71086","article-title":"Pyroptosis in inflammatory diseases and cancer","volume":"12","author":"Rao","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.102576_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jare.2020.08.004","article-title":"Role of pyroptosis in spinal cord injury and its therapeutic implications","volume":"28","author":"Al Mamun","year":"2021","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102576_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.tice.2015.03.007","article-title":"Neuroprotective effects of safranal in a rat model of traumatic injury to the spinal cord by anti-apoptotic, anti-inflammatory and edema-attenuating","volume":"47","author":"Zhang","year":"2015","journal-title":"Tissue Cell"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102576_bib16","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.bmcl.2016.01.015","article-title":"Tetramethylpyrazine improves the recovery of spinal cord injury via Akt\/Nrf2\/HO-1 pathway","volume":"26","author":"Wang","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102576_bib17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1006\/bbrc.1999.0958","article-title":"Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor","volume":"260","author":"Yang","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.mtbio.2025.102576_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23102476","article-title":"Synthesis and structure-activity relationship of daphnetin derivatives as potent antioxidant agents","volume":"23","author":"Xia","year":"2018","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102576_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20040850","article-title":"Daphnetin: a novel anti-helicobacter pylori agent","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102576_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jep.2018.08.024","article-title":"The phytochemistry, pharmacokinetics, pharmacology and toxicity of euphorbia semen","volume":"227","author":"Zhu","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"30","key":"10.1016\/j.mtbio.2025.102576_bib21","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.2174\/1381612043382710","article-title":"Natural and synthetic coumarin derivatives with anti-inflammatory\/antioxidant activities","volume":"10","author":"Fylaktakidou","year":"2004","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102576_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11064-013-1218-6","article-title":"Daphnetin, a natural coumarin derivative, provides the neuroprotection against glutamate-induced toxicity in HT22 cells and ischemic brain injury","volume":"39","author":"Du","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mtbio.2025.102576_bib23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.freeradbiomed.2017.02.016","article-title":"Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death","volume":"106","author":"Lv","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102576_bib24","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s11064-020-02960-0","article-title":"Daphnetin ameliorates experimental autoimmune encephalomyelitis through regulating heme Oxygenase-1","volume":"45","author":"Wang","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mtbio.2025.102576_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2816056","article-title":"Daphnetin protects against cerebral Ischemia\/reperfusion injury in mice via inhibition of TLR4\/NF-kappaB signaling pathway","volume":"2016","author":"Liu","year":"2016","journal-title":"BioMed. Res. Int."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102576_bib26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1124\/pr.115.012070","article-title":"Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come","volume":"68","author":"Yingchoncharoen","year":"2016","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102576_bib27","first-page":"250","article-title":"Vesicular systems containing curcumin and their applications in respiratory disorders - a mini review","volume":"5","author":"Chellappan","year":"2017","journal-title":"Pharm. Nanotechnol."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102576_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics8040036","article-title":"Evaluation of extrusion technique for nanosizing liposomes","volume":"8","author":"Ong","year":"2016","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4068\/cmj.2021.57.1.27","article-title":"Liposomes: biomedical applications","volume":"57","author":"Kim","year":"2021","journal-title":"Chonnam. Med. J."},{"issue":"8","key":"10.1016\/j.mtbio.2025.102576_bib30","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1021\/acsnano.6b03148","article-title":"Liposomes coated with isolated macrophage membrane can target lung metastasis of breast cancer","volume":"10","author":"Cao","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.102576_bib31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jconrel.2021.07.032","article-title":"Macrophage-biomimetic anti-inflammatory liposomes for homing and treating of aortic dissection","volume":"337","author":"Liu","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.102576_bib32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jconrel.2020.01.039","article-title":"A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice","volume":"320","author":"Guo","year":"2020","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib33","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/s41467-018-04390-7","article-title":"Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus","volume":"9","author":"Kim","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mtbio.2025.102576_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.brainres.2016.12.007","article-title":"Salvianolic acid A ameliorates the integrity of blood-spinal cord barrier via miR-101\/Cul3\/Nrf2\/HO-1 signaling pathway","volume":"1657","author":"Yu","year":"2017","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib36","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jss.2013.11.1118","article-title":"Salvianolic acid B attenuates spinal cord ischemia-reperfusion-induced neuronal injury and oxidative stress by activating the extracellular signal-regulated kinase pathway in rats","volume":"188","author":"Fu","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.mtbio.2025.102576_bib37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuint.2019.01.013","article-title":"Protocatechuic acid improves functional recovery after spinal cord injury by attenuating blood-spinal cord barrier disruption and hemorrhage in rats","volume":"124","author":"Park","year":"2019","journal-title":"Neurochem. Int."},{"issue":"1\u20132","key":"10.1016\/j.mtbio.2025.102576_bib38","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jns.2012.10.009","article-title":"Tetramethylpyrazine accelerates the function recovery of traumatic spinal cord in rat model by attenuating inflammation","volume":"324","author":"Hu","year":"2013","journal-title":"J. Neurol. Sci."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102576_bib39","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1142\/S0192415X13500912","article-title":"Effects of tetramethylpyrazine on microglia activation in spinal cord compression injury of mice","volume":"41","author":"Shin","year":"2013","journal-title":"Am. J. Chin. Med."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102576_bib40","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s10571-020-00878-3","article-title":"Tetramethylpyrazine protects blood-spinal cord barrier integrity by modulating microglia polarization through activation of STAT3\/SOCS3 and inhibition of NF-small ka, CyrillicB signaling pathways in experimental autoimmune encephalomyelitis mice","volume":"41","author":"Zhang","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.mtbio.2025.102576_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096502","article-title":"Immunosuppressive activity of daphnetin, one of coumarin derivatives, is mediated through suppression of NF-kappaB and NFAT signaling pathways in mouse T cells","volume":"9","author":"Song","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2025.102576_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/963248","article-title":"Review on natural coumarin lead compounds for their pharmacological activity","volume":"2013","author":"Venugopala","year":"2013","journal-title":"BioMed. Res. Int."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102576_bib43","doi-asserted-by":"crossref","first-page":"14542","DOI":"10.3390\/molecules190914542","article-title":"Neuroprotective effects of daphnetin against NMDA receptor-mediated excitotoxicity","volume":"19","author":"Yang","year":"2014","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.7150\/ijms.27005","article-title":"Activation of the Nrf2\/HO-1 signaling pathway contributes to the protective effects of baicalein against oxidative stress-induced DNA damage and apoptosis in HEI193 Schwann cells","volume":"16","author":"Jeong","year":"2019","journal-title":"Int. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102576_bib45","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1002\/jcb.27698","article-title":"Daphnetin protects hippocampal neurons from oxygen-glucose deprivation-induced injury","volume":"120","author":"Zhi","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00018-015-2050-8","article-title":"Factors controlling permeability of the blood-brain barrier","volume":"73","author":"Almutairi","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102576_bib47","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.it.2012.07.004","article-title":"Capture, crawl, cross: the T cell code to breach the blood-brain barriers","volume":"33","author":"Engelhardt","year":"2012","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102576_bib48","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/glia.21094","article-title":"Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFkappaB signaling, MAPK, and Jak1\/Stat1 pathways","volume":"59","author":"Gorina","year":"2011","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102576_bib49","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.bbrc.2010.03.111","article-title":"Astrocytes modulate the chemokine network in a pathogen-specific manner","volume":"394","author":"McKimmie","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102576_bib50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.1107","article-title":"Immune function of astrocytes","volume":"36","author":"Dong","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.mtbio.2025.102576_bib51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12974-014-0144-0","article-title":"Astrocyte galectin-9 potentiates microglial TNF secretion","volume":"11","author":"Steelman","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mtbio.2025.102576_bib52","first-page":"683","article-title":"Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages","volume":"5","author":"Dey","year":"2014","journal-title":"Front. Immunol."},{"issue":"43","key":"10.1016\/j.mtbio.2025.102576_bib53","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mtbio.2025.102576_bib54","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12974-015-0327-3","article-title":"Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury","volume":"12","author":"Haan","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"20","key":"10.1016\/j.mtbio.2025.102576_bib55","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.4103\/1673-5374.143423","article-title":"Function of microglia and macrophages in secondary damage after spinal cord injury","volume":"9","author":"Zhou","year":"2014","journal-title":"Neural Regen. Res."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102576_bib56","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/glia.22774","article-title":"Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris","volume":"63","author":"Wang","year":"2015","journal-title":"Glia"},{"issue":"Pt 1","key":"10.1016\/j.mtbio.2025.102576_bib57","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/brain\/awp304","article-title":"Beneficial effects of secretory leukocyte protease inhibitor after spinal cord injury","volume":"133","author":"Ghasemlou","year":"2010","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.mtbio.2025.102576_bib58","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1523\/JNEUROSCI.5770-09.2010","article-title":"Fenretinide promotes functional recovery and tissue protection after spinal cord contusion injury in mice","volume":"30","author":"Lopez-Vales","year":"2010","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102576_bib59","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.mtbio.2025.102576_bib60","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ni.2109","article-title":"Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils","volume":"12","author":"Galli","year":"2011","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib61","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1523\/JNEUROSCI.3593-06.2007","article-title":"The Ca2+-activated K+ channel KCNN4\/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration","volume":"27","author":"Kaushal","year":"2007","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib62","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.conb.2006.09.004","article-title":"The role of extracellular matrix in CNS regeneration","volume":"17","author":"Busch","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102576_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2006.09.006","article-title":"The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system","volume":"54","author":"Galtrey","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.mtbio.2025.102576_bib64","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.2147\/IJN.S87148","article-title":"Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease","volume":"10","author":"Fonseca-Santos","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.102576_bib65","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2015.00286","article-title":"Advances and challenges of liposome assisted drug delivery","volume":"6","author":"Sercombe","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102576_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10030151","article-title":"Development of dual drug loaded nanosized liposomal formulation by A reengineered ethanolic injection method and its pre-clinical pharmacokinetic studies","volume":"10","author":"Sarfraz","year":"2018","journal-title":"Pharmaceutics"},{"issue":"9","key":"10.1016\/j.mtbio.2025.102576_bib67","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"10.1016\/j.mtbio.2025.102576_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11100543","article-title":"Active cellular and subcellular targeting of nanoparticles for drug delivery","volume":"11","author":"Nag","year":"2019","journal-title":"Pharmaceutics"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425011470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425011470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:05:42Z","timestamp":1773821142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425011470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":68,"alternative-id":["S2590006425011470"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102576","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering a targeted daphnetin delivery system to enhance spinal cord injury treatment effectiveness","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102576","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102576"}}