{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:00:24Z","timestamp":1793473224588,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003807","name":"People's Government of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFE0106000"],"award-info":[{"award-number":["2022YFE0106000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401173"],"award-info":[{"award-number":["82401173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mtbio.2025.102640","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:01:38Z","timestamp":1765008098000},"page":"102640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Synergetic regulation of osteoimmune microenvironment and osteogenesis by decellularized amnion membrane for guided bone regeneration"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0036-5503","authenticated-orcid":false,"given":"Tong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-6442","authenticated-orcid":false,"given":"Hai Ming","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.102640_bib1","doi-asserted-by":"crossref","first-page":"13991","DOI":"10.1021\/acsami.1c20809","article-title":"Spatiotemporal management of the osteoimmunomodulation of fibrous scaffolds by loading a novel amphiphilic nanomedicine","volume":"14","author":"He","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.102640_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jhsa.2018.10.032","article-title":"Bone graft substitutes: current concepts and future expectations","volume":"44","author":"Lobb","year":"2019","journal-title":"J. Hand. Surg. Am."},{"key":"10.1016\/j.mtbio.2025.102640_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1600-0501.2010.01922.x","article-title":"Guided bone regeneration: biological principle and therapeutic applications","volume":"21","author":"Retzepi","year":"2010","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.mtbio.2025.102640_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1741-7015-10-81","article-title":"The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence","volume":"10","author":"Dimitriou","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.mtbio.2025.102640_bib5","first-page":"54","article-title":"Barrier membranes for tissue regeneration in dentistry","volume":"8","author":"Sasaki","year":"2021","journal-title":"Biomater. Investig. Dent."},{"key":"10.1016\/j.mtbio.2025.102640_bib6","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1021\/acsapm.3c00095","article-title":"Effect of dehydrothermal treatment on the structure and properties of a collagen-based heterogeneous bilayer membrane","volume":"5","author":"Yang","year":"2023","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib7","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1152\/physrev.00036.2016","article-title":"Osteoimmunology: the conceptual framework unifying the immune and skeletal systems","volume":"97","author":"Okamoto","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mtbio.2025.102640_bib8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.2741\/4600","article-title":"Osteoimmunology: the nexus between bone and immune system","volume":"23","author":"Dar","year":"2018","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.mtbio.2025.102640_bib9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.actbio.2021.08.023","article-title":"Immunomodulatory bioactive glasses for tissue regeneration","volume":"133","author":"Zheng","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102640_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imbio.2012.01.020","article-title":"Does complement play a role in bone development and regeneration?","volume":"218","author":"Schoengraf","year":"2013","journal-title":"Immunobiology"},{"key":"10.1016\/j.mtbio.2025.102640_bib11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3389\/fimmu.2019.00797","article-title":"Experience in the adaptive immunity impacts bone homeostasis, remodeling, and healing","volume":"10","author":"Bucher","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.102640_bib12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/intimm\/dxy054","article-title":"Macrophages in inflammation, repair and regeneration","volume":"30","author":"Oishi","year":"2018","journal-title":"Int. Immunol."},{"key":"10.1016\/j.mtbio.2025.102640_bib13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41419-020-02982-0","article-title":"Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming","volume":"11","author":"Yan","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2025.102640_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.140399","article-title":"Targeted therapy for autoimmune diseases based on multifunctional frame nucleic acid system: blocking TNF-\u03b1-NF-\u03baB signaling and mediating macrophage polarization","volume":"454","author":"Zhang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2025.102640_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300601","article-title":"A curcumin\u2010modified coordination polymers with ROS scavenging and macrophage phenotype regulating properties for efficient ulcerative colitis treatment","volume":"10","author":"Yao","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2025.102640_bib16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mtbio.2025.102640_bib17","article-title":"Quercetin\u2010loaded ceria nanocomposite potentiate dual\u2010directional immunoregulation via macrophage polarization against periodontal inflammation","volume":"17","author":"Wang","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.102640_bib18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.archoralbio.2017.03.006","article-title":"Enhanced activity of macrophage M1\/M2 phenotypes in periodontitis","volume":"96","author":"Yang","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.mtbio.2025.102640_bib19","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3390\/antiox11091662","article-title":"Bacterial metabolite reuterin attenuated LPS-induced oxidative stress and inflammation response in HD11 macrophages","volume":"11","author":"Xu","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.mtbio.2025.102640_bib20","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1021\/acsnano.8b08785","article-title":"Synergistic oxygen generation and reactive oxygen species scavenging by manganese ferrite\/ceria co-decorated nanoparticles for rheumatoid arthritis treatment","volume":"13","author":"Kim","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.102640_bib21","first-page":"243","article-title":"A hierarchical biomimetic periosteum combined immunomodulatory and osteogenic functions for bone regeneration","author":"Li","year":"2022","journal-title":"Compos. B Eng."},{"key":"10.1016\/j.mtbio.2025.102640_bib22","first-page":"231","article-title":"Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment","volume":"31","author":"Zhang","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202402139","article-title":"Decellularized amnion membrane triggers macrophage polarization for desired host immune response","volume":"13","author":"Zhang","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1076\/0271-3683(200003)2031-9FT173","article-title":"Growth factor mRNA and protein in preserved human amniotic membrane","volume":"20","author":"Koizumi","year":"2000","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.mtbio.2025.102640_bib25","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1021\/acsbiomaterials.0c00881","article-title":"Mineralized human amniotic membrane as a biomimetic scaffold for hard tissue engineering applications","volume":"6","author":"Sabouri","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.mtbio.2025.102640_bib26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.biomaterials.2011.09.065","article-title":"The effects of acellular amniotic membrane matrix on osteogenic differentiation and ERK1\/2 signaling in human dental apical papilla cells","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib27","doi-asserted-by":"crossref","first-page":"101631","DOI":"10.1016\/j.tice.2021.101631","article-title":"Biofabrication of allogenic bone grafts using cellularized amniotic scaffolds for application in efficient bone healing","volume":"73","author":"Lakkireddy","year":"2021","journal-title":"Tissue Cell"},{"key":"10.1016\/j.mtbio.2025.102640_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.mtbio.2025.102640_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mtbio.2025.102640_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mtbio.2025.102640_bib31","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.7150\/thno.37931","article-title":"Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.102640_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biomaterials.2012.09.041","article-title":"The osteogenic activity of strontium loaded titania nanotube arrays on titanium substrates","volume":"34","author":"Zhao","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib33","article-title":"Adipose\u2010derived stem cells for tissue engineering and regenerative medicine applications","volume":"2016","author":"Dai","year":"2016","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.mtbio.2025.102640_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.15283\/ijsc.2014.7.2.135","article-title":"Characterization of mesenchymal stem cells derived from rat bone marrow and adipose tissue: a comparative study","volume":"7","author":"Lotfy","year":"2014","journal-title":"Int. J. Stem. Cells."},{"key":"10.1016\/j.mtbio.2025.102640_bib35","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.sdentj.2023.07.019","article-title":"Combination adipose-derived mesenchymal stem cells-demineralized dentin matrix increase bone marker expression in periodontitis rats","volume":"35","author":"Sandra Sari","year":"2023","journal-title":"Saudi Dent. J."},{"key":"10.1016\/j.mtbio.2025.102640_bib36","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41598-018-37528-0","article-title":"Periodontal regeneration by allogeneic transplantation of adipose tissue derived multi-lineage progenitor stem cells in vivo","volume":"9","author":"Venkataiah","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102640_bib37","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.msec.2009.02.013","article-title":"Evaluation of electrospun fibrous scaffolds of poly (dl-lactide) and poly (ethylene glycol) for skin tissue engineering","volume":"29","author":"Cui","year":"2009","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.mtbio.2025.102640_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201970246","article-title":"Polymer fiber scaffolds for bone and cartilage tissue engineering","volume":"29","author":"Zhang","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib39","doi-asserted-by":"crossref","first-page":"8642","DOI":"10.1021\/acs.langmuir.5b02362","article-title":"Investigating the potential of amnion-based scaffolds as a barrier membrane for guided bone regeneration","volume":"31","author":"Li","year":"2015","journal-title":"Langmuir"},{"key":"10.1016\/j.mtbio.2025.102640_bib40","first-page":"91","article-title":"Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg","volume":"6","author":"Cheng","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/polym14050941","article-title":"Biopolymer material from human spongiosa for regenerative medicine application","volume":"14","author":"Tsiklin","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.mtbio.2025.102640_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121260","article-title":"An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties","volume":"280","author":"Chen","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.actbio.2021.05.042","article-title":"Topological structure of electrospun membrane regulates immune response, angiogenesis and bone regeneration","volume":"129","author":"Jin","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102640_bib44","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1073\/pnas.0903269107","article-title":"Geometric cues for directing the differentiation of mesenchymal stem cells","volume":"107","author":"Kilian","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mtbio.2025.102640_bib45","doi-asserted-by":"crossref","first-page":"38780","DOI":"10.1021\/acsami.8b14745","article-title":"Topographically defined, biodegradable nanopatterned patches to regulate cell fate and acceleration of bone regeneration","volume":"10","author":"Lee","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.102640_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119548","article-title":"Hierarchical microchanneled scaffolds modulate multiple tissue-regenerative processes of immune-responses, angiogenesis, and stem cell homing","volume":"227","author":"Won","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121604","article-title":"Immunomodulatory strategies for bone regeneration: a review from the perspective of disease types","volume":"286","author":"Su","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119552","article-title":"Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio-and osteogenesis","volume":"227","author":"Qiu","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib49","article-title":"Polydopamine decorated microneedles with Fe\u2010MSC\u2010derived nanovesicles encapsulation for wound healing","volume":"9","author":"Ma","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2025.102640_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/951390","article-title":"Tissues use resident dendritic cells and macrophages to maintain homeostasis and to regain homeostasis upon tissue injury: the immunoregulatory role of changing tissue environments","volume":"2012","author":"Lech","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mtbio.2025.102640_bib51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.actbio.2014.10.022","article-title":"Localized delivery of dexamethasone-21-phosphate via microdialysis implants in rat induces M (GC) macrophage polarization and alters CCL2 concentrations","volume":"12","author":"Keeler","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102640_bib52","article-title":"High-performance silk\/polylactic acid composite scaffold material with immunomodulation and osteogenesis function","volume":"29","author":"Rui","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.102640_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1283383","article-title":"The role of decorin in autoimmune and inflammatory diseases","volume":"2022","author":"Dong","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.mtbio.2025.102640_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202200521","article-title":"Immunoregulation in diabetic wound repair with a photoenhanced glycyrrhizic acid hydrogel scaffold","volume":"34","author":"Qian","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121683","article-title":"ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation","volume":"287","author":"Li","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50114-2","article-title":"Novel mitochondrial complex I-inhibiting peptides restrain NADH dehydrogenase activity","volume":"9","author":"Xue","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102640_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202270257","article-title":"Osteoimmunity\u2010regulating biomimetically hierarchical scaffold for augmented bone regeneration","volume":"34","author":"Zhang","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib58","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1039\/C7BM00869D","article-title":"The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration","volume":"6","author":"Chen","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2025.102640_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904341","article-title":"Biomimetic nanosilica\u2013collagen scaffolds for in situ bone regeneration: toward a cell\u2010free, one\u2010step surgery","volume":"31","author":"Wang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib60","article-title":"3D bioprinting of in situ vascularized tissue engineered bone for repairing large segmental bone defects","volume":"16","author":"Shen","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.102640_bib61","article-title":"Immunomodulatory multifunctional janus collagen-based membrane for advanced bone regeneration","volume":"16","author":"Yang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102640_bib62","first-page":"116","article-title":"Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration","volume":"18","author":"Lin","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/jbm.b.30261","article-title":"In vitro response of MC3T3\u2010E1 preosteoblasts within three\u2010dimensional apatite\u2010coated PLGA scaffolds","volume":"75","author":"Chou","year":"2005","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.mtbio.2025.102640_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203106","article-title":"Mitochondrial calcium ion nanogluttons alleviate periodontitis via controlling mPTPs","volume":"12","author":"He","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib65","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biomaterials.2014.10.017","article-title":"Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds","volume":"37","author":"Spiller","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4704","article-title":"A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair","volume":"6","author":"Yuan","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2025.102640_bib67","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/JLB.2MIR0817-349R","article-title":"The PI3K\/AKT signaling pathway in regulatory T-cell development, stability, and function","volume":"103","author":"Pompura","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.mtbio.2025.102640_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121037","article-title":"Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration","volume":"276","author":"Liu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102640_bib69","article-title":"A glutathione peroxidase\u2010mimicking nanozyme precisely alleviates reactive oxygen species and promotes periodontal bone regeneration","volume":"13","author":"Zhu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.102640_bib70","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s13287-022-03052-2","article-title":"ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK\/MAPK and PI3K-Akt signaling pathways","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425012128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425012128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:53:35Z","timestamp":1773878015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425012128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":70,"alternative-id":["S2590006425012128"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102640","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergetic regulation of osteoimmune microenvironment and osteogenesis by decellularized amnion membrane for guided bone regeneration","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102640"}}