{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:04:25Z","timestamp":1791396265124,"version":"4.3.3"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["T-B-080"],"award-info":[{"award-number":["T-B-080"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172186"],"award-info":[{"award-number":["82172186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L222126"],"award-info":[{"award-number":["L222126"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.mtbio.2025.102657","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:47:50Z","timestamp":1765212470000},"page":"102657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1\/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline"],"prefix":"10.1016","volume":"36","author":[{"given":"Yaxin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaomin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiguang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-0930","authenticated-orcid":false,"given":"Xu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mtbio.2025.102657_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70128","article-title":"Federated learning with multi-cohort real-world data for predicting the progression from mild cognitive impairment to Alzheimer's disease","volume":"21","author":"Pan","year":"2025","journal-title":"Alzheimer's Dementia : the journal of the Alzheimer's Association"},{"issue":"10","key":"10.1016\/j.mtbio.2025.102657_bib2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S1474-4422(20)30277-5","article-title":"Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues","volume":"19","author":"Benedict","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mtbio.2025.102657_bib3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ebiom.2018.10.021","article-title":"Surgery, neuroinflammation and cognitive impairment","volume":"37","author":"Alam","year":"2018","journal-title":"EBioMedicine"},{"issue":"7973","key":"10.1016\/j.mtbio.2025.102657_bib4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mtbio.2025.102657_bib5","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/s41593-023-01323-6","article-title":"The contribution of the peripheral immune system to neurodegeneration","volume":"26","author":"Berriat","year":"2023","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102657_bib6","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1177\/0271678X16655551","article-title":"Matrix metalloproteinases in the brain and blood-brain barrier: versatile breakers and makers","volume":"36","author":"Rempe","year":"2016","journal-title":"J. Cerebr. Blood Flow Metabol. : official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"761","key":"10.1016\/j.mtbio.2025.102657_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adm8563","article-title":"Microglia-specific IL-10 gene delivery inhibits neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease","volume":"16","author":"Bido","year":"2024","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.mtbio.2025.102657_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41582-023-00822-1","article-title":"Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration","volume":"19","author":"Patani","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102657_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00109-024-02444-6","article-title":"The role of the immunosuppressive PD-1\/PD-L1 checkpoint pathway in the aging process and age-related diseases","volume":"102","author":"Salminen","year":"2024","journal-title":"J. Mol. Med."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00109-024-02504-x","article-title":"The role of inhibitory immune checkpoint receptors in the pathogenesis of Alzheimer's disease","volume":"103","author":"Salminen","year":"2025","journal-title":"J. Mol. Med."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41467-019-08352-5","article-title":"PD-1\/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model","volume":"10","author":"Rosenzweig","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102657_bib12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/acschemneuro.9b00640","article-title":"Potential neuroprotective effect of the HMGB1 inhibitor glycyrrhizin in neurological disorders","volume":"11","author":"Paudel","year":"2020","journal-title":"ACS Chem. Neurosci."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102657_bib13","doi-asserted-by":"crossref","first-page":"15788","DOI":"10.3390\/molecules181215788","article-title":"Glycyrrhizin alleviates neuroinflammation and memory deficit induced by systemic lipopolysaccharide treatment in mice","volume":"18","author":"Song","year":"2013","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.mtbio.2025.102657_bib14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41573-021-00139-y","article-title":"Strategies for delivering therapeutics across the blood-brain barrier","volume":"20","author":"Terstappen","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102657_bib15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1021\/acs.bioconjchem.3c00174","article-title":"PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective","volume":"34","author":"Tenchov","year":"2023","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.mtbio.2025.102657_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112999","article-title":"Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): a current overview of active targeting in brain diseases","volume":"221","author":"Teixeira","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s40820-019-0330-9","article-title":"Cell membrane coating technology: a promising strategy for biomedical applications","volume":"11","author":"Liu","year":"2019","journal-title":"Nano-Micro Lett."},{"issue":"16","key":"10.1016\/j.mtbio.2025.102657_bib18","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.1021\/acs.nanolett.2c01863","article-title":"Engineered macrophage-membrane-coated nanoparticles with enhanced PD-1 expression induce immunomodulation for a synergistic and targeted antiglioblastoma activity","volume":"22","author":"Yin","year":"2022","journal-title":"Nano Lett."},{"issue":"43","key":"10.1016\/j.mtbio.2025.102657_bib19","doi-asserted-by":"crossref","first-page":"11488","DOI":"10.1073\/pnas.1714267114","article-title":"Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management","volume":"114","author":"Thamphiwatana","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1\u20132","key":"10.1016\/j.mtbio.2025.102657_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ijpharm.2017.12.048","article-title":"A novel lactoferrin-modified stealth liposome for hepatoma-delivery of triiodothyronine","volume":"537","author":"Pireddu","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.mtbio.2025.102657_bib21","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.3892\/ol.2014.2449","article-title":"A dual-targeting liposome conjugated with transferrin and arginine-glycine-aspartic acid peptide for glioma-targeting therapy","volume":"8","author":"Qin","year":"2014","journal-title":"Oncol. Lett."},{"issue":"24","key":"10.1016\/j.mtbio.2025.102657_bib22","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1002\/pmic.201500551","article-title":"Mass spectrometry of transferrin glycoforms to detect congenital disorders of glycosylation: Site-specific profiles and pitfalls","volume":"16","author":"Wada","year":"2016","journal-title":"Proteomics"},{"issue":"6","key":"10.1016\/j.mtbio.2025.102657_bib23","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.3390\/ijms24065283","article-title":"Establishing co-culture blood-brain barrier models for different neurodegeneration conditions to understand its effect on BBB integrity","volume":"24","author":"Park","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102657_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2023.578273","article-title":"Lipopolysaccharide-induced animal models for neuroinflammation-An overview","volume":"387","author":"da Silva","year":"2024","journal-title":"J. Neuroimmunol."},{"issue":"11","key":"10.1016\/j.mtbio.2025.102657_bib25","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/ptr.5893","article-title":"Toxicological effects of Glycyrrhiza glabra (Licorice): a review","volume":"31","author":"Nazari","year":"2017","journal-title":"Phytother Res. : PTR"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40824-023-00391-w","article-title":"Inhibition of DAMP actions in the tumoral microenvironment using lactoferrin-glycyrrhizin conjugate for glioblastoma therapy","volume":"27","author":"Kim","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.mtbio.2025.102657_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainres.2010.03.012","article-title":"Dexamethasone prevents LPS-induced microglial activation and astroglial impairment in an experimental bacterial meningitis co-culture model","volume":"1329","author":"Hinkerohe","year":"2010","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.mtbio.2025.102657_bib28","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.3747\/co.21.1769","article-title":"Use of dexamethasone in patients with high-grade glioma: a clinical practice guideline","volume":"21","author":"Kostaras","year":"2014","journal-title":"Curr. Oncol."},{"issue":"4","key":"10.1016\/j.mtbio.2025.102657_bib29","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.3390\/pharmaceutics15041056","article-title":"Time to kill and time to heal: the multifaceted role of lactoferrin and lactoferricin in host defense","volume":"15","author":"Ohradanova-Repic","year":"2023","journal-title":"Pharmaceutics"},{"issue":"35","key":"10.1016\/j.mtbio.2025.102657_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq0118","article-title":"Precise control of transmembrane current via regulating bionic lipid membrane composition","volume":"10","author":"Shang","year":"2024","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.mtbio.2025.102657_bib31","doi-asserted-by":"crossref","first-page":"10958","DOI":"10.1021\/acsomega.3c10346","article-title":"Long-term stable liposome modified by PEG-lipid in natural seawater","volume":"9","author":"Izumi","year":"2024","journal-title":"ACS Omega"},{"issue":"12","key":"10.1016\/j.mtbio.2025.102657_bib32","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1016\/j.apsb.2023.08.021","article-title":"Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration","volume":"13","author":"Wang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"29","key":"10.1016\/j.mtbio.2025.102657_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202308325","article-title":"Synthetic biomimetic liposomes harness efferocytosis machinery for highly efficient macrophages-targeted drug delivery to alleviate inflammation","volume":"11","author":"Han","year":"2024","journal-title":"Adv. Sci."},{"issue":"38","key":"10.1016\/j.mtbio.2025.102657_bib34","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1039\/D0TB01686A","article-title":"Highly biosafe biomimetic stem cell membrane-disguised nanovehicles for cartilage regeneration","volume":"8","author":"Zhang","year":"2020","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/pharmaceutics17010036","article-title":"Liposomal formulations: a recent update","volume":"17","author":"Agrawal","year":"2024","journal-title":"Pharmaceutics"},{"issue":"11","key":"10.1016\/j.mtbio.2025.102657_bib36","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1016\/j.apsb.2024.07.009","article-title":"Exemplifying interspecies variation of liposome in vivo fate by the effects of anti-PEG antibodies","volume":"14","author":"Wu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102657_bib37","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1021\/acsnano.0c05792","article-title":"Enhancing inflammation targeting using tunable leukocyte-based biomimetic nanoparticles","volume":"15","author":"Zinger","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib38","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s12951-022-01746-6","article-title":"Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment","volume":"20","author":"Wu","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"6","key":"10.1016\/j.mtbio.2025.102657_bib39","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/jpp\/rgad089","article-title":"Engineering carrier nanoparticles with biomimetic moieties for improved intracellular targeted delivery of mRNA therapeutics and vaccines","volume":"76","author":"Puccetti","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.apsb.2017.12.002","article-title":"Biomimetic nanoparticles for inflammation targeting","volume":"8","author":"Jin","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/j.mtbio.2025.102657_bib41","doi-asserted-by":"crossref","first-page":"C135","DOI":"10.1152\/ajpcell.00136.2018","article-title":"Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke","volume":"316","author":"Yang","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"Pt A","key":"10.1016\/j.mtbio.2025.102657_bib42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a strategy for improving nanoparticle-based drug and gene delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102657_bib43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/aps.2009.199","article-title":"Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations","volume":"31","author":"Gao","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"issue":"41","key":"10.1016\/j.mtbio.2025.102657_bib44","doi-asserted-by":"crossref","first-page":"28228","DOI":"10.1021\/acsnano.4c08157","article-title":"Biomimetic nanomodulator regulates oxidative and inflammatory stresses to treat sepsis-associated encephalopathy","volume":"18","author":"Qu","year":"2024","journal-title":"ACS Nano"},{"issue":"16","key":"10.1016\/j.mtbio.2025.102657_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202201095","article-title":"Anionic lipid nanoparticles preferentially deliver mRNA to the hepatic reticuloendothelial system","volume":"34","author":"Pattipeiluhu","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2025.102657_bib46","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.2147\/JIR.S362006","article-title":"Differential regional vulnerability of the brain to mild neuroinflammation induced by systemic LPS treatment in mice","volume":"15","author":"Jung","year":"2022","journal-title":"J. Inflamm. Res."},{"issue":"8","key":"10.1016\/j.mtbio.2025.102657_bib47","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.3390\/ijms25084435","article-title":"Cognitive impairment in neurological diseases","volume":"25","author":"Benito-Le\u00f3n","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102657_bib48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1515\/mr-2022-0046","article-title":"Versatile biomimetic nanomedicine for treating cancer and inflammation disease","volume":"3","author":"Zhao","year":"2023","journal-title":"Medical review (2021)"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102657_bib49","first-page":"5125","article-title":"HMGB1 mediates microglia activation via the TLR4\/NF-\u03baB pathway in coriaria lactone induced epilepsy","volume":"17","author":"Shi","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mtbio.2025.102657_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3389\/fncel.2019.00363","article-title":"Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain","volume":"13","author":"Miranda","year":"2019","journal-title":"Front. Cell. Neurosci."},{"issue":"Pt 3","key":"10.1016\/j.mtbio.2025.102657_bib51","article-title":"Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-\u039ab-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice","volume":"319","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102657_bib53","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.apsb.2025.01.015","article-title":"Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer's disease","volume":"15","author":"Wei","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.mtbio.2025.102657_bib54","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer'S disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib55","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease","volume":"19","author":"Singh","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mtbio.2025.102657_bib56","doi-asserted-by":"crossref","unstructured":"Y.T. Lin, C.Y. Ho, G.C. Sun, et al., Targeting acetylated high mobility group box 1 protein (HMGB1) and toll-like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose-fed rats, Br. J. Pharmacol. (2024). 1\u201318. Epub ahead of print.","DOI":"10.1111\/bph.17402"},{"key":"10.1016\/j.mtbio.2025.102657_bib57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1742-2094-7-30","article-title":"Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation","volume":"7","author":"Wilms","year":"2010","journal-title":"J. Neuroinflammation"},{"issue":"17","key":"10.1016\/j.mtbio.2025.102657_bib58","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1016\/j.neuron.2023.05.022","article-title":"PD-L1\/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior","volume":"111","author":"Zhao","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.mtbio.2025.102657_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.877936","article-title":"PD-1\/PD-L1 axis in neuroinflammation: new insights","volume":"13","author":"Manenti","year":"2022","journal-title":"Front. Neurol."},{"issue":"2","key":"10.1016\/j.mtbio.2025.102657_bib60","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1021\/acsnano.0c07973","article-title":"Neutrophil-like cell-membrane-coated nanozyme therapy for ischemic brain damage and long-term neurological functional recovery","volume":"15","author":"Feng","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.102657_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121904","article-title":"Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke","volume":"291","author":"Li","year":"2022","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.mtbio.2025.102657_bib62","doi-asserted-by":"crossref","first-page":"8417","DOI":"10.1021\/acsami.3c17092","article-title":"Melatonin-Loaded nanoparticles augment mitophagy to retard Parkinson's disease","volume":"16","author":"Biswal","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib63","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12951-025-03415-w","article-title":"Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability","volume":"23","author":"Liu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.102657_bib64","article-title":"Engineered exosomes improve the effects of curcumin on protecting mitochondria of neurons in Alzheimer's disease","volume":"32","author":"Ding","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"24","key":"10.1016\/j.mtbio.2025.102657_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202306675","article-title":"Hybrid membrane-coated nanoparticles for precise targeting and synergistic therapy in Alzheimer's disease","volume":"11","author":"Lin","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib66","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12974-022-02398-x","article-title":"PD-L1 signaling in reactive astrocytes counteracts neuroinflammation and ameliorates neuronal damage after traumatic brain injury","volume":"19","author":"Gao","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.mtbio.2025.102657_bib67","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1038\/s41467-023-40982-8","article-title":"PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation","volume":"14","author":"Linnerbauer","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102657_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1227049","article-title":"Neurological adverse events associated with PD-1\/PD-L1 immune checkpoint inhibitors","volume":"17","author":"Zhou","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mtbio.2025.102657_bib69","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.actbio.2023.03.002","article-title":"Genetically engineered PD-1 displaying nanovesicles for synergistic checkpoint blockades and chemo-metabolic therapy against non-small cell lung cancer","volume":"161","author":"Li","year":"2023","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.mtbio.2025.102657_bib70","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/j.ymthe.2023.04.011","article-title":"Genetically engineered nanovesicles mobilize synergistic antitumor immunity by ADAR1 silence and PDL1 blockade","volume":"31","author":"Ding","year":"2023","journal-title":"Mol. Ther. : the journal of the American Society of Gene Therapy"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425012293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425012293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:21:45Z","timestamp":1773901305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425012293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":70,"alternative-id":["S2590006425012293"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102657","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1\/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102657"}}