{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:15:26Z","timestamp":1773918926969,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52025035"],"award-info":[{"award-number":["52025035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203198"],"award-info":[{"award-number":["52203198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52495010"],"award-info":[{"award-number":["52495010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.mtbio.2025.102671","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T16:21:27Z","timestamp":1765642887000},"page":"102671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Active-targeted nano-hemostatic for hemostasis and brain microenvironment optimization in intracerebral hemorrhage therapy"],"prefix":"10.1016","volume":"36","author":[{"given":"Junyan","family":"An","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4726-4305","authenticated-orcid":false,"given":"Zhaohui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.102671_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41551-021-00697-x","article-title":"Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients","volume":"5","author":"Demen\u00e9","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2025.102671_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.5853\/jos.2023.01942.e1","article-title":"Cerebral amyloid angiopathy: an undeniable small vessel disease","volume":"26","author":"Wang","year":"2024","journal-title":"J Stroke"},{"key":"10.1016\/j.mtbio.2025.102671_bib3","article-title":"Edaravone dexborneol provides neuroprotective benefits by suppressing ferroptosis in experimental intracerebral hemorrhage","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2025.102671_bib4","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1161\/STR.0000000000000464","article-title":"2024 AHA\/ASA performance and quality measures for spontaneous intracerebral hemorrhage: a report from the American heart association\/american stroke association","volume":"55","author":"Ruff","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.mtbio.2025.102671_bib5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/STROKEAHA.123.046253","article-title":"Associated factors of long-term functional outcome and recovery pattern after intracerebral hemorrhage: a prospective population-based study in ulaanbaatar, Mongolia","volume":"56","author":"Sakamoto","year":"2025","journal-title":"Stroke"},{"key":"10.1016\/j.mtbio.2025.102671_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJMoa042991","article-title":"Recombinant activated factor VII for acute intracerebral hemorrhage","volume":"352","author":"Mayer","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.102671_bib7","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S1474-4422(20)30369-0","article-title":"Tranexamic acid in patients with intracerebral haemorrhage (STOP-AUST): a multicentre, randomised, placebo-controlled, phase 2 trial","volume":"19","author":"Meretoja","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mtbio.2025.102671_bib8","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/S0140-6736(18)31033-X","article-title":"Tranexamic acid for hyperacute primary IntraCerebral haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial","volume":"391","author":"Sprigg","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2025.102671_bib9","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1056\/NEJMoa2313040","article-title":"Andexanet for factor Xa inhibitor-associated acute intracerebral hemorrhage","volume":"390","author":"Connolly","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.102671_bib10","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s42003-025-07983-3","article-title":"Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhage","volume":"8","author":"Malojirao","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mtbio.2025.102671_bib11","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1001\/jama.2019.13014","article-title":"Association of surgical hematoma evacuation vs conservative treatment with functional outcome in patients with cerebellar intracerebral hemorrhage","volume":"322","author":"Kuramatsu","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.mtbio.2025.102671_bib12","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1039\/D0NR06249A","article-title":"Nanoparticles improved resveratrol brain delivery and its therapeutic efficacy against intracerebral hemorrhage","volume":"13","author":"Mo","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2025.102671_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300797","article-title":"Platelet-membrane-coated polydopamine nanoparticles for neuroprotection by reducing oxidative stress and repairing damaged vessels in intracerebral hemorrhage","volume":"12","author":"Xu","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.102671_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jconrel.2025.01.007","article-title":"Drug delivery strategy of hemostatic drugs for intracerebral hemorrhage","volume":"379","author":"An","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2025.102671_bib15","article-title":"Advances of nanotechnology for intracerebral hemorrhage therapy","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2025.102671_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1208\/s12249-024-02736-7","article-title":"Quercetin-loaded nanostructured lipid carrier in situ gel for brain targeting through intranasal route: formulation, in vivo pharmacokinetic and pharmacodynamic studies","volume":"25","author":"Sonawane","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.mtbio.2025.102671_bib17","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41551-024-01250-2","article-title":"Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood-brain barrier","volume":"9","author":"Shamul","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2025.102671_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfutfo.2025.01.014","article-title":"Recent advances and application challenges of quercetin-loaded delivery systems: from material selection to bioavailability","author":"Bai","year":"2025","journal-title":"Journal of Future Foods"},{"key":"10.1016\/j.mtbio.2025.102671_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112772","article-title":"Platelets and their role in hemostasis and thrombosis-from physiology to pathophysiology and therapeutic implications","volume":"23","author":"Scridon","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102671_bib20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12959-023-00463-w","article-title":"Structure, signal transduction, activation, and inhibition of integrin \u03b1IIb\u03b23","volume":"21","author":"Xin","year":"2023","journal-title":"Thromb. J."},{"key":"10.1016\/j.mtbio.2025.102671_bib21","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1016\/j.jtha.2023.03.041","article-title":"Quantitative super-resolution imaging of platelet degranulation reveals differential release of von Willebrand factor and von Willebrand factor propeptide from alpha-granules","volume":"21","author":"Swinkels","year":"2023","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.mtbio.2025.102671_bib22","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1016\/j.biomaterials.2012.12.045","article-title":"In vitro and in vivo hemostatic capabilities of a functionally integrated platelet-mimetic liposomal nanoconstruct","volume":"34","author":"Modery-Pawlowski","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102671_bib23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/ars.2021.0072","article-title":"Targeting oxidative stress and inflammatory response for blood-brain barrier protection in intracerebral hemorrhage","volume":"37","author":"Chen","year":"2022","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mtbio.2025.102671_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12964-023-01453-1","article-title":"Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity","volume":"22","author":"Dillemans","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.mtbio.2025.102671_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102010","article-title":"Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy","volume":"44","author":"Han","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.mtbio.2025.102671_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137386","article-title":"Protective effect of arzanol against H(2)O(2)-Induced oxidative stress damage in differentiated and undifferentiated SH-SY5Y cells","volume":"25","author":"Piras","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102671_bib27","article-title":"H(2)O(2)-Activated serotonin precursor probe for mapping neuronal redox homeostasis reveals 5-HT interactions with neighboring proteins under oxidative stress","volume":"12","author":"Liu","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2025.102671_bib28","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1021\/acs.molpharmaceut.5c00231","article-title":"Self-Assembled fingolimod (FTY720)-Loaded polymeric micelles protect brain from injury in intracerebral hemorrhage","volume":"22","author":"Yang","year":"2025","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.mtbio.2025.102671_bib29","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/nm1102-1227","article-title":"Platelets in atherothrombosis","volume":"8","author":"Ruggeri","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2025.102671_bib30","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1182\/blood-2004-04-1257","article-title":"Integrins: dynamic scaffolds for adhesion and signaling in platelets","volume":"104","author":"Shattil","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.mtbio.2025.102671_bib31","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1083\/jcb.99.6.2123","article-title":"Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization","volume":"99","author":"Wagner","year":"1984","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mtbio.2025.102671_bib32","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1021\/bm300192t","article-title":"Peptide-decorated liposomes promote arrest and aggregation of activated platelets under flow on vascular injury relevant protein surfaces in vitro","volume":"13","author":"Ravikumar","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.mtbio.2025.102671_bib33","doi-asserted-by":"crossref","first-page":"9247","DOI":"10.1021\/acsomega.3c08310","article-title":"Experimental study on rapid hemostasis using peptide hydrogels","volume":"9","author":"Zeng","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.mtbio.2025.102671_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105948","article-title":"Brain edema formation and therapy after intracerebral hemorrhage","volume":"176","author":"Wan","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mtbio.2025.102671_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnrt.2024.100136","article-title":"The 2023 yearbook of neurorestoratology","volume":"12","author":"Huang","year":"2024","journal-title":"J. Neurorestoratol."},{"key":"10.1016\/j.mtbio.2025.102671_bib36","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12967-023-04044-3","article-title":"CCL5\/CCR5-mediated peripheral inflammation exacerbates blood\u2012brain barrier disruption after intracerebral hemorrhage in mice","volume":"21","author":"Lin","year":"2023","journal-title":"J. Transl. Med."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425012438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425012438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:21:51Z","timestamp":1773901311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425012438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":36,"alternative-id":["S2590006425012438"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102671","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Active-targeted nano-hemostatic for hemostasis and brain microenvironment optimization in intracerebral hemorrhage therapy","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102671"}}