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Wagner, L. de Laporte, Microgels enable iPSCs to assemble, expand, and differentiate into organoids \u2013 from sizable to high throughput, bioRxiv [Preprint] (2025, cited December 3rd, 2025). https:\/\/doi.org\/10.1101\/2025.10.20.683388.","DOI":"10.1101\/2025.10.20.683388"},{"key":"10.1016\/j.mtbio.2025.102737_bib66","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"A threshold selection method from gray-level histograms","volume":"9","author":"Otsu","year":"1979","journal-title":"IEEE Trans. Syst. 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