{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:36:18Z","timestamp":1793730978945,"version":"4.6.1"},"reference-count":205,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000958","name":"American Association for the Advancement of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","award":["D2022023"],"award-info":[{"award-number":["D2022023"]}],"id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20241040"],"award-info":[{"award-number":["BK20241040"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403500"],"award-info":[{"award-number":["82403500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005134","name":"WILEY","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000704","name":"Royal Society of Chemistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["1020241241"],"award-info":[{"award-number":["1020241241"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2025.102758","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:50:05Z","timestamp":1768031405000},"page":"102758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Targeting IBD treatment: smart drug delivery systems for oral administration"],"prefix":"10.1016","volume":"37","author":[{"given":"Jiabin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-134X","authenticated-orcid":false,"given":"Changyong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2025.102758_bib1","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1038\/540S97a","article-title":"Inflammatory bowel disease","volume":"540","author":"Hodson","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.102758_bib2","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2025.102758_bib3","first-page":"17","article-title":"I.B.D. the global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the global burden of disease study 2017","volume":"2020","author":"Collaborators","year":"2017","journal-title":"The Lancet. Gastroenterology & Hepatology"},{"key":"10.1016\/j.mtbio.2025.102758_bib4","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/gutjnl-2012-303661","article-title":"Geographical variability and environmental risk factors in inflammatory bowel disease","volume":"62","author":"Ng","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2025.102758_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/17474124.2021.1840976","article-title":"Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia","volume":"15","author":"Wei","year":"2021","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.mtbio.2025.102758_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00000658-200001000-00006","article-title":"Risk factors for surgery and postoperative recurrence in crohn's disease","volume":"231","author":"Bernell","year":"2000","journal-title":"Ann. Surg."},{"key":"10.1016\/j.mtbio.2025.102758_bib7","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.cgh.2020.10.039","article-title":"Contemporary risk of surgery in patients with ulcerative colitis and crohn's disease: a meta-analysis of population-based cohorts","volume":"19","author":"Tsai","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mtbio.2025.102758_bib8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.crohns.2010.02.001","article-title":"The pattern and outcome of acute severe colitis","volume":"4","author":"Dinesen","year":"2010","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.mtbio.2025.102758_bib9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/apt.13491","article-title":"Review article: the practical management of acute severe ulcerative colitis","volume":"43","author":"Seah","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.mtbio.2025.102758_bib10","article-title":"Holistic healthcare in inflammatory bowel disease: time for patient-centric approaches?","volume":"72","author":"P","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2025.102758_bib11","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1053\/j.gastro.2022.01.023","article-title":"What does disease progression look like in ulcerative colitis, and how might it be prevented?","volume":"162","author":"Krugliak Cleveland","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib12","article-title":"Ulcerative colitis","volume":"380","author":"I","year":"2012","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.mtbio.2025.102758_bib13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41586-019-1856-1","article-title":"Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis","volume":"577","author":"Kakiuchi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2025.102758_bib14","article-title":"Risk of colorectal cancer in Asian patients with ulcerative colitis: a systematic review and meta-analysis","volume":"2","author":"S","year":"2017","journal-title":"The lancet. Gastroenterology & hepatology"},{"key":"10.1016\/j.mtbio.2025.102758_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.actbio.2024.09.007","article-title":"Stimulus-Responsive drug delivery nanoplatforms for inflammatory bowel disease therapy","volume":"188","author":"Long","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102758_bib16","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.7150\/thno.73650","article-title":"Turmeric-Derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis","volume":"12","author":"Gao","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.102758_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300051","article-title":"Sensitive quercetin nanoparticles ameliorate DSS\u2010Induced colitis in mice by colon\u2010specific delivery","volume":"68","author":"Wang","year":"2024","journal-title":"Molecular Nutrition Food Res"},{"key":"10.1016\/j.mtbio.2025.102758_bib19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijpharm.2016.05.043","article-title":"Effect of particle size on their accumulation in an inflammatory lesion in a dextran sulfate sodium (DSS)-Induced colitis model","volume":"509","author":"Watanabe","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2025.102758_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biomaterials.2019.05.012","article-title":"Multi-Bioresponsive silk fibroin-based nanoparticles with on-Demand cytoplasmic drug release capacity for CD44-Targeted alleviation of ulcerative colitis","volume":"212","author":"Gou","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102758_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202311890","article-title":"Colon targeting ph-responsive coacervate microdroplets for treatment of ulcerative colitis","volume":"20","author":"Tian","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.102758_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-019-1912-0","article-title":"Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis","volume":"21","author":"Hu","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.mtbio.2025.102758_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121125","article-title":"A ROS-Responsive fluorescent probe detecting experimental colitis by functional polymeric nanoparticles","volume":"609","author":"Wang","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2025.102758_bib24","doi-asserted-by":"crossref","first-page":"55966","DOI":"10.1021\/acsami.1c19457","article-title":"Antioxidant enzymes sequestered within lipid\u2013polymer hybrid nanoparticles for the local treatment of inflammatory bowel disease","volume":"13","author":"Le","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.102758_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02749-1","article-title":"Oral enzyme-responsive nanoprobes for targeted theranostics of inflammatory bowel disease","volume":"22","author":"Cao","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.102758_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejpb.2018.01.016","article-title":"Inflamed site-specific drug delivery System based on the interaction of human Serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis","volume":"125","author":"Iwao","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.mtbio.2025.102758_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118556","article-title":"Oral delivery of Infliximab using nano-in-microparticles for the treatment of inflammatory bowel disease","volume":"273","author":"Li","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2025.102758_bib28","doi-asserted-by":"crossref","first-page":"12679","DOI":"10.1039\/D1CS00029B","article-title":"Soft materials as biological and artificial membranes","volume":"50","author":"Tang","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.mtbio.2025.102758_bib30","doi-asserted-by":"crossref","first-page":"16339","DOI":"10.1039\/D0NR03680C","article-title":"Transport of artificial virus-like nanocarriers through intestinal monolayers via microfold cells","volume":"12","author":"Tong","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2025.102758_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jconrel.2014.03.039","article-title":"Budesonide loaded nanoparticles with pH-Sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases","volume":"183","author":"Ali","year":"2014","journal-title":"J Control Release"},{"key":"10.1016\/j.mtbio.2025.102758_bib32","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.nano.2017.04.007","article-title":"Discrimination between ulcerative colitis and Crohn's disease using phage display identified peptides and virus-mimicking synthetic nanoparticles","volume":"13","author":"Facchin","year":"2017","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.actbio.2022.05.046","article-title":"Active targeting redox-responsive mannosylated prodrug Nanocolloids promote tumor recognition and cell internalization for enhanced Colon cancer chemotherapy","volume":"147","author":"Gao","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102758_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106122","article-title":"Preparation and characterization of colon-targeted pH\/Time-Dependent nanoparticles using anionic and cationic polymethacrylate polymers","volume":"171","author":"Turanl\u0131","year":"2022","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib36","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.nano.2015.02.018","article-title":"Advances in oral nano-delivery systems for Colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue","volume":"11","author":"Hua","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib37","article-title":"Lipid nanoparticles with fine\u2010tuned composition show enhanced Colon targeting as a platform for mRNA therapeutics","volume":"12","author":"Rampado","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib38","article-title":"Chondroitin sulfate functionalized palmitic acid and Cysteine cografted-quaternized chitosan for CD44 and gut microbiota dual-targeted delivery of curcumin","volume":"20","author":"Xie","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.102758_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.addr.2014.12.003","article-title":"Non-genetic engineering of cells for drug delivery and cell-based therapy","volume":"91","author":"Wang","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.102758_bib40","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/jbm.a.36305","article-title":"Intestinal organoids containing Poly(Lactic\u2010Co\u2010glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases","volume":"106","author":"Davoudi","year":"2018","journal-title":"J Biomedical Materials Res"},{"key":"10.1016\/j.mtbio.2025.102758_bib41","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1039\/C4NR06377E","article-title":"An intestinal trojan horse for gene delivery","volume":"7","author":"Peng","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2025.102758_bib42","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/ibd\/izab193","article-title":"Antitumor necrosis factor-like ligand 1A therapy targets tissue inflammation and fibrosis pathways and reduces gut pathobionts in ulcerative colitis","volume":"28","author":"Hassan-Zahraee","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.mtbio.2025.102758_bib43","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2022.07.016","article-title":"SMAD4 suppresses colitis-associated carcinoma through inhibition of CCL20\/CCR6-Mediated inflammation","volume":"163","author":"Hanna","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106146","article-title":"Emerging pharmacotherapy for inflammatory bowel diseases","volume":"178","author":"Luo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mtbio.2025.102758_bib45","article-title":"Faecal metabolome and its determinants in inflammatory bowel disease","volume":"72","author":"A","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2025.102758_bib46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/ecco-jcc\/jjab177","article-title":"ECCO Guidelines on therapeutics in ulcerative colitis: surgical treatment","volume":"16","author":"Spinelli","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.mtbio.2025.102758_bib47","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1111\/apt.14672","article-title":"Systematic review with Meta-Analysis: endoscopic and histologic placebo rates in induction and maintenance trials of ulcerative colitis","volume":"47","author":"Ma","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.mtbio.2025.102758_bib48","article-title":"Combination tacrolimus and ustekinumab therapy is effective in inducing clinical, biochemical and endoscopic remission in refractory moderate to severe ulcerative colitis","volume":"21","author":"R","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.mtbio.2025.102758_bib49","article-title":"Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"6","author":"B","year":"2021","journal-title":"The lancet. Gastroenterology & hepatology"},{"key":"10.1016\/j.mtbio.2025.102758_bib50","article-title":"Efficacy and safety of maintenance ustekinumab for ulcerative colitis through 3 years: UNIFI long-term extension","volume":"16","author":"Mt","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.mtbio.2025.102758_bib51","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1053\/j.gastro.2022.02.033","article-title":"Higher vs standard Adalimumab induction and maintenance dosing regimens for treatment of ulcerative colitis: SERENE UC trial results","volume":"162","author":"Pan\u00e9s","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib52","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1215734","article-title":"Vedolizumab as induction and maintenance therapy for ulcerative colitis","volume":"369","author":"Feagan","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib53","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cgh.2021.02.043","article-title":"Efficacy and safety of tofacitinib in ulcerative colitis based on prior tumor necrosis factor inhibitor failure status","volume":"20","author":"Sandborn","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mtbio.2025.102758_bib54","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak\u2013STAT signaling in the immune System","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mtbio.2025.102758_bib55","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/apt.17162","article-title":"Increasing rates of venous thromboembolism among hospitalised patients with inflammatory bowel disease: a nationwide analysis","volume":"56","author":"Faye","year":"2022","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.mtbio.2025.102758_bib56","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41575-020-0273-0","article-title":"JAK-STAT pathway targeting for the treatment of inflammatory bowel disease","volume":"17","author":"Salas","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mtbio.2025.102758_bib57","article-title":"Immune checkpoint inhibitor therapy in colorectal cancer-the role of cellular pathology","volume":"29","author":"Ac","year":"2021","journal-title":"Int. J. Surg. Pathol."},{"key":"10.1016\/j.mtbio.2025.102758_bib58","article-title":"Ozanimod for the treatment of ulcerative colitis","volume":"162","author":"R","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib59","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s40265-022-01786-0","article-title":"Lenacapavir: first approval","volume":"82","author":"Paik","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.mtbio.2025.102758_bib60","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1126\/science.adh2718","article-title":"Phage therapy in noncommunicable diseases","volume":"382","author":"Kviatcovsky","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2025.102758_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104409","article-title":"Natural medicines for the treatment of fatigue: bioactive components, pharmacology, and mechanisms","volume":"148","author":"Luo","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mtbio.2025.102758_bib62","article-title":"Use of faecal transplantation with a novel diet for mild to moderate active ulcerative colitis: the CRAFT UC randomised controlled trial","volume":"16","author":"C","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.mtbio.2025.102758_bib63","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/ibd\/izaa049","article-title":"Lactic acid bacteria isolated from Korean kimchi activate the vitamin D receptor-autophagy signaling pathways","volume":"26","author":"Lu","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.mtbio.2025.102758_bib64","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.gastro.2006.11.041","article-title":"Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial","volume":"132","author":"Colombel","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib65","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMoa0904492","article-title":"Infliximab, azathioprine, or combination therapy for Crohn's disease","volume":"362","author":"Colombel","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib66","article-title":"Oral metal-free melanin nanozymes for natural and durable targeted treatment of Inflammatory Bowel Disease (IBD)","volume":"19","author":"Q","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.102758_bib67","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fphar.2020.00524","article-title":"Advances in oral drug delivery for regional targeting in the gastrointestinal tract - influence of physiological, pathophysiological and pharmaceutical factors","volume":"11","author":"Hua","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.102758_bib68","article-title":"Advances in oral drug delivery systems: challenges and opportunities","volume":"15","author":"J","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2025.102758_bib69","article-title":"Liposome-Based Drug Co-Delivery systems in cancer cells","volume":"71","author":"S","year":"2017","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1016\/j.mtbio.2025.102758_bib70","article-title":"pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents","volume":"8","author":"M","year":"2016","journal-title":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"},{"key":"10.1016\/j.mtbio.2025.102758_bib71","article-title":"A Facile strategy to prepare an enzyme-responsive mussel mimetic coating for drug delivery based on mesoporous Silica nanoparticles","volume":"33","author":"C","year":"2017","journal-title":"Langmuir : the ACS journal of surfaces and colloids"},{"key":"10.1016\/j.mtbio.2025.102758_bib72","article-title":"TPGS-Functionalized polydopamine-modified mesoporous silica as drug nanocarriers for enhanced lung cancer chemotherapy against multidrug resistance","volume":"13","author":"W","year":"2017","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2025.102758_bib73","article-title":"Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models","volume":"133","author":"M","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mtbio.2025.102758_bib74","article-title":"Superparamagnetic Iron oxide nanoparticles: cytotoxicity, metabolism, and cellular behavior in biomedicine applications","volume":"16","author":"H","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.102758_bib75","article-title":"Carbon nanotubes in biomedicine","volume":"378","author":"V","year":"2020","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.mtbio.2025.102758_bib76","article-title":"Quantum dots and their interaction with biological systems","volume":"23","author":"N","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib77","article-title":"Applications of semiconductor fabrication methods to nanomedicine: a review of recent inventions and techniques","volume":"3","author":"A","year":"2013","journal-title":"Recent Pat. Nanomed."},{"key":"10.1016\/j.mtbio.2025.102758_bib78","article-title":"Stimuli-Responsive nanocarriers for drug delivery","volume":"12","author":"S","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2025.102758_bib79","article-title":"Nanostructured multifunctional stimuli-responsive Glycopolypeptide-Based copolymers for biomedical applications","volume":"354","author":"M","year":"2023","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102758_bib80","article-title":"Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications","volume":"64","author":"E","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.102758_bib81","article-title":"Drug delivery strategies in the therapy of inflammatory bowel disease","volume":"71","author":"C","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"12","key":"10.1016\/j.mtbio.2025.102758_bib82","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1097\/MIB.0000000000000533","article-title":"New insights into the mechanisms of action of anti-tumor necrosis factor-\u03b1 monoclonal antibodies in inflammatory bowel disease","volume":"21","author":"Slevin","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.mtbio.2025.102758_bib83","article-title":"Genetically engineered pH-Responsive silk sericin nanospheres with efficient therapeutic effect on ulcerative colitis","volume":"144","author":"S","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102758_bib84","article-title":"An AIEgen-Based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT\/NIR-II fluorescent imaging and inhibiting NLRP3 inflammasome","volume":"283","author":"L","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102758_bib85","article-title":"Colon-Targeted adhesive Hydrogel microsphere for regulation of gut immunity and flora","volume":"8","author":"H","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib86","article-title":"Efficacy and safety of elective switching from intravenous to subcutaneous infliximab [CT-P13]: a multicentre cohort Study","volume":"16","author":"Pj","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.mtbio.2025.102758_bib87","first-page":"5","article-title":"3D printed infliximab suppositories for rectal biologic delivery","author":"A","year":"2023","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.mtbio.2025.102758_bib88","article-title":"A novel strategy for treating inflammatory bowel disease by targeting delivery of methotrexate through Glucan particles","volume":"9","author":"Y","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.102758_bib89","article-title":"Emerging therapies for inflammatory bowel disease","volume":"35","author":"R","year":"2018","journal-title":"Adv. Ther."},{"key":"10.1016\/j.mtbio.2025.102758_bib90","article-title":"Safety and efficacy of AJM300, an oral antagonist of \u03914 Integrin, in induction therapy for patients with active ulcerative colitis","volume":"149","author":"N","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib91","article-title":"Subcutaneous ustekinumab provides clinical benefit for two-thirds of patients with Crohn's disease refractory to anti-tumor necrosis factor agents","volume":"14","author":"P","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol. : the official clinical practice journal of the American Gastroenterological Association"},{"key":"10.1016\/j.mtbio.2025.102758_bib92","article-title":"Anti-IL-12\/23p40 antibodies for induction of remission in Crohn's disease","volume":"11","author":"Jk","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.mtbio.2025.102758_bib93","article-title":"Induction therapy with the selective Interleukin-23 inhibitor risankizumab in patients with moderate-to-severe crohn's disease: a randomised, Double-Blind, placebo-controlled phase 2 Study","volume":"389","author":"Bg","year":"2017","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.mtbio.2025.102758_bib94","article-title":"Risankizumab in patients with moderate to severe crohn's disease: an open-label extension Study","volume":"3","author":"Bg","year":"2018","journal-title":"The lancet. Gastroenterology & hepatology"},{"key":"10.1016\/j.mtbio.2025.102758_bib95","article-title":"Effects of AVX-470, an oral, locally acting anti-tumour necrosis factor antibody, on tissue biomarkers in patients with active ulcerative colitis","volume":"10","author":"Ds","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.mtbio.2025.102758_bib96","article-title":"Bacteremia as an adverse event of fecal microbiota transplantation in a patient with Crohn's disease and recurrent Clostridium Difficile infection","volume":"8","author":"R","year":"2014","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.mtbio.2025.102758_bib97","article-title":"Antibiotics in IBD: still a role in the biological era?","volume":"24","author":"O","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.mtbio.2025.102758_bib98","volume":"vol. 4","author":"Sl","year":"2012"},{"key":"10.1016\/j.mtbio.2025.102758_bib99","article-title":"Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials","volume":"8","author":"Nb","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib100","article-title":"The probiotic mixture VSL#3 dampens LPS-Induced chemokine expression in human dendritic cells by inhibition of STAT-1 phosphorylation","volume":"9","author":"R","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2025.102758_bib101","article-title":"Assessing the efficacy and safety of fecal microbiota transplantation and probiotic VSL#3 for active ulcerative colitis: a systematic review and meta-analysis","volume":"15","author":"X","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2025.102758_bib102","article-title":"Food-Specific IgGs are highly increased in the sera of patients with inflammatory bowel disease and are clinically relevant to the pathogenesis","volume":"57","author":"N","year":"2018","journal-title":"Intern. Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib103","article-title":"[Efficacy of Yunnan Baiyao as an Adjuvant Treatment for Active Ulcerative Colitis: An Open-Label Randomized Controlled Study]","volume":"36","author":"Wz","year":"2016","journal-title":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University"},{"key":"10.1016\/j.mtbio.2025.102758_bib104","article-title":"A Chinese herb Tripterygium Wilfordii hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety","volume":"31","author":"J","year":"2011","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.mtbio.2025.102758_bib105","article-title":"Oral delivery of Micro\/Nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: challenges, advances and future perspectives","volume":"334","author":"Am","year":"2021","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102758_bib106","article-title":"Objective evaluation of small bowel and colonic transit time using pH telemetry in athletes with gastrointestinal symptoms","volume":"38","author":"Ka","year":"2004","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib107","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1053\/j.gastro.2010.10.036","article-title":"Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis","volume":"139","author":"Sartor","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib108","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12929-018-0483-8","article-title":"Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground Hypothesis","volume":"25","author":"Yu","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib109","article-title":"Small intestinal transit time and intraluminal pH in ileocecal resected patients with Crohn's disease","volume":"43","author":"J","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib110","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1097\/MEG.0000000000002157","article-title":"Small intestinal bacterial overgrowth and orocecal transit time in patients of nonalcoholic Fatty liver disease","volume":"33","author":"Shi","year":"2021","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mtbio.2025.102758_bib111","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0378-5173(92)90245-W","article-title":"The transit rate of different-sized model dosage forms through the human Colon and the effects of a lactulose-induced catharsis","volume":"87","author":"Watts","year":"1992","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2025.102758_bib112","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1053\/j.gastro.2014.01.058","article-title":"Diet and the intestinal microbiome: associations, functions, and implications for health and disease","volume":"146","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib113","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/jps.24365","article-title":"Animal farm: considerations in animal gastrointestinal physiology and relevance to drug delivery in humans","volume":"104","author":"Hatton","year":"2015","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.mtbio.2025.102758_bib114","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/0884533613490740","article-title":"Consequences of gastrointestinal surgery on drug absorption","volume":"28","author":"Titus","year":"2013","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.mtbio.2025.102758_bib115","first-page":"23","article-title":"Electrolyte and acid-base disorders in inflammatory bowel disease","volume":"26","author":"Barkas","year":"2013","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.mtbio.2025.102758_bib116","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1136\/gut.19.8.735","article-title":"Acid microclimate in coeliac and Crohn's disease: a model for folate malabsorption","volume":"19","author":"Lucas","year":"1978","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2025.102758_bib117","article-title":"Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease","volume":"9","author":"B","year":"2012","journal-title":"Expet Opin. Drug Deliv."},{"key":"10.1016\/j.mtbio.2025.102758_bib118","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/003655201753265082","article-title":"The bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics","author":"Linskens","year":"2001","journal-title":"Scand. J. Gastroenterol. Suppl."},{"key":"10.1016\/j.mtbio.2025.102758_bib119","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3748\/wjg.v20.i5.1165","article-title":"Intestinal barrier in inflammatory bowel disease","volume":"20","author":"Antoni","year":"2014","journal-title":"World J. Gastroenterol. : WJG"},{"key":"10.1016\/j.mtbio.2025.102758_bib120","article-title":"Size-Dependent nanoparticulate drug delivery in inflammatory bowel diseases","volume":"13","author":"J","year":"2016","journal-title":"Expet Opin. Drug Deliv."},{"key":"10.1016\/j.mtbio.2025.102758_bib121","article-title":"Nanogels of a succinylated glycol chitosan-succinyl prednisolone conjugate: release behavior, gastrointestinal distribution, and systemic absorption","volume":"21","author":"H","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib122","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12929-023-00935-1","article-title":"Akkermansia Muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143\/145","volume":"30","author":"Wade","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib123","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1365-2982.2012.01953.x","article-title":"Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea","volume":"24","author":"Gracie","year":"2012","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.mtbio.2025.102758_bib124","article-title":"Role of exosomes in the development of the immune microenvironment in hepatocellular carcinoma","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.102758_bib125","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2174\/156720112803529774","article-title":"Biochemical and physiological considerations of the Colon in design and development of novel drug delivery systems","volume":"9","author":"Vadlamudi","year":"2012","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.mtbio.2025.102758_bib126","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbrc.2022.06.061","article-title":"Measurement of intraluminal pH changes in the gastrointestinal tract of mice with gastrointestinal diseases","volume":"620","author":"Sun","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mtbio.2025.102758_bib127","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jconrel.2016.06.016","article-title":"Nanoparticles for oral delivery: design, evaluation and state-of-the-art","volume":"240","author":"Date","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.mtbio.2025.102758_bib128","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jps.23828","article-title":"pH-Sensitive nanoparticles of curcumin-celecoxib combination: evaluating drug synergy in ulcerative colitis model","volume":"103","author":"Gugulothu","year":"2014","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.mtbio.2025.102758_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2008.12.013","article-title":"pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced Colitis Rat model","volume":"72","author":"Makhlof","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.mtbio.2025.102758_bib130","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3109\/10837450.2011.557732","article-title":"Preparation and characterization of nanocapsules for colon-targeted drug delivery System","volume":"17","author":"Kshirsagar","year":"2012","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.mtbio.2025.102758_bib131","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1023\/A:1012248721523","article-title":"Biodistribution of long-circulating PEG-Grafted nanocapsules in mice: effects of PEG chain length and density","volume":"18","author":"Mosqueira","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.mtbio.2025.102758_bib132","article-title":"pH-Responsive interface conversion efficient oral drug delivery platform for alleviating inflammatory bowel disease","volume":"12","author":"Y","year":"2024","journal-title":"Frontiers in chemistry"},{"key":"10.1016\/j.mtbio.2025.102758_bib133","article-title":"pH-Responsive CuS\/DSF\/EL\/PVP nanoplatform alleviates inflammatory bowel disease in mice via regulating gut immunity and microbiota","volume":"178","author":"J","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102758_bib134","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41580-022-00456-z","article-title":"Defining roles of specific Reactive Oxygen Species (ROS) in cell biology and physiology","volume":"23","author":"Sies","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2025.102758_bib135","article-title":"ROS-Responsive nanoparticles for oral delivery of Luteolin and targeted therapy of ulcerative colitis by regulating pathological microenvironment","volume":"14","author":"Tan","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2025.102758_bib136","article-title":"A curcumin-modified coordination polymers with ROS scavenging and macrophage phenotype regulating properties for efficient ulcerative colitis treatment","volume":"10","author":"H","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib137","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmat2859","article-title":"Orally delivered thioketal nanoparticles loaded with TNF-\u03b1-siRNA target inflammation and inhibit gene expression in the intestines","volume":"9","author":"Wilson","year":"2010","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2025.102758_bib138","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1053\/j.gastro.2012.06.043","article-title":"An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice","volume":"143","author":"Vong","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib139","article-title":"\u201cDual Sensitive Supramolecular Curcumin Nanoparticles\u201d in \u201cAdvanced Yeast Particles\u201d mediate macrophage reprogramming, ROS scavenging and inflammation resolution for ulcerative colitis treatment","volume":"21","author":"X","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2025.102758_bib140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2015.05.275","article-title":"Specific accumulation of orally administered redox nanotherapeutics in the inflamed Colon reducing inflammation with dose-response efficacy","volume":"210","author":"Vong","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.mtbio.2025.102758_bib141","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.biomaterials.2016.08.010","article-title":"A superoxide Dismutase\/Catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease","volume":"105","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102758_bib142","article-title":"Colon-Targeted oral nanoparticles based on ROS-Scavenging hydroxyethyl starch-curcumin conjugates for efficient inflammatory bowel disease therapy","volume":"623","author":"C","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2025.102758_bib143","article-title":"An efficient enzyme-triggered controlled release System for colon-targeted oral delivery to combat dextran Sodium sulfate (DSS)-Induced colitis in mice","volume":"28","author":"S","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.mtbio.2025.102758_bib144","article-title":"Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells","volume":"101","author":"C","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mtbio.2025.102758_bib145","article-title":"Chitosan-Modified lipid nanodrug delivery System for the targeted and responsive treatment of ulcerative colitis","volume":"230","author":"Sq","year":"2020","journal-title":"Carbohydrate polymers"},{"key":"10.1016\/j.mtbio.2025.102758_bib146","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1074\/jbc.M117.811299","article-title":"Ligand-Activated Epidermal Growth Factor Receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation","volume":"293","author":"Tanaka","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2025.102758_bib147","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00018-023-04768-x","article-title":"Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling","volume":"80","author":"Zukowska","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib148","article-title":"Dual-Targeted nanoparticle-in-microparticle System for ulcerative colitis therapy","volume":"12","author":"Y","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.102758_bib149","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2018.06.037","article-title":"Transferrin and transferrin receptors update","volume":"133","author":"Kawabata","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib150","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.dld.2019.06.012","article-title":"Gut Microbiota, dysbiosis and Colon lavage","volume":"51","author":"Drago","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.mtbio.2025.102758_bib151","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00284-023-03253-9","article-title":"Comprehensive analysis of the physiological characterization of Escherichia Coli nissle 1917","volume":"80","author":"Ramadevi","year":"2023","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.mtbio.2025.102758_bib152","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1039\/D2TB00300G","article-title":"Oral nanozyme-engineered probiotics for the treatment of ulcerative colitis","volume":"10","author":"Zhao","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2025.102758_bib153","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abp8798","article-title":"Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases","volume":"8","author":"Liu","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2025.102758_bib154","doi-asserted-by":"crossref","first-page":"14718","DOI":"10.1021\/acsnano.3c02646","article-title":"Gastrointestinal microenvironment responsive nanoencapsulation of probiotics and drugs for synergistic therapy of intestinal diseases","volume":"17","author":"Peng","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.102758_bib155","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41565-023-01346-x","article-title":"Artificial-Enzymes-Armed Bifidobacterium Longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis","volume":"18","author":"Cao","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.mtbio.2025.102758_bib156","article-title":"Enhanced macrophage delivery to the Colon using magnetic lipoplexes with a magnetic field","volume":"26","author":"Y","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.mtbio.2025.102758_bib157","article-title":"A new colitis therapy strategy via the target colonization of magnetic nanoparticle-internalized Roseburia Intestinalis","volume":"7","author":"M","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib158","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"X","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.mtbio.2025.102758_bib159","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.addr.2018.10.002","article-title":"Light-Responsive nanomedicine for biophotonic imaging and targeted therapy","volume":"138","author":"Son","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.102758_bib160","article-title":"Advanced light delivery materials and systems for photomedicines","volume":"194","author":"Sj","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.102758_bib161","article-title":"Light-Switchable systems for remotely controlled drug delivery","volume":"267","author":"G","year":"2017","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102758_bib162","article-title":"PPARGC1A affects inflammatory responses in photodynamic therapy (PDT)-Treated Inflammatory Bowel Disease (IBD)","volume":"202","author":"C","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.102758_bib163","article-title":"Photodynamic effects with 5-Aminolevulinic acid on cytokines and exosomes in human peripheral blood mononuclear cells from patients with Crohn's disease","volume":"24","author":"K","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib164","article-title":"Photodynamic therapy","volume":"32","author":"Am","year":"2014","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.mtbio.2025.102758_bib165","article-title":"Photosensitizers for photodynamic therapy","volume":"8","author":"M","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2025.102758_bib166","article-title":"Impact of antimicrobial photodynamic therapy on the bond-strength and penetration of endodontic sealers: a systematic review","volume":"41","author":"Kh","year":"2023","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.mtbio.2025.102758_bib167","article-title":"Photothermal therapy","volume":"325","author":"D","year":"2020","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102758_bib168","article-title":"Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery","volume":"268","author":"Cm","year":"2017","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102758_bib169","first-page":"163","article-title":"Hyperthermia and smart drug delivery systems for solid tumor therapy","author":"Alb","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2025.102758_bib170","article-title":"Temperature-Triggered in situ forming lipid mesophase Gel for local treatment of ulcerative colitis","volume":"14","author":"M","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2025.102758_bib171","article-title":"Thermosensitive polymer Hydrogel as a physical shield on colonic mucosa for colitis treatment","volume":"9","author":"Z","year":"2021","journal-title":"Journal of materials chemistry"},{"key":"10.1016\/j.mtbio.2025.102758_bib172","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1039\/D0BM01324B","article-title":"An NIR-Activated polymeric nanoplatform with ROS- and temperature-sensitivity for combined photothermal therapy and chemotherapy of pancreatic cancer","volume":"8","author":"Zhan","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2025.102758_bib173","doi-asserted-by":"crossref","first-page":"50692","DOI":"10.1021\/acsami.2c17827","article-title":"pH\/ROS dual-sensitive natural polysaccharide nanoparticles enhance \u201cOne Stone Four Birds\u201d effect of rhein on ulcerative colitis","volume":"14","author":"Qi","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2025.102758_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121937","article-title":"ROS-Triggered self-disintegrating and pH-Responsive astaxanthin nanoparticles for regulating the intestinal barrier and colitis","volume":"292","author":"Zhang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102758_bib175","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1021\/acsbiomaterials.3c01191","article-title":"Cyclosporine A-Encapsulated pH\/ROS dual-responsive nanoformulations for the targeted treatment of colitis in mice","volume":"9","author":"Li","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.mtbio.2025.102758_bib176","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/1061186X.2022.2052887","article-title":"Dual-Targeted colon-based integrated Micelle drug delivery System for treatment of ulcerative colitis","volume":"30","author":"Miao","year":"2022","journal-title":"J. Drug Target."},{"key":"10.1016\/j.mtbio.2025.102758_bib177","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2147\/IJN.S338897","article-title":"ROS-Generating amine-functionalized magnetic nanoparticles coupled with carboxymethyl Chitosan for pH-Responsive release of doxorubicin","volume":"17","author":"Obireddy","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.mtbio.2025.102758_bib178","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.actbio.2015.06.037","article-title":"The role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity","volume":"25","author":"Wydra","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2025.102758_bib179","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijpharm.2014.07.009","article-title":"pH-Sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease","volume":"473","author":"Beloqui","year":"2014","journal-title":"Int J Pharm"},{"key":"10.1016\/j.mtbio.2025.102758_bib180","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2022.08.018","article-title":"Corrigendum to \u201cIn Situ Hydrogel Capturing Nitric Oxide Microbubbles Accelerates the Healing of Diabetic Foot\u201d","volume":"350","author":"Zhao","year":"2022","journal-title":"J Control Release"},{"key":"10.1016\/j.mtbio.2025.102758_bib181","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm1148","article-title":"A substitution in the glutathione reductase lowers Electron leakage and inflammation in modern humans","volume":"8","author":"Coppo","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2025.102758_bib182","doi-asserted-by":"crossref","first-page":"17287","DOI":"10.1021\/acsnano.4c14373","article-title":"Reactive oxygen species-responsive polymer drug delivery System targeted oxidative stressed Colon cells to ameliorate colitis","volume":"19","author":"Cai","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2025.102758_bib183","article-title":"Oral administration of therapeutic enzyme capsule for the management of inflammatory bowel disease","volume":"17","author":"X","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.102758_bib184","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biomaterials.2018.07.006","article-title":"Receptor mediated transcytosis in biological barrier: the influence of receptor character and their ligand density on the transmembrane pathway of active-targeting nanocarriers","volume":"180","author":"Song","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102758_bib185","article-title":"Colorectal cancer in inflammatory bowel disease: mechanisms and management","volume":"162","author":"Sc","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib186","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/pharmaceutics15020467","article-title":"Controlled release of felodipine from 3D-Printed tablets with constant surface area: influence of surface geometry","volume":"15","author":"Thanawuth","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2025.102758_bib187","article-title":"Photodynamic therapy - mechanisms, photosensitizers and combinations","volume":"106","author":"S","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.mtbio.2025.102758_bib188","article-title":"Recent advances in nanomedicines for photodynamic therapy (PDT)-Driven cancer immunotherapy","volume":"12","author":"B","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.102758_bib189","article-title":"Photodynamic therapy as salvage therapy for residual microscopic cancer after ultra-low anterior resection: a case report","volume":"7","author":"Sq","year":"2019","journal-title":"World journal of clinical cases"},{"key":"10.1016\/j.mtbio.2025.102758_bib190","article-title":"Photodynamic therapy improves the clinical efficacy of advanced colorectal cancer and recruits immune cells into the tumor immune microenvironment","volume":"13","author":"B","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2025.102758_bib191","doi-asserted-by":"crossref","DOI":"10.1055\/s-0030-1256382","article-title":"Low dose endoluminal photodynamic therapy improves murine T cell-mediated colitis","volume":"43","author":"Favre","year":"2011","journal-title":"Endoscopy"},{"key":"10.1016\/j.mtbio.2025.102758_bib192","article-title":"Photodynamic therapy relieves colitis and prevents colitis-associated carcinogenesis in mice","volume":"21","author":"A","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.mtbio.2025.102758_bib193","article-title":"Neat1-miRNA204-5p-PI3K-AKT axis as a potential mechanism for photodynamic therapy treated colitis in mice","volume":"24","author":"K","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.mtbio.2025.102758_bib194","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.746725","article-title":"Photodynamic therapy of novel photosensitizer ameliorates TNBS-Induced ulcerative colitis via inhibition of AOC1","volume":"12","author":"Rong","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2025.102758_bib195","article-title":"Photodynamic therapy in the treatment of bladder cancer: past challenges and Current innovations","volume":"4","author":"R","year":"2018","journal-title":"European urology focus"},{"key":"10.1016\/j.mtbio.2025.102758_bib196","article-title":"pDNA-Loaded bubble liposomes as potential ultrasound imaging and gene delivery agents","volume":"34","author":"Y","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102758_bib197","article-title":"Crucial factors and emerging concepts in ultrasound-triggered drug delivery","volume":"164","author":"B","year":"2012","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.mtbio.2025.102758_bib198","article-title":"Cell-Cycle-Specific cellular responses to sonoporation","volume":"7","author":"P","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2025.102758_bib199","article-title":"Ultrasound-Mediated gastrointestinal drug delivery","volume":"7","author":"Cm","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mtbio.2025.102758_bib200","article-title":"Perfluorooctylbromide nanoparticles for ultrasound imaging and drug delivery","volume":"13","author":"X","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2025.102758_bib201","article-title":"Ultrasound-Mediated delivery of RNA to colonic mucosa of live mice","volume":"152","author":"Cm","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2025.102758_bib202","article-title":"Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery","volume":"34","author":"R","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2025.102758_bib203","article-title":"Multi-Responsive hydrogels for drug delivery and tissue engineering applications","volume":"1","author":"Jm","year":"2014","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.mtbio.2025.102758_bib204","article-title":"OPTICORETM, an innovative and accurate colonic targeting technology","volume":"583","author":"F","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2025.102758_bib205","article-title":"A dual pH and Microbiota-Triggered coating (PhloralTM) for fail-safe colonic drug release","volume":"583","author":"F","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2025.102758_bib206","article-title":"Dual stimuli-responsive delivery System for self-regulated colon-targeted delivery of poorly water-soluble drugs","volume":"157","author":"Me","year":"2024","journal-title":"Biomaterials advances"},{"key":"10.1016\/j.mtbio.2025.102758_bib207","article-title":"Mn3O4 nanozyme loaded thermosensitive PDLLA-PEG-PDLLA hydrogels for the treatment of inflammatory bowel disease","volume":"15","author":"Z","year":"2023","journal-title":"ACS applied materials & interfaces"},{"key":"10.1016\/j.mtbio.2025.102758_bib208","article-title":"Advances in colon-targeted drug technologies","volume":"41","author":"C","year":"2025","journal-title":"Curr. Opin. Gastroenterol."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425013304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006425013304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:12:15Z","timestamp":1774357935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006425013304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":205,"alternative-id":["S2590006425013304"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102758","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting IBD treatment: smart drug delivery systems for oral administration","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102758"}}