{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:03:32Z","timestamp":1774361012789,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12272031"],"award-info":[{"award-number":["12272031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20363"],"award-info":[{"award-number":["U23A20363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2026.102786","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T16:32:59Z","timestamp":1768235579000},"page":"102786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Stiff matrix promotes lung cancer cell migration through down-regulating the Piezo1 channel expression to facilitate Ca2+-dependent filopodia formation"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-7273","authenticated-orcid":false,"given":"Xiaoling","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juncheng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7524-2241","authenticated-orcid":false,"given":"Lu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2326-2814","authenticated-orcid":false,"given":"Qianyu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haikun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqi","family":"Men","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6398-0411","authenticated-orcid":false,"given":"Lin-Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huawei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mtbio.2026.102786_bib1","first-page":"17","article-title":"Cancer statistics","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.mtbio.2026.102786_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lungcan.2021.11.015","article-title":"A risk prediction model for selecting high-risk population for computed tomography lung cancer screening in China","volume":"163","author":"Guo","year":"2022","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.mtbio.2026.102786_bib3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-022-01252-0","article-title":"Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy","volume":"15","author":"Jiang","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102786_bib4","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/jcb.27681","article-title":"Extracellular matrix (ECM) stiffness and degradation as cancer drivers","volume":"120","author":"Najafi","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102786_bib5","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aaafbc","article-title":"Matrix stiffness and tumor-associated macrophages modulate epithelial to mesenchymal transition of human adenocarcinoma cells","volume":"10","author":"Alonso-Nocelo","year":"2018","journal-title":"Biofabrication"},{"issue":"9","key":"10.1016\/j.mtbio.2026.102786_bib6","article-title":"Matrix stiffness regulates migration of human lung fibroblasts","volume":"5","author":"Asano","year":"2017","journal-title":"Phys. Rep."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102786_bib7","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1016\/j.bbrc.2017.12.115","article-title":"Regulation of PD-L1 expression by matrix stiffness in lung cancer cells","volume":"495","author":"Miyazawa","year":"2018","journal-title":"Biochem Bioph Res Co"},{"issue":"5","key":"10.1016\/j.mtbio.2026.102786_bib8","doi-asserted-by":"crossref","first-page":"F693","DOI":"10.1152\/ajprenal.00545.2020","article-title":"Role of the polycystins as mechanosensors of extracellular stiffness","volume":"320","author":"Nigro","year":"2021","journal-title":"Am J Physiol-Renal"},{"issue":"6000","key":"10.1016\/j.mtbio.2026.102786_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"issue":"7388","key":"10.1016\/j.mtbio.2026.102786_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature10801","article-title":"The role of Piezo in mechanical nociception","volume":"483","author":"Kim","year":"2012","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.mtbio.2026.102786_bib11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrm.2017.92","article-title":"Piezos thrive under pressure: mechanically activated ion channels in health and disease","volume":"18","author":"Murthy","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"19","key":"10.1016\/j.mtbio.2026.102786_bib12","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.3390\/cancers14194955","article-title":"Mechanosensitive ion channel PIEZO1 signaling in the Hall-Marks of cancer: structure and functions","volume":"14","author":"Zhao","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102786_bib13","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1111\/jcmm.16217","article-title":"Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis","volume":"25","author":"Wang","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102786_bib14","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181679","article-title":"Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration","volume":"39","author":"Huang","year":"2019","journal-title":"Biosci. Rep."},{"issue":"7","key":"10.1016\/j.mtbio.2026.102786_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040346","article-title":"Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration","volume":"7","author":"McHugh","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.mtbio.2026.102786_bib16","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/1759-7714.15278","article-title":"PIEZO1 acts as a cancer suppressor by regulating the ROS\/Wnt\/\u03b2-catenin axis","volume":"15","author":"Bo","year":"2024","journal-title":"Thorac. Cancer"},{"issue":"5957","key":"10.1016\/j.mtbio.2026.102786_bib17","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1175862","article-title":"Actin, a central player in cell shape and movement","volume":"326","author":"Pollard","year":"2009","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.mtbio.2026.102786_bib18","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.cellsig.2013.07.006","article-title":"Filopodia as sensors","volume":"25","author":"Heckman","year":"2013","journal-title":"Cell. Signal."},{"issue":"5","key":"10.1016\/j.mtbio.2026.102786_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4161\/cam.5.5.17723","article-title":"Filopodia and adhesion in cancer cell motility","volume":"5","author":"Arjonen","year":"2011","journal-title":"Cell Adhes. Migrat."},{"key":"10.1016\/j.mtbio.2026.102786_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ceb.2015.06.007","article-title":"Filopodia in cell adhesion, 3D migration and cancer cell invasion","volume":"36","author":"Jacquemet","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"issue":"7","key":"10.1016\/j.mtbio.2026.102786_bib21","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.7150\/ijbs.56694","article-title":"NDRG1 regulates Filopodia-induced colorectal cancer invasiveness via modulating CDC42 activity","volume":"17","author":"Aikemu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102786_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089767","article-title":"Substrate stiffness regulates filopodial activities in lung cancer cells","volume":"9","author":"Liou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2026.102786_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.588556","article-title":"Direct visualization of actin filaments and actin-binding proteins in neuronal cells","volume":"8","author":"Jung","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"Pt 14","key":"10.1016\/j.mtbio.2026.102786_bib24","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1242\/jcs.03017","article-title":"Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells","volume":"119","author":"Song","year":"2006","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102786_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2443.1999.00235.x","article-title":"Cooperation of two actin-binding proteins, cofilin and Aip1, in Saccharomyces cerevisiae","volume":"4","author":"Iida","year":"1999","journal-title":"Genes Cells"},{"issue":"47","key":"10.1016\/j.mtbio.2026.102786_bib26","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1523\/JNEUROSCI.2836-04.2004","article-title":"Brain-derived neurotrophic factor regulation of retinal growth cone filopodial dynamics is mediated through actin depolymerizing factor\/cofilin","volume":"24","author":"Gehler","year":"2004","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.mtbio.2026.102786_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1447-073x.2004.00087.x","article-title":"Regulating filopodial dynamics through actin-depolymerizing factor\/cofilin","volume":"79","author":"Fass","year":"2004","journal-title":"Anat. Sci. Int."},{"issue":"7388","key":"10.1016\/j.mtbio.2026.102786_bib28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature10812","article-title":"Piezo proteins are pore-forming subunits of mechanically activated channels","volume":"483","author":"Coste","year":"2012","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.mtbio.2026.102786_bib29","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.3390\/cells10112815","article-title":"Channeling the force: piezo1 mechanotransduction in cancer metastasis","volume":"10","author":"Dombroski","year":"2021","journal-title":"Cells"},{"issue":"7773","key":"10.1016\/j.mtbio.2026.102786_bib30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41586-019-1499-2","article-title":"Force-induced conformational changes in PIEZO1","volume":"573","author":"Lin","year":"2019","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.mtbio.2026.102786_bib31","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1074\/jbc.M411494200","article-title":"Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin","volume":"280","author":"Wang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102786_bib32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s10020-021-00360-w","article-title":"G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1","volume":"27","author":"Sun","year":"2021","journal-title":"Mol. Med."},{"key":"10.1016\/j.mtbio.2026.102786_bib33","article-title":"Preparation of hydrogel substrates with tunable mechanical properties","volume":"10","author":"Tse","year":"2010","journal-title":"Curr. Protoc. Cell Biol. Chapter."},{"issue":"18","key":"10.1016\/j.mtbio.2026.102786_bib34","first-page":"1511","article-title":"Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening","volume":"19","author":"Klein","year":"2009"},{"key":"10.1016\/j.mtbio.2026.102786_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-61779-207-6_8","article-title":"Transwell((R)) invasion assays","volume":"769","author":"Marshall","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102786_bib36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00424-012-1182-z","article-title":"Involvement of large conductance Ca(2+)-activated K (+) channel in laminar shear stress-induced inhibition of vascular smooth muscle cell proliferation","volume":"465","author":"Jia","year":"2013","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"10","key":"10.1016\/j.mtbio.2026.102786_bib37","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1002\/jcp.30349","article-title":"Stimulation of vascular smooth muscle cell proliferation by stiff matrix via the IK(Ca) channel-dependent Ca(2+) signaling","volume":"236","author":"Jia","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102786_bib38","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1038\/s41467-022-35034-6","article-title":"Membrane curvature governs the distribution of Piezo1 in live cells","volume":"13","author":"Yang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.102786_bib39","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.bbrc.2020.11.012","article-title":"Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells","volume":"534","author":"Suzuki","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mtbio.2026.102786_bib40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cellsig.2018.01.020","article-title":"Ripk3 regulates cardiac microvascular reperfusion injury: the role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action\/filopodia-based cellular migration","volume":"45","author":"Zhou","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mtbio.2026.102786_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65415","article-title":"Correction: spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing","volume":"10","author":"Holt","year":"2021","journal-title":"eLife"},{"issue":"3","key":"10.1016\/j.mtbio.2026.102786_bib42","doi-asserted-by":"crossref","first-page":"E390","DOI":"10.1073\/pnas.1717230115","article-title":"Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration","volume":"115","author":"Kim","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.mtbio.2026.102786_bib43","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.7150\/ijbs.87829","article-title":"Pharmacological manipulation of TRPC5 by kaempferol attenuates metastasis of gastrointestinal cancer via inhibiting calcium involved in the formation of filopodia","volume":"20","author":"Yu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mtbio.2026.102786_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13297","article-title":"L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling","volume":"7","author":"Jacquemet","year":"2016","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102786_bib45","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200809046","article-title":"Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis","volume":"185","author":"Hotulainen","year":"2009","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.mtbio.2026.102786_bib46","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.neuropharm.2004.06.030","article-title":"Regulation of ADF\/cofilin phosphorylation and synaptic function by LIM-kinase","volume":"47","author":"Meng","year":"2004","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.mtbio.2026.102786_bib47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0896-6273(02)00758-4","article-title":"Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice","volume":"35","author":"Meng","year":"2002","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.mtbio.2026.102786_bib48","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/MCB.01832-07","article-title":"Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion","volume":"28","author":"Ding","year":"2008","journal-title":"Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.mtbio.2026.102786_bib49","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/j.bmcl.2015.03.024","article-title":"Rho-associated kinase signaling is required for osteopontin-induced cell invasion through inactivating cofilin in human non-small cell lung cancer cell lines","volume":"25","author":"Kang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"1","key":"10.1016\/j.mtbio.2026.102786_bib50","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12964-021-00763-6","article-title":"Hhex inhibits cell migration via regulating RHOA\/CDC42-CFL1 axis in human lung cancer cells","volume":"19","author":"Li","year":"2021","journal-title":"Cell Commun. Signal."},{"issue":"47","key":"10.1016\/j.mtbio.2026.102786_bib51","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1038\/onc.2010.356","article-title":"ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A","volume":"29","author":"Oleinik","year":"2010","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.mtbio.2026.102786_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32458","article-title":"Piezo1 - Serine\/threonine-protein phosphatase 2A - Cofilin1 biochemical mechanotransduction axis controls F-actin dynamics and cell migration","volume":"10","author":"Morena","year":"2024","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.mtbio.2026.102786_bib53","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/19336950.2022.2099381","article-title":"Piezo1 activation facilitates ovarian cancer metastasis via Hippo\/YAP signaling axis","volume":"16","author":"Xiong","year":"2022","journal-title":"Channels"},{"issue":"32","key":"10.1016\/j.mtbio.2026.102786_bib54","article-title":"Piezo1 activation improves NSCLC liver metastasis immunotherapy by overriding matrix stiffness-mediated bimodal PD-L1\/CXCL10 regulation","volume":"12","author":"Ma","year":"2025","journal-title":"Adv. Sci. (Weinh.)"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426000281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426000281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:13:07Z","timestamp":1774357987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426000281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":54,"alternative-id":["S2590006426000281"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102786","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stiff matrix promotes lung cancer cell migration through down-regulating the Piezo1 channel expression to facilitate Ca2+-dependent filopodia formation","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102786"}}