{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:15:52Z","timestamp":1789398952207,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03003"],"award-info":[{"award-number":["2023C03003"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272163"],"award-info":[{"award-number":["82272163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472164"],"award-info":[{"award-number":["82472164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2026.102805","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:46:36Z","timestamp":1768520796000},"page":"102805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["CS-NO releasing hydrogel protects against neuron apoptosis and inflammation through suppressing the HIF-1\u03b1 and MAPK pathway in stroke"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4884-0606","authenticated-orcid":false,"given":"Fei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar Badry","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irum Naz","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javaria","family":"Sundus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keming","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8879-4227","authenticated-orcid":false,"given":"Suhong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qining","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-4347","authenticated-orcid":false,"given":"Marong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mtbio.2026.102805_bib1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1474-4422(18)30499-X","article-title":"Global and regional burden of stroke during 1990\u20132016: a systematic analysis for the global burden of Disease Study 2016","volume":"18","author":"Feigin","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mtbio.2026.102805_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121814","article-title":"Molecular mechanisms of ischemia and glutamate excitotoxicity","volume":"328","author":"Neves","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.mtbio.2026.102805_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-physiol-021113-170322","article-title":"Hypoxia-inducible factor 1 and cardiovascular disease","volume":"76","author":"Semenza","year":"2014","journal-title":"Annu. Rev. Physiol."},{"issue":"4","key":"10.1016\/j.mtbio.2026.102805_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol Cell"},{"issue":"5516","key":"10.1016\/j.mtbio.2026.102805_bib5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"issue":"5516","key":"10.1016\/j.mtbio.2026.102805_bib6","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science."},{"key":"10.1016\/j.mtbio.2026.102805_bib7","doi-asserted-by":"crossref","first-page":"6814","DOI":"10.1039\/C3CS60467E","article-title":"Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain","volume":"43","author":"Mukherjee","year":"2014","journal-title":"Chem. Soc. Rev."},{"issue":"23","key":"10.1016\/j.mtbio.2026.102805_bib8","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","article-title":"Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia","volume":"27","author":"Baranova","year":"2007","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.mtbio.2026.102805_bib9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3390\/biom11081097","article-title":"Nitric oxide-dependent pathways as critical factors in the consequences and recovery after brain ischemic hypoxia","volume":"11","author":"Wiero\u0144ska","year":"2021","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.mtbio.2026.102805_bib10","doi-asserted-by":"crossref","first-page":"e513","DOI":"10.1161\/CIRCULATIONAHA.119.040624","article-title":"Letter by Xie et al Regarding Article, \"Cardiovascular Disease-Related Morbidity and Mortality in Women With a History of Pregnancy Complications\"","volume":"140","author":"Xie","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.mtbio.2026.102805_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00018-024-05120-7","article-title":"Combinatorial regulation by ERK1\/2 and CK1\u03b4 protein kinases leads to HIF-1\u03b1 association with microtubules and facilitates its symmetrical distribution during mitosis","volume":"81","author":"Arseni","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.mtbio.2026.102805_bib12","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.cell.2013.09.057","article-title":"Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors","volume":"155","author":"Emerling","year":"2013","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.mtbio.2026.102805_bib13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1515\/bc.2010.054","article-title":"Role of N-acetyl-N-nitroso-tryptophan as nitric oxide donor in the modulation of HIF-1-dependent signaling","volume":"391","author":"Berchner-Pfannschmidt","year":"2010","journal-title":"Biol. Chem."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102805_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.molcel.2007.02.024","article-title":"Regulation of HIF-1alpha stability through S-nitrosylation","volume":"26","author":"Li","year":"2007","journal-title":"Mol Cell"},{"issue":"7","key":"10.1016\/j.mtbio.2026.102805_bib15","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1074\/jbc.R111.285742","article-title":"Regulation by S-nitrosylation of protein post-translational modification","volume":"287","author":"Hess","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102805_bib16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","article-title":"Hypoxia-inducible factors and the response to hypoxic stress","volume":"40","author":"Majmundar","year":"2010","journal-title":"Mol Cell"},{"issue":"5","key":"10.1016\/j.mtbio.2026.102805_bib17","doi-asserted-by":"crossref","first-page":"798","DOI":"10.3390\/cells12050798","article-title":"Transcriptional response to hypoxia: the role of HIF-1-Associated Co-Regulators","volume":"12","author":"Yfantis","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2026.102805_bib18","article-title":"An injectable dual-function hydrogel protects against myocardial Ischemia\/Reperfusion Injury by modulating ROS\/NO disequilibrium","volume":"9","author":"Hao","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.102805_bib19","doi-asserted-by":"crossref","first-page":"14013","DOI":"10.1074\/jbc.M209702200","article-title":"MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300","volume":"278","author":"Sang","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3\u20134","key":"10.1016\/j.mtbio.2026.102805_bib20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ceca.2004.02.007","article-title":"Nitric oxide and cerebral ischemic preconditioning","volume":"36","author":"Huang","year":"2004","journal-title":"Cell Calcium"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102805_bib21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/sj.jcbfm.9600058","article-title":"Obligatory role of inducible nitric oxide synthase in ischemic preconditioning","volume":"25","author":"Cho","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.mtbio.2026.102805_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.746486","article-title":"Immune modulation as a key mechanism for the protective effects of remote ischemic conditioning after stroke","volume":"12","author":"Abbasi-Habashi","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.mtbio.2026.102805_bib23","first-page":"171","article-title":"Ischemic tolerance as an active and intrinsic neuroprotective mechanism","volume":"92","author":"Stetler","year":"2009","journal-title":"Handb. Clin. Neurol."},{"issue":"5","key":"10.1016\/j.mtbio.2026.102805_bib24","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.bbi.2009.09.010","article-title":"Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation","volume":"24","author":"Denes","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"14","key":"10.1016\/j.mtbio.2026.102805_bib25","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1523\/JNEUROSCI.19-14-05910.1999","article-title":"Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage","volume":"19","author":"Eliasson","year":"1999","journal-title":"J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.mtbio.2026.102805_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0006-8993(00)02927-9","article-title":"Enhancement of whole cell calcium currents following transient MCAO","volume":"884","author":"Bruehl","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.mtbio.2026.102805_bib27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00004647-199903000-00011","article-title":"Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning","volume":"19","author":"Gidday","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.mtbio.2026.102805_bib28","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1126\/science.7522345","article-title":"Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase","volume":"265","author":"Huang","year":"1994","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102805_bib29","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0002-9440(10)62560-6","article-title":"Overexpression of endothelial nitric oxide synthase in endothelial cells is protective against ischemia-reperfusion injury in mouse skeletal muscle","volume":"160","author":"Ozaki","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.mtbio.2026.102805_bib30","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1177\/0271678X20973787","article-title":"Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice","volume":"41","author":"Lenz","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.mtbio.2026.102805_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.niox.2020.06.004","article-title":"Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states","volume":"102","author":"Ally","year":"2020","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.mtbio.2026.102805_bib32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.mtbio.2026.102805_bib33","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1161\/01.STR.27.8.1373","article-title":"Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia","volume":"27","author":"Iadecola","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.mtbio.2026.102805_bib34","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.2147\/JIR.S461427","article-title":"Mechanisms of postischemic stroke angiogenesis: a multifaceted approach","volume":"17","author":"Hu","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.mtbio.2026.102805_bib35","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI9369","article-title":"VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain","volume":"106","author":"Zhang","year":"2000","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102805_bib36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10571-023-01437-2","article-title":"Drivers of chronic pathology following ischemic stroke: a descriptive review","volume":"44","author":"Goodman","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.mtbio.2026.102805_bib37","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1172\/JCI1560","article-title":"Nitric oxide synthase modulates angiogenesis in response to tissue ischemia","volume":"101","author":"Murohara","year":"1998","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mtbio.2026.102805_bib38","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nature09599","article-title":"S-glutathionylation uncouples eNOS and regulates its cellular and vascular function","volume":"468","author":"Chen","year":"2010","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102805_bib39","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/life12040537","article-title":"Endothelial dysfunction and cardiovascular risk in obstructive sleep apnea: a review article","volume":"12","author":"Peracaula","year":"2022","journal-title":"Life"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102805_bib40","first-page":"H1600","article-title":"Impaired wound healing and angiogenesis in eNOS-deficient mice","volume":"277","author":"Lee","year":"1999","journal-title":"Am. J. Physiol."},{"issue":"7","key":"10.1016\/j.mtbio.2026.102805_bib41","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0092-8674(94)90005-1","article-title":"Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation","volume":"79","author":"Mannick","year":"1994","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102805_bib42","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1172\/JCI117869","article-title":"Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels","volume":"95","author":"Genaro","year":"1995","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102805_bib43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.187.3.415","article-title":"Disruption of fas receptor signaling by nitric oxide in eosinophils","volume":"187","author":"Hebestreit","year":"1998","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.mtbio.2026.102805_bib44","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1210\/endo.136.7.7540548","article-title":"Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production","volume":"136","author":"Chun","year":"1995","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102805_bib45","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.185.4.601","article-title":"Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases","volume":"185","author":"Dimmeler","year":"1997","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.mtbio.2026.102805_bib46","first-page":"415","article-title":"Nitric oxide inhibits APO-1\/Fas-mediated cell death","volume":"9","author":"Dimmeler","year":"1998","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.mtbio.2026.102805_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154298","article-title":"Thymoquinone has a synergistic effect with PHD inhibitors to ameliorate ischemic brain damage in mice","volume":"104","author":"Amin","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mtbio.2026.102805_bib48","article-title":"Targeting oxidative stress injury after ischemic stroke in conscious rats: limited benefits with apocynin highlight the need to incorporate long term recovery","volume":"2013","author":"Weston","year":"2013","journal-title":"Stroke Res. Treat."},{"key":"10.1016\/j.mtbio.2026.102805_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.703084","article-title":"Hypoxia-Inducible factor (HIF) in ischemic stroke and neurodegenerative disease","volume":"9","author":"Mitroshina","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.mtbio.2026.102805_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04286","article-title":"Hypoxia-inducible factor-1\u03b1 in acute ischemic stroke: neuroprotection for better clinical outcome","volume":"6","author":"Amalia","year":"2020","journal-title":"Heliyon"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426000475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426000475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:03:58Z","timestamp":1774357438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426000475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"alternative-id":["S2590006426000475"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102805","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CS-NO releasing hydrogel protects against neuron apoptosis and inflammation through suppressing the HIF-1\u03b1 and MAPK pathway in stroke","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102805"}}