{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:51:36Z","timestamp":1787961096155,"version":"build-2784847793"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqnz20221168"],"award-info":[{"award-number":["tsqnz20221168"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tstp20240853"],"award-info":[{"award-number":["tstp20240853"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572730"],"award-info":[{"award-number":["82572730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2026.102827","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:13:29Z","timestamp":1769102009000},"page":"102827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration"],"prefix":"10.1016","volume":"37","author":[{"given":"Rui","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hecheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglin","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxi","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunbo","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhen","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-1514","authenticated-orcid":false,"given":"Zhijian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10294","key":"10.1016\/j.mtbio.2026.102827_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0140-6736(21)00733-9","article-title":"Low back pain","volume":"398","author":"Knezevic","year":"2021","journal-title":"Lancet."},{"key":"10.1016\/j.mtbio.2026.102827_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12503","article-title":"Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs","volume":"7","author":"Nakamichi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.102827_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102323","article-title":"The role of oxidative stress in intervertebral disc degeneration: mechanisms and therapeutic implications","volume":"98","author":"Chen","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102827_bib4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of cytokines in intervertebral disc degeneration: pain and disc content","volume":"10","author":"Risbud","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mtbio.2026.102827_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2023.112119","article-title":"The mechanisms and functions of tnf-\u03b1 in intervertebral disc degeneration","volume":"174","author":"Pan","year":"2023","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mtbio.2026.102827_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122132","article-title":"Repair of degenerative nucleus pulposus by polyphenol nanosphere-encapsulated hydrogel gene delivery system","volume":"298","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.102827_bib7","first-page":"564","article-title":"Single-cell rna sequencing-guided engineering of mitochondrial therapies for intervertebral disc degeneration by regulating mtdna\/sparc-sting signaling","volume":"48","author":"Yang","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.102827_bib8","first-page":"350","volume":"vol. 7","author":"Zhu","year":"2024"},{"issue":"20","key":"10.1016\/j.mtbio.2026.102827_bib9","article-title":"Ros-activated nanohydrogel scaffolds with multi-factors controlled release for targeted dual-lineage repair of osteochondral defects","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102827_bib10","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1021\/acsnano.4c16875","article-title":"Neuronal dual-specificity phosphatase 26 inhibition via reactive-oxygen-species responsive mesoporous-silica-loaded hydrogel for spinal cord injury repair","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.mtbio.2026.102827_bib11","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1021\/acs.chemrev.2c00179","article-title":"Self-healing injectable hydrogels for tissue regeneration","volume":"123","author":"Bertsch","year":"2023","journal-title":"Chem Rev"},{"key":"10.1016\/j.mtbio.2026.102827_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114021","article-title":"Recent advances and challenges of injectable hydrogels in drug delivery","volume":"385","author":"Guo","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.102827_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113748","article-title":"Hydrophobic ion pairing enables co-loading of water-soluble drugs in polymeric micelles","volume":"382","author":"Shalmani","year":"2025","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.mtbio.2026.102827_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404255","article-title":"Hyaluronic acid-based self-healing hydrogels for diabetic wound healing","volume":"14","author":"Chhillar","year":"2025","journal-title":"Adv. Healthcare Mater."},{"issue":"26","key":"10.1016\/j.mtbio.2026.102827_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202503776","article-title":"Tumor microenvironment-responsive polymer delivery platforms for cancer therapy","volume":"64","author":"Shi","year":"2025","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.mtbio.2026.102827_bib16","article-title":"Tri-modal adhesion switchable hydrogel with precise regulation of interfacial states via a solvent microenvironment reconstruction strategy","volume":"519","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2026.102827_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156875","article-title":"Deciphering the therapeutic potential of sinigrin: a promising anti-inflammatory agent for chronic disease management","volume":"144","author":"Du","year":"2025","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.mtbio.2026.102827_bib18","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/1440-1681.13668","article-title":"Expression of anti and pro-inflammatory genes in human endothelial cells activated by 25-hydroxycholesterol: a comparison of rivaroxaban and dabigatran","volume":"49","author":"Gorzelak-Pabi\u015b","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"15","key":"10.1016\/j.mtbio.2026.102827_bib19","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.7150\/thno.45359","article-title":"Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ros-dependent nlrp3 inflammasome activation","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.102827_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2025.214177","article-title":"Ph- and glucose-responsive antioxidant hydrogel promotes diabetic wound healing","volume":"169","author":"Zhang","year":"2025","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.mtbio.2026.102827_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123273","article-title":"Regulation of osteoimmune microenvironment via functional dynamic hydrogel for diabetic bone regeneration","volume":"320","author":"Yang","year":"2025","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.mtbio.2026.102827_bib22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1039\/D4BM01221F","article-title":"Reactive oxygen species-scavenging biomaterials for neural regenerative medicine","volume":"13","author":"Wei","year":"2025","journal-title":"Biomater. Sci."},{"issue":"4","key":"10.1016\/j.mtbio.2026.102827_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202414294","article-title":"Cohesion regulation of polyphenol cross-linked hydrogel adhesives: from intrinsic cross-link to designs of temporal responsiveness","volume":"35","author":"Xing","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"8","key":"10.1016\/j.mtbio.2026.102827_bib24","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s44160-024-00560-2","article-title":"Applications of synthetic polymers directed toward living cells","volume":"3","author":"Zhang","year":"2024","journal-title":"Nat. Synth."},{"key":"10.1016\/j.mtbio.2026.102827_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2024.112003","article-title":"Inflammation-regulated and nutrient-supplied scaffolds promote bone regeneration in diabetic microenvironment in vivo","volume":"291","author":"Wang","year":"2025","journal-title":"Compos. B Eng."},{"issue":"5","key":"10.1016\/j.mtbio.2026.102827_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202306105","article-title":"Hydrogen ion capturing hydrogel microspheres for reversing inflammaging","volume":"36","author":"Zheng","year":"2024","journal-title":"Adv Mater"},{"issue":"40","key":"10.1016\/j.mtbio.2026.102827_bib27","article-title":"Mechanical signal-tailored hydrogel microspheres recruit and train stem cells for precise differentiation","volume":"35","author":"Chen","year":"2023","journal-title":"Adv Mater"},{"key":"10.1016\/j.mtbio.2026.102827_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.actbio.2021.06.045","article-title":"Bioactive in situ crosslinkable polymer-peptide hydrogel for cell delivery to the intervertebral disc in a rat model","volume":"131","author":"Barcellona","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.102827_bib29","article-title":"Morusin alleviates spinal cord injury in rats by regulating macrophage reprogramming through targeting rela and nrf2","author":"Liu","year":"2025","journal-title":"Phytother Res."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102827_bib30","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1038\/s41467-025-58278-4","article-title":"Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology","volume":"16","author":"GhavamiNejad","year":"2025","journal-title":"Nat. Commun."},{"issue":"43","key":"10.1016\/j.mtbio.2026.102827_bib31","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1039\/D4PY00567H","article-title":"A novel amine-first strategy suitable for preparing both functional and engineering bio-polyamides: furfurylamine as the sole furan source for bisfuranic diamine\/diacid monomers","volume":"15","author":"Shu","year":"2024","journal-title":"Polym Chem-Uk"},{"key":"10.1016\/j.mtbio.2026.102827_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.124081","article-title":"Dopamine triacrylamide-crosslinked chitosan\/polyacrylic acid cryogels for rapid and efficient adsorption of anionic dyes from wastewater","volume":"368","author":"Jia","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2026.102827_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106865","article-title":"Functional properties and molecular docking of different nanoparticles with ros-sensitive phenylboronylated chitosan as the carrier","volume":"202","author":"Liu","year":"2024","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"9","key":"10.1016\/j.mtbio.2026.102827_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14237","article-title":"Pip5k1gamma promotes anabolism of nucleus pulposus cells and intervertebral disc homeostasis by activating camkii-ampk pathway in aged mice","volume":"23","author":"Chen","year":"2024","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.mtbio.2026.102827_bib35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.7150\/ijbs.16770","article-title":"17beta-estradiol attenuates tnf-\u03b1-induced premature senescence of nucleus pulposus cells through regulating the ros\/nf-\u03bab pathway","volume":"13","author":"Li","year":"2017","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102827_bib36","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1038\/s41467-021-25453-2","article-title":"Long-term treatment with senolytic drugs dasatinib and quercetin ameliorates age-dependent intervertebral disc degeneration in mice","volume":"12","author":"Novais","year":"2021","journal-title":"Nat. Commun."},{"issue":"534","key":"10.1016\/j.mtbio.2026.102827_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay2380","article-title":"Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy","volume":"12","author":"Sloan","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mtbio.2026.102827_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jmbbm.2019.03.024","article-title":"Biomechanical test protocols to detect minor injury effects in intervertebral discs","volume":"95","author":"Torre","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102827_bib39","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.joca.2016.10.002","article-title":"Resistin promotes ccl4 expression through toll-like receptor-4 and activation of the p38-mapk and nf-\u03bab signaling pathways: implications for intervertebral disc degeneration","volume":"25","author":"Li","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.mtbio.2026.102827_bib40","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.wneu.2021.09.066","article-title":"Fundamentals of intervertebral disc degeneration","volume":"157","author":"Kirnaz","year":"2022","journal-title":"World Neurosurg."},{"key":"10.1016\/j.mtbio.2026.102827_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101902","article-title":"Epigenetic modifications of inflammation in intervertebral disc degeneration","volume":"87","author":"Kang","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mtbio.2026.102827_bib42","article-title":"Application trends and strategies of hydrogel delivery systems in intervertebral disc degeneration: a bibliometric review","volume":"28","author":"Wang","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.102827_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114066","article-title":"Hydrogel delivery systems in intervertebral disc degeneration: current status and future perspectives","volume":"386","author":"Zhang","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.102827_bib44","first-page":"306","article-title":"Microenvironment responsive nanocomposite hydrogel with nir photothermal therapy, vascularization and anti-inflammation for diabetic infected wound healing","volume":"26","author":"Zhu","year":"2023","journal-title":"Bioact. Mater."},{"issue":"49","key":"10.1016\/j.mtbio.2026.102827_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202404732","article-title":"Hydrogel and microgel collaboration for spatiotemporal delivery of biofactors to awaken nucleus pulposus-derived stem cells for endogenous repair of disc","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.102827_bib46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biomaterials.2017.03.013","article-title":"Biomaterials for intervertebral disc regeneration and repair","volume":"129","author":"Bowles","year":"2017","journal-title":"Biomaterials"},{"issue":"36","key":"10.1016\/j.mtbio.2026.102827_bib47","article-title":"Modulating macrophage-nucleus pulposus cell crosstalk via sequential drug delivery attenuates disc degeneration","volume":"12","author":"Kong","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.mtbio.2026.102827_bib48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00586-007-0414-y","article-title":"Are animal models useful for studying human disc disorders\/degeneration?","volume":"17","author":"Alini","year":"2008","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.mtbio.2026.102827_bib49","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jconrel.2022.12.037","article-title":"Applications of polydopaminic nanomaterials in mucosal drug delivery","volume":"353","author":"Bedhiafi","year":"2023","journal-title":"J. Contr. Release"},{"issue":"25","key":"10.1016\/j.mtbio.2026.102827_bib50","article-title":"Rescuing nucleus pulposus cells from senescence via dual-functional greigite nanozyme to alleviate intervertebral disc degeneration","volume":"10","author":"Shi","year":"2023","journal-title":"Adv. Sci. (Weinh.)"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426000700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426000700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:22:26Z","timestamp":1774358546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426000700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"alternative-id":["S2590006426000700"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102827","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sequential delivery of sinigrin and dabigatran by an in situ self-stabilizing dynamic hydrogel attenuates intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102827","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102827"}}