{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:38:07Z","timestamp":1789601887840,"version":"build-2803163510"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C02041"],"award-info":[{"award-number":["2023C02041"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272303"],"award-info":[{"award-number":["32272303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2026.102884","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:20:26Z","timestamp":1769818826000},"page":"102884","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Feasibility of combining JAK1 gene editing via CRISPR-CasRx with EGCG\u2013lactoferrin nanoparticle therapy in a microneedle-based platform for atopic dermatitis"],"prefix":"10.1016","volume":"37","author":[{"given":"Huanqing","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panjie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youying","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-6888","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mtbio.2026.102884_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mtbio.2026.102884_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115903","article-title":"Extract alleviates atopy-like lesions in NC\/Nga mice via inhibition of the JAK1-STAT1\/3 pathway","volume":"169","author":"Kim","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2026.102884_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.mtbio.2026.102884_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1068260","article-title":"JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: an updated review","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.mtbio.2026.102884_bib5","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s40257-020-00548-6","article-title":"Selective JAK1 inhibitors for the treatment of atopic dermatitis: focus on upadacitinib and abrocitinib","volume":"21","author":"Ferreira","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"issue":"4","key":"10.1016\/j.mtbio.2026.102884_bib6","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jaci.2021.08.009","article-title":"JAK inhibitors in the treatment of atopic dermatitis","volume":"148","author":"Chovatiya","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102884_bib7","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.jaad.2017.12.019","article-title":"Emerging therapies for atopic dermatitis: JAK inhibitors","volume":"78","author":"Cotter","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102884_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/jdv.19426","article-title":"The safety of systemic janus kinase inhibitors in atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials","volume":"38","author":"Yoon","year":"2024","journal-title":"J. Eur. Acad. Dermatol."},{"issue":"9","key":"10.1016\/j.mtbio.2026.102884_bib9","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1038\/d41591-024-00056-8","article-title":"Next-generation CRISPR-based gene-editing therapies tested in clinical trials","volume":"30","author":"Healey","year":"2024","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.mtbio.2026.102884_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202206517","article-title":"Engineered extracellular vesicle-delivered CRISPR\/CasRx as a novel RNA editing tool","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102884_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13024-024-00794-w","article-title":"RNA-targeting CRISPR\/CasRx system relieves disease symptoms in Huntington'S disease models","volume":"20","author":"Lin","year":"2025","journal-title":"Mol. Neurodegener."},{"issue":"10302","key":"10.1016\/j.mtbio.2026.102884_bib12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0140-6736(21)00438-4","article-title":"Current and future status of JAK inhibitors","volume":"398","author":"McLornan","year":"2021","journal-title":"Lancet"},{"issue":"26","key":"10.1016\/j.mtbio.2026.102884_bib13","doi-asserted-by":"crossref","first-page":"33121","DOI":"10.1021\/acsami.4c05435","article-title":"Hydrogel-based treatment of house dust mite-induced atopic dermatitis through triple cleaning of mites, bacteria, and ROS-related inflammation","volume":"16","author":"He","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.mtbio.2026.102884_bib14","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1038\/s41467-023-38209-x","article-title":"Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis","volume":"14","author":"Jia","year":"2023","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.mtbio.2026.102884_bib15","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/antiox12071317","article-title":"Antioxidant effects of catechins (EGCG), andrographolide, and curcuminoids compounds for skin protection, cosmetics, and dermatological uses: an update","volume":"12","author":"Messire","year":"2023","journal-title":"Antioxidants"},{"issue":"9","key":"10.1016\/j.mtbio.2026.102884_bib16","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.intimp.2008.04.002","article-title":"Epigallocatechin-3-gallate improves extract-induced atopic dermatitis-like skin lesions in NC\/Nga mice by suppressing macrophage migration inhibitory factor","volume":"8","author":"Noh","year":"2008","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.mtbio.2026.102884_bib17","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1080\/10408398.2019.1565490","article-title":"Nanochemoprevention with therapeutic benefits: an updated review focused on epigallocatechin gallate delivery","volume":"60","author":"Yang","year":"2020","journal-title":"Crit. Rev. Food Sci."},{"key":"10.1016\/j.mtbio.2026.102884_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115198","article-title":"Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy","volume":"207","author":"Silvestrini","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.102884_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120355","article-title":"Lactoferrin, a multi-functional glycoprotein: active therapeutic, drug nanocarrier & targeting ligand","volume":"263","author":"Elzoghby","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.102884_bib20","article-title":"Nose-to-brain delivery of self-assembled curcumin-lactoferrin nanoparticles: characterization, neuroprotective effect and pharmacokinetic study","volume":"11","author":"Li","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2026.102884_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132812","article-title":"Effects of ultrasound and thermal treatment on the interaction between hyaluronic scid and lactoferrin: preparation, structures and functionalities","volume":"272","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102884_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF03353783","article-title":"Hydrogel microneedle arrays for transdermal drug delivery","volume":"6","author":"Hong","year":"2014","journal-title":"Nano-Micro Lett."},{"issue":"5","key":"10.1016\/j.mtbio.2026.102884_bib23","first-page":"474","article-title":"Gene delivery to the skin - how far have we come? Trends","volume":"39","author":"Ul Ain","year":"2021","journal-title":"Biotechnol."},{"issue":"6","key":"10.1016\/j.mtbio.2026.102884_bib24","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/s41587-020-0456-9","article-title":"Massively parallel cas13 screens reveal principles for guide RNA design","volume":"38","author":"Wessels","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"50","key":"10.1016\/j.mtbio.2026.102884_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj0624","article-title":"Genome-editing prodrug: targeted delivery and conditional stabilization of CRISPR-Cas9 for precision therapy of inflammatory disease","volume":"7","author":"Yan","year":"2021","journal-title":"Sci. Adv."},{"issue":"16","key":"10.1016\/j.mtbio.2026.102884_bib26","doi-asserted-by":"crossref","first-page":"7126","DOI":"10.1039\/D1FO00481F","article-title":"Co-encapsulation of (-)-epigallocatechin-3-gallate and piceatannol\/oxyresveratrol in \u03b2-lactoglobulin: effect of ligand-protein binding on the antioxidant activity, stability, solubility and cytotoxicity","volume":"12","author":"Liu","year":"2021","journal-title":"Food Funct."},{"issue":"51","key":"10.1016\/j.mtbio.2026.102884_bib27","doi-asserted-by":"crossref","first-page":"20500","DOI":"10.1021\/acs.jafc.3c06887","article-title":"The multifaceted roles of bovine lactoferrin: molecular structure, isolation methods, analytical characteristics, and biological properties","volume":"71","author":"Dyrda-Terniuk","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.mtbio.2026.102884_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tifs.2018.06.013","article-title":"Recent development of lactoferrin-based vehicles for the delivery of bioactive compounds: complexes, emulsions, and nanoparticles","volume":"79","author":"Liu","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.mtbio.2026.102884_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.porgcoat.2023.108099","article-title":"Lactoferrin-polyphenol composite nanocoating with enhanced chemical stability and cell-compatibility","volume":"187","author":"Kim","year":"2024","journal-title":"Prog. Org. Coating"},{"key":"10.1016\/j.mtbio.2026.102884_bib30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuint.2016.01.006","article-title":"Neuroprotective effect of curcumin-loaded lactoferrin nano particles against rotenone induced neurotoxicity","volume":"95","author":"Bollimpelli","year":"2016","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102884_bib31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3109\/10717544.2013.766781","article-title":"Studies on lactoferrin nanoparticles of gambogic acid for oral delivery","volume":"20","author":"Zhang","year":"2013","journal-title":"Drug Deliv."},{"issue":"13","key":"10.1016\/j.mtbio.2026.102884_bib32","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1021\/jf300307t","article-title":"Preservation of (-)-epigallocatechin-3-gallate antioxidant properties loaded in heat treated \u03b2-lactoglobulin nanoparticles","volume":"60","author":"Li","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.mtbio.2026.102884_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01018","article-title":"Chijabyukpi-tang inhibits pro-inflammatory cytokines and chemokines the Nrf2\/HO-1 signaling pathway in TNF-\u03b1\/IFN-\u03b3-stimulated HaCaT cells and ameliorates 2,4-dinitrochlorobenzene-Induced atopic dermatitis-like skin lesions in mice","volume":"11","author":"Lee","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"30","key":"10.1016\/j.mtbio.2026.102884_bib34","doi-asserted-by":"crossref","first-page":"7633","DOI":"10.1016\/j.biomaterials.2011.06.073","article-title":"The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles","volume":"32","author":"Hsieh","year":"2011","journal-title":"Biomaterials"},{"issue":"31","key":"10.1016\/j.mtbio.2026.102884_bib35","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1080\/10408398.2023.2237126","article-title":"Encapsulation of polyphenols in protein-based nanoparticles: preparation, properties, and applications","volume":"64","author":"Li","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"5","key":"10.1016\/j.mtbio.2026.102884_bib36","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1021\/acs.nanolett.1c04899","article-title":"Therapeutic hydrogel patch to treat atopic dermatitis by regulating oxidative stress","volume":"22","author":"Kim","year":"2022","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102884_bib37","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/jsfa.13836","article-title":"Enhancing the effects of curcumin on oxidative stress injury in brain vascular endothelial cells using lactoferrin peptide nano-micelles: antioxidant activity and mechanism","volume":"105","author":"Chen","year":"2025","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.mtbio.2026.102884_bib38","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijbiomac.2021.08.089","article-title":"Nanoparticle impregnated self-supporting protein gel for enhanced reduction in oxidative stress: a molecular dynamics insight for lactoferrin-polyphenol interaction","volume":"189","author":"Raychaudhuri","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.mtbio.2026.102884_bib39","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/17435889.2025.2462521","article-title":"Nanotechnology-driven EGCG: bridging antioxidant and therapeutic roles in metabolic and cancer pathways","volume":"20","author":"Esmaeili","year":"2025","journal-title":"Nanomedicine-UK"},{"issue":"10348","key":"10.1016\/j.mtbio.2026.102884_bib40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(22)01199-0","article-title":"Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial","volume":"400","author":"Reich","year":"2022","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.mtbio.2026.102884_bib41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2018.02.033","article-title":"Transcriptome engineering with RNA-targeting type VI-D CRISPR effectors","volume":"173","author":"Konermann","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.102884_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102897","article-title":"An effective vaginal gel to deliver CRISPR\/Cas9 system encapsulated in poly (\u03b2-amino ester) nanoparticles for vaginal gene therapy","volume":"58","author":"Niu","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mtbio.2026.102884_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2023.152327","article-title":"JAK inhibitors: is specificity at all relevant?","volume":"64","author":"Gadina","year":"2024","journal-title":"Semin. Arthritis Rheum."},{"issue":"12","key":"10.1016\/j.mtbio.2026.102884_bib44","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1021\/acs.molpharmaceut.4c00894","article-title":"Microneedles as an emerging platform for transdermal delivery of phytochemicals","volume":"21","author":"Gowda","year":"2024","journal-title":"Mol. Pharm."},{"issue":"11","key":"10.1016\/j.mtbio.2026.102884_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe2888","article-title":"Microneedle-assisted genome editing: a transdermal dtrategy of targeting by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders","volume":"7","author":"Wan","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.102884_bib46","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jconrel.2024.01.013","article-title":"Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer'S disease treatment","volume":"366","author":"Ruan","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.102884_bib47","article-title":"Role of skin-homing t-cells in recurrent episodes of atopic dermatitis: a review","volume":"16","author":"Guo","year":"2025","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.mtbio.2026.102884_bib48","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.3390\/ijms26094191","article-title":"Therapeutic effects of Sigesbeckia pubescens Makino against atopic dermatitis-like skin inflammation through the JAK2\/STAT signaling pathway","volume":"26","author":"Song","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.102884_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118168","article-title":"Hyaluronic acid based microneedle array: recent applications in drug delivery and cosmetology","volume":"267","author":"Saha","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102884_bib50","first-page":"81","article-title":"Effect of hyaluronic acid initial concentration on cross-linking efficiency of hyaluronic acid-based hydrogels used in biomedical and cosmetic applications","volume":"72","author":"Al-Sibani","year":"2017","journal-title":"Pharmazie"},{"issue":"14","key":"10.1016\/j.mtbio.2026.102884_bib51","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1039\/C6CS00636A","article-title":"Cellular uptake of nanoparticles: journey inside the cell","volume":"46","author":"Behzadi","year":"2017","journal-title":"Chem. Soc. Rev."},{"issue":"9","key":"10.1016\/j.mtbio.2026.102884_bib52","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1021\/acs.accounts.8b00292","article-title":"Cellular uptake of nanoparticles versus small molecules: a matter of size","volume":"51","author":"Mosquera","year":"2018","journal-title":"Accounts Chem. Res."},{"key":"10.1016\/j.mtbio.2026.102884_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/cnma.202500043","article-title":"Physicochemical and surface properties of nanoparticles: effects on cellular pathway and uptake","author":"Zhang","year":"2025","journal-title":"ChemNanoMat"},{"key":"10.1016\/j.mtbio.2026.102884_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115177","article-title":"The contribution of mouse models to understanding atopic dermatitis","volume":"203","author":"Sanjel","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102884_bib55","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/imm.12539","article-title":"Comparative analysis of mediastinal fat-associated lymphoid cluster development and lung cellular infiltration in murine autoimmune disease models and the corresponding normal control strains","volume":"147","author":"Elewa","year":"2016","journal-title":"Immunology"},{"issue":"12","key":"10.1016\/j.mtbio.2026.102884_bib56","article-title":"Mechanistic evaluation of EGCG against atopic dermatitis: an and study","volume":"19","author":"Tang","year":"2024","journal-title":"Nat. Prod. Commun."},{"issue":"19","key":"10.1016\/j.mtbio.2026.102884_bib57","doi-asserted-by":"crossref","first-page":"24308","DOI":"10.1021\/acsami.4c02634","article-title":"Superoxide dismutase-mimetic polyphenol-based carbon dots for multimodal bioimaging and treatment of atopic dermatitis","volume":"16","author":"Han","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.mtbio.2026.102884_bib58","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jaad.2022.03.012","article-title":"Topical janus kinase-signal transducers and activators of transcription inhibitor tofacitinib is effective in reducing nonatopic dermatitis chronic itch: a case series","volume":"87","author":"Ju","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.mtbio.2026.102884_bib59","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jaad.2021.04.085","article-title":"Efficacy and safety of ruxolitinib cream for the treatment of atopic dermatitis: results from 2 phase 3, randomized, double-blind studies","volume":"85","author":"Papp","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"issue":"18","key":"10.1016\/j.mtbio.2026.102884_bib60","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1073\/pnas.0501912102","article-title":"Mast cells enhance T cell activation: importance of mast cell-derived TNF","volume":"102","author":"Nakae","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mtbio.2026.102884_bib61","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.2147\/IJN.S212260","article-title":"Integrating tacrolimus into eutectic oil-based microemulsion for atopic dermatitis: simultaneously enhancing percutaneous delivery and treatment efficacy with relieving side effects","volume":"14","author":"Wang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2026.102884_bib62","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fcell.2019.00068","article-title":"Unraveling the ECM-immune cell crosstalk in skin diseases","volume":"7","author":"Bhattacharjee","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2026.102884_bib63","article-title":"Jiu-Wei-Yong-an formula suppresses JAK1\/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions","volume":"295","author":"Gu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102884_bib64","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12016-021-08880-3","article-title":"Update on the pathogenesis and therapy of atopic dermatitis","volume":"61","author":"Li","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102884_bib65","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4062\/biomolther.2024.177","article-title":"Allergy inhibition using naturally occurring compounds targeting thymic stromal lymphopoietin pathways: a comprehensive review","volume":"33","author":"Vinh","year":"2025","journal-title":"Biomol. Ther."},{"issue":"12","key":"10.1016\/j.mtbio.2026.102884_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70029","article-title":"Atopic dermatitis: pathogenesis and therapeutic intervention","volume":"5","author":"Yue","year":"2024","journal-title":"MedComm"},{"issue":"3","key":"10.1016\/j.mtbio.2026.102884_bib67","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.alit.2016.12.002","article-title":"Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies","volume":"66","author":"Furue","year":"2017","journal-title":"Allergol. Int."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102884_bib68","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/path.4887","article-title":"IL-1\u03b2 induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermis","volume":"242","author":"Bernard","year":"2017","journal-title":"J. Pathol."},{"issue":"12","key":"10.1016\/j.mtbio.2026.102884_bib69","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.3390\/ijms19123973","article-title":"Topical application of JAK1\/JAK2 inhibitor momelotinib exhibits significant anti-inflammatory responses in DNCB-induced atopic dermatitis model mice","volume":"19","author":"Jin","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.mtbio.2026.102884_bib70","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.3390\/jcm11154431","article-title":"The JAK\/STAT pathway and its selective inhibition in the treatment of atopic dermatitis: a systematic review","volume":"11","author":"Tsiogka","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mtbio.2026.102884_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108200","article-title":"N-heterocyclic functionalized chalcone derivatives as anti-inflammatory agents for atopic dermatitis treatment by inhibiting JAK1\/STAT3 signaling pathway","volume":"156","author":"Huang","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"11","key":"10.1016\/j.mtbio.2026.102884_bib72","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3390\/ph14111081","article-title":"EGCG inhibits tumor growth in melanoma by targeting JAK-STAT signaling and its downstream PD-L1\/PD-L2-PD1 axis in tumors and enhancing cytotoxic T-cell responses","volume":"14","author":"Menon","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"6","key":"10.1016\/j.mtbio.2026.102884_bib73","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1365-2133.1998.02273.x","article-title":"8-Hydroxydeoxyguanosine in urine as an index of oxidative damage to DNA in the evaluation of atopic dermatitis","volume":"138","author":"Tsuboi","year":"1998","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.mtbio.2026.102884_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.649820","article-title":"The protective effect of polyherbal formulation, harak formula, on UVA-induced photoaging of human dermal fibroblasts and mouse skin promoting Nrf2-regulated antioxidant defense","volume":"12","author":"Lohakul","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.102884_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111107","article-title":"Histone deacetylase 3 inhibition alleviates 2,4-dinitrochlorobenzene-in-duced atopic dermatitis via epigenetically upregulating Nrf2\/HO-1 signaling pathway","volume":"126","author":"Zhou","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mtbio.2026.102884_bib76","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.envpol.2018.04.038","article-title":"Epigallocatechin-3-gallate attenuates microcystin-LR-induced apoptosis in human umbilical vein endothelial cells through activation of the NRF2\/HO-1 pathway","volume":"239","author":"Shi","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.mtbio.2026.102884_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117014","article-title":"Protective effects of epigallocatechin gallate against ischemia reperfusion injury in rat skeletal muscle via activating Nrf2\/HO-1 signaling pathway","volume":"239","author":"Zhao","year":"2019","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102884_bib78","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/cells10030515","article-title":"Heme oxgenase-1, a cardinal modulator of regulated cell death and inflammation","volume":"10","author":"Ryter","year":"2021","journal-title":"Cells"},{"issue":"14","key":"10.1016\/j.mtbio.2026.102884_bib79","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1089\/ars.2019.7991","article-title":"Regulation of the expression of heme oxygenase-1:Signal transduction, gene promoter activation, and beyond","volume":"32","author":"Medina","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mtbio.2026.102884_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102308","article-title":"The significance of precisely regulating heme oxygenase-1 expression: another avenue for treating age-related ocular disease?","volume":"97","author":"Wei","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.mtbio.2026.102884_bib81","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2249.2004.02649.x","article-title":"Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model","volume":"138","author":"Chen","year":"2004","journal-title":"Clin. Exp. Immunol."},{"issue":"8","key":"10.1016\/j.mtbio.2026.102884_bib82","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1468-3083.2011.04133.x","article-title":"The effect of topically applied corticosteroids on interleukin 1\u03b2 levels in patients with atopic dermatitis","volume":"26","author":"Nutan","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.102884_bib83","doi-asserted-by":"crossref","DOI":"10.1002\/biof.70013","article-title":"The role of NRF2 transcription factor in inflammatory skin diseases","volume":"51","author":"Salman","year":"2025","journal-title":"Biofactors"},{"issue":"2","key":"10.1016\/j.mtbio.2026.102884_bib84","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jid.2022.08.048","article-title":"Quantitative proteomics identifies reduced NRF2 activity and mitochondrial dysfunction in atopic dermatitis","volume":"143","author":"Koch","year":"2023","journal-title":"J. Invest. Dermatol."},{"issue":"19","key":"10.1016\/j.mtbio.2026.102884_bib85","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202422134","article-title":"Precise PBAEs: a highly efficient single-molecularly defined gene-delivery system","volume":"64","author":"Ma","year":"2025","journal-title":"Angew. Chem.-Int. Edit."},{"key":"10.1016\/j.mtbio.2026.102884_bib86","doi-asserted-by":"crossref","DOI":"10.1038\/s41596-024-01138-0","article-title":"Circular vectors as an efficient, fully synthetic, cell-free approach for preparing small circular DNA as a plasmid substitute for guide RNA expression in CRISPR-Cas9 genome editing","author":"Oliynyk","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mtbio.2026.102884_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121876","article-title":"In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications","volume":"291","author":"Huang","year":"2022","journal-title":"Biomaterials"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426001274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426001274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:46:14Z","timestamp":1774356374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426001274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":87,"alternative-id":["S2590006426001274"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102884","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feasibility of combining JAK1 gene editing via CRISPR-CasRx with EGCG\u2013lactoferrin nanoparticle therapy in a microneedle-based platform for atopic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102884","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102884"}}