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Rev."},{"issue":"1","key":"10.1016\/j.mtbio.2026.102886_bib185","doi-asserted-by":"crossref","first-page":"397","DOI":"10.7150\/thno.50741","article-title":"Progenitor cell-derived exosomes endowed with VEGF plasmids enhance osteogenic induction and vascular remodeling in large segmental bone defects","volume":"11","author":"Zha","year":"2021","journal-title":"Theranostics"},{"issue":"7","key":"10.1016\/j.mtbio.2026.102886_bib186","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/jgm.392","article-title":"Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues","volume":"5","author":"Tarkka","year":"2003","journal-title":"J. Gene Med."},{"key":"10.1016\/j.mtbio.2026.102886_bib187","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1017\/S1462399410001493","article-title":"Gene therapy for bone healing","volume":"12","author":"Evans","year":"2010","journal-title":"Expert Rev. Mol. 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