{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:55:01Z","timestamp":1777902901215,"version":"3.51.4"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004053","name":"Masanori Kawano Memorial Public Interest Foundation for Promotion of Pediatrics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2026.102969","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T17:00:47Z","timestamp":1772038847000},"page":"102969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hepatocyte growth factor in biosheets promotes autonomous regeneration of cutaneous tissue after transplantation onto a full-thickness skin defect"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6669-1676","authenticated-orcid":false,"given":"Keisuke","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Komura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Konno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-4482","authenticated-orcid":false,"given":"Kunio","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Inaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-7439","authenticated-orcid":false,"given":"Sanshiro","family":"Kanazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiyo","family":"Asawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-2976","authenticated-orcid":false,"given":"Atsuhiko","family":"Hikita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-8318","authenticated-orcid":false,"given":"Jun","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-8019","authenticated-orcid":false,"given":"Makoto","family":"Komura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.102969_bib1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/jbm.a.35958","article-title":"The pathology of the foreign body reaction against biomaterials","volume":"105","author":"Klopfleisch","year":"2017","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"10.1016\/j.mtbio.2026.102969_bib2","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1097\/PRS.0000000000001193","article-title":"The foreign body response: at the interface of surgery and bioengineering","volume":"135","author":"Major","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3727\/000000004783983828","article-title":"In vivo tissue-engineered small-caliber arterial graft prosthesis consisting of autologous tissue (biotube)","volume":"13","author":"Nakayama","year":"2004","journal-title":"Cell Transplant."},{"key":"10.1016\/j.mtbio.2026.102969_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10047-012-0676-y","article-title":"Implantation study of small-caliber \u201cbiotube\u201d vascular grafts in a rat model","volume":"16","author":"Yamanami","year":"2013","journal-title":"J. Artif. Organs"},{"key":"10.1016\/j.mtbio.2026.102969_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbm.b.30981","article-title":"Architecture of an in vivo-tissue engineered autologous conduit \u201cBiovalve\u201d","volume":"86","author":"Hayashida","year":"2008","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.mtbio.2026.102969_bib6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jpedsurg.2015.10.068","article-title":"Patch tracheoplasty in body tissue engineering using collagenous connective tissue membranes (biosheets)","volume":"51","author":"Satake","year":"2016","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib7","doi-asserted-by":"crossref","first-page":"E518","DOI":"10.1002\/term.1859","article-title":"In-body tissue-engineered collagenous connective tissue membranes (BIOSHEETs) for potential corneal stromal substitution","volume":"10","author":"Takiyama","year":"2016","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.mtbio.2026.102969_bib8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/jbm.b.31510","article-title":"Autologous small-caliber \u201cbiotube\u201d vascular grafts with argatroban loading: a histomorphological examination after implantation to rabbits","volume":"92","author":"Watanabe","year":"2010","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.mtbio.2026.102969_bib9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.biomaterials.2018.09.032","article-title":"Development of long in vivo tissue-engineered \u201cBiotube\u201d vascular grafts","volume":"185","author":"Nakayama","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.102969_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s10047-016-0894-9","article-title":"Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography","volume":"19","author":"Ishii","year":"2016","journal-title":"J. Artif. Organs"},{"key":"10.1016\/j.mtbio.2026.102969_bib11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.ejvs.2018.03.011","article-title":"One year rat study of iBTA-induced \u201cmicrobiotube\u201d microvascular grafts with an ultra-small diameter of 0.6 mm","volume":"55","author":"Ishii","year":"2018","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s10047-015-0859-4","article-title":"Development of an in vivo tissue-engineered vascular graft with designed wall thickness (biotube type C) based on a novel caged mold","volume":"19","author":"Furukoshi","year":"2016","journal-title":"J. Artif. Organs"},{"key":"10.1016\/j.mtbio.2026.102969_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10047-018-1035-4","article-title":"Wall thickness control in biotubes prepared using type-C mold","volume":"21","author":"Terazawa","year":"2018","journal-title":"J. Artif. Organs"},{"key":"10.1016\/j.mtbio.2026.102969_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jbm.b.31841","article-title":"Long-term animal implantation study of biotube-autologous small-caliber vascular graft fabricated by in-body tissue architecture","volume":"98","author":"Watanabe","year":"2011","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.mtbio.2026.102969_bib15","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.athoracsur.2016.06.095","article-title":"First successful clinical application of the in vivo tissue-engineered autologous vascular graft","volume":"102","author":"Kato","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/1129729819852550","article-title":"Initial 3-year results of first human use of an in-body tissue-engineered autologous \"biotube\" vascular graft for hemodialysis","volume":"21","author":"Nakayama","year":"2020","journal-title":"J. Vasc. Access"},{"key":"10.1016\/j.mtbio.2026.102969_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jpedsurg.2017.11.004","article-title":"Patch esophagoplasty using an in-body-tissue-engineered collagenous connective tissue membrane","volume":"53","author":"Okuyama","year":"2018","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib18","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jpedsurg.2021.03.025","article-title":"A new method of primary engineering of esophagus using orthotopic in-body tissue architecture","volume":"56","author":"Suzuki","year":"2021","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.reth.2020.10.006","article-title":"Urinary bladder reconstruction using autologous collagenous connective tissue membrane \"biosheet(R)\" induced by in-body tissue architecture: a pilot study","volume":"15","author":"Iimori","year":"2020","journal-title":"Regen Ther"},{"key":"10.1016\/j.mtbio.2026.102969_bib20","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s10029-018-1799-8","article-title":"iBTA-induced bovine biosheet for repair of abdominal wall defects in a beagle model: proof of concept","volume":"22","author":"Nakayama","year":"2018","journal-title":"Hernia"},{"key":"10.1016\/j.mtbio.2026.102969_bib21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10029-018-1866-1","article-title":"One-year follow-up study of iBTA-induced allogenic biosheet for repair of abdominal wall defects in a beagle model: a pilot study","volume":"23","author":"Terazawa","year":"2019","journal-title":"Hernia"},{"key":"10.1016\/j.mtbio.2026.102969_bib22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.reth.2019.07.004","article-title":"Fabrication of an anatomy-mimicking BIO-AIR-TUBE with engineered cartilage","volume":"11","author":"Komura","year":"2019","journal-title":"Regen Ther"},{"key":"10.1016\/j.mtbio.2026.102969_bib23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jpedsurg.2017.11.035","article-title":"Engineering and repair of diaphragm using biosheet (a collagenous connective tissue membrane) in rabbits","volume":"53","author":"Suzuki","year":"2018","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12080735","article-title":"Skin wound healing process and new emerging technologies for skin wound care and regeneration","volume":"12","author":"Tottoli","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2026.102969_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1055\/s-0033-1352529","article-title":"Tissue engineering of skin for wound coverage","volume":"23","author":"Biedermann","year":"2013","journal-title":"Eur. J. Pediatr. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.reth.2022.05.008","article-title":"Current regenerative medicine-based approaches for skin regeneration: a review of literature and a report on clinical applications in Japan","volume":"21","author":"Shimizu","year":"2022","journal-title":"Regen Ther"},{"key":"10.1016\/j.mtbio.2026.102969_bib27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature24487","article-title":"Regeneration of the entire human epidermis using transgenic stem cells","volume":"551","author":"Hirsch","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.102969_bib28","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/bit.28659","article-title":"Engineering of a decellularized bovine skin coated with antibiotics-loaded electrospun fibers with synergistic antibacterial activity for the treatment of infectious wounds","volume":"121","author":"Alizadeh","year":"2024","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.mtbio.2026.102969_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/pat.70247","article-title":"Engineering of a bilayer film made from decellularized amniotic membrane and emulsion for skin tissue engineering applications","volume":"36","author":"Majidi","year":"2025","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.mtbio.2026.102969_bib30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/aor.14674","article-title":"Fabrication and characterization of a hydrocolloid wound dressing functionalized with human placental derived extracellular matrix for management of skin wounds: an animal study","volume":"48","author":"Jafari","year":"2024","journal-title":"Artif. Organs"},{"key":"10.1016\/j.mtbio.2026.102969_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122141","article-title":"Snail-inspired AFG\/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization","volume":"299","author":"Zhou","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.102969_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering11050435","article-title":"Evaluation of skin wound healing with biosheets containing somatic stem cells in a dog model: a pilot study","volume":"11","author":"Maeta","year":"2024","journal-title":"Bioengineering"},{"key":"10.1016\/j.mtbio.2026.102969_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/bioengineering11050462","article-title":"Dramatic wound closing effect of a single application of an iBTA-Induced autologous biosheet on severe diabetic foot ulcers involving the heel area","volume":"11","author":"Higashita","year":"2024","journal-title":"Bioengineering"},{"key":"10.1016\/j.mtbio.2026.102969_bib34","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jbiosc.2021.07.003","article-title":"Involvement of somatic stem cells in encapsulation of foreign-body reaction in canine subcutaneous biotube tissue formation","volume":"132","author":"Sato","year":"2021","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.mtbio.2026.102969_bib35","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/term.2914","article-title":"Mesenchymal stem cells: cell therapy and regeneration potential","volume":"13","author":"Brown","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.mtbio.2026.102969_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22169006","article-title":"Furnishing wound repair by the subcutaneous fascia","volume":"22","author":"Jiang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.102969_bib37","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jcyt.2019.08.002","article-title":"Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT(R)) mesenchymal Stromal Cell committee position statement on nomenclature","volume":"21","author":"Viswanathan","year":"2019","journal-title":"Cytotherapy"},{"key":"10.1016\/j.mtbio.2026.102969_bib38","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1089\/scd.2011.0551","article-title":"Positional identity of murine mesenchymal stem cells resident in different organs is determined in the postsegmentation mesoderm","volume":"21","author":"Sagi","year":"2012","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.mtbio.2026.102969_bib39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/cbin.10240","article-title":"Isolation and characterization of lung resident mesenchymal stem cells capable of differentiating into alveolar epithelial type II cells","volume":"38","author":"Gong","year":"2014","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.mtbio.2026.102969_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1566670","article-title":"Optimal Sca-1-based procedure for purifying mouse adipose-derived mesenchymal stem cells with enhanced proliferative and differentiation potential","volume":"13","author":"Tao","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2026.102969_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030756","article-title":"Murine mesenchymal stromal cells retain biased differentiation plasticity towards their tissue of origin","volume":"9","author":"Ng","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2026.102969_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euprot.2016.09.002","article-title":"Multi-omics \"upstream analysis\" of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer","volume":"13","author":"Kel","year":"2016","journal-title":"EuPA Open Proteom"},{"key":"10.1016\/j.mtbio.2026.102969_bib43","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190418","article-title":"Biology and therapeutic potential of interleukin-10","volume":"217","author":"Saraiva","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mtbio.2026.102969_bib44","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/j.cell.2023.07.036","article-title":"TGF-beta signaling in health and disease","volume":"186","author":"Massague","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.102969_bib45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4196\/kjpp.24.309","article-title":"Roles of PDGF\/PDGFR signaling in various organs","volume":"29","author":"Jung","year":"2025","journal-title":"KOREAN J. PHYSIOL. PHARMACOL."},{"key":"10.1016\/j.mtbio.2026.102969_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031293","article-title":"Cell cycle-dependent transcription: the cyclin dependent kinase Cdk1 is a direct regulator of basal transcription machineries","volume":"23","author":"Enserink","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.mtbio.2026.102969_bib47","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1440-1746.2010.06549.x","article-title":"Hepatocyte growth factor twenty years on: much more than a growth factor","volume":"26","author":"Nakamura","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mtbio.2026.102969_bib48","first-page":"3","article-title":"Hepatocyte growth factor stimulated angiogenesis without inflammation: differential actions between hepatocyte growth factor, vascular endothelial growth factor and basic fibroblast growth factor, vascul","volume":"57","author":"Kaga","year":"2012","journal-title":"Pharmacologist"},{"key":"10.1016\/j.mtbio.2026.102969_bib49","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/sj.gt.3301379","article-title":"Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease","volume":"8","author":"Taniyama","year":"2001","journal-title":"Gene Ther."},{"key":"10.1016\/j.mtbio.2026.102969_bib50","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ejvs.2024.07.016","article-title":"Recombinant human hepatocyte growth factor plasmids for treating patients with chronic limb threatening ischaemia: a systematic review and meta-analysis","volume":"68","author":"Di","year":"2024","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib51","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1002\/jnr.21372","article-title":"Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury","volume":"85","author":"Kitamura","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mtbio.2026.102969_bib52","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1089\/neu.2019.6854","article-title":"Phase I\/II study of intrathecal administration of recombinant human hepatocyte growth factor in patients with acute spinal cord injury: a double-blind, randomized clinical trial of safety and efficacy","volume":"37","author":"Nagoshi","year":"2020","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mtbio.2026.102969_bib53","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/path.1578","article-title":"Diverse and potent activities of HGF\/SF in skin wound repair","volume":"203","author":"Bevan","year":"2004","journal-title":"J. Pathol."},{"key":"10.1016\/j.mtbio.2026.102969_bib54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1523-1747.2003.12039.x","article-title":"Neutralization of hepatocyte growth factor leads to retarded cutaneous wound healing associated with decreased neovascularization and granulation tissue formation","volume":"120","author":"Yoshida","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mtbio.2026.102969_bib55","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1038\/s41598-022-07156-w","article-title":"Dried human cultured epidermis accelerates wound healing in diabetic mouse skin defect wounds","volume":"12","author":"Sakamoto","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2026.102969_bib56","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1038\/s41598-025-87592-6","article-title":"MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2026.102969_bib57","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3389\/fcell.2020.00801","article-title":"HGF\/c-Met axis: the advanced development in digestive system cancer","volume":"8","author":"Shao","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2026.102969_bib58","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41392-025-02313-9","article-title":"Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies","volume":"10","author":"Han","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.102969_bib59","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/s13287-022-03181-8","article-title":"Stem cell-based therapy for pulmonary fibrosis","volume":"13","author":"Cheng","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2026.102969_bib60","article-title":"Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2026.102969_bib61","article-title":"Mesenchymal stem cell-based immunomodulation: properties and clinical application","volume":"2018","author":"Wang","year":"2018","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.mtbio.2026.102969_bib62","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbmt.2020.01.018","article-title":"A phase 3, single-arm, prospective study of Remestemcel-L, Ex vivo culture-expanded adult human mesenchymal stromal cells for the treatment of pediatric patients who failed to respond to steroid treatment for acute graft-versus-host disease","volume":"26","author":"Kurtzberg","year":"2020","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.mtbio.2026.102969_bib63","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13287-025-04272-y","article-title":"Efficacy of mesenchymal stem cell-based therapies in the treatment of perianal fistulizing Crohn's disease: a systematic review and meta-analysis","volume":"16","author":"Guillo","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2026.102969_bib64","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13287-022-02941-w","article-title":"Mesenchymal stem cell transplantation in newly diagnosed type-1 diabetes patients: a phase I\/II randomized placebo-controlled clinical trial","volume":"13","author":"Izadi","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2026.102969_bib65","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biochi.2025.07.011","article-title":"The promise of cell-based therapies in diabetes: a review of mesenchymal stem cell applications and trials","volume":"237","author":"Li","year":"2025","journal-title":"Biochimie"},{"key":"10.1016\/j.mtbio.2026.102969_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12196311","article-title":"Mesenchymal stem cell therapy in multiple sclerosis: a systematic review and meta-analysis","volume":"12","author":"Islam","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mtbio.2026.102969_bib67","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1007\/s12015-022-10429-6","article-title":"Paracrine factors released by stem cells of mesenchymal origin and their effects in cardiovascular disease: a systematic review of pre-clinical studies","volume":"18","author":"Mabotuwana","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.mtbio.2026.102969_bib68","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/stmcls\/sxae055","article-title":"Hepatocyte growth factor facilitates the repair of spinal cord injuries by driving the chemotactic migration of mesenchymal stem cells through the beta-catenin\/TCF4\/Nedd9 signaling pathway","volume":"42","author":"Hu","year":"2024","journal-title":"Stem Cell."},{"key":"10.1016\/j.mtbio.2026.102969_bib69","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s13287-019-1488-2","article-title":"Mesenchymal stem cells induce dendritic cell immune tolerance via paracrine hepatocyte growth factor to alleviate acute lung injury","volume":"10","author":"Lu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mtbio.2026.102969_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay6994","article-title":"In vivo priming of human mesenchymal stem cells with hepatocyte growth factor-engineered mesenchymal stem cells promotes therapeutic potential for cardiac repair","volume":"6","author":"Park","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.102969_bib71","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1182\/blood.V99.8.2997","article-title":"Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils","volume":"99","author":"Grenier","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.mtbio.2026.102969_bib72","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/01.TA.0000111752.60500.DA","article-title":"Hepatocyte growth factor in polymorphonuclear leukocytes is increased in patients with systemic inflammatory response syndrome","volume":"56","author":"Matsushima","year":"2004","journal-title":"J. Trauma"},{"key":"10.1016\/j.mtbio.2026.102969_bib73","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2312855121","article-title":"Tumor-neutrophil cross talk orchestrates the tumor microenvironment to determine the bladder cancer progression","volume":"121","author":"Jing","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mtbio.2026.102969_bib74","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2025-336300","article-title":"CD177(+) neutrophils drive extracellular matrix remodelling and HGF-alpha release in ALPPS-induced liver regeneration","author":"Yan","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2026.102969_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103593","article-title":"A simple and effective flow cytometry-based method for identification and quantification of tissue infiltrated leukocyte subpopulations in a mouse model of peripheral arterial disease","volume":"21","author":"Kumaraswami","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.102969_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.jim.2022.113403","article-title":"Optimized flow cytometry assays to monitor neutrophil activation in human and mouse whole blood samples","volume":"512","author":"Ledderose","year":"2023","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.mtbio.2026.102969_bib77","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1439-0264.2002.00357.x","article-title":"Labelling of rat endothelial cells with antibodies to vWF, RECA-1, PECAM-1, ICAM-1, OX-43 and ZO-1","volume":"31","author":"Ulger","year":"2002","journal-title":"Anat. Histol. Embryol."},{"key":"10.1016\/j.mtbio.2026.102969_bib78","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1369\/jhc.4A6514.2005","article-title":"Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues","volume":"54","author":"Pusztaszeri","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.mtbio.2026.102969_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/ma18112561","article-title":"Most important biomedical and pharmaceutical applications of silicones","volume":"18","author":"Chrusciel","year":"2025","journal-title":"Materials"},{"key":"10.1016\/j.mtbio.2026.102969_bib80","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jpedsurg.2022.01.005","article-title":"Ultrasound-guided percutaneous insertion of Broviac lines in infants less than 5kg: prospective study of 100 consecutive procedures","volume":"57","author":"Reddy","year":"2022","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.mtbio.2026.102969_bib81","doi-asserted-by":"crossref","first-page":"757","DOI":"10.15252\/msb.20145625","article-title":"Ultrasensitive proteome analysis using paramagnetic bead technology","volume":"10","author":"Hughes","year":"2014","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.mtbio.2026.102969_bib82","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41596-018-0082-x","article-title":"Single-pot, solid-phase-enhanced sample preparation for proteomics experiments","volume":"14","author":"Hughes","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mtbio.2026.102969_bib83","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s13361-018-2122-8","article-title":"Improving precursor selectivity in data-independent acquisition using overlapping windows","volume":"30","author":"Amodei","year":"2019","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.mtbio.2026.102969_bib84","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1021\/acs.jproteome.2c00023","article-title":"Single-shot 10K proteome approach: over 10,000 protein identifications by data-independent acquisition-based single-shot proteomics with ion mobility spectrometry","volume":"21","author":"Kawashima","year":"2022","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mtbio.2026.102969_bib85","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1021\/acs.jproteome.3c00146","article-title":"Development of a simple and stable NanoESI spray system using suction wind from the MS inlet","volume":"22","author":"Kawashima","year":"2023","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mtbio.2026.102969_bib86","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41592-019-0426-7","article-title":"Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning","volume":"16","author":"Gessulat","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mtbio.2026.102969_bib87","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41467-020-15346-1","article-title":"Generating high quality libraries for DIA MS with empirically corrected peptide predictions","volume":"11","author":"Searle","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.102969_bib88","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mtbio.2026.102969_bib89","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0014-5793(87)80475-1","article-title":"Purification and subunit structure of hepatocyte growth factor from rat platelets","volume":"224","author":"Nakamura","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mtbio.2026.102969_bib90","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/342440a0","article-title":"Molecular cloning and expression of human hepatocyte growth factor","volume":"342","author":"Nakamura","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.102969_bib91","doi-asserted-by":"crossref","first-page":"G420","DOI":"10.1152\/ajpgi.00216.2011","article-title":"Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression","volume":"302","author":"Xu","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426002127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426002127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:44:01Z","timestamp":1777635841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426002127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":91,"alternative-id":["S2590006426002127"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102969","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocyte growth factor in biosheets promotes autonomous regeneration of cutaneous tissue after transplantation onto a full-thickness skin defect","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102969","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102969"}}