{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:36:16Z","timestamp":1783607776938,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004739","name":"Chinese Academy of Sciences Youth Innovation Promotion Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2026.102973","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:25:34Z","timestamp":1772151934000},"page":"102973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Biomimetic sequentially gated nanotuners based on amorphous metal\u2013organic frameworks for reprogramming the metabolism-ferroptosis-immunity crosstalk in gliomas"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-9777","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijia","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7305-5852","authenticated-orcid":false,"given":"Yinghui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.102973_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-024-00516-y","article-title":"Glioma","volume":"10","author":"Weller","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.mtbio.2026.102973_bib2","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/s41467-025-57190-1","article-title":"Engineering nanozyme immunomodulator with magnetic targeting effect for cascade-enzyodynamic and ultrasound-reinforced metallo-immunotherapy in prostate carcinoma","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.102973_bib3","doi-asserted-by":"crossref","first-page":"24884","DOI":"10.1021\/jacs.5c07105","article-title":"Cathepsin B-Ignited nanorocket to blast tumor lysosomes for TLR-fortified lysosomal immunotherapy with dual-switchable fluorescence\/magnetic resonance imaging","volume":"147","author":"Chen","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2026.102973_bib4","article-title":"Efficiently enhancing ferroptosis-mediated immunosensitization in lung cancer by an inhalable immune activation nanoplatform","volume":"35","author":"Chen","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.102973_bib5","doi-asserted-by":"crossref","first-page":"37641","DOI":"10.1021\/jacs.5c12775","article-title":"Genetically engineered biomimetic nanoparticles for synergistic activation of glioma-associated macrophages against glioblastoma","volume":"147","author":"Luo","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2026.102973_bib6","doi-asserted-by":"crossref","first-page":"26980","DOI":"10.1021\/acsnano.5c09310","article-title":"Immuno-initiator rectifies immunodeficiency to restore immune function and potentiate immunotherapy against IDH mutant glioma","volume":"19","author":"Zhou","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.102973_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41392-020-00326-0","article-title":"NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications","volume":"5","author":"Ju","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.102973_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2026.102973_bib9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.102973_bib10","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.1254","article-title":"Hypoxia studies with pimonidazole in vivo","volume":"4","author":"Aguilera","year":"2014","journal-title":"Bio-protocol"},{"key":"10.1016\/j.mtbio.2026.102973_bib11","doi-asserted-by":"crossref","first-page":"15472","DOI":"10.1002\/anie.202103015","article-title":"ZIF-based nanoparticles combine X-Ray-Induced nitrosative stress with autophagy management for hypoxic prostate cancer therapy","volume":"60","author":"Li","year":"2021","journal-title":"Angew. Chem.-Int. Edit."},{"key":"10.1016\/j.mtbio.2026.102973_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41586-020-2682-1","article-title":"Cancer SLC43A2 alters T cell methionine metabolism and histone methylation","volume":"585","author":"Bian","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.102973_bib13","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3390\/cells11101603","article-title":"Methionine deprivation reveals the pivotal roles of cell cycle progres sion in ferroptosis that is induced by cysteine starvation","volume":"11","author":"Homma","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2026.102973_bib14","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1038\/s41467-023-40518-0","article-title":"Intermittent dietary methionine deprivation facilitates tumoral ferrop tosis and synergizes with checkpoint blockade","volume":"14","author":"Xue","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.102973_bib15","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1038\/s41467-023-40345-3","article-title":"A bimetallic nanoplatform for STING activation and CRISPR\/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune responses","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.102973_bib16","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41467-023-36630-w","article-title":"Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism","volume":"14","author":"Upadhyayula","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.102973_bib17","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41565-025-01867-7","article-title":"Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth","volume":"20","author":"Alonso-Valenteen","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.mtbio.2026.102973_bib18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41551-023-01150-x","article-title":"Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons","volume":"8","author":"Gu","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2026.102973_bib19","doi-asserted-by":"crossref","first-page":"21154","DOI":"10.1021\/acsnano.5c06051","article-title":"Enhanced nano-vaccine utilizing biomineralized virus-like particles for efficient glioblastoma immunotherapy via the nose-to-brain delivery pathway","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.102973_bib20","article-title":"A biomimetic nanoplatform for multimodal imaging-guided therapy of esophageal cancer via synergistic activation of cuproptosis and ferroptosis","volume":"34","author":"Ren","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.102973_bib21","article-title":"Biomimetic lipopolysaccharide-free bacterial outer membrane-functionalized nanoparticles for brain-targeted drug delivery","volume":"9","author":"Chen","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2026.102973_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nrmicro.2016.178","article-title":"A journey into the brain: insight into how bacterial pathogens cross blood\u2013brain barriers","volume":"15","author":"Coureuil","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.mtbio.2026.102973_bib23","doi-asserted-by":"crossref","first-page":"23276","DOI":"10.1021\/acsnano.5c06202","article-title":"Cancer cell membrane-coated homodimer prodrug nanoassemblies to simultaneously deliver prodrugs and immune adjuvants for combined chemo-immunotherapy","volume":"19","author":"Zhao","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.102973_bib24","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307899120","article-title":"Pathogenic bacteria exploit transferrin receptor transcytosis to penet rate the blood\u2013brain barrier","volume":"120","author":"Cheng","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mtbio.2026.102973_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202109213","article-title":"Neisseria meningitidis opca Protein\/MnO2 hybrid nano particles for overcoming the blood\u2013brain barrier to treat glioblastoma","volume":"34","author":"Dong","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.102973_bib26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s42003-020-01165-z","article-title":"2-Nitroimidazoles induce mitochondrial stress and ferroptosis in gliom a stem cells residing in a hypoxic niche","volume":"3","author":"Koike","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mtbio.2026.102973_bib27","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1021\/ja00248a028","article-title":"Products of the reductions of 2-nitroimidazoles","volume":"109","author":"McClelland","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2026.102973_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-019-1011-z","article-title":"Structure of the human LAT1\u20134F2hc heteromeric amino acid transporter c omplex","volume":"568","author":"Yan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.102973_bib29","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1038\/s41596-022-00713-7","article-title":"Nanocarriers based on bacterial membrane materials for cancer vaccine delivery","volume":"17","author":"Zhao","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mtbio.2026.102973_bib30","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1038\/s41467-022-32837-5","article-title":"Bacteria loaded with glucose polymer and photosensitive ICG silicon-na noparticles for glioblastoma photothermal immunotherapy","volume":"13","author":"Sun","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.102973_bib31","article-title":"Cascade specific endogenous Fe3+ interference and in situ catalysis for tumor therapy with stemness suppression","volume":"12","author":"Chen","year":"2024","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.mtbio.2026.102973_bib32","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.31635\/ccschem.023.202303514","article-title":"Zinc ion-induced immune responses in antitumor immunotherapy","volume":"6","author":"Yang","year":"2024","journal-title":"CCS Chem."},{"key":"10.1016\/j.mtbio.2026.102973_bib33","article-title":"Ultrathin clay nanoparticles-mediated mutual reinforcement of ferroptosis and cancer immunotherapy","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.102973_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202310178","article-title":"A semiconducting iron-chelating nano-immunomodulator for specific and sensitized sono-metallo-immunotherapy of cancer","volume":"62","author":"He","year":"2023","journal-title":"Angew. Chem.-Int. Edit."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426002164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426002164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:35:09Z","timestamp":1777635309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426002164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":34,"alternative-id":["S2590006426002164"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102973","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic sequentially gated nanotuners based on amorphous metal\u2013organic frameworks for reprogramming the metabolism-ferroptosis-immunity crosstalk in gliomas","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102973","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102973"}}