{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:20:04Z","timestamp":1791300004042,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Provincial Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2026.102975","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T07:51:18Z","timestamp":1772265078000},"page":"102975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Liposomal hydrogel-based oral vaccine delivery for targeted induction of intestinal mucosal immunity"],"prefix":"10.1016","volume":"37","author":[{"given":"Zhiwei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baochao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-9625","authenticated-orcid":false,"given":"Lili","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.102975_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1126\/science.abe3685","article-title":"Making a bed for viral infections","volume":"370","author":"Mirchandani","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2026.102975_bib2","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.cell.2021.03.037","article-title":"The origins of viral infection sleuth","volume":"184","author":"Guan","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.102975_bib3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-animal-022114-111038","article-title":"Strategies for design and application of enteric viral vaccines","volume":"3","author":"Chattha","year":"2015","journal-title":"Ann. Rev. Anim. Biosci."},{"key":"10.1016\/j.mtbio.2026.102975_bib4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev-immunol-032414-112315","article-title":"Exploiting mucosal immunity for antiviral vaccines","volume":"34","author":"Iwasaki","year":"2016","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2026.102975_bib5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nri1777","article-title":"Mucosal vaccines: the promise and the challenge","volume":"6","author":"Neutra","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2026.102975_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.addr.2015.03.007","article-title":"Delivery strategies to enhance oral vaccination against enteric infections","volume":"91","author":"Davitt","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.102975_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.144371","article-title":"A novel oral biomimetic delivery system enhancing both the mucosal and systemic immunity of influenza virus vaccine","volume":"470","author":"Lu","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2026.102975_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136690","article-title":"Cistanche deserticola polysaccharide-functionalized dendritic fibrous nano-silica as oral delivery system for H(9)N(2) vaccine to promote systemic and mucosal immune response","volume":"282","author":"He","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.102975_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.addr.2017.04.008","article-title":"Current state and challenges in developing oral vaccines","volume":"114","author":"Vela Ramirez","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.102975_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biomaterials.2015.04.017","article-title":"Attuning hydroxypropyl methylcellulose phthalate to oral delivery vehicle for effective and selective delivery of protein vaccine in ileum","volume":"59","author":"Singh","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.102975_bib11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jconrel.2016.07.051","article-title":"Role of nanoparticle size, shape and surface chemistry in oral drug delivery","volume":"238","author":"Banerjee","year":"2016","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.102975_bib12","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jconrel.2013.09.007","article-title":"\u03b2-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination","volume":"172","author":"De Smet","year":"2013","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.102975_bib13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.biomaterials.2018.03.014","article-title":"Aluminum hydroxide colloid vaccine encapsulated in yeast shells with enhanced humoral and cellular immune responses","volume":"167","author":"Liu","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.102975_bib14","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1021\/acsnano.1c04996","article-title":"Lipid nanoparticles\u2500from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement","volume":"15","author":"Tenchov","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.102975_bib15","article-title":"Construction strategy of functionalized liposomes and multidimensional application","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.102975_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.132107","article-title":"Zwitterionic polydopamine modified nanoparticles as an efficient nanoplatform to overcome both the mucus and epithelial barriers","volume":"428","author":"Hu","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2026.102975_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12951-017-0319-9","article-title":"Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines","volume":"15","author":"De Serrano","year":"2017","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.102975_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0168-3659(01)00227-9","article-title":"Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine","volume":"71","author":"Bernkop-Schn\u00fcrch","year":"2001","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.102975_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jconrel.2024.05.041","article-title":"Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract","volume":"371","author":"Esih","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.102975_bib20","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41577-021-00583-2","article-title":"Mucosal vaccines - fortifying the frontiers","volume":"22","author":"Lavelle","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2026.102975_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202105530","article-title":"Nanovaccines mediated subcutis-to-intestine cascade for improved protection against intestinal infections","volume":"18","author":"Zhong","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.102975_bib22","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/j.vaccine.2014.03.025","article-title":"Oral retinyl palmitate or retinoic acid corrects mucosal IgA responses toward an intranasal influenza virus vaccine in vitamin A deficient mice","volume":"32","author":"Surman","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.mtbio.2026.102975_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mam.2011.11.001","article-title":"Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance","volume":"33","author":"Cassani","year":"2012","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.mtbio.2026.102975_bib24","article-title":"All-trans-retinoic acid-adjuvanted mRNA vaccine induces mucosal anti-tumor immune responses for treating colorectal cancer","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.102975_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf4822","article-title":"IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches","volume":"352","author":"Reboldi","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2026.102975_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msad052","article-title":"Global dynamics of porcine enteric coronavirus PEDV epidemiology, evolution, and transmission","volume":"40","author":"Zhang","year":"2023","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.mtbio.2026.102975_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.mtbio.2026.102975_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02958-23","article-title":"PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge","volume":"15","author":"Zhao","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.mtbio.2026.102975_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biomaterials.2017.10.022","article-title":"Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery","volume":"151","author":"Fan","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.102975_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2022.11.032","article-title":"Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin","volume":"353","author":"Wu","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.102975_bib31","article-title":"Intestine-targeted explosive hydrogel microsphere promotes uric acid excretion for gout therapy","volume":"36","author":"Tang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.102975_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102155","article-title":"Orally hierarchical targeting delivery systems relieve colitis by protecting host mitochondria and modulating gut microbiota","volume":"55","author":"Xing","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.mtbio.2026.102975_bib33","article-title":"Pollen-inspired adhesive multilobe microparticles from microfluidics for intestinal drug delivery","volume":"35","author":"Huang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.102975_bib34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijbiomac.2020.02.079","article-title":"Biodistribution and pharmacokinetics of thiolated chitosan nanoparticles for oral delivery of insulin in vivo","volume":"150","author":"Sudhakar","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.102975_bib35","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.apsb.2022.08.010","article-title":"Recent progress in application of nanovaccines for enhancing mucosal immune responses","volume":"13","author":"Du","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2026.102975_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-023-01557-7","article-title":"Vaccine adjuvants: mechanisms and platforms","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Targeted Ther."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426002188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426002188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:27:09Z","timestamp":1777634829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426002188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":36,"alternative-id":["S2590006426002188"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102975","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liposomal hydrogel-based oral vaccine delivery for targeted induction of intestinal mucosal immunity","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.102975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102975"}}