{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:53:14Z","timestamp":1776207194548,"version":"3.50.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR24H060001"],"award-info":[{"award-number":["LR24H060001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY24H170001"],"award-info":[{"award-number":["LY24H170001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03072"],"award-info":[{"award-number":["2024C03072"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03091"],"award-info":[{"award-number":["2023C03091"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo Municipality","doi-asserted-by":"publisher","award":["2024Z211"],"award-info":[{"award-number":["2024Z211"]}],"id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo Municipality","doi-asserted-by":"publisher","award":["2023Z194"],"award-info":[{"award-number":["2023Z194"]}],"id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo Municipality","doi-asserted-by":"publisher","award":["2024Z206"],"award-info":[{"award-number":["2024Z206"]}],"id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023ZL497"],"award-info":[{"award-number":["2023ZL497"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372454"],"award-info":[{"award-number":["82372454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330077"],"award-info":[{"award-number":["82330077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472407"],"award-info":[{"award-number":["82472407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2422022"],"award-info":[{"award-number":["T2422022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mtbio.2026.103000","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:23:27Z","timestamp":1772900607000},"page":"103000","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["An alkaline nanosized platelet vesicle-based hydrogel for the treatment of osteoporotic bone defects"],"prefix":"10.1016","volume":"37","author":[{"given":"Ke","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-2561","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanqiu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lintao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yining","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouyan","family":"Zu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qichen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-4395","authenticated-orcid":false,"given":"Shunwu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-2850","authenticated-orcid":false,"given":"Pengfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqing","family":"Shangguan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-1796","authenticated-orcid":false,"given":"Lei","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103000_bib1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0002-9343(93)90218-E","article-title":"Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis","volume":"94","year":"1993","journal-title":"Am. J. Med."},{"key":"10.1016\/j.mtbio.2026.103000_bib2","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2026.103000_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s42765-024-00451-3","article-title":"Fishnet-inspired 3D scaffold fabricated from mesh-like electrospun membranes promoted osteoporotic bone regeneration","volume":"7","author":"Xiao","year":"2025","journal-title":"Adv. Fiber Mater."},{"key":"10.1016\/j.mtbio.2026.103000_bib4","article-title":"A recombinant parathyroid hormone-related peptide locally applied in osteoporotic bone defect","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.103000_bib5","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1186\/s13018-021-02821-8","article-title":"Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.mtbio.2026.103000_bib6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.31616\/asj.2022.0441","article-title":"Management of osteoporotic vertebral fracture: review update 2022","volume":"16","author":"Jang","year":"2022","journal-title":"Asian Spine J."},{"key":"10.1016\/j.mtbio.2026.103000_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41413-022-00224-x","article-title":"Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration","volume":"10","author":"Wu","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.mtbio.2026.103000_bib8","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jcot.2018.08.003","article-title":"Osseointegration of osteoporotic bone implants: role of stem cells, silica and strontium - a concise review","volume":"10","author":"Chandran","year":"2019","journal-title":"J Clin Orthop Trauma"},{"key":"10.1016\/j.mtbio.2026.103000_bib9","doi-asserted-by":"crossref","first-page":"nwae076","DOI":"10.1093\/nsr\/nwae076","article-title":"Biomaterial design for regenerating aged bone: materiobiological advances and paradigmatic shifts","volume":"11","author":"Dai","year":"2024","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.mtbio.2026.103000_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jor.24170","article-title":"Cellular biology of fracture healing","volume":"37","author":"Bahney","year":"2019","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.mtbio.2026.103000_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3390\/ijms20010083","article-title":"Anabolic therapies in osteoporosis and bone regeneration","volume":"20","author":"Russow","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103000_bib12","doi-asserted-by":"crossref","first-page":"24113","DOI":"10.1074\/jbc.M301716200","article-title":"Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity","volume":"278","author":"Kusu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2026.103000_bib13","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/nm.2489","article-title":"Suppression of bone formation by osteoclastic expression of semaphorin 4D","volume":"17","author":"Negishi-Koga","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2026.103000_bib14","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/nm.3668","article-title":"PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis","volume":"20","author":"Xie","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2026.103000_bib15","doi-asserted-by":"crossref","first-page":"17543","DOI":"10.1021\/jacs.0c07309","article-title":"Smart nanosacrificial layer on the bone surface prevents osteoporosis through acid-base neutralization regulated biocascade effects","volume":"142","author":"Lin","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2026.103000_bib16","first-page":"F442","article-title":"Acidosis inhibits osteoblastic and stimulates osteoclastic activity in vitro","volume":"262","author":"Krieger","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mtbio.2026.103000_bib17","doi-asserted-by":"crossref","first-page":"415S","DOI":"10.1093\/jn\/138.2.415S","article-title":"Extracellular pH regulates bone cell function","volume":"138","author":"Arnett","year":"2008","journal-title":"J. Nutr."},{"key":"10.1016\/j.mtbio.2026.103000_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41580-023-00676-x","article-title":"Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology","volume":"25","author":"Settembre","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103000_bib19","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41581-023-00692-2","article-title":"The role of lysosomes in metabolic and autoimmune diseases","volume":"19","author":"Gros","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.mtbio.2026.103000_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1431566","article-title":"Lysosomal biogenesis and function in osteoclasts: a comprehensive review","volume":"12","author":"Jiang","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2026.103000_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-pathmechdis-031521-040919","article-title":"Osteoclasts, master sculptors of bone","volume":"18","author":"Veis","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.mtbio.2026.103000_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103000_bib23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jbmr.1727","article-title":"The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis","volume":"28","author":"Voronov","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mtbio.2026.103000_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.matt.2022.12.002","article-title":"A natural extracellular matrix hydrogel through selective nutrient restriction for hyperinflammatory starvation therapy","volume":"6","author":"Chen","year":"2023","journal-title":"Matter"},{"key":"10.1016\/j.mtbio.2026.103000_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.freeradbiomed.2024.06.002","article-title":"Biological functions and biomedical applications of extracellular vesicles derived from blood cells","volume":"222","author":"Pan","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103000_bib26","article-title":"Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction","volume":"18","author":"Dai","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103000_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1026386","article-title":"Platelets and platelet extracellular vesicles in drug delivery therapy: a review of the current status and future prospects","volume":"13","author":"Dai","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103000_bib28","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1039\/C8BM01480A","article-title":"Platelet-derived nanovesicles for hemostasis without release of pro-inflammatory cytokines","volume":"7","author":"Jung","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2026.103000_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature15373","article-title":"Nanoparticle biointerfacing by platelet membrane cloaking","volume":"526","author":"Hu","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103000_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.matt.2020.05.017","article-title":"Calming cytokine storm in pneumonia by targeted delivery of TPCA-1 using platelet-derived extracellular vesicles","volume":"3","author":"Ma","year":"2020","journal-title":"Matter"},{"key":"10.1016\/j.mtbio.2026.103000_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12989-016-0168-y","article-title":"Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms","volume":"13","author":"Ou","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.mtbio.2026.103000_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1001572","article-title":"Toxicity of metal-based nanoparticles: challenges in the nano era","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2026.103000_bib33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jat.4534","article-title":"The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity","volume":"44","author":"Li","year":"2024","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.mtbio.2026.103000_bib34","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.7150\/thno.30206","article-title":"Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103000_bib35","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1021\/acs.nanolett.2c04295","article-title":"Neutralization of intracellular pH homeostasis to inhibit osteoclasts based on a spatiotemporally selective delivery system","volume":"23","author":"Tian","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.mtbio.2026.103000_bib36","article-title":"A complex microenvironment-targeted strategy based on antibiotic-loaded platelet-derived extracellular vesicles for infected wound repair","volume":"0","author":"Dai","year":"2026","journal-title":"Cell Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103000_bib37","doi-asserted-by":"crossref","first-page":"39043","DOI":"10.1074\/jbc.M111.256768","article-title":"Inactivation of glycogen synthase kinase-3\u03b2 is required for osteoclast differentiation","volume":"286","author":"Jang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2026.103000_bib38","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1172\/JCI34257","article-title":"Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice","volume":"118","author":"Jin","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mtbio.2026.103000_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31268","article-title":"Nodal negatively regulates osteoclast differentiation by inducing STAT1 phosphorylation","volume":"239","author":"Kim","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mtbio.2026.103000_bib40","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3389\/fimmu.2018.01508","article-title":"Interferon-gamma-mediated osteoimmunology","volume":"9","author":"Tang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2026.103000_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.imlet.2018.12.003","article-title":"A dual role of TGF-\u03b2 in human osteoclast differentiation mediated by Smad1 versus Smad3 signaling","volume":"206","author":"Lee","year":"2019","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.mtbio.2026.103000_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105379","article-title":"AMPK\u03b11 negatively regulates osteoclastogenesis and mitigates pathological bone loss","volume":"299","author":"Ribeiro","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2026.103000_bib43","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jbmr.2974","article-title":"SOD2 and Sirt3 control osteoclastogenesis by regulating mitochondrial ROS","volume":"32","author":"Kim","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mtbio.2026.103000_bib44","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/jbmr.3927","article-title":"PARP1 hinders histone H2B occupancy at the NFATc1 promoter to restrain osteoclast differentiation","volume":"35","author":"Wang","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mtbio.2026.103000_bib45","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1039\/C8BM00100F","article-title":"Regulating the local pH level of titanium via Mg-Fe layered double hydroxides films for enhanced osteogenesis","volume":"6","author":"Li","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2026.103000_bib46","first-page":"17","article-title":"Increased osteoblast viability at alkaline pH in vitro provides a new perspective on bone regeneration","volume":"10","author":"Galow","year":"2017","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.mtbio.2026.103000_bib47","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41419-021-03394-4","article-title":"FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation","volume":"12","author":"Hu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2026.103000_bib48","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.celrep.2015.07.050","article-title":"Presenilin 1 maintains lysosomal Ca2+ homeostasis by regulating vATPase-mediated lysosome acidification","volume":"12","author":"Lee","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.mtbio.2026.103000_bib49","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mtbio.2026.103000_bib50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41525-022-00312-1","article-title":"Ano5 modulates calcium signaling during bone homeostasis in gnathodiaphyseal dysplasia","volume":"7","author":"Li","year":"2022","journal-title":"npj Genom. Med."},{"key":"10.1016\/j.mtbio.2026.103000_bib51","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-065X.2009.00821.x","article-title":"Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation","volume":"231","author":"Negishi-Koga","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.mtbio.2026.103000_bib52","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/jbmr.2986","article-title":"Lysosomal Ca2+ signaling is essential for osteoclastogenesis and bone remodeling","volume":"32","author":"Erkhembaatar","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mtbio.2026.103000_bib53","doi-asserted-by":"crossref","first-page":"ra42","DOI":"10.1126\/scisignal.2002790","article-title":"The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis","volume":"5","author":"Roczniak-Ferguson","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mtbio.2026.103000_bib54","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1080\/15548627.2021.1896906","article-title":"Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response","volume":"17","author":"Jeong","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.mtbio.2026.103000_bib55","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/emboj.2012.32","article-title":"A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB","volume":"31","author":"Settembre","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.mtbio.2026.103000_bib56","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase","volume":"334","author":"Zoncu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2026.103000_bib57","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev-physiol-021119-034425","article-title":"Osteoclasts provide coupling signals to osteoblast lineage cells through multiple mechanisms","volume":"82","author":"Sims","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mtbio.2026.103000_bib58","doi-asserted-by":"crossref","first-page":"eabn3333","DOI":"10.1126\/sciadv.abn3333","article-title":"Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system","volume":"8","author":"Wang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.103000_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202312081","article-title":"Magnetic aggregation-induced bone-targeting nanocarrier with effects of Piezo1 activation and osteogenic-angiogenic coupling for osteoporotic bone repair","volume":"36","author":"Guan","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103000_bib60","first-page":"429","article-title":"Reversing the imbalance in bone homeostasis via sustained release of SIRT-1 agonist to promote bone healing under osteoporotic condition","volume":"19","author":"Zhang","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103000_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2024.111358","article-title":"Exosomes from young plasma alleviate osteoporosis through miR-217-5p-regulated osteogenesis of bone marrow mesenchymal stem cell","volume":"276","author":"Meng","year":"2024","journal-title":"Compos. B Eng."},{"key":"10.1016\/j.mtbio.2026.103000_bib62","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1056\/NEJMoa1916525","article-title":"Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates","volume":"383","author":"Black","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mtbio.2026.103000_bib63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"International task force on Osteonecrosis of the jaw, diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mtbio.2026.103000_bib64","article-title":"Effective osteoporosis treatment by Polypeptosome-Mediated neutralization of acid bone microenvironment","author":"Jiang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103000_bib65","article-title":"Breaking osteoclast-acid vicious cycle to rescue osteoporosis via an acid responsive organic framework-based neutralizing and gene editing platform","volume":"20","author":"Lin","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.103000_bib66","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/s41467-023-36484-2","article-title":"Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts","volume":"14","author":"Ng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103000_bib67","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1177\/0363546509349921","article-title":"Platelet-rich plasma: from basic science to clinical applications","volume":"37","author":"Foster","year":"2009","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.mtbio.2026.103000_bib68","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jconrel.2020.11.064","article-title":"Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy","volume":"329","author":"Ma","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103000_bib69","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.biomaterials.2016.10.003","article-title":"Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia","volume":"111","author":"Wei","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103000_bib70","first-page":"1149","article-title":"Engineered biomimetic platelet membrane-coated nanoparticles block Staphylococcus aureus cytotoxicity and protect against lethal systemic infection","volume":"7","author":"Kim","year":"2021","journal-title":"Engineering (Beijing)"},{"key":"10.1016\/j.mtbio.2026.103000_bib71","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2499029","article-title":"The emerging roles of platelet-derived extracellular vesicles in disease","volume":"57","author":"Lou","year":"2025","journal-title":"Ann. Med."},{"key":"10.1016\/j.mtbio.2026.103000_bib72","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13312","article-title":"Human platelet lysate-derived extracellular vesicles enhance angiogenesis through miR-126","volume":"55","author":"Bordin","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.mtbio.2026.103000_bib73","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3892\/mmr.2014.2374","article-title":"Platelet-derived growth factor promotes osteoblast proliferation by activating G-protein-coupled receptor kinase interactor-1","volume":"10","author":"Wu","year":"2014","journal-title":"Mol. Med. Rep."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426002437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426002437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:05:18Z","timestamp":1776204318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426002437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":73,"alternative-id":["S2590006426002437"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103000","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An alkaline nanosized platelet vesicle-based hydrogel for the treatment of osteoporotic bone defects","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103000","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103000"}}