{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:02:19Z","timestamp":1790067739214,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073180"],"award-info":[{"award-number":["52073180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mtbio.2026.103086","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:04:06Z","timestamp":1774973046000},"page":"103086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mannosylated graphene oxide nanotherapeutics co-delivering docetaxel and a STING agonist reprogram myeloid cells and potentiate antitumor immunity"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-5405","authenticated-orcid":false,"given":"Zang","family":"Xin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Dezhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Jingyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xuyuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shengjie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yingying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yinjuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4197-8545","authenticated-orcid":false,"given":"Wang","family":"Xinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103086_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217865","article-title":"The role of tumor microenvironment and immune cell crosstalk in triple-negative breast cancer (TNBC): emerging therapeutic opportunities","volume":"628","author":"Sabit","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mtbio.2026.103086_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114389","article-title":"Focused ultrasound-triggered doxorubicin liposomes reshape tumor microenvironment to boost checkpoint depletion in triple-negative breast cancer model","volume":"388","author":"Lee","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103086_bib3","article-title":"A MnO2-based tumor-seeking nanoplatform for enhanced chemoimmunotherapy against 4T1 breast cancer","volume":"33","author":"Gong","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103086_bib4","series-title":"Exploration","article-title":"Cancer immunotherapy based on the bidirectional reprogramming of the tumor microenvironment by a \u201cBrakes Off\/Step on the Accelerator\u201d core\u2010shell manganese Phosphate\/siPD\u2010L1 modulator","author":"Xia","year":"2025"},{"key":"10.1016\/j.mtbio.2026.103086_bib5","article-title":"STING-activating polymers boost lymphatic delivery of mRNA vaccine to potentiate cancer immunotherapy","volume":"37","author":"Zhang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103086_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111647","article-title":"STING activation and overcoming the challenges associated with STING agonists using ADC (antibody-drug conjugate) and other delivery systems","volume":"128","author":"Vasiyani","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mtbio.2026.103086_bib7","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1039\/D4BM01532K","article-title":"Enhancing nano-immunotherapy of cancer through cGAS-STING pathway modulation","volume":"13","author":"Fu","year":"2025","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2026.103086_bib8","article-title":"Enhancing cancer chemo-immunotherapy: innovative approaches for overcoming immunosuppression by functional nanomaterials","volume":"8","author":"Wang","year":"2024","journal-title":"Small Methods"},{"key":"10.1016\/j.mtbio.2026.103086_bib9","article-title":"Deformable nanocarriers for enhanced drug delivery and cancer therapy","volume":"4","author":"Cao","year":"2024","journal-title":"Exploration (Beijing)"},{"key":"10.1016\/j.mtbio.2026.103086_bib10","article-title":"Mannose-functionalized antigen nanoparticles for targeted dendritic cells, accelerated endosomal escape and enhanced MHC-I antigen presentation","volume":"197","author":"Pei","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.mtbio.2026.103086_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jconrel.2024.07.004","article-title":"Tumor phagocytosis-driven STING activation invigorates antitumor immunity and reprograms the tumor micro-environment","volume":"373","author":"Lee","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103086_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12645-024-00304-z","article-title":"A novel photocleavable amino-modified graphene for covalent purification of N-glycans from hepatocellular carcinoma patients' serum for potential biomarkers discovery","volume":"16","author":"Chao","year":"2025","journal-title":"Cancer Nanotechnology"},{"key":"10.1016\/j.mtbio.2026.103086_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114396","article-title":"Tiny tools, big vision: a minireview on carbonized nanomaterials in ophthalmology","volume":"388","author":"Unnikrishnan","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103086_bib14","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.2147\/IJN.S402249","article-title":"A targeted and pH-Responsive nano-graphene oxide nanoparticle loaded with doxorubicin for synergetic chemo-photothermal therapy of oral squamous cell carcinoma","volume":"18","author":"Li","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2026.103086_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11051-016-3399-9","article-title":"Alternative mannosylation method for nanomaterials: application to oxidized debris-free multiwalled carbon nanotubes","volume":"18","author":"de Sousa","year":"2016","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.mtbio.2026.103086_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114710","article-title":"Mannose modified graphene oxide drug-delivery system targets cancer stem cells and tumor-associated macrophages to promote immunotherapeutic efficacy","volume":"253","author":"Wang","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.mtbio.2026.103086_bib17","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1039\/C7TB02997G","article-title":"Covalent functionalization of graphene oxide with d-mannose: evaluating the hemolytic effect and protein corona formation","volume":"6","author":"de Sousa","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2026.103086_bib18","article-title":"Recent advances in cancer nanomedicine: from smart targeting to personalized therapeutics - pioneering a new era in precision oncology","volume":"36","author":"Younas","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103086_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-002155","article-title":"Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity","volume":"9","author":"Wang","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.mtbio.2026.103086_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111378","article-title":"Mannose-functionalized antigen nanoparticles for targeted dendritic cells, accelerated endosomal escape and enhanced MHC-I antigen presentation","volume":"197","author":"Pei","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.mtbio.2026.103086_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119515","article-title":"Iron chelated melanin-like nanoparticles for tumor-associated macrophage repolarization and cancer therapy","volume":"225","author":"Rong","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103086_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11051-016-3399-9","article-title":"Alternative mannosylation method for nanomaterials: application to oxidized debris-free multiwalled carbon nanotubes","volume":"18","author":"de Sousa","year":"2016","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.mtbio.2026.103086_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ph18091245","article-title":"Advances in the application of graphene and its derivatives in drug delivery systems","volume":"18","author":"Jin","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.mtbio.2026.103086_bib24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.actbio.2022.05.046","article-title":"Active targeting redox-responsive mannosylated prodrug nanocolloids promote tumor recognition and cell internalization for enhanced colon cancer chemotherapy","volume":"147","author":"Gao","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103086_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125678","article-title":"Construction of multi-program responsive vitamin E succinate-chitosan-histidine nanocarrier and its response strategy in tumor therapy","volume":"246","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103086_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ijpharm.2019.03.037","article-title":"A surfactant-like chemotherapeutic agent as a nanocarrier for delivering photosensitizers against cancer: a facile drug-delivering-drug strategy","volume":"562","author":"Wang","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2026.103086_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ma14174853","article-title":"Impact of polyethylene glycol functionalization of graphene oxide on anticoagulation and haemolytic properties of human blood","volume":"14","author":"Kamenska","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.mtbio.2026.103086_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202300319","article-title":"Magnetic mesoporous janus microrollers for combined Chemo- and photothermal ablation therapy","volume":"7","author":"Aybar Tural","year":"2024","journal-title":"Adv. Therapeut."},{"key":"10.1016\/j.mtbio.2026.103086_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1752-153X-7-39","article-title":"Fabrication of biocompatible and mechanically reinforced graphene oxide-chitosan nanocomposite films","volume":"7","author":"Zuo","year":"2013","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.mtbio.2026.103086_bib30","article-title":"Synergistic target-attacking tumor cells and M2 macrophages via a triple-responsive nanoassembly for complete metastasis blocking","volume":"14","author":"Wang","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103086_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202300319","article-title":"Magnetic mesoporous janus microrollers for combined chemo\u2010and photothermal ablation therapy","volume":"7","author":"Aybar Tural","year":"2024","journal-title":"Adv. Therap."},{"key":"10.1016\/j.mtbio.2026.103086_bib32","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1021\/acsabm.9b01108","article-title":"Reduced graphene Oxide\/mesoporous silica nanocarriers for pH-Triggered drug release and photothermal therapy","volume":"3","author":"Liu","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.mtbio.2026.103086_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124287","article-title":"Magnetic graphene oxide functionalized alginate-g-poly(2-hydroxypropylmethacrylamide) nanoplatform for near-infrared Light\/pH\/magnetic field-sensitive drug release and chemo\/phototherapy","volume":"659","author":"G\u00fcnc\u00fcm","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2026.103086_bib34","doi-asserted-by":"crossref","first-page":"858","DOI":"10.34133\/research.0858","article-title":"Delivery-Graded programmable micelles achieve enhanced tumor starvation through combined glutamine deprivation and angiogenesis inhibition","volume":"8","author":"Wei","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.mtbio.2026.103086_bib35","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1016\/j.apsb.2022.03.017","article-title":"An antigen self-assembled and dendritic cell-targeted nanovaccine for enhanced immunity against cancer","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2026.103086_bib36","doi-asserted-by":"crossref","first-page":"14522","DOI":"10.1021\/acsnano.1c04068","article-title":"Dual inhibition of endoplasmic reticulum stress and oxidation stress manipulates the polarization of macrophages under hypoxia to sensitize immunotherapy","volume":"15","author":"Jiang","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103086_bib37","article-title":"Harnessing macrophages for precision drug delivery and cancer therapy: strategies, advances and challenges","volume":"35","author":"Ji","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103086_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154757","article-title":"Glycyrrhetinic acid suppresses breast cancer metastasis by inhibiting M2-like macrophage polarization via activating JNK1\/2 signaling","volume":"114","author":"Cheng","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mtbio.2026.103086_bib39","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00011-024-01907-3","article-title":"Dissection of pro-tumoral macrophage subtypes and immunosuppressive cells participating in M2 polarization","volume":"73","author":"Sezginer","year":"2024","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.mtbio.2026.103086_bib40","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1039\/D5BM00284B","article-title":"An injectable oncolytic hydrogel platform for in situ dendritic cell vaccination to boost antitumor immunity","volume":"13","author":"Wang","year":"2025","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2026.103086_bib41","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.actbio.2023.09.033","article-title":"Copper indium selenium nanomaterials for photo-amplified immunotherapy through simultaneously enhancing cytotoxic T lymphocyte recruitment and M1 polarization of macrophages","volume":"171","author":"Chen","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103086_bib42","doi-asserted-by":"crossref","first-page":"20218","DOI":"10.1021\/acsnano.3c05991","article-title":"All-in-One engineering multifunctional nanoplatforms for sensitizing tumor low-temperature photothermal therapy in vivo","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103086_bib43","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s42004-025-01705-w","article-title":"Avenues for integrating photothermal therapy in cancer clinic","volume":"8","author":"Patnaik","year":"2025","journal-title":"Commun. Chem."},{"key":"10.1016\/j.mtbio.2026.103086_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.987491","article-title":"Tumor imaging and photothermal therapy in second near infrared window: a systematic review and meta-analysis","volume":"12","author":"Fan","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mtbio.2026.103086_bib45","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41467-019-14065-6","article-title":"Distinct effects of general anesthetics on lung metastasis mediated by IL-6\/JAK\/STAT3 pathway in mouse models","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103086_bib46","article-title":"Photothermal-enhanced dual inhibition of lactate\/kynurenine metabolism for promoting tumor immunotherapy","volume":"8","author":"Xie","year":"2023","journal-title":"Small Methods"},{"key":"10.1016\/j.mtbio.2026.103086_bib47","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1038\/s41467-022-30436-y","article-title":"Multifunctional metal-organic framework-based nanoreactor for starvation\/oxidation improved indoleamine 2,3-dioxygenase-blockade tumor immunotherapy","volume":"13","author":"Dai","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103086_bib48","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41467-024-55751-4","article-title":"Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung","volume":"16","author":"Zhu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103086_bib49","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1016\/j.vaccine.2019.07.093","article-title":"Enhancement of autophagy as a strategy for development of new DNA vaccine candidates against Japanese encephalitis","volume":"37","author":"Zhao","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.mtbio.2026.103086_bib50","article-title":"Programmed initiation and enhancement of cGAS\/STING pathway for tumour immunotherapy via tailor-designed ZnFe2O4-based nanosystem","volume":"3","author":"Yang","year":"2023","journal-title":"Exploration (Beijing)"},{"key":"10.1016\/j.mtbio.2026.103086_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112816","article-title":"Evaluation of the adjuvant effect of imiquimod and CpG ODN 1826 in chimeric DNA vaccine against Japanese encephalitis","volume":"140","author":"Zang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mtbio.2026.103086_bib52","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s12951-021-01202-x","article-title":"Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer","volume":"19","author":"Chen","year":"2021","journal-title":"J. Nanobiotechnol."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426003297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426003297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:15:05Z","timestamp":1790064905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426003297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":52,"alternative-id":["S2590006426003297"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103086","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mannosylated graphene oxide nanotherapeutics co-delivering docetaxel and a STING agonist reprogram myeloid cells and potentiate antitumor immunity","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103086"}}