{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:05:59Z","timestamp":1790064359951,"version":"4.0.1"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025LZL006"],"award-info":[{"award-number":["ZR2025LZL006"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202408248"],"award-info":[{"award-number":["tsqn202408248"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mtbio.2026.103104","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:21:48Z","timestamp":1775755308000},"page":"103104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Precise delivery of medical gases by engineered nanomedicine for enhanced liver fibrosis therapy"],"prefix":"10.1016","volume":"38","author":[{"given":"Peiyuan","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenpu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengyi","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-1574","authenticated-orcid":false,"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103104_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.946832","article-title":"Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis","volume":"13","author":"Wen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2026.103104_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103104_bib3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.cgh.2024.08.020","article-title":"Global prevalence of advanced liver fibrosis and cirrhosis in the general population: a systematic review and meta-analysis","volume":"23","author":"Zamani","year":"2025","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103104_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41392-024-02072-z","article-title":"Liver diseases: epidemiology, causes, trends and predictions","volume":"10","author":"Gan","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.103104_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1535370215597194","article-title":"Epithelial-mesenchymal transition: an emerging target in tissue fibrosis","volume":"241","author":"Li","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103104_bib6","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3390\/nu14020352","article-title":"Gut microbiome and organ fibrosis","volume":"14","author":"Costa","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.mtbio.2026.103104_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24044004","article-title":"Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation","volume":"24","author":"Antar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41423-025-01313-7","article-title":"Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells","volume":"22","author":"Kostallari","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.mtbio.2026.103104_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s44324-025-00063-4","article-title":"ECM formation and degradation during fibrosis, repair, and regeneration","volume":"3","author":"Mayorca-Guiliani","year":"2025","journal-title":"Npj Metab Health Dis"},{"key":"10.1016\/j.mtbio.2026.103104_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147873","article-title":"Liver fibrosis: from basic science towards clinical progress, focusing on the central role of hepatic stellate cells","volume":"25","author":"Akk\u0131z","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib11","first-page":"41","article-title":"Extracellular matrix remodeling in chronic liver disease, curr. Tissue microenviron","volume":"2","author":"Ortiz","year":"2021","journal-title":"Rep"},{"key":"10.1016\/j.mtbio.2026.103104_bib12","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jceh.2022.04.021","article-title":"Overview of complications in cirrhosis","volume":"12","author":"Premkumar","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103104_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ph18091321","article-title":"Present and future perspectives in the treatment of liver fibrosis","volume":"18","author":"Cerrito","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.mtbio.2026.103104_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ph17121724","article-title":"Pharmacotherapy of liver fibrosis and hepatitis: recent advances","volume":"17","author":"Zhao","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.mtbio.2026.103104_bib15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12985-024-02589-3","article-title":"Mechanisms underlying the compromised clinical efficacy of interferon in clearing HBV","volume":"21","author":"Lei","year":"2024","journal-title":"Virol. J."},{"key":"10.1016\/j.mtbio.2026.103104_bib16","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S1473-3099(20)30692-7","article-title":"Once-daily tenofovir disoproxil fumarate in treatment-naive Taiwanese patients with chronic hepatitis B and minimally raised alanine aminotransferase (TORCH-B): a multicentre, double-blind, placebo-controlled, parallel-group, randomised trial","volume":"21","author":"Hsu","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.mtbio.2026.103104_bib17","article-title":"Evaluation of the clinical and economic value of sofosbuvir\/velpatasvir (SOF\/VEL) in patients with chronic hepatitis C in Spain during the last 5 years, gastroent","volume":"47","author":"Esteban","year":"2024","journal-title":"Hepat-Barc."},{"key":"10.1016\/j.mtbio.2026.103104_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12876-024-03200-3","article-title":"Successful therapy with tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) does not guarantee amelioration of liver damage assessing by transient elastography. A retrospective - prospective multicenter study","volume":"24","author":"Kranidioti","year":"2024","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.mtbio.2026.103104_bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5114\/ceh.2024.141699","article-title":"Treatment of HCV infection in patients with steatotic liver disease","volume":"10","author":"Flisiak","year":"2024","journal-title":"Clin. Exp. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103104_bib20","article-title":"Advances in the management of alcohol-associated liver disease","volume":"12","author":"Anouti","year":"2024","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"10.1016\/j.mtbio.2026.103104_bib21","first-page":"523","article-title":"Rifaximin-\u03b1 for liver fibrosis in patients with alcohol-related liver disease (GALA-RIF): a randomised, double-blind, placebo-controlled, phase 2 trial, Lancet Gastroenterol","volume":"8","author":"Israelsen","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.mtbio.2026.103104_bib22","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jceh.2022.02.001","article-title":"Current medical treatment for alcohol-associated liver disease","volume":"12","author":"Ayares","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103104_bib23","article-title":"Resmetirom: the first disease-specific treatment for MASH","volume":"2025","author":"Mousa","year":"2025","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.mtbio.2026.103104_bib24","article-title":"SGLT-2 inhibitors as novel treatments of multiple organ fibrosis","volume":"10","author":"Hu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.mtbio.2026.103104_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics18010086","article-title":"The effect of GLP-1 agonists on patients with metabolic-associated steatotic liver disease: a systematic review and meta-analysis","volume":"18","author":"Tornea","year":"2026","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2026.103104_bib26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jhep.2020.02.027","article-title":"STELLAR-3, STELLAR-4 investigators, Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: results from randomized phase III STELLAR trials","volume":"73","author":"Harrison","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103104_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111556","article-title":"The liver fibrosis niche: novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix","volume":"143","author":"Matsuda","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.mtbio.2026.103104_bib28","doi-asserted-by":"crossref","DOI":"10.1172\/JCI186421","article-title":"Dissecting the mechanisms of MASLD fibrosis in the era of single-cell and spatial omics","volume":"135","author":"Colella","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.mtbio.2026.103104_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202301349","article-title":"Gas therapy: generating, delivery, and biomedical applications","volume":"8","author":"Ghaffari-Bohlouli","year":"2024","journal-title":"Small Methods"},{"key":"10.1016\/j.mtbio.2026.103104_bib30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4103\/mgr.MEDGASRES-D-24-00115","article-title":"Nanobubbles: a bridge connecting nanomedicine and gas medicine","volume":"15","author":"Xiao","year":"2025","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.mtbio.2026.103104_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/smll.70298","article-title":"Synergistic effect of prolonged oxygenation and reactive oxygen species scavenging on diabetic wound healing using an injectable thermoresponsive hydrogel","volume":"21","author":"Lee","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.103104_bib32","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jconrel.2022.08.055","article-title":"Controlled therapeutic delivery of CO from carbon monoxide-releasing molecules (CORMs)","volume":"350","author":"Choi","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103104_bib33","article-title":"A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: mechanisms and perspectives","volume":"41","author":"Y\u0131ld\u0131z","year":"2025","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.mtbio.2026.103104_bib34","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2026.103104_bib35","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.tips.2015.05.001","article-title":"Nitric oxide in liver diseases","volume":"36","author":"Iwakiri","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib36","series-title":"Liver Pathophysiology: Therapies and Antioxidants","first-page":"791","article-title":"Nitric oxide and the liver","author":"Oughran","year":"2017"},{"key":"10.1016\/j.mtbio.2026.103104_bib37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jare.2020.05.010","article-title":"Implications of hydrogen sulfide in liver pathophysiology: mechanistic insights and therapeutic potential","volume":"27","author":"Sun","year":"2021","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.mtbio.2026.103104_bib38","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1089\/ars.2021.0213","article-title":"Sulfur dioxide: endogenous generation, biological effects, detection, and therapeutic potential","volume":"36","author":"Huang","year":"2022","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mtbio.2026.103104_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102378","article-title":"Nano-enabled strategies for greenhouse gases emission mitigation: a comprehensive review","volume":"57","author":"Sun","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.mtbio.2026.103104_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.216746","article-title":"Integrative gas-based therapeutics for cancer treatment: recent advances and multi-therapy innovations","volume":"539","author":"Zhang","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.mtbio.2026.103104_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/VIW.20200185","article-title":"Novel gas-based nanomedicines for cancer therapy","volume":"3","author":"Yao","year":"2022","journal-title":"View"},{"key":"10.1016\/j.mtbio.2026.103104_bib42","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.7150\/thno.98884","article-title":"Nanotechnology based gas delivery system: a \u201cgreen\u201d strategy for cancer diagnosis and treatment","volume":"14","author":"Chen","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103104_bib43","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1039\/C3TB21259A","article-title":"A platform for nitric oxide delivery","volume":"2","author":"Kim","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2026.103104_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abl4135","article-title":"Delivery of therapeutic carbon monoxide by gas-entrapping materials","volume":"14","author":"Byrne","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mtbio.2026.103104_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126905","article-title":"Nanomaterial-mediated sustainable hydrogen supply induces lateral root formation via nitrate reductase-dependent nitric oxide","volume":"405","author":"Wang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2026.103104_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303259","article-title":"Nitric oxide: physiological functions, delivery, and biomedical applications","volume":"10","author":"Andrabi","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib47","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.1016\/j.bmcl.2013.08.066","article-title":"Nitroreductase-activated nitric oxide (NO) prodrugs","volume":"23","author":"Sharma","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.mtbio.2026.103104_bib48","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.1021\/acsnano.3c02303","article-title":"Advanced nitric oxide generating nanomedicine for therapeutic applications","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103104_bib49","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ijpharm.2019.05.043","article-title":"Rapid and continuous accumulation of nitric oxide-releasing liposomes in tumors to augment the enhanced permeability and retention (EPR) effect","volume":"565","author":"Yoshikawa","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2026.103104_bib50","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s12274-019-2307-x","article-title":"Stimuli-responsive nitric oxide generator for light-triggered synergistic cancer photothermal\/gas therapy","volume":"12","author":"Huang","year":"2019","journal-title":"Nano Res."},{"key":"10.1016\/j.mtbio.2026.103104_bib51","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1039\/D0NR07484E","article-title":"Advanced nitric oxide donors: chemical structure of NO drugs, NO nanomedicines and biomedical applications","volume":"13","author":"Yang","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.mtbio.2026.103104_bib52","doi-asserted-by":"crossref","DOI":"10.1039\/D5BM01825K","article-title":"Engineering delivery platforms for controlled nitric oxide release","author":"Choi","year":"2026","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib53","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.mie.2014.11.014","article-title":"GYY4137, a novel water-soluble, H2S-releasing molecule","volume":"554","author":"Rose","year":"2015","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mtbio.2026.103104_bib54","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.chembiol.2018.01.011","article-title":"N-acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and sulfane sulfur production","volume":"25","author":"Ezeri\u0146a","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.mtbio.2026.103104_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101984","article-title":"Hydrogen sulfide: an emerging precision strategy for gas therapy","volume":"11","author":"Ding","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103104_bib56","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1021\/acsnano.6b06815","article-title":"Magnetic nanoliposomes as in situ microbubble bombers for multimodality image-guided cancer theranostics","volume":"11","author":"Liu","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103104_bib57","article-title":"Engineering a hydrogen\u2010sulfide\u2010based nanomodulator to normalize hyperactive photothermal immunogenicity for combination cancer therapy","volume":"33","author":"Li","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103104_bib58","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1039\/D1BM00941A","article-title":"Vitamin E-facilitated carbon monoxide pro-drug nanomedicine for efficient light-responsive combination cancer therapy","volume":"9","author":"Opoku-Damoah","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib59","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1039\/D2TB02599J","article-title":"Carbon monoxide therapy: a promising strategy for cancer","volume":"11","author":"Chai","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2026.103104_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2026.113235","article-title":"Cytotoxicity of metal-containing carbon monoxide-releasing molecules: a current assessment","volume":"277","author":"Kubeil","year":"2026","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.mtbio.2026.103104_bib61","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.1039\/D4DT00087K","article-title":"Metal-based carbon monoxide releasing molecules with promising cytotoxic properties","volume":"53","author":"Mansour","year":"2024","journal-title":"Dalton Trans."},{"key":"10.1016\/j.mtbio.2026.103104_bib62","first-page":"30","article-title":"Recent advances in carbon monoxide-releasing nanomaterials","volume":"37","author":"Ning","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103104_bib63","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.1021\/acsabm.4c01165","article-title":"Ultrasound-Responsive lipid nanoplatform with nitric oxide and carbon monoxide release for cancer sono-gaso-therapy","volume":"7","author":"Opoku-Damoah","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.mtbio.2026.103104_bib64","article-title":"Elucidating the molecular pathways and therapeutic interventions of gaseous mediators in the context of fibrosis","volume":"13","author":"Li","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.mtbio.2026.103104_bib65","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3206982","article-title":"Gasotransmitters: potential therapeutic molecules of fibrotic diseases","volume":"2021","author":"Chen","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mtbio.2026.103104_bib68","article-title":"Medical gas therapy for tissue, organ, and CNS protection: a systematic review of effects, mechanisms, and challenges","volume":"9","author":"Zafonte","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib69","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4103\/mgr.MEDGASRES-D-23-00041","article-title":"Medical implications of gas producing probiotics: anti-inflammation and immunity enhancement for ameliorating disease severity","volume":"14","author":"Porwal","year":"2024","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.mtbio.2026.103104_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115230","article-title":"Carbon monoxide and its role in human physiology: a brief historical perspective","volume":"204","author":"Kashfi","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103104_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176843","article-title":"Carbon monoxide attenuates cellular senescence-mediated pulmonary fibrosis via modulating p53\/PAI-1 pathway","volume":"980","author":"Wang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103104_bib72","series-title":"Comprehensive Guide to Hepatitis Advances","first-page":"311","article-title":"Metabolic-associated fatty liver disease: epidemiology, natural history and diagnosis, current paradigm and definitions for MAFLD","author":"Armandi","year":"2023"},{"key":"10.1016\/j.mtbio.2026.103104_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1291501","article-title":"Metabolic-associated fatty liver disease: a selective review of pathogenesis, diagnostic approaches, and therapeutic strategies","volume":"11","author":"Habibullah","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.mtbio.2026.103104_bib74","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.actbio.2023.08.009","article-title":"Exploring the therapeutic potential of a nano micelle containing a carbon monoxide-releasing molecule for metabolic-associated fatty liver disease by modulating hypoxia-inducible factor-1\u03b1","volume":"169","author":"Cui","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103104_bib75","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbrc.2019.03.017","article-title":"Carbon monoxide induces the assembly of stress granule through the integrated stress response","volume":"512","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mtbio.2026.103104_bib76","first-page":"484","article-title":"CO-Induced TTP activation alleviates cellular senescence and age-dependent hepatic steatosis via downregulation of PAI-1","volume":"14","author":"Park","year":"2023","journal-title":"Aging Dis"},{"key":"10.1016\/j.mtbio.2026.103104_bib77","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41467-020-14413-x","article-title":"Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS","volume":"11","author":"Wan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103104_bib78","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.clinre.2019.03.008","article-title":"Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial","volume":"43","author":"Korovljev","year":"2019","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.mtbio.2026.103104_bib79","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/807635","article-title":"Hydrogen gas presents a promising therapeutic strategy for sepsis","volume":"2014","author":"Xie","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.mtbio.2026.103104_bib80","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.7150\/thno.80494","article-title":"A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases","volume":"13","author":"Tao","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103104_bib81","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3892\/mmr.2017.6120","article-title":"Hydrogen-rich saline improves non-alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPAR\u03b1 and PPAR\u03b3","volume":"15","author":"Zhai","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mtbio.2026.103104_bib82","doi-asserted-by":"crossref","first-page":"G450","DOI":"10.1152\/ajpgi.00158.2020","article-title":"Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling","volume":"320","author":"Li","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mtbio.2026.103104_bib83","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/smll.201402870","article-title":"The use of nanoparticles to deliver nitric oxide to hepatic stellate cells for treating liver fibrosis and portal hypertension","volume":"11","author":"Duong","year":"2015","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.103104_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105739","article-title":"Hepatic stellate cells role in the course of metabolic disorders development - a molecular overview","volume":"170","author":"Bourebaba","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mtbio.2026.103104_bib85","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/cas.13945","article-title":"Nitric oxide inhibits autophagy and promotes apoptosis in hepatocellular carcinoma","volume":"110","author":"Zhang","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib86","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1111\/liv.13476","article-title":"Role and regulation of autophagy and apoptosis by nitric oxide in hepatic stellate cells during acute liver failure","volume":"37","author":"Jin","year":"2017","journal-title":"Liver Int."},{"key":"10.1016\/j.mtbio.2026.103104_bib87","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s12274-020-2833-6","article-title":"Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis","volume":"13","author":"Liang","year":"2020","journal-title":"Nano Res."},{"key":"10.1016\/j.mtbio.2026.103104_bib88","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jconrel.2025.01.036","article-title":"Targeted delivery of polymeric NO-donor micelles to hepatic stellate cells for restoration of liver function and inhibition of hepatic fibrosis","volume":"379","author":"Yang","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103104_bib89","article-title":"Role of hydrogen sulfide in the treatment of fibrosis","volume":"13","author":"Chirindoth","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.mtbio.2026.103104_bib90","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.niox.2014.02.006","article-title":"Hydrogen sulfide and the liver","volume":"41","author":"Mani","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.mtbio.2026.103104_bib91","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/FJC.0b013e3181ac8e12","article-title":"S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia\/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway","volume":"54","author":"Wang","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103104_bib92","first-page":"1337","article-title":"S-allyl-cysteine attenuates carbon tetrachloride-induced liver fibrosis in rats by targeting STAT3\/SMAD3 pathway","volume":"10","author":"Gong","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.mtbio.2026.103104_bib93","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/jat.3734","article-title":"Hydrogen sulfide attenuates paraquat-induced epithelial-mesenchymal transition of human alveolar epithelial cells through regulating transforming growth factor-\u03b21\/Smad2\/3 signaling pathway","volume":"39","author":"Bai","year":"2019","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.mtbio.2026.103104_bib94","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.bbapap.2014.01.002","article-title":"H2S and its role in redox signaling","volume":"1844","author":"Kabil","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mtbio.2026.103104_bib95","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.3760\/cma.j.issn.0366-6999.20133031","article-title":"Advances in the study on endogenous sulfur dioxide in the cardiovascular system","volume":"127","author":"Tian","year":"2014","journal-title":"Chin. Med. J. (Taipei)"},{"key":"10.1016\/j.mtbio.2026.103104_bib96","first-page":"1289","article-title":"Potential therapeutic effect of SO2 on fibrosis","volume":"34","author":"Wang","year":"2019","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.mtbio.2026.103104_bib97","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0168-8278(02)00429-4","article-title":"Liver fibrosis \u2013 from bench to bedside","volume":"38","author":"Friedman","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103104_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.137557","article-title":"Sulfur dioxide-releasing nanomotors improve the therapeutic effect of liver fibrosis by restoring the fenestrae of sinusoids","volume":"692","author":"Chen","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2026.103104_bib99","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3390\/metabo12070609","article-title":"The role of ferritin in health and disease: recent advances and understandings","volume":"12","author":"Kotla","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.mtbio.2026.103104_bib100","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s12276-022-00859-0","article-title":"Ferritin - a multifaceted protein scaffold for biotherapeutics","volume":"54","author":"Lee","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mtbio.2026.103104_bib101","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202410748","article-title":"Enhanced ferritin-manganese interaction by nanoplatinum growth enabling liver fibrosis 3D magnetic resonance visualization and synergistic therapy with real-time monitoring","volume":"34","author":"Cui","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2026.103104_bib102","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1912746","article-title":"Methane medicine: a rising star gas with powerful Anti-Inflammation, antioxidant, and antiapoptosis properties","volume":"2018","author":"Jia","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mtbio.2026.103104_bib103","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40635-019-0278-6","article-title":"Methane and inflammation - a review (fight fire with fire)","volume":"7","author":"Poles","year":"2019","journal-title":"Intensive Care Med. Exp."},{"key":"10.1016\/j.mtbio.2026.103104_bib104","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6565283","article-title":"Methane-Rich saline counteracts cholestasis-induced liver damage via regulating the TLR4\/NF-\u03baB\/NLRP3 inflammasome pathway","volume":"2019","author":"Li","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mtbio.2026.103104_bib105","doi-asserted-by":"crossref","DOI":"10.1097\/SHK.0000000000001310","article-title":"Methane-Rich saline protects against sepsis-induced liver damage by regulating the PPAR-\u03b3\/NF-\u03baB signaling pathway","volume":"52","author":"Li","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.mtbio.2026.103104_bib106","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10735-017-9728-1","article-title":"Methane alleviates carbon tetrachloride induced liver injury in mice: anti-inflammatory action demonstrated by increased PI3K\/Akt\/GSK-3\u03b2-mediated IL-10 expression","volume":"48","author":"Yao","year":"2017","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.mtbio.2026.103104_bib107","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7067619","article-title":"Methane alleviates acetaminophen-induced liver injury by inhibiting inflammation, oxidative stress, endoplasmic reticulum stress, and apoptosis through the Nrf2\/HO-1\/NQO1 signaling pathway","volume":"2019","author":"Feng","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mtbio.2026.103104_bib108","doi-asserted-by":"crossref","DOI":"10.1007\/s40843-025-3679-8","article-title":"Inhalable acid-responsive methane nanocapsule for remodeling fibrogenic microenvironment to alleviate idiopathic pulmonary fibrosis","author":"Jin","year":"2026","journal-title":"Sci. China Mater."},{"key":"10.1016\/j.mtbio.2026.103104_bib109","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado1648","article-title":"Hyperammonemia induces programmed liver cell death","volume":"11","author":"Kerbert","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.103104_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jceh.2024.101361","article-title":"The story of ammonia in liver disease: an unraveling continuum","volume":"14","author":"Anand","year":"2024","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103104_bib111","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/hep.30890","article-title":"Ammonia scavenging prevents progression of fibrosis in experimental nonalcoholic Fatty liver disease","volume":"71","author":"De Chiara","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.mtbio.2026.103104_bib112","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404553","article-title":"Gasotransmitters in modern medicine: promises and challenges in the use of porous crystalline carriers","volume":"14","author":"Pinto","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103104_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123492","article-title":"Micro-\/nanomotors as platforms for gas therapy","volume":"324","author":"Sun","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103104_bib114","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.3390\/polym14122416","article-title":"Photo-Responsive micelles with controllable and Co-Release of carbon monoxide, formaldehyde and doxorubicin","volume":"14","author":"Zheng","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.mtbio.2026.103104_bib115","doi-asserted-by":"crossref","first-page":"35029","DOI":"10.1021\/jacs.4c13872","article-title":"Visible light triggerable CO releasing micelles","volume":"146","author":"Hanson","year":"2024","journal-title":"J. Am. Chem. Soc."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426003479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426003479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:42:59Z","timestamp":1790062979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426003479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":113,"alternative-id":["S2590006426003479"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103104","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Precise delivery of medical gases by engineered nanomedicine for enhanced liver fibrosis therapy","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103104"}}