{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:02:30Z","timestamp":1790067750187,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270113"],"award-info":[{"award-number":["82270113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2522033"],"award-info":[{"award-number":["T2522033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mtbio.2026.103116","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:51:47Z","timestamp":1776671507000},"page":"103116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Nanocarriers engineering for efficient NSUN2 silencing and immune responsive therapy in metastatic colorectal cancer"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-6130","authenticated-orcid":false,"given":"Kamran","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuchen","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9517-1325","authenticated-orcid":false,"given":"Longguang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s44197-025-00348-3","article-title":"Assessing the colorectal cancer landscape: a comprehensive exploration of future trends in 216 countries and territories from 2021 to 2040","volume":"15","author":"Olfatifar","year":"2025","journal-title":"J. Epidemiol.Glob. Health"},{"key":"10.1016\/j.mtbio.2026.103116_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2147\/CLEP.S388323","article-title":"Temporal trends in the disease burden of colorectal cancer with its risk factors at the global and national level from 1990 to 2019, and projections until 2044","volume":"15","author":"Liu","year":"2023","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.mtbio.2026.103116_bib3","first-page":"640","volume":"8","author":"Lu","year":"2025"},{"issue":"6","key":"10.1016\/j.mtbio.2026.103116_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065588","article-title":"From biology to diagnosis and treatment: the ariadne's thread in cancer of unknown primary","volume":"24","author":"Mathew","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103116_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2217\/pme-2021-0128","article-title":"Microsatellite instability testing in colorectal patients with Lynch syndrome: lessons learned from a case report and how to avoid such pitfalls","volume":"19","author":"Adeleke","year":"2022","journal-title":"Per Med"},{"issue":"4","key":"10.1016\/j.mtbio.2026.103116_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24303","article-title":"Role of m(5) C RNA methylation regulators in colorectal cancer prognosis and immune microenvironment","volume":"36","author":"Fang","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib7","article-title":"m5C regulator-mediated methylation modification phenotypes characterized by distinct tumor microenvironment immune heterogenicity in colorectal cancer","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103116_bib8","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41419-021-04127-3","article-title":"NSUN2 modified by SUMO-2\/3 promotes gastric cancer progression and regulates mRNA m5C methylation","volume":"12","author":"Hu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103116_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1028","article-title":"Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression","volume":"12","author":"Zhu","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.mtbio.2026.103116_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115023","article-title":"Hypoxia-induced NSUN2 promotes the progression of colon cancer by modulating the discrepant cleavage of tRNA-Arg","volume":"161","author":"Luan","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"39","key":"10.1016\/j.mtbio.2026.103116_bib11","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.1038\/s41388-021-01978-0","article-title":"NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization","volume":"40","author":"Su","year":"2021","journal-title":"Oncogene"},{"issue":"13","key":"10.1016\/j.mtbio.2026.103116_bib12","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.10612","article-title":"Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer","volume":"8","author":"Yi","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s11658-025-00781-z","article-title":"NSUN2-tRNA(Val-CAC)-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression","volume":"30","author":"Wang","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103116_bib14","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1111\/cas.14190","article-title":"NOP 2\/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL 6 in gallbladder carcinoma","volume":"110","author":"Gao","year":"2019","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41420-023-01521-y","article-title":"NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discov."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103116_bib16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1089\/nat.2022.0004","article-title":"Delivery of RNA therapeutics: the great endosomal escape","volume":"32","author":"Dowdy","year":"2022","journal-title":"Nucleic Acid Ther"},{"key":"10.1016\/j.mtbio.2026.103116_bib17","first-page":"951","volume":"8","author":"Ye","year":"2025"},{"issue":"31","key":"10.1016\/j.mtbio.2026.103116_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202404608","article-title":"Beyond lipids: exploring advances in polymeric gene delivery in the lipid nanoparticles era","volume":"36","author":"Jogdeo","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103116_bib19","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.2147\/IJN.S466490","article-title":"Research advances of lipid nanoparticles in the treatment of colorectal cancer","author":"Zhang","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2026.103116_bib20","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jcis.2025.02.012","article-title":"An albumin-prodrug injectable formulation for synergistic cancer immunotherapy","volume":"686","author":"Li","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2026.103116_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126593","article-title":"In vitro and in vivo evaluation of immune response of poly (lactic acid) nanoparticles with different end groups","volume":"253","author":"Gao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"16","key":"10.1016\/j.mtbio.2026.103116_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202409021","article-title":"Advances in polymer\u2010based self\u2010adjuvanted nanovaccines","volume":"21","author":"Ling","year":"2025","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s40644-025-00903-y","article-title":"Fluorescence imaging of MALAT1 expression using a Cy5. 5-labeled antisense oligonucleotide in lung cancer and epidermal carcinoma cells","volume":"25","author":"Liu","year":"2025","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.mtbio.2026.103116_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123350","article-title":"Improved immunocompatibility of active targeting liposomes by attenuating nucleophilic attack of cyclic RGD peptides on complement 3","author":"Meng","year":"2025","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11051-025-06545-2","article-title":"In-silico design, characterization, and liposome anchoring simulation of amphiphilic RGD peptides for enhanced nanoparticle functionalization in integrin-targeted drug delivery","volume":"28","author":"Maikifi","year":"2026","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.mtbio.2026.103116_bib26","series-title":"Mechanisms, Techniques, and Models","first-page":"3","article-title":"Uncharted waters: zebrafish cancer models navigate a course for oncogene discovery, cancer and zebrafish","author":"Ceol","year":"2016"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103116_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"Fearon","year":"2012","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103116_bib28","first-page":"319","article-title":"Body condition scoring: a rapid and accurate method for assessing health status in mice","volume":"49","author":"Ullman-Culler\u00e9","year":"1999","journal-title":"Comp. Med."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103116_bib29","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/jcsm.13478","article-title":"Body weight and composition endpoints in cancer cachexia clinical trials: systematic review 4 of the cachexia endpoints series","volume":"15","author":"Brown","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"10","key":"10.1016\/j.mtbio.2026.103116_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101174","article-title":"Global colorectal cancer burden in 2020 and projections to 2040","volume":"14","author":"Xi","year":"2021","journal-title":"Transl. Oncol."},{"issue":"7","key":"10.1016\/j.mtbio.2026.103116_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1001\/jama.2021.0106","article-title":"Diagnosis and treatment of metastatic colorectal cancer: a review","volume":"325","author":"Biller","year":"2021","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.mtbio.2026.103116_bib32","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.3748\/wjg.v29.i10.1569","article-title":"Systemic treatment for metastatic colorectal cancer","volume":"29","author":"Leowattana","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40880-019-0368-6","article-title":"Current cancer situation in China: good or bad news from the 2018 global cancer statistics?","volume":"39","author":"Feng","year":"2019","journal-title":"Cancer Commun."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103116_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12091534","article-title":"Surgery for T4 colorectal cancer in older patients: determinants of outcomes","volume":"12","author":"Osseis","year":"2022","journal-title":"J Pers Med"},{"issue":"8","key":"10.1016\/j.mtbio.2026.103116_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13082038","article-title":"Agnostic biomarkers and molecular signatures in colorectal cancer-guiding chemotherapy and predicting response","volume":"13","author":"Kyrochristou","year":"2025","journal-title":"Biomedicines"},{"issue":"16","key":"10.1016\/j.mtbio.2026.103116_bib36","doi-asserted-by":"crossref","first-page":"8404","DOI":"10.7150\/thno.112332","article-title":"Epitranscriptomic mechanisms and implications of RNA m5C modification in cancer","volume":"15","author":"Mao","year":"2025","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib37","article-title":"The dynamic RNA modification 5\u2010methylcytosine and its emerging role as an epitranscriptomic mark","volume":"10","author":"Trixl","year":"2019","journal-title":"Wiley Interdiscip. Rev.: RNA"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib38","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1186\/s12967-025-06985-3","article-title":"m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"20","key":"10.1016\/j.mtbio.2026.103116_bib39","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1093\/nar\/gkl765","article-title":"Identification of human tRNA: m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the","volume":"34","author":"Brzezicha","year":"2006","journal-title":"Nucleic acids research"},{"key":"10.1016\/j.mtbio.2026.103116_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115023","article-title":"Hypoxia-induced NSUN2 promotes the progression of colon cancer by modulating the discrepant cleavage of tRNA-Arg","volume":"161","author":"Luan","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1039\/D3CS00194F","article-title":"Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity","volume":"53","author":"Zhang","year":"2024","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib42","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s11658-025-00787-7","article-title":"The emerging role of human transmembrane RGD-based counter-receptors of integrins in health and disease","volume":"30","author":"Caba\u00f1as","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.mtbio.2026.103116_bib43","article-title":"Roles and mechanisms of NSUN2-mediated RNA m5C modification in cancer progression and immune modulation","volume":"16","author":"Li","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103116_bib44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s11671-025-04379-4","article-title":"Curcumin-based biocompatible nanocarriers: a contemporary perspective in functional foods and biomedical applications","volume":"20","author":"Alshammari","year":"2025","journal-title":"Discover Nano"},{"key":"10.1016\/j.mtbio.2026.103116_bib45","first-page":"1","article-title":"Next-generation materials for nucleic acid delivery","author":"van der Meel","year":"2025","journal-title":"Nat. Rev. Mater."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103116_bib46","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41573-024-00977-6","article-title":"The 60-year evolution of lipid nanoparticles for nucleic acid delivery","volume":"23","author":"Cullis","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103116_bib47","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1080\/17425247.2024.2400293","article-title":"Biodegradable nanoplatforms for antigen delivery: part I\u2013state of the art review of polymeric nanoparticles for cancer immunotherapy","volume":"21","author":"Vega","year":"2024","journal-title":"Expet Opin. Drug Deliv."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426003601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426003601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:17:00Z","timestamp":1790065020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426003601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":47,"alternative-id":["S2590006426003601"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103116","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanocarriers engineering for efficient NSUN2 silencing and immune responsive therapy in metastatic colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103116"}}