{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:10:05Z","timestamp":1792426205867,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006711","name":"Changzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mtbio.2026.103160","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:45:27Z","timestamp":1777272327000},"page":"103160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Biomimetic double-layered electrospun nanofibrous scaffold with mussel adhesive protein coating and TGF-\u03b23 encapsulation for enhanced tendon-bone healing in rotator cuff tears"],"prefix":"10.1016","volume":"38","author":[{"given":"Sheng","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dachuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofan","family":"zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-9953","authenticated-orcid":false,"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4701-7769","authenticated-orcid":false,"given":"Song","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103160_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-024-00492-3","article-title":"Rotator cuff tears","volume":"10","author":"Bedi","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.mtbio.2026.103160_bib2","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.arthro.2024.06.040","article-title":"Fatty infiltration, tear size, and retraction size are significant risk factors for retear after arthroscopic rotator cuff repair: a systematic review","volume":"41","author":"Darbandi","year":"2025","journal-title":"Arthroscopy"},{"key":"10.1016\/j.mtbio.2026.103160_bib3","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.RVW.19.00039","article-title":"Rotator cuff retears","volume":"8","author":"Rossi","year":"2020","journal-title":"JBJS Rev."},{"key":"10.1016\/j.mtbio.2026.103160_bib4","article-title":"Tissue mimetic membranes for healing augmentation of tendon-bone interface in rotator cuff repair","volume":"37","author":"Zhu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103160_bib5","article-title":"Strategies for promoting tendon-bone healing: current status and prospects","volume":"11","author":"Yang","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2026.103160_bib6","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/jor.23810","article-title":"Integrating soft and hard tissues via interface tissue engineering","volume":"36","author":"Patel","year":"2018","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.mtbio.2026.103160_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1089\/ten.teb.2023.0295","article-title":"The structure, biology, and mechanical function of tendon\/ligament-bone interfaces","volume":"30","author":"Wang","year":"2024","journal-title":"Tissue Eng., Part B"},{"key":"10.1016\/j.mtbio.2026.103160_bib8","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nmat4863","article-title":"The microstructure and micromechanics of the tendon-bone insertion","volume":"16","author":"Rossetti","year":"2017","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2026.103160_bib9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nmat4906","article-title":"The tendon-to-bone attachment: unification through disarray","volume":"16","author":"Genin","year":"2017","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2026.103160_bib10","doi-asserted-by":"crossref","DOI":"10.1177\/20417314221144714","article-title":"Advanced strategies for constructing interfacial tissues of bone and tendon\/ligament","volume":"13","author":"Luo","year":"2022","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.mtbio.2026.103160_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ado6948","article-title":"A bioinspired mineralized collagen scaffold promotes enthesis healing and activates Gli1 expression in preclinical models","volume":"17","author":"Zhang","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mtbio.2026.103160_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2023.110726","article-title":"Microenvironment responsive hypoxia-mimetic DFO composite hydrogel for on-demand neovascularization to promote tendon-to-bone healing","volume":"259","author":"Xu","year":"2023","journal-title":"Compos. B Eng."},{"key":"10.1016\/j.mtbio.2026.103160_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120789","article-title":"Engineering multi-tissue units for regenerative medicine: Bone-tendon-muscle units of the rotator cuff","volume":"272","author":"Wang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103160_bib14","first-page":"2491","article-title":"Biomimetic strategies for tendon\/ligament-to-bone interface regeneration","volume":"6","author":"Lei","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103160_bib15","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/s41467-025-57499-x","article-title":"Janus hydrogel microrobots with bioactive ions for the regeneration of tendon-bone interface","volume":"16","author":"Ding","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103160_bib16","first-page":"207","article-title":"Engineering a stem cell-embedded bilayer hydrogel with biomimetic collagen mineralization for tendon-bone interface healing","volume":"49","author":"Lei","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103160_bib17","article-title":"Inflammation-responsive functional core-shell micro-hydrogels promote rotator cuff tendon-to-bone healing by recruiting MSCs and immuno-modulating nacrophages in rats","volume":"14","author":"Chen","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103160_bib18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1177\/03635465241310530","article-title":"An aligned-to-random PLGA\/Col1-PLGA\/nHA bilayer electrospun nanofiber membrane enhances tendon-to-bone healing in a murine model","volume":"53","author":"Xu","year":"2025","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.mtbio.2026.103160_bib19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jare.2024.01.020","article-title":"Advances focusing on the application of decellularization methods in tendon-bone healing","volume":"67","author":"Zhong","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.mtbio.2026.103160_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1394714","article-title":"Application of decellularized tissue for soft-hard interregional regeneration","volume":"13","author":"Suzuki","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2026.103160_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.eng.2024.01.031","article-title":"Minimally invasive implantable biomaterials for bone reconstruction","volume":"46","author":"Han","year":"2025","journal-title":"Engineering"},{"key":"10.1016\/j.mtbio.2026.103160_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202401009","article-title":"An encapsulation-free and hierarchical porous triboelectric scaffold with dynamic hydrophilicity for efficient cartilage regeneration","volume":"36","author":"Luo","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103160_bib23","doi-asserted-by":"crossref","first-page":"26077","DOI":"10.1039\/D4RA04043K","article-title":"Electrospinning technology: a promising approach for tendon-bone interface tissue engineering","volume":"14","author":"Liang","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.mtbio.2026.103160_bib24","first-page":"104","article-title":"Three-dimensional biofabrication of nanosecond laser micromachined nanofibre meshes for tissue engineered scaffolds","volume":"4","author":"McWilliam","year":"2023","journal-title":"Biomater Transl"},{"key":"10.1016\/j.mtbio.2026.103160_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.645544","article-title":"Tissue engineering for the insertions of tendons and lgaments: an overview of electrospun biomaterials and structures","volume":"9","author":"Sensini","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2026.103160_bib26","first-page":"54","article-title":"Biomaterial-based scaffolds in promotion of cartilage regeneration: recent advances and emerging applications","volume":"41","author":"Liang","year":"2023","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.mtbio.2026.103160_bib27","first-page":"18","article-title":"Biomimicking design of artificial periosteum for promoting bone healing","volume":"36","author":"Yang","year":"2022","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.mtbio.2026.103160_bib28","first-page":"272","article-title":"Preclinical evaluation of acute systemic toxicity of magnesium incorporated poly(lactic-co-glycolic acid) porous scaffolds by three-dimensional printing","volume":"2","author":"Long","year":"2021","journal-title":"Biomater Transl"},{"key":"10.1016\/j.mtbio.2026.103160_bib29","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1021\/acs.chemrev.2c00621","article-title":"Protein-based biological materials: molecular design and artificial production","volume":"123","author":"Miserez","year":"2023","journal-title":"Chem Rev"},{"key":"10.1016\/j.mtbio.2026.103160_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb7620","article-title":"Structure and sequence features of mussel adhesive protein lead to its salt-tolerant adhesion ability","volume":"6","author":"Ou","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.103160_bib31","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/acsbiomaterials.4c01378","article-title":"Advances in mussel adhesion proteins and mussel-inspired material electrospun nanofibers for their application in wound repair","volume":"10","author":"Dai","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.mtbio.2026.103160_bib32","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1021\/acs.biomac.5c02120","article-title":"A modular bioadhesive incorporating mussel adhesive protein and EGF for robust growth factor immobilization and enhanced wound healing","volume":"27","author":"Zhu","year":"2026","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.mtbio.2026.103160_bib33","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.2147\/IJN.S206313","article-title":"Effect of mussel adhesive protein coating on osteogenesis in vitro and osteointegration in vivo to alkali-treated titanium with nanonetwork structures","volume":"14","author":"Yin","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2026.103160_bib34","article-title":"Current biological strategies to enhance surgical treatment for rotator cuff repair","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2026.103160_bib35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s12951-024-02712-0","article-title":"Enhanced effects of slowly co-released TGF-\u03b23 and BMP-2 from biomimetic calcium phosphate-coated silk fibroin scaffolds in the repair of osteochondral defects","volume":"22","author":"Chen","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103160_bib36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41413-022-00239-4","article-title":"The role of TGF-beta3 in cartilage development and osteoarthritis","volume":"11","author":"Du","year":"2023","journal-title":"Bone Res."},{"key":"10.1016\/j.mtbio.2026.103160_bib37","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.3390\/pharmaceutics15041303","article-title":"Release of TGF-\u03b2(3) from surface-modified PCL fiber mats triggers a dose-dependent chondrogenic differentiation of human mesenchymal stromal cells","volume":"15","author":"Berten-Schunk","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2026.103160_bib38","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12951-023-01987-z","article-title":"Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering","volume":"21","author":"Chen","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103160_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2025.112260","article-title":"Silk fibroin electrospun scaffolds with sustained dual release of growth factors enhance acute liver failure treatment","volume":"296","author":"Liu","year":"2025","journal-title":"Compos. B Eng."},{"key":"10.1016\/j.mtbio.2026.103160_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139663","article-title":"Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: a review","volume":"296","author":"Ramakrishnan","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103160_bib41","article-title":"Multifunctional nanofibrous scaffolds with angle-ply microstructure and co-delivery capacity promote partial repair and total replacement of intervertebral disc","volume":"11","author":"Han","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103160_bib42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.actbio.2023.05.034","article-title":"Sustained release of basic fibroblast growth factor in micro\/nanofibrous scaffolds promotes annulus fibrosus regeneration","volume":"166","author":"Tu","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103160_bib43","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3892\/ijmm.2020.4788","article-title":"LINC00473 rescues human bone marrow mesenchymal stem cells from apoptosis induced by dexamethasone through the PEBP1-mediated Akt\/Bad\/Bcl-2 signaling pathway","volume":"47","author":"Xu","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mtbio.2026.103160_bib44","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.ijbiomac.2019.09.136","article-title":"Improved cellular bioactivity by heparin immobilization on polycarbonate film via an aminolysis modification for potential tendon repair","volume":"142","author":"Guo","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103160_bib45","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jse.2008.09.004","article-title":"Reconstruction of large rotator-cuff tears with acellular dermal matrix grafts in rats","volume":"18","author":"Ide","year":"2009","journal-title":"J. Shoulder Elb. Surg."},{"key":"10.1016\/j.mtbio.2026.103160_bib46","article-title":"Effects of applying platelet-rich plasma during arthroscopic rotator cuff repair: a systematic review and meta-analysis of randomised controlled trials","volume":"10","author":"Yang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2026.103160_bib47","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1016\/j.jse.2021.05.010","article-title":"Risk factors affecting rotator cuff retear after arthroscopic repair: a meta-analysis and systematic review","volume":"30","author":"Zhao","year":"2021","journal-title":"J. Shoulder Elb. Surg."},{"key":"10.1016\/j.mtbio.2026.103160_bib48","first-page":"85","article-title":"Biological approaches to the repair and regeneration of the rotator cuff tendon-bone enthesis: a literature review","volume":"4","author":"Abdalla","year":"2023","journal-title":"J Biomater Transl"},{"key":"10.1016\/j.mtbio.2026.103160_bib49","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/cells15030300","article-title":"Form meets function: Fiber architecture directs proliferation and differentiation in gingival keratinocytes","volume":"15","author":"Ramminger","year":"2026","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2026.103160_bib50","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/jbm.a.33291","article-title":"The effects of electrospun TSF nanofiber diameter and alignment on neuronal differentiation of human embryonic stem cells","volume":"100","author":"Wang","year":"2012","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.mtbio.2026.103160_bib51","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1089\/ten.2006.0078","article-title":"Design strategies of tissue engineering scaffolds with controlled fiber orientation","volume":"13","author":"Murugan","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.mtbio.2026.103160_bib52","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.jbiomech.2005.05.021","article-title":"Collagen fiber orientation at the tendon to bone insertion and its influence on stress concentrations","volume":"39","author":"Thomopoulos","year":"2006","journal-title":"J. Biomech."},{"key":"10.1016\/j.mtbio.2026.103160_bib53","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.1039\/C9TB01516G","article-title":"Pro-chondrogenic and immunomodulatory melatonin-loaded electrospun membranes for tendon-to-bone healing","volume":"7","author":"Song","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mtbio.2026.103160_bib54","first-page":"63","article-title":"Mesenchymal stem cells and macrophages and their interactions in tendon-bone healing","volume":"39","author":"Chen","year":"2023","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.mtbio.2026.103160_bib55","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4252\/wjsc.v13.i7.753","article-title":"Stem cell therapies in tendon-bone healing","volume":"13","author":"Xu","year":"2021","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.mtbio.2026.103160_bib56","first-page":"91","article-title":"A bio-inductive collagen scaffold that supports human primary tendon-derived cell growth for rotator cuff repair","volume":"31","author":"Chen","year":"2021","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.mtbio.2026.103160_bib57","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.actbio.2020.07.020","article-title":"Regeneration of the rotator cuff tendon-to-bone interface using umbilical cord-derived mesenchymal stem cells and gradient extracellular matrix scaffolds from adipose tissue in a rat model","volume":"114","author":"Yea","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103160_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107300","article-title":"PI3K\/AKT signaling pathway: molecular mechanisms and therapeutic potential in depression","volume":"206","author":"Guo","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mtbio.2026.103160_bib59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12967-021-03226-1","article-title":"MiR-30c-5p loss-induced PELI1 accumulation regulates cell proliferation and migration via activating PI3K\/AKT pathway in papillary thyroid carcinoma","volume":"20","author":"Zheng","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mtbio.2026.103160_bib60","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12951-021-00942-0","article-title":"Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K\/Akt pathways","volume":"19","author":"Wang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103160_bib61","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9941253","article-title":"Role of PI3K\/AKT signaling pathway in nucleus pulposus cells","volume":"2021","author":"Xiao","year":"2021","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.mtbio.2026.103160_bib62","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13075-022-02895-7","article-title":"Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K\/AKt pathway","volume":"24","author":"Wang","year":"2022","journal-title":"Arthritis Res. Ther."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426004047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426004047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:07:25Z","timestamp":1790064445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426004047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":62,"alternative-id":["S2590006426004047"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103160","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic double-layered electrospun nanofibrous scaffold with mussel adhesive protein coating and TGF-\u03b23 encapsulation for enhanced tendon-bone healing in rotator cuff tears","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103160"}}