{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:00:43Z","timestamp":1790067643182,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mtbio.2026.103161","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:32:25Z","timestamp":1778765545000},"page":"103161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A ROS-responsive \u201cone-two punch\u201d nanozyme for self-supplying oxygen and suppressing immune rejection in heart transplantation"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-3560","authenticated-orcid":false,"given":"Zhaohua","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouguo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengni","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103161_bib1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1080\/14737159.2016.1239530","article-title":"Advances in diagnostics for transplant rejection","volume":"16","author":"Nasr","year":"2016","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.mtbio.2026.103161_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41423-019-0216-2","article-title":"The innate immune response to allotransplants: mechanisms and therapeutic potentials","volume":"16","author":"Ochando","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.mtbio.2026.103161_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2018.03.042","article-title":"Hypoxia, oxidative stress and inflammation","volume":"125","author":"McGarry","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103161_bib4","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/s41423-023-01058-1","article-title":"Neutrophil diversity and plasticity: implications for organ transplantation","volume":"20","author":"Qu","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.mtbio.2026.103161_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.599511","article-title":"Damage-associated molecular patterns in myocardial infarction and heart transplantation: the road to translational success","volume":"11","author":"Silvis","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2026.103161_bib6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1161\/CIRCULATIONAHA.121.057400","article-title":"Donor macrophages modulate rejection after heart transplantation","volume":"146","author":"Kopecky","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.mtbio.2026.103161_bib7","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1161\/CIRCRESAHA.121.318005","article-title":"Immune cells and immunotherapy for cardiac injury and repair","volume":"128","author":"Rurik","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.mtbio.2026.103161_bib8","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1182\/blood.V88.10.3837.bloodjournal88103837","article-title":"Cyclosporine A inhibits tissue factor expression in monocytes\/macrophages","volume":"88","author":"Holschermann","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.mtbio.2026.103161_bib9","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/ajt.14543","article-title":"Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model","volume":"18","author":"Zhao","year":"2018","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.mtbio.2026.103161_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00007890-200002270-00032","article-title":"Blocking of CD44\u2013hyaluronic acid interaction prolongs rat allograft survival","volume":"69","author":"Zhang","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.mtbio.2026.103161_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/08923973.2021.1966033","article-title":"Transplantation and immunosuppression: a review of novel transplant-related immunosuppressant drugs","volume":"43","author":"Parlakpinar","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.mtbio.2026.103161_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00395-021-00904-5","article-title":"Single-cell transcriptomic identified HIF1A as a target for attenuating acute rejection after heart transplantation","volume":"116","author":"Chang","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.mtbio.2026.103161_bib13","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.2165\/00003495-200666170-00010","article-title":"Tacrolimus: in heart transplant recipients","volume":"66","author":"McCormack","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.mtbio.2026.103161_bib14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2165\/00003088-200443100-00001","article-title":"Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation","volume":"43","author":"Staatz","year":"2004","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.mtbio.2026.103161_bib15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1166\/jbn.2019.2777","article-title":"Albumin based nanomedicine for enhancing tacrolimus safety and lymphatic targeting efficiency","volume":"15","author":"Zhang","year":"2019","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.mtbio.2026.103161_bib16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/ten.tea.2021.0218","article-title":"Calcium phosphate and silicate-based nanoparticles: history and emerging trends","volume":"28","author":"van Rijt","year":"2022","journal-title":"Tissue Eng."},{"key":"10.1016\/j.mtbio.2026.103161_bib17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jcis.2021.12.107","article-title":"Carbon dots as nanocatalytic medicine for anti-inflammation therapy","volume":"611","author":"Kong","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2026.103161_bib18","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1021\/jacs.6b01784","article-title":"An implantable depot that can generate oxygen in situ for overcoming hypoxia-induced resistance to anticancer drugs in chemotherapy","volume":"138","author":"Huang","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2026.103161_bib19","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.1021\/nn501640q","article-title":"Graphene quantum dots-band-aids used for wound disinfection","volume":"8","author":"Sun","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103161_bib20","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2014from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2026.103161_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111803","article-title":"CaO2\/Fe3O4 nanocomposites for oxygen-independent generation of radicals and cancer therapy","volume":"204","author":"Mamat","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.mtbio.2026.103161_bib23","doi-asserted-by":"crossref","DOI":"10.4028\/b-4W7Te2","article-title":"Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy","volume":"6","author":"Liu","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.103161_bib24","doi-asserted-by":"crossref","first-page":"24455","DOI":"10.1021\/acsami.6b08119","article-title":"Polydopamine-encapsulated Fe3O4 with an adsorbed HSP70 inhibitor for improved photothermal inactivation of bacteria","volume":"8","author":"Liu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2026.103161_bib25","article-title":"A self-supplying H2O2-modified nanozyme-loaded hydrogel for root canal biofilm eradication","volume":"23","author":"Song","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103161_bib26","article-title":"Engineering H2O2 and O2 self-supplying nanoreactor to conduct synergistic chemiexcited photodynamic and calcium-overloaded therapy in orthotopic hepatic tumors","volume":"11","author":"Chen","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103161_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202405090","article-title":"Macrophage membrane-camouflaged nanozymes for combating the oxidative stress\u2013microvascular perfusion negative feedback in ischemia\u2013reperfusion-induced acute kidney injury","volume":"14","author":"Xia","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103161_bib28","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41563-020-0680-1","article-title":"Metabolic labeling and targeted modulation of dendritic cells","volume":"19","author":"Wang","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2026.103161_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jenvman.2018.01.068","article-title":"Synthesis and characterization of stabilized oxygen-releasing CaO2 nanoparticles for bioremediation","volume":"212","author":"Yeh","year":"2018","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.mtbio.2026.103161_bib30","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3390\/molecules27041326","article-title":"Determination of antioxidants by DPPH radical scavenging activity and quantitative phytochemical analysis of Ficus religiosa","volume":"27","author":"Baliyan","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.mtbio.2026.103161_bib31","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1128\/MCB.00348-14","article-title":"The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1","volume":"34","author":"de la Fuente","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103161_bib32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2143\/AC.61.2.2014329","article-title":"Pro-inflammatory cytokines and their receptors in chronic heart failure: do they really matter?","volume":"61","author":"Conraads","year":"2006","journal-title":"Acta Cardiol."},{"key":"10.1016\/j.mtbio.2026.103161_bib33","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4049\/jimmunol.169.1.522","article-title":"Analysis of the innate and adaptive phases of allograft rejection by cluster analysis of transcriptional profiles","volume":"169","author":"Christopher","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.mtbio.2026.103161_bib34","first-page":"126","article-title":"Ischemia-reperfusion damage, Eurasian J","volume":"45","author":"Yapca","year":"2013","journal-title":"M\u00e9d. Sur"},{"key":"10.1016\/j.mtbio.2026.103161_bib35","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.7150\/ijms.52691","article-title":"Macrophage polarization and liver ischemia-reperfusion injury","volume":"18","author":"Wang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.mtbio.2026.103161_bib36","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.4049\/jimmunol.0802212","article-title":"Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia","volume":"182","author":"Zheng","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.mtbio.2026.103161_bib37","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1097\/TP.0000000000004572","article-title":"An immune atlas of T cells in transplant rejection: pathways and therapeutic opportunities","volume":"107","author":"Short","year":"2023","journal-title":"Transplantation"},{"key":"10.1016\/j.mtbio.2026.103161_bib38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","article-title":"Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.103161_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202207227","article-title":"Lymph-node-targeted drug delivery for effective immunomodulation to prolong the long-term survival after heart transplantation","volume":"35","author":"Che","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103161_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202406758","article-title":"Reactive oxygen species responsive multifunctional fusion extracellular nanovesicles: prospective treatments for acute heart transplant rejection","volume":"36","author":"Lu","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103161_bib21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1186\/s12951-022-01752-8","article-title":"Acidic and hypoxic tumor microenvironment regulation by CaO2-loaded polydopamine nanoparticles","volume":"20","author":"Ruan","year":"2022","journal-title":"J. Nanobiotechnol."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426004059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426004059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:11:38Z","timestamp":1790064698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426004059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":40,"alternative-id":["S2590006426004059"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103161","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A ROS-responsive \u201cone-two punch\u201d nanozyme for self-supplying oxygen and suppressing immune rejection in heart transplantation","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103161"}}