{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:09:02Z","timestamp":1790064542115,"version":"4.0.1"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC2504305"],"award-info":[{"award-number":["2022YFC2504305"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472556"],"award-info":[{"award-number":["82472556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2025A1515011535"],"award-info":[{"award-number":["2025A1515011535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024A1515012825"],"award-info":[{"award-number":["2024A1515012825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Department of Science and Technology of Guangdong Province","doi-asserted-by":"publisher","award":["2024A0505040014"],"award-info":[{"award-number":["2024A0505040014"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032574","name":"Beijing Zhongke Baice Technology Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1515230004"],"award-info":[{"award-number":["2021B1515230004"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mtbio.2026.103176","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:41:07Z","timestamp":1778341267000},"page":"103176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A honeysuckle-decorated nanoimmunomodulator hijacks Macrophage-BMSC crosstalk to promote arthritic regeneration"],"prefix":"10.1016","volume":"38","author":[{"given":"Yuan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiqian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mincheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daorong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3208-5726","authenticated-orcid":false,"given":"Zhiqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10264","key":"10.1016\/j.mtbio.2026.103176_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: a lancet commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"issue":"9991","key":"10.1016\/j.mtbio.2026.103176_bib2","first-page":"376","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Osteoarthritis. Lancet"},{"issue":"10","key":"10.1016\/j.mtbio.2026.103176_bib3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","article-title":"Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis","volume":"12","author":"Robinson","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"12","key":"10.1016\/j.mtbio.2026.103176_bib4","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nri.2017.103","article-title":"Regulation of immunity and inflammation by hypoxia in immunological niches","volume":"17","author":"Taylor","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2026.103176_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-immunol-101320-031555","article-title":"Functional hallmarks of healthy macrophage responses: their regulatory basis and disease relevance","volume":"40","author":"Sheu","year":"2022","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103176_bib6","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation","volume":"18","author":"Netea","year":"2017","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103176_bib7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/bdrc.21042","article-title":"Toward regeneration of articular cartilage","volume":"99","author":"Iwamoto","year":"2013","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"7","key":"10.1016\/j.mtbio.2026.103176_bib8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41584-023-00979-5","article-title":"Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies","volume":"19","author":"Muthu","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mtbio.2026.103176_bib9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.omtn.2022.03.016","article-title":"MicroRNA-378 contributes to osteoarthritis by regulating chondrocyte autophagy and bone marrow mesenchymal stem cell chondrogenesis","volume":"28","author":"Feng","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.mtbio.2026.103176_bib10","article-title":"Icariin-loaded hydrogel regulates bone marrow mesenchymal stem cell chondrogenic differentiation and promotes cartilage repair in osteoarthritis","volume":"10","author":"Zhu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103176_bib11","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s11010-020-04047-4","article-title":"lncRNA-CRNDE regulates BMSC chondrogenic differentiation and promotes cartilage repair in osteoarthritis through SIRT1\/SOX9","volume":"476","author":"Shi","year":"2021","journal-title":"Mol. Cell. Biochem."},{"issue":"7","key":"10.1016\/j.mtbio.2026.103176_bib12","article-title":"Precise cell type electrical stimulation therapy via force-electric hydrogel microspheres for cartilage healing","volume":"37","author":"Han","year":"2025","journal-title":"Adv Mater"},{"issue":"4","key":"10.1016\/j.mtbio.2026.103176_bib13","first-page":"209","article-title":"Immunomodulatory actions of mesenchymal stromal cells (MSCs) in osteoarthritis of the","volume":"1","author":"Babu","year":"2021","journal-title":"Knee"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103176_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031618","article-title":"State of the art: the immunomodulatory role of MSCs for osteoarthritis","volume":"23","author":"Kwon","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103176_bib15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103176_bib16","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.joca.2016.04.010","article-title":"Direct in vivo evidence of activated macrophages in human osteoarthritis","volume":"24","author":"Kraus","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.mtbio.2026.103176_bib17","article-title":"Effects of synovial macrophages in osteoarthritis","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103176_bib18","article-title":"Nanomedicines Reprogram Synovial macrophages by scavenging nitric oxide and silencing CA9 in progressive osteoarthritis","volume":"10","author":"Yan","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.103176_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cytogfr.2019.03.004","article-title":"Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee","volume":"46","author":"Xie","year":"2019","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.mtbio.2026.103176_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in rheumatoid arthritis synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.mtbio.2026.103176_bib21","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.joca.2016.07.018","article-title":"Cartilage inflammation and degeneration is enhanced by pro-inflammatory (M1) macrophages in vitro, but not inhibited directly by anti-inflammatory (M2) macrophages","volume":"24","author":"Utomo","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103176_bib22","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.joca.2014.05.021","article-title":"Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state","volume":"22","author":"Fahy","year":"2014","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103176_bib23","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/jcp.24861","article-title":"Anti-inflammatory\/tissue repair macrophages enhance the cartilage-forming capacity of human bone marrow-derived mesenchymal stromal cells","volume":"230","author":"Sesia","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mtbio.2026.103176_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jconrel.2024.09.052","article-title":"An injectable self-lubricating supramolecular polymer hydrogel loaded with platelet lysate to boost osteoarthritis treatment","volume":"376","author":"Zhang","year":"2024","journal-title":"J Control Release"},{"issue":"11","key":"10.1016\/j.mtbio.2026.103176_bib25","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1016\/j.apsb.2024.07.008","article-title":"Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetin-mediated leverage of glycolysis and OXPHOS","volume":"14","author":"Zhang","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2026.103176_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biomaterials.2017.12.025","article-title":"Mesenchymal stem cell-macrophage crosstalk and bone healing","volume":"196","author":"Pajarinen","year":"2019","journal-title":"Biomaterials"},{"issue":"21","key":"10.1016\/j.mtbio.2026.103176_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202313406","article-title":"Atomic engineering of single-atom nanozymes for biomedical applications","volume":"36","author":"Shen","year":"2024","journal-title":"Adv Mater"},{"issue":"13","key":"10.1016\/j.mtbio.2026.103176_bib28","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1002\/anie.201912182","article-title":"An enzyme-mimicking single-atom catalyst as an efficient multiple reactive oxygen and nitrogen species Scavenger for sepsis management","volume":"59","author":"Cao","year":"2020","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.mtbio.2026.103176_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120390","article-title":"Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization","volume":"264","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"issue":"46","key":"10.1016\/j.mtbio.2026.103176_bib30","article-title":"Safety landscape of therapeutic nanozymes and future research directions","volume":"11","author":"Tagaras","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103176_bib31","doi-asserted-by":"crossref","DOI":"10.1080\/14686996.2023.2203832","article-title":"Anion-templated silver nanoclusters: precise synthesis and geometric structure","volume":"24","author":"Horita","year":"2023","journal-title":"Sci. Technol. Adv. Mater."},{"issue":"20","key":"10.1016\/j.mtbio.2026.103176_bib32","doi-asserted-by":"crossref","first-page":"9904","DOI":"10.7150\/thno.66518","article-title":"Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"issue":"26","key":"10.1016\/j.mtbio.2026.103176_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201700278","article-title":"Self-Supplying O2 through the catalase-like activity of gold nanoclusters for photodynamic therapy against hypoxic cancer cells","volume":"13","author":"Liu","year":"2017","journal-title":"Small"},{"issue":"31","key":"10.1016\/j.mtbio.2026.103176_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202405679","article-title":"A cyclometalated Ruthenium(II) complex induces oncosis for synergistic activation of innate and adaptive immunity","volume":"63","author":"Feng","year":"2024","journal-title":"Angew Chem. Int. Ed. Engl."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103176_bib35","doi-asserted-by":"crossref","first-page":"9592","DOI":"10.1038\/s41467-024-53824-y","article-title":"Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects","volume":"15","author":"Bai","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103176_bib36","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s41467-025-56179-0","article-title":"Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103176_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122923","article-title":"Ru single-atom nanozymes targeting ROS-ferroptosis pathways for enhanced endometrial regeneration in intrauterine adhesion therapy","volume":"315","author":"Liang","year":"2025","journal-title":"Biomaterials"},{"issue":"28","key":"10.1016\/j.mtbio.2026.103176_bib38","doi-asserted-by":"crossref","first-page":"31205","DOI":"10.1021\/acsami.0c07886","article-title":"An ultrasmall RuO2 nanozyme exhibiting multienzyme-like activity for the prevention of Acute Kidney injury","volume":"12","author":"Liu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"48","key":"10.1016\/j.mtbio.2026.103176_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202411618","article-title":"Constructing electron-rich Ru clusters on non-stoichiometric copper hydroxide for superior biocatalytic ROS scavenging to treat inflammatory spinal cord injury","volume":"36","author":"Liu","year":"2024","journal-title":"Adv Mater"},{"issue":"22","key":"10.1016\/j.mtbio.2026.103176_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/nu16223954","article-title":"Anti-Inflammatory effects of honeysuckle leaf against lipopolysaccharide-induced neuroinflammation on BV2 microglia","volume":"16","author":"Kweon","year":"2024","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.mtbio.2026.103176_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12091678","article-title":"The antioxidant and prebiotic activities of mixtures Honey\/Biomimetic NaDES and polyphenols show differences between honeysuckle and raspberry extracts","volume":"12","author":"Dimitriu","year":"2023","journal-title":"Antioxidants"},{"issue":"15","key":"10.1016\/j.mtbio.2026.103176_bib42","first-page":"6133","article-title":"Chemical composition of honeysuckle (Lonicerae japonicae) extracts and their potential in inhibiting the SARS-CoV-2 spike protein and ACE2 binding, suppressing ACE2, and scavenging radicals","volume":"71","author":"Gao","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.mtbio.2026.103176_bib43","article-title":"Downregulation of cardiac inflammation via the CaMKII \u03b4\/NF-\u03baB pathway in heart failure by Lonicerae Japonicae Flos and Angelicae Sinensis Radix","volume":"136","author":"Tang","year":"2024","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.mtbio.2026.103176_bib44","doi-asserted-by":"crossref","first-page":"9000","DOI":"10.18632\/aging.103161","article-title":"The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress","volume":"12","author":"Lu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mtbio.2026.103176_bib45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2021.12.006","article-title":"The immune microenvironment in cartilage injury and repair","volume":"140","author":"Li","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103176_bib46","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.addr.2018.12.015","article-title":"Articular fibrocartilage - why does hyaline cartilage fail to repair?","volume":"146","author":"Armiento","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7734","key":"10.1016\/j.mtbio.2026.103176_bib47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","article-title":"PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation","volume":"564","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103176_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1193765","article-title":"Macrophages-bone marrow mesenchymal stem cells crosstalk in bone healing","volume":"11","author":"Fan","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2026.103176_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/srep38308","article-title":"Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism","volume":"6","author":"Vasandan","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103176_bib50","article-title":"Analysis of mitochondrial transfer in direct Co-cultures of human monocyte-derived macrophages (MDM) and Mesenchymal Stem Cells (MSC)","volume":"7","author":"Jackson","year":"2017","journal-title":"Bio Protoc"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103176_bib51","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12967-019-1999-8","article-title":"Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy","volume":"17","author":"Jin","year":"2019","journal-title":"J. Transl. Med."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103176_bib52","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ni.3772","article-title":"Limiting inflammation-the negative regulation of NF-\u03baB and the NLRP3 inflammasome","volume":"18","author":"Afonina","year":"2017","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103176_bib53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s13238-012-2118-2","article-title":"Regulation of HMGB1 release by inflammasomes","volume":"4","author":"Lu","year":"2013","journal-title":"Protein Cell"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103176_bib54","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/viru.2.2.15480","article-title":"HMGB1 release by inflammasomes","volume":"2","author":"Vande Walle","year":"2011","journal-title":"Virulence"},{"key":"10.1016\/j.mtbio.2026.103176_bib55","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-immunol-030409-101323","article-title":"HMGB1 is a therapeutic target for sterile inflammation and infection","volume":"29","author":"Andersson","year":"2011","journal-title":"Annu. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.mtbio.2026.103176_bib56","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.4049\/jimmunol.1000803","article-title":"Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia","volume":"185","author":"Lamkanfi","year":"2010","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.mtbio.2026.103176_bib57","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41423-019-0204-6","article-title":"Cell-cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models","volume":"16","author":"Li","year":"2019","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103176_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020781","article-title":"Macrophage-Derived inflammation induces a transcriptome makeover in mesenchymal stromal cells enhancing their potential for tissue repair","volume":"22","author":"Maldonado-Lasunci\u00f3n","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"26","key":"10.1016\/j.mtbio.2026.103176_bib59","doi-asserted-by":"crossref","first-page":"11942","DOI":"10.1073\/pnas.1003893107","article-title":"A critical cysteine is required for HMGB1 binding to toll-like receptor 4 and activation of macrophage cytokine release","volume":"107","author":"Yang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mtbio.2026.103176_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103255","article-title":"Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1\/TLR4\/STAT3 axis in M1 macrophages","volume":"75","author":"Feng","year":"2024","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103176_bib61","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pharmthera.2013.10.010","article-title":"Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease","volume":"141","author":"Yates","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103176_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/biom9110683","article-title":"Oleanolic acid exerts a neuroprotective effect against microglial cell activation by modulating cytokine release and antioxidant defense systems","volume":"9","author":"Castellano","year":"2019","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.mtbio.2026.103176_bib63","first-page":"RA233","article-title":"COX-2 inhibitors and metabolism of essential fatty acids","volume":"11","author":"Das","year":"2005","journal-title":"Med. Sci. Monit."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103176_bib64","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3109\/13880209.2011.621714","article-title":"Free radical scavenging activity of conjugated linoleic acid as single or mixed isomers","volume":"50","author":"Ali","year":"2012","journal-title":"Pharm. Biol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103176_bib65","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4067\/S0716-97602004000200013","article-title":"Omega-3 fatty acids and antioxidants in edible wild plants","volume":"37","author":"Simopoulos","year":"2004","journal-title":"Biol. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103176_bib66","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1038\/s41467-018-05800-6","article-title":"Resolution of chronic inflammatory disease: universal and tissue-specific concepts","volume":"9","author":"Schett","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103176_bib67","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.plipres.2013.12.001","article-title":"Regulation of energy metabolism by long-chain fatty acids","volume":"53","author":"Nakamura","year":"2013","journal-title":"Prog. Lipid Res."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103176_bib68","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/CIRCULATIONAHA.123.065769","article-title":"Omega-3 fatty acids and arrhythmias","volume":"150","author":"Marcus","year":"2024","journal-title":"Circulation"},{"issue":"7744","key":"10.1016\/j.mtbio.2026.103176_bib69","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41586-019-0904-1","article-title":"Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity","volume":"566","author":"Vriens","year":"2019","journal-title":"Nature"},{"issue":"40","key":"10.1016\/j.mtbio.2026.103176_bib70","article-title":"Reprogramming of Fatty acid metabolism via PPAR\u03b1-Orchestrated FADS2 in Keratinocytes modulates skin inflammation in psoriasis","volume":"12","author":"Cai","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"Pt 1","key":"10.1016\/j.mtbio.2026.103176_bib71","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.freeradbiomed.2022.10.303","article-title":"LC-MS\/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products","volume":"193","author":"Pang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103176_bib72","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4600029","article-title":"Thrombin induces COX-2 and PGE2 expression via PAR1\/PKCalpha\/MAPK-Dependent NF-kappaB activation in Human tracheal smooth muscle cells","volume":"2022","author":"Yang","year":"2022","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.mtbio.2026.103176_bib73","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.2147\/JIR.S523172","article-title":"Feedback regulation of sPLA2-COX\/5-LOX-Ca2+ in seminal plasma and its impact on sperm quality parameters","volume":"18","author":"Liu","year":"2025","journal-title":"J. Inflamm. Res."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103176_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1483","article-title":"Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway","volume":"13","author":"Li","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"7","key":"10.1016\/j.mtbio.2026.103176_bib75","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1096\/fj.201900196R","article-title":"15-Epi-LXA4 and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture","volume":"33","author":"Dakin","year":"2019","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103176_bib76","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13024-025-00824-1","article-title":"The role of n-3-derived specialised pro-resolving mediators (SPMs) in microglial mitochondrial respiration and inflammation resolution in Alzheimer's disease","volume":"20","author":"Slayo","year":"2025","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103176_bib77","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41392-020-00280-x","article-title":"The updated landscape of tumor microenvironment and drug repurposing","volume":"5","author":"Jin","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103176_bib78","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s12951-025-03495-8","article-title":"Intelligent ROS therapy driven by iron-based nanozyme with controllable catalytic activity for infected wound healing","volume":"23","author":"Deng","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.mtbio.2026.103176_bib79","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jconrel.2021.08.033","article-title":"Nanoceria, the versatile nanoparticles: promising biomedical applications","volume":"338","author":"Saifi","year":"2021","journal-title":"J Control Release"},{"key":"10.1016\/j.mtbio.2026.103176_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.339171","article-title":"Dual-mode immunoassay for diethylstilbestrol based on peroxidase activity and photothermal effect of black phosphorus-gold nanoparticle nanohybrids","volume":"1187","author":"Ding","year":"2021","journal-title":"Anal. Chim. Acta"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426004205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426004205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:43:09Z","timestamp":1790062989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426004205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":80,"alternative-id":["S2590006426004205"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103176","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A honeysuckle-decorated nanoimmunomodulator hijacks Macrophage-BMSC crosstalk to promote arthritic regeneration","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103176"}}