{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:01:50Z","timestamp":1790067710578,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mtbio.2026.103267","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:35:41Z","timestamp":1779320141000},"page":"103267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Engineered skin commensal nanogels mitigate psoriasiform inflammation through dual regulation of cutaneous flora and host immunity"],"prefix":"10.1016","volume":"38","author":[{"given":"Yang","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7472-0495","authenticated-orcid":false,"given":"Xiaoling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10281","key":"10.1016\/j.mtbio.2026.103267_bib1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"issue":"19","key":"10.1016\/j.mtbio.2026.103267_bib2","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103267_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/jfb15020049","article-title":"Advanced platelet lysate aerogels: biomaterials for regenerative applications","volume":"15","author":"Tibourtine","year":"2024","journal-title":"J. Funct. Biomater."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103267_bib4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1186\/s13287-020-01930-1","article-title":"Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel","volume":"11","author":"Jahangir","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"24","key":"10.1016\/j.mtbio.2026.103267_bib5","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.3390\/polym13244392","article-title":"Chitosan reinforced with Kenaf Nanocrystalline cellulose as an effective carrier for the delivery of platelet lysate in the acceleration of wound healing","volume":"13","author":"Bhatnagar","year":"2021","journal-title":"Polymers"},{"issue":"16","key":"10.1016\/j.mtbio.2026.103267_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202304318","article-title":"Human adipose tissue lysate\u2010based hydrogel for lasting immunomodulation to effectively improve spinal cord injury repair","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"issue":"18","key":"10.1016\/j.mtbio.2026.103267_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e37521","article-title":"Regulation of tumor antigens-dependent immunotherapy via the hybrid M1 macrophage\/tumor lysates Hydrogel","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"issue":"5","key":"10.1016\/j.mtbio.2026.103267_bib6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3390\/biomedicines10051037","article-title":"Gut\u2013skin axis: unravelling the connection between the gut microbiome and psoriasis","volume":"10","author":"Thye","year":"2022","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.mtbio.2026.103267_bib7","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jaad.2019.06.024","article-title":"Psoriatic lesions are characterized by higher bacterial load and imbalance between Cutibacterium and Corynebacterium","volume":"82","author":"Quan","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.mtbio.2026.103267_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-018-0533-1","article-title":"Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization","volume":"6","author":"Chang","year":"2018","journal-title":"Microbiome"},{"issue":"7689","key":"10.1016\/j.mtbio.2026.103267_bib9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature25177","article-title":"Skin microbiota\u2013host interactions","volume":"553","author":"Chen","year":"2018","journal-title":"Nature"},{"issue":"378","key":"10.1016\/j.mtbio.2026.103267_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah4680","article-title":"Antimicrobials from human skin commensal bacteria protect against Corynebacterium aureus and are deficient in atopic dermatitis","volume":"9","author":"Nakatsuji","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103267_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.15212\/bioi-2022-0015","article-title":"Optimization of ultra-small nanoparticles for enhanced drug delivery","volume":"4","author":"He","year":"2023","journal-title":"BIO Integration"},{"issue":"13","key":"10.1016\/j.mtbio.2026.103267_bib14","doi-asserted-by":"crossref","first-page":"14859","DOI":"10.1021\/acsami.1c19180","article-title":"Skin-permeable nano-lithocholic lipidoid efficiently alleviates psoriasis-like chronic skin inflammations","volume":"14","author":"Rachamalla","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103267_bib15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4103\/mgr.MEDGASRES-D-24-00027","article-title":"H 2 protects H9c2 cells from hypoxia\/reoxygenation injury by inhibiting the Wnt\/CX3CR1 signaling pathway","volume":"15","author":"Wang","year":"2025","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.mtbio.2026.103267_bib16","doi-asserted-by":"crossref","DOI":"10.22203\/eCM.v047a13","article-title":"Immune responses around biomaterials for vital pulp therapy","author":"Dai","year":"2024","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.mtbio.2026.103267_bib17","doi-asserted-by":"crossref","DOI":"10.22203\/eCM.v047a01","article-title":"Alginate hydrogel-guided rAAV-mediated FGF-2 and TGF-\u03b2 delivery and overexpression stimulates the biological activities of human meniscal fibrochondrocytes for meniscus repair","author":"Venkatesan","year":"2024","journal-title":"Eur. Cell. Mater."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103267_bib18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jdv.12106","article-title":"Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): the correlation between disease severity and psychological burden in patients treated with biological therapies","volume":"28","author":"Mattei","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.mtbio.2026.103267_bib19","series-title":"Molecular Cloning of CD68, a Human Macrophage Marker Related to Lysosomal Glycoproteins","author":"Holness","year":"1993"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103267_bib20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103267_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1517\/14740338.2016.1140743","article-title":"Long-term side effects of glucocorticoids","volume":"15","author":"Oray","year":"2016","journal-title":"Expert Opin. Drug Saf."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103267_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4103\/2045-9912.385942","article-title":"Possible role of high calcium concentrations in rat neocortical neurons in inducing hyper excitatory behavior during emergence from sevoflurane: a proposed pathophysiology","volume":"14","author":"Ramlan","year":"2024","journal-title":"Med. Gas Res."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103267_bib23","first-page":"121","article-title":"Hyperbaric oxygen therapy increases the effect of 5-fluorouracil chemotherapy on experimental colorectal cancer in mice","volume":"14","author":"achado","year":"2024","journal-title":"Med. Gas Res."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103267_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00403-024-03602-z","article-title":"Unveiling the skin microbial guardians and assailants in psoriasis subtypes: a Mendelian randomization study","volume":"317","author":"Zhang","year":"2024","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.mtbio.2026.103267_bib25","first-page":"253","article-title":"Living symbiotic bacteria-involved skin dressing to combat indigenous pathogens for microbiome-based biotherapy toward atopic dermatitis","volume":"21","author":"Liu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103267_bib26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.actbio.2024.06.006","article-title":"Innate lymphoid cell-based immunomodulatory hydrogel microspheres containing Cutibacterium acnes extracellular vesicles for the treatment of psoriasis","volume":"184","author":"Xu","year":"2024","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103267_bib27","first-page":"12","article-title":"The role of gut microbiota metabolites in the regeneration and protection of nervous tissue: a narrative review","volume":"1","author":"Kostiuchenko","year":"2024","journal-title":"Regen. Med. Rep."},{"issue":"6673","key":"10.1016\/j.mtbio.2026.103267_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103267_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0092-8674(01)00455-X","article-title":"Regulation of T cell immunity by dendritic cells","volume":"106","author":"Lanzavecchia","year":"2001","journal-title":"Cell"},{"issue":"7161","key":"10.1016\/j.mtbio.2026.103267_bib30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature06175","article-title":"Taking dendritic cells into medicine","volume":"449","author":"Steinman","year":"2007","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.mtbio.2026.103267_bib31","doi-asserted-by":"crossref","first-page":"7488","DOI":"10.3390\/ijms21207488","article-title":"New treatment addressing the pathogenesis of psoriasis","volume":"21","author":"Tokuyama","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426005119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426005119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:20:18Z","timestamp":1790065218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426005119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"alternative-id":["S2590006426005119"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103267","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered skin commensal nanogels mitigate psoriasiform inflammation through dual regulation of cutaneous flora and host immunity","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103267"}}