{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:21:25Z","timestamp":1793366485853,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mtbio.2026.103380","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T22:27:49Z","timestamp":1781994469000},"page":"103380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Multiregulatory hydrogel supramolecular nanomedicine for reprogramming cartilage homeostasis in osteoarthritis"],"prefix":"10.1016","volume":"39","author":[{"given":"Yibo","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songjie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenggang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1908-4278","authenticated-orcid":false,"given":"Chenyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-6792","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103380_bib1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S2665-9913(23)00163-7","volume":"5","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.mtbio.2026.103380_bib2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3892\/etm.2023.12180","volume":"26","author":"Geng","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.mtbio.2026.103380_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110452","volume":"129","author":"Ansari","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2026.103380_bib4","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2026.103380_bib5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbapap.2011.06.020","volume":"1824","author":"Troeberg","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mtbio.2026.103380_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4895050","volume":"2016","author":"Rose","year":"2016","journal-title":"Dis. Markers"},{"key":"10.1016\/j.mtbio.2026.103380_bib7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","volume":"8","author":"Yao","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.mtbio.2026.103380_bib8","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103380_bib9","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1038\/s12276-022-00879-w","volume":"54","author":"Zhu","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mtbio.2026.103380_bib10","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.7150\/ijbs.85585","volume":"20","author":"Lin","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mtbio.2026.103380_bib11","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3390\/biom12101357","volume":"12","author":"Kao","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.mtbio.2026.103380_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmt.2025.100102","volume":"12","author":"Lu","year":"2025","journal-title":"Biomedical Technology"},{"key":"10.1016\/j.mtbio.2026.103380_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2014.2","volume":"2","author":"Shen","year":"2014","journal-title":"Bone Res."},{"key":"10.1016\/j.mtbio.2026.103380_bib14","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.3390\/ijms24065364","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103380_bib15","volume":"15","author":"Liao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103380_bib16","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.3390\/biomedicines11082244","volume":"11","author":"Su","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.mtbio.2026.103380_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123581","volume":"360","author":"Rahimi","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2026.103380_bib18","volume":"36","author":"Xiao","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2026.103380_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12938-025-01342-3","volume":"24","author":"Li","year":"2025","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.mtbio.2026.103380_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.617141","volume":"9","author":"Echeverria Molina","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.mtbio.2026.103380_bib21","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.2147\/IJN.S465243","volume":"19","author":"Yi","year":"2024","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.mtbio.2026.103380_bib22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41392-023-01536-y","volume":"8","author":"Fan","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.mtbio.2026.103380_bib23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.tips.2021.12.004","volume":"43","author":"Gao","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mtbio.2026.103380_bib24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s42114-025-01245-w","volume":"8","author":"Ma","year":"2025","journal-title":"Adv. Compos. Hybrid Mater."},{"key":"10.1016\/j.mtbio.2026.103380_bib25","volume":"35","author":"Yu","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103380_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/ijms20010009","volume":"20","author":"Soriano-Roman\u00ed","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103380_bib27","volume":"274","author":"Ribeiro","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2026.103380_bib28","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.3390\/ijms23137395","volume":"23","author":"Ding","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103380_bib29","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1021\/acs.jafc.4c11101","volume":"73","author":"Hsu","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.mtbio.2026.103380_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12906-023-04317-w","volume":"24","author":"Elhawary","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.mtbio.2026.103380_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173026","volume":"874","author":"Jin","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103380_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111221","volume":"222","author":"Xu","year":"2025","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mtbio.2026.103380_bib33","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.2147\/IJN.S267321","volume":"15","author":"Bao","year":"2020","journal-title":"Int. J. Nanomedicine."},{"key":"10.1016\/j.mtbio.2026.103380_bib34","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/gast.2001.29590","volume":"121","author":"Malassagne","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2026.103380_bib35","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3389\/fendo.2019.00499","volume":"10","author":"Zhou","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mtbio.2026.103380_bib36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1021\/acsnano.3c09011","volume":"18","author":"Xu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103380_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.fuel.2024.133197","volume":"381","author":"Munawar","year":"2025","journal-title":"Fuel"},{"key":"10.1016\/j.mtbio.2026.103380_bib38","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fphys.2016.00180","volume":"7","author":"Kalamegam","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mtbio.2026.103380_bib39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s41232-022-00202-0","volume":"42","author":"Saito","year":"2022","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.mtbio.2026.103380_bib40","first-page":"1261","volume":"67","author":"Kozhemyakina","year":"2015","journal-title":"Rheumatol."},{"key":"10.1016\/j.mtbio.2026.103380_bib41","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2019152118","volume":"118","author":"Haseeb","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mtbio.2026.103380_bib42","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/jcb.25099","volume":"116","author":"Shi","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mtbio.2026.103380_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.freeradbiomed.2015.06.014","volume":"88","author":"Jiang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103380_bib44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3390\/biom15010149","volume":"15","author":"Liu","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.mtbio.2026.103380_bib45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.molcel.2019.09.005","volume":"76","author":"Kirkin","year":"2019","journal-title":"Mol. Cell."},{"key":"10.1016\/j.mtbio.2026.103380_bib46","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tibs.2024.12.010","volume":"50","author":"Hayes","year":"2025","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mtbio.2026.103380_bib47","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2174\/0929866528666211027113349","volume":"28","author":"Khan","year":"2021","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.mtbio.2026.103380_bib48","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13075-017-1302-4","volume":"19","author":"van Caam","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.mtbio.2026.103380_bib49","doi-asserted-by":"crossref","first-page":"700","DOI":"10.34133\/research.0700","volume":"8","author":"Pang","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.mtbio.2026.103380_bib50","doi-asserted-by":"crossref","first-page":"1412S","DOI":"10.1177\/19476035211003324","volume":"13","author":"Yang","year":"2021","journal-title":"Cartilage"},{"key":"10.1016\/j.mtbio.2026.103380_bib51","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103380_bib52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2019.1606647","volume":"16","author":"Yang","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.mtbio.2026.103380_bib53","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.3390\/polym15143012","volume":"15","author":"Malektaj","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.mtbio.2026.103380_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124275","volume":"239","author":"Tan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103380_bib55","volume":"5","author":"Ahsan","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.mtbio.2026.103380_bib56","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.xphs.2015.11.019","volume":"105","author":"Qi","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.mtbio.2026.103380_bib57","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.3390\/cells9071606","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2026.103380_bib58","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3390\/jcm14041272","volume":"14","author":"Glinkowski","year":"2025","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mtbio.2026.103380_bib59","volume":"318","author":"Liu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103380_bib60","doi-asserted-by":"crossref","first-page":"306","DOI":"10.34133\/research.0306","volume":"7","author":"Chen","year":"2024","journal-title":"Research"},{"key":"10.1016\/j.mtbio.2026.103380_bib61","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmat2116","volume":"7","author":"Rothenfluh","year":"2008","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2026.103380_bib62","first-page":"2372","volume":"6","author":"Xue","year":"2021","journal-title":"Bioact. Mater."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426006253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426006253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:19:20Z","timestamp":1787026760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426006253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":62,"alternative-id":["S2590006426006253"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103380","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiregulatory hydrogel supramolecular nanomedicine for reprogramming cartilage homeostasis in osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103380"}}