{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:28:35Z","timestamp":1787027315539,"version":"build-2736575974"},"reference-count":185,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mtbio.2026.103390","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:23:03Z","timestamp":1782231783000},"page":"103390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nanomedicine targeting ECM stiffness: restoring mechanical homeostasis for cancer immunotherapy"],"prefix":"10.1016","volume":"39","author":[{"given":"Mengru","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanran","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-0649","authenticated-orcid":false,"given":"Yiting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4449-6725","authenticated-orcid":false,"given":"Zhidong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103390_bib1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/s41467-025-56299-7","article-title":"Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis","volume":"16","author":"Maiques","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41467-025-67709-1","article-title":"Glassy adhesion dynamics govern transitions between sub-diffusive and super-diffusive cancer cell migration on viscoelastic substrates","volume":"17","author":"Sharma","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib3","article-title":"Unleashing a dual\u2010warhead nanomedicine to precisely sensitize immunotherapy for pancreatic ductal adenocarcinoma","volume":"34","author":"Zhang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2026.103390_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189198","article-title":"The key role of matrix stiffness in colorectal cancer immunotherapy: mechanisms and therapeutic strategies","volume":"1879","author":"Chen","year":"2024","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2025.189463","article-title":"The mechanical landscape of cancer: exploring mechanical characteristics-based therapeutic approaches","volume":"1880","author":"Chen","year":"2025","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib6","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.7150\/ijbs.102706","article-title":"Unveiling the role of mechanical microenvironment in hepatocellular carcinoma: molecular mechanisms and implications for therapeutic strategies","volume":"20","author":"Hong","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mtbio.2026.103390_bib7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41419-024-06697-4","article-title":"Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy","volume":"15","author":"Mai","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2026.103390_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-023-01744-8","article-title":"Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments","volume":"22","author":"Yuan","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib9","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1158\/2159-8290.CD-24-0002","article-title":"The interplay between extracellular matrix remodeling and cancer therapeutics","volume":"14","author":"Prakash","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.mtbio.2026.103390_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s43556-026-00403-w","article-title":"TGF-\u03b2 in tumor development and progression: mechanisms and therapeutics","volume":"7","author":"Liu","year":"2026","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.mtbio.2026.103390_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107958","article-title":"Hyaluronic acid and its role in pancreatic cancer: mechanisms of tumor progression, drug resistance, and therapeutic targeting","volume":"221","author":"Cai","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib12","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1186\/s12951-025-03815-y","article-title":"Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy","volume":"23","author":"Gong","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103390_bib13","article-title":"Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation","volume":"118","author":"Li","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mtbio.2026.103390_bib14","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12943-025-02384-w","article-title":"Non-canonical ALK7 pathways promote pancreatic cancer metastasis through \u03b2-catenin\/MMP-mediated basement membrane breakdown and intravasation","volume":"24","author":"Kolarzyk","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12964-025-02380-z","article-title":"Biomechanics of the tumor extracellular matrix and regulatory T cells: regulatory mechanisms and potential therapeutic targets","volume":"23","author":"Huang","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.mtbio.2026.103390_bib16","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.actbio.2025.03.001","article-title":"Overcoming matrix barriers for enhanced immune infiltration using siRNA-coated metal-organic frameworks","volume":"196","author":"Zeng","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103390_bib17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7150\/ijbs.121356","article-title":"Mechanical microenvironment in tumor immune evasion: bidirectional regulation between matrix stiffness and immune cells and its therapeutic implications","volume":"22","author":"Ai","year":"2026","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mtbio.2026.103390_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122900","article-title":"Matrix stiffening from collagen fibril density and alignment modulates YAP-mediated T-cell immune suppression","volume":"315","author":"Sapudom","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103390_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb2756","article-title":"Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts","volume":"15","author":"Calvo","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103390_bib20","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-022-05496-1","article-title":"Ovarian cancer mutational processes drive site-specific immune evasion","volume":"612","author":"V\u00e1zquez-Garc\u00eda","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103390_bib21","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1016\/j.cell.2024.04.023","article-title":"Osr2 functions as a biomechanical checkpoint to aggravate CD8(+) T cell exhaustion in tumor","volume":"187","author":"Zhang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.103390_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/md17120668","article-title":"Sinulariolide inhibits gastric cancer cell migration and invasion through downregulation of the EMT process and suppression of FAK\/PI3K\/AKT\/mTOR and MAPKs signaling pathways","volume":"17","author":"Wu","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.mtbio.2026.103390_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40164-024-00591-7","article-title":"Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications","volume":"14","author":"Peng","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.mtbio.2026.103390_bib24","article-title":"Piezo1 activation improves NSCLC liver metastasis immunotherapy by overriding matrix stiffness-mediated bimodal PD-L1\/CXCL10 regulation","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.mtbio.2026.103390_bib25","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41419-025-07736-4","article-title":"Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1","volume":"16","author":"Ke","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2026.103390_bib26","article-title":"Matrix-Rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility","volume":"12","author":"Shin","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.mtbio.2026.103390_bib27","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/s41551-021-00709-w","article-title":"Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts","volume":"5","author":"Walker","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2026.103390_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41565-023-01535-8","article-title":"Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases","volume":"19","author":"Mittelheisser","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.mtbio.2026.103390_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114448","article-title":"Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer","volume":"188","author":"Li","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.103390_bib30","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s43246-025-01006-8","article-title":"Stabilization of adhesions controls F-actin architecture in mechanotransduction","volume":"6","author":"Carney","year":"2025","journal-title":"Commun. Mater."},{"key":"10.1016\/j.mtbio.2026.103390_bib31","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41392-023-01501-9","article-title":"Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets","volume":"8","author":"Di","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.103390_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12929-025-01211-0","article-title":"Decoding collagen cues: the interplay of integrins and discoidin domain receptors in health and disease","volume":"33","author":"Trono","year":"2026","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.mtbio.2026.103390_bib33","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.34133\/research.1121","article-title":"Integrin-Mediated mechanosensing of modeled lymph Node Microenvironment promotes T cell activation via nuclear deformation","volume":"9","author":"Feng","year":"2026","journal-title":"Research"},{"key":"10.1016\/j.mtbio.2026.103390_bib34","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1158\/2159-8290.CD-24-1712","article-title":"The immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer","volume":"15","author":"Xie","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.mtbio.2026.103390_bib35","article-title":"Targeting focal adhesion kinase: from molecular mechanisms to next-generation cancer therapeutics","author":"Chen","year":"2026","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.mtbio.2026.103390_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41419-022-04502-8","article-title":"Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma","volume":"13","author":"Del Mistro","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2026.103390_bib37","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.gendis.2023.02.037","article-title":"Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho\/ROCK feedback loop","volume":"10","author":"Qin","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.mtbio.2026.103390_bib38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.actbio.2019.02.015","article-title":"ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness","volume":"88","author":"Peng","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103390_bib39","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mtbio.2026.103390_bib40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13045-025-01717-y","article-title":"Extracellular matrix dynamics in tumor immunoregulation: from tumor microenvironment to immunotherapy","volume":"18","author":"Hu","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.mtbio.2026.103390_bib41","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1038\/s41467-018-07387-4","article-title":"Integrin CD11b activation drives anti-tumor innate immunity","volume":"9","author":"Schmid","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib42","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1038\/s41467-023-38598-z","article-title":"Chemo-mechanical diffusion waves explain collective dynamics of immune cell podosomes","volume":"14","author":"Gong","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib43","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41590-025-02134-6","article-title":"Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer","volume":"26","author":"Shakiba","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mtbio.2026.103390_bib44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2021.12.025","article-title":"Tumor-stroma TGF-\u03b21-THBS2 feedback circuit drives pancreatic ductal adenocarcinoma progression via integrin \u03b1(v)\u03b2(3)\/CD36-mediated activation of the MAPK pathway","volume":"528","author":"Nan","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mtbio.2026.103390_bib45","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.2147\/JIR.S469948","article-title":"Deciphering EIF3D's role in immune regulation and malignant progression: a pan-cancer analysis with a focus on Colon adenocarcinoma","volume":"17","author":"Zhou","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib46","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41392-025-02520-4","article-title":"Dysadherin\/YAP axis fuels stem plasticity and immune escape in liver cancer","volume":"10","author":"Jang","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.103390_bib47","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jhep.2024.02.008","article-title":"Syngeneic murine models with distinct immune microenvironments represent subsets of human intrahepatic cholangiocarcinoma","volume":"80","author":"Tomlinson","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103390_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq2395","article-title":"Noncanonical role of Golgi-associated macrophage TAZ in chronic inflammation and tumorigenesis","volume":"11","author":"Park","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.103390_bib49","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cmet.2023.04.013","article-title":"Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment","volume":"35","author":"Wang","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.mtbio.2026.103390_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103813","article-title":"Emerging roles of mechanically activated ion channels in autoimmune disease","volume":"24","author":"Zeng","year":"2025","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.mtbio.2026.103390_bib51","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1136\/annrheumdis-2021-220295","article-title":"Mechanosensitive TRPV4 is required for crystal-induced inflammation","volume":"80","author":"Lan","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.mtbio.2026.103390_bib52","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1158\/0008-5472.CAN-12-4521","article-title":"Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse","volume":"73","author":"Stylianopoulos","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib53","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010151","article-title":"Hypoxia upregulates the expression of PD-L1 via NPM1 in breast cancer","volume":"13","author":"Yu","year":"2025","journal-title":"J. ImmunoTher. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib54","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41467-023-36747-y","article-title":"Inhibition of ALKBH5 attenuates I\/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib55","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1038\/s41467-023-37021-x","article-title":"Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression","volume":"14","author":"Li Mow Chee","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib56","article-title":"Cyclic stretch induced epigenetic activation of periodontal ligament cells, Mater","volume":"26","author":"Bae","year":"2024","journal-title":"Today Bio"},{"key":"10.1016\/j.mtbio.2026.103390_bib57","doi-asserted-by":"crossref","first-page":"21258","DOI":"10.1073\/pnas.2006765117","article-title":"Nuclear mechanosensing controls MSC osteogenic potential through HDAC epigenetic remodeling","volume":"117","author":"Killaars","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mtbio.2026.103390_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aeb1271","article-title":"Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory","volume":"12","author":"Boyle","year":"2026","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.103390_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114722","article-title":"Mechanotherapy in oncology: targeting nuclear mechanics and mechanotransduction","volume":"194","author":"Liu","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.103390_bib60","doi-asserted-by":"crossref","DOI":"10.1063\/5.0255473","article-title":"Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis","volume":"9","author":"Yokoyama","year":"2025","journal-title":"APL Bioeng."},{"key":"10.1016\/j.mtbio.2026.103390_bib61","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/nmat4729","article-title":"Transcription upregulation via force-induced direct stretching of chromatin","volume":"15","author":"Tajik","year":"2016","journal-title":"Nat. Mater."},{"key":"10.1016\/j.mtbio.2026.103390_bib62","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1038\/s41590-025-02330-4","article-title":"Analysis of the three-dimensional genome of exhausted CD8(+) T cells reveals a critical role of IRF8 in their differentiation and functions in cancer","volume":"26","author":"Li","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mtbio.2026.103390_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116176","article-title":"Matrix-induced nuclear remodeling and mechano-therapeutics","volume":"44","author":"Lee","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.mtbio.2026.103390_bib64","doi-asserted-by":"crossref","first-page":"eadp3236","DOI":"10.1126\/scitranslmed.adp3236","article-title":"Biselective remodeling of the melanoma tumor microenvironment prevents metastasis and enhances immune activation in mouse models","volume":"17","author":"Afratis","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mtbio.2026.103390_bib65","doi-asserted-by":"crossref","first-page":"7956","DOI":"10.1038\/s41467-024-52230-8","article-title":"IL-2 delivery to CD8(+) T cells during infection requires MRTF\/SRF-dependent gene expression and cytoskeletal dynamics","volume":"15","author":"Maurice","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib66","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200053","article-title":"Mechanosensing through YAP controls T cell activation and metabolism","volume":"217","author":"Meng","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mtbio.2026.103390_bib67","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13046-025-03555-9","article-title":"Bridging innate and adaptive tumor immunity: cgas-sting pathway activation to potentiate immune checkpoint blockade","volume":"44","author":"Li","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib68","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ccell.2025.12.002","article-title":"Targeting STING to generate therapeutic anti-tumor immunity","volume":"44","author":"Fahey","year":"2026","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mtbio.2026.103390_bib69","article-title":"CaMKK2 regulates macrophage polarization induced by matrix stiffness: implications for shaping the immune response in stiffened tissues","volume":"12","author":"Guan","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.mtbio.2026.103390_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106236","article-title":"Matrix stiffness regulates macrophage polarization in atherosclerosis","volume":"179","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib71","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41392-025-02325-5","article-title":"Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.103390_bib72","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-013098","article-title":"Reciprocal regulation of hMENA and TGF-\u03b2 signaling in cancer-associated fibroblasts promotes EMT, immunosuppression, poor prognosis, and ICT resistance in NSCLC","volume":"14","author":"Melchionna","year":"2026","journal-title":"J. ImmunoTher. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib73","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s10555-023-10122-1","article-title":"Helicobacter pylori-activated fibroblasts as a silent partner in gastric cancer development","volume":"42","author":"Krzysiek-Maczka","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.mtbio.2026.103390_bib74","first-page":"1503","article-title":"Overexpression of carbonyl reductase 1 inhibits malignant behaviors and epithelial mesenchymal transition by suppressing TGF-\u03b2 signaling in uterine leiomyosarcoma cells","volume":"18","author":"Kajimura","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.mtbio.2026.103390_bib75","article-title":"Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies","volume":"9","author":"Nishikawa","year":"2021","journal-title":"J. ImmunoTher. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib76","article-title":"Tumor microenvironment heterogeneity and progression mechanisms in intrahepatic cholangiocarcinoma: a study based on single-cell and spatial transcriptomic sequencing","author":"Li","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.mtbio.2026.103390_bib77","doi-asserted-by":"crossref","first-page":"9394","DOI":"10.1038\/s41467-024-53593-8","article-title":"HIF1\u03b1-regulated glycolysis promotes activation-induced cell death and IFN-\u03b3 induction in hypoxic T cells","volume":"15","author":"Shen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib78","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41568-024-00785-5","article-title":"Cross-priming in cancer immunology and immunotherapy","volume":"25","author":"Luri-Rey","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib79","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1021\/acs.analchem.5c05327","article-title":"Orthogonal investigation at single-particle and ensemble levels uncovers lipoprotein-extracellular vesicle binding","volume":"98","author":"Music\u00f2","year":"2026","journal-title":"Anal. Chem."},{"key":"10.1016\/j.mtbio.2026.103390_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217491","article-title":"Tertiary lymphoid structures as a biomarker in immunotherapy and beyond: advancing towards clinical application","volume":"613","author":"Cui","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mtbio.2026.103390_bib81","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s42254-025-00874-w","article-title":"Mechanobiology across timescales","volume":"7","author":"Cheng","year":"2025","journal-title":"Nat. Rev. Phys."},{"key":"10.1016\/j.mtbio.2026.103390_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216583","article-title":"The post-chemotherapy changes of tumor physical microenvironment: targeting extracellular matrix to address chemoresistance","volume":"582","author":"Li","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mtbio.2026.103390_bib83","article-title":"Targeting Tumor physical microenvironment for improved radiotherapy","volume":"6","author":"Wang","year":"2022","journal-title":"Small Methods"},{"key":"10.1016\/j.mtbio.2026.103390_bib84","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ccell.2014.10.006","article-title":"Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia","volume":"26","author":"Jain","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mtbio.2026.103390_bib85","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41565-025-01924-1","article-title":"A collagenase nanogel backpack improves CAR-T cell therapy outcomes in pancreatic cancer","volume":"20","author":"Zhao","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.mtbio.2026.103390_bib86","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846557","article-title":"Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival","volume":"20","author":"Cortes","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mtbio.2026.103390_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114319","article-title":"Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy","volume":"186","author":"Zhang","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.103390_bib88","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz0868","article-title":"Physical traits of cancer","volume":"370","author":"Nia","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2026.103390_bib98","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/nyas.14358","article-title":"Tissue stiffness contributes to YAP activation in bladder cancer patients undergoing transurethral resection","volume":"1473","author":"Ghasemi","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mtbio.2026.103390_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/cells14211707","article-title":"Impact of the ECM on the mechanical memory of cancer cells","volume":"14","author":"Mierke","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.mtbio.2026.103390_bib100","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.crad.2017.04.009","article-title":"Comparison of 3D and 2D shear-wave elastography for differentiating benign and malignant breast masses: focus on the diagnostic performance","volume":"72","author":"Choi","year":"2017","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.mtbio.2026.103390_bib101","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1111\/cas.12720","article-title":"Assessment of elasticity of colorectal cancer tissue, clinical utility, pathological and phenotypical relevance","volume":"106","author":"Kawano","year":"2015","journal-title":"Cancer Sci."},{"key":"10.1016\/j.mtbio.2026.103390_bib102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110588","article-title":"High-resolution mechanical imaging of glioblastoma by multifrequency magnetic resonance elastography","volume":"9","author":"Streitberger","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mtbio.2026.103390_bib103","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41556-023-01126-8","article-title":"Author Correction: tissue mechanics promote IDH1-dependent HIF1\u03b1-tenascin C feedback to regulate glioblastoma aggression","volume":"25","author":"Miroshnikova","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103390_bib104","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1186\/s12885-021-08982-3","article-title":"Inhibition of matrix stiffness relating integrin \u03b21 signaling pathway inhibits tumor growth in vitro and in hepatocellular cancer xenografts","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib105","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1016\/j.bbrc.2017.12.115","article-title":"Regulation of PD-L1 expression by matrix stiffness in lung cancer cells","volume":"495","author":"Miyazawa","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib106","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1164\/rccm.201204-0754OC","article-title":"Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation","volume":"186","author":"Booth","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mtbio.2026.103390_bib107","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2017.54","article-title":"Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells","volume":"6","author":"Rice","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.mtbio.2026.103390_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e20472","article-title":"Diagnostic performance of a new two-dimensional shear wave elastography expression using siemens ultrasound system combined with ACR TI-RADS for classification of benign and malignant thyroid nodules: a prospective multi-center study","volume":"9","author":"Qi","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.mtbio.2026.103390_bib89","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1038\/s41467-020-18794-x","article-title":"Concepts of extracellular matrix remodelling in tumour progression and metastasis","volume":"11","author":"Winkler","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib90","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1038\/s41388-025-03521-x","article-title":"Oncogenic effects of ECM remodeling in obesity and breast cancer","volume":"44","author":"Hawes","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.mtbio.2026.103390_bib91","doi-asserted-by":"crossref","first-page":"39667","DOI":"10.1021\/acsnano.5c10650","article-title":"Programmed cell death protein 1 engagement impairs cytoskeletal forces and nuclear mechanotransduction in T cells","volume":"19","author":"Zhao","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103390_bib92","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.chembiol.2025.11.004","article-title":"Immunity in motion: the role of mechanics in macrophage biology","volume":"32","author":"Khanmohammadi","year":"2025","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.mtbio.2026.103390_bib93","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16071254","article-title":"Tumor-Infiltrating lymphocyte level consistently correlates with lower stiffness measured by shear-wave elastography: Subtype-Specific analysis of its implication in breast cancer","volume":"16","author":"Eun","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mtbio.2026.103390_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnmrs.2024.05.002","article-title":"Magnetic resonance elastography in a nutshell: tomographic imaging of soft tissue viscoelasticity for detecting and staging disease with a focus on inflammation","volume":"144\u2013145","author":"Meyer","year":"2024","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"10.1016\/j.mtbio.2026.103390_bib95","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1073\/pnas.1913511116","article-title":"How tissue fluidity influences brain tumor progression","volume":"117","author":"Streitberger","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mtbio.2026.103390_bib96","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s42254-024-00707-2","article-title":"Mechanical properties of human tumour tissues and their implications for cancer development","volume":"6","author":"Massey","year":"2024","journal-title":"Nat. Rev. Phys."},{"key":"10.1016\/j.mtbio.2026.103390_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105200","article-title":"Boosting antitumor efficacy of nanoparticles by modulating tumor mechanical microenvironment","volume":"105","author":"Zhang","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mtbio.2026.103390_bib109","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1021\/acs.nanolett.4c05199","article-title":"Tunable integrin-ligand coupling strength modulates cellular adaptive mechanosensing","volume":"25","author":"Zhang","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.mtbio.2026.103390_bib110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","article-title":"Integrins as biomechanical sensors of the microenvironment","volume":"20","author":"Kechagia","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103390_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70415","article-title":"Cancer-Associated fibroblasts: origin, classification, tumorigenicity, and targeting for cancer therapy","volume":"6","author":"Fan","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.mtbio.2026.103390_bib112","article-title":"Synergistic chemoimmunotherapy augmentation via sequential nanocomposite Hydrogel-Mediated reprogramming of cancer-associated fibroblasts in Osteosarcoma","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103390_bib113","article-title":"The DAG\/PKC\/CREB1\/TGF-\u03b21 axis drives shear-wave elastography stiffness and malignant progression in triple-negative breast cancer via lipid metabolic reprogramming","volume":"17","author":"Wang","year":"2026","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2026.103390_bib114","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1038\/s41551-025-01396-7","article-title":"ROCK-dependent mechanotransduction of macroscale forces drives fibrosis in degenerative spinal disease","volume":"9","author":"Hadzipasic","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2026.103390_bib115","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-022-00104-y","article-title":"Nanodelivery of nucleic acids","volume":"2","author":"Mendes","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.mtbio.2026.103390_bib116","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101852118","article-title":"An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications","volume":"118","author":"Millul","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mtbio.2026.103390_bib117","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.actbio.2022.03.050","article-title":"Partial ligand shielding nanoparticles improve pancreatic ductal adenocarcinoma treatment via a multifunctional paradigm for tumor stroma reprogramming","volume":"145","author":"Zhao","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103390_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119772","article-title":"Remodeling extracellular matrix based on functional covalent organic framework to enhance tumor photodynamic therapy","volume":"234","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103390_bib119","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40164-025-00691-y","article-title":"Targeting collagen to optimize cancer immunotherapy","volume":"14","author":"Wang","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.mtbio.2026.103390_bib120","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jconrel.2022.10.017","article-title":"HPMA copolymer-collagen hybridizing peptide conjugates targeted to breast tumor extracellular matrix","volume":"353","author":"Subrahmanyam","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103390_bib121","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1158\/0008-5472.CAN-13-2990","article-title":"Curative properties of noninternalizing antibody-drug conjugates based on maytansinoids","volume":"74","author":"Perrino","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib122","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1039\/D4NA00823E","article-title":"Binding affinity and transport studies of engineered photocrosslinkable affibody-enzyme-nanoparticle constructs","volume":"7","author":"Curry","year":"2025","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.mtbio.2026.103390_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142486","article-title":"Hyaluronic acid-functionalized nanomedicines for CD44-receptors-mediated targeted cancer therapy: a review of selective targetability and biodistribution to tumor microenvironment","volume":"308","author":"Al Jayoush","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103390_bib124","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202204283","article-title":"Colloidal polyelectrolyte complexes from hyaluronic acid: preparation and biomedical applications","volume":"18","author":"Le","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.103390_bib125","doi-asserted-by":"crossref","first-page":"11517","DOI":"10.1021\/acsnano.4c16280","article-title":"Engineered cell membrane coating technologies for biomedical applications: from nanoscale to macroscale","volume":"19","author":"An","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103390_bib126","article-title":"Stealth missiles with precision guidance: a novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology","volume":"33","author":"Zhou","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103390_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114367","article-title":"Enhancing TIM-3 immunotherapy with epirubicin-loaded pH sensitive fusion membrane nanoparticles for effective glioblastoma treatment","volume":"388","author":"Zhu","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103390_bib128","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.apsb.2022.05.010","article-title":"Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy","volume":"13","author":"Liu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2026.103390_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2025.102877","article-title":"Overcoming the p-EMT-mediated stromal barrier at the tumor periphery with hybrid membrane-camouflaged nanoplatform for enhanced chemotherapy","volume":"65","author":"Liu","year":"2025","journal-title":"Nano Today"},{"key":"10.1016\/j.mtbio.2026.103390_bib130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.912029","article-title":"Quercetin alleviates pulmonary fibrosis in mice exposed to Silica by inhibiting macrophage senescence","volume":"13","author":"Geng","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103390_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107799","article-title":"Pharmacological mechanisms and drug delivery systems of ginsenoside Rg3: a comprehensive review","volume":"216","author":"Yao","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib132","first-page":"126","article-title":"CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer, Bioact","volume":"54","author":"Liu","year":"2025","journal-title":"Mater"},{"key":"10.1016\/j.mtbio.2026.103390_bib133","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/tox.22899","article-title":"Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non-small cell lung cancer cells","volume":"35","author":"Tan","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.mtbio.2026.103390_bib134","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1248\/bpb.b14-00603","article-title":"Stereoisomer-specific anticancer activities of ginsenoside Rg3 and Rh2 in HepG2 cells: disparity in cytotoxicity and autophagy-inducing effects due to 20(S)-epimers","volume":"38","author":"Cheong","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.mtbio.2026.103390_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132626","article-title":"Optimization and mechanisms of proteolytic enzyme immobilization onto large-pore mesoporous silica nanoparticles: enhanced tumor penetration","volume":"271","author":"Qiu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103390_bib136","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007","article-title":"Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma","volume":"21","author":"Provenzano","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mtbio.2026.103390_bib137","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/gutjnl-2012-302529","article-title":"Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer","volume":"62","author":"Jacobetz","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2026.103390_bib138","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1021\/acsnano.9b02395","article-title":"Collagenase nanoparticles enhance the penetration of drugs into pancreatic tumors","volume":"13","author":"Zinger","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103390_bib139","doi-asserted-by":"crossref","first-page":"173","DOI":"10.34133\/bmr.0173","article-title":"Nanotension relief agent enhances tissue penetration by reducing solid stress in pancreatic ductal adenocarcinoma via Rho\/ROCK pathway inhibition","volume":"29","author":"Yu","year":"2025","journal-title":"Biomater. Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib140","doi-asserted-by":"crossref","first-page":"61583","DOI":"10.1021\/acsami.4c10404","article-title":"Stromal reprogramming optimizes KRAS-Specific chemotherapy inducing antitumor immunity in pancreatic cancer","volume":"16","author":"Hu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2026.103390_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2025.149954","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases as the biomarkers of Alzheimer's disease: a meta-analysis","volume":"1869","author":"Mak","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.mtbio.2026.103390_bib142","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1080\/10408398.2024.2438408","article-title":"Microbial collagenases: an updated review on their characterization, degradation mechanisms, and current applications","volume":"65","author":"Gao","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.mtbio.2026.103390_bib143","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/cac2.12392","article-title":"Signaling pathways in cancer-associated fibroblasts: recent advances and future perspectives","volume":"43","author":"Fang","year":"2023","journal-title":"Cancer Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib144","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1039\/D5MH00927H","article-title":"Reimagining drug nanocarriers: clinical realities and smarter strategies for targeted drug delivery","volume":"12","author":"Baker","year":"2025","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.mtbio.2026.103390_bib145","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.omtn.2016.12.008","article-title":"Silencing of carbohydrate sulfotransferase 15 hinders Murine pulmonary Fibrosis development","volume":"6","author":"Kai","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.mtbio.2026.103390_bib146","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.543","article-title":"miR-1246 promotes osteosarcoma cell migration via NamiRNA-enhancer network dependent on Argonaute 2","volume":"5","author":"Yang","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.mtbio.2026.103390_bib147","article-title":"Ultrasound-activated miR-195-5p\/shikonin nanobubbles remodel immunosuppressive microenvironment via immunogenic cell death to potentiate PD-1\/PD-L1 blockade in hepatocellular carcinoma, Mater","volume":"34","author":"Tan","year":"2025","journal-title":"Today Bio"},{"key":"10.1016\/j.mtbio.2026.103390_bib148","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.actbio.2017.01.003","article-title":"Efficient tuning of siRNA dose response by combining mixed polymer nanocarriers with simple kinetic modeling","volume":"50","author":"Greco","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103390_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113782","article-title":"Smart on-demand drug release strategies for cancer combination therapy","volume":"383","author":"Huang","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103390_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120574","article-title":"Tumor microenvironment triple-responsive nanoparticles enable enhanced tumor penetration and synergetic chemo-photodynamic therapy","volume":"268","author":"Shu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103390_bib151","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12951-025-03134-2","article-title":"Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification","volume":"23","author":"Gong","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103390_bib152","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1021\/acsnano.5c18112","article-title":"The biology of endosomal escape: strategies for enhanced delivery of therapeutics","volume":"20","author":"Chahal","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103390_bib153","article-title":"Fatty acid oxidation-glycolysis metabolic transition affects ECM homeostasis in Silica-Induced pulmonary fibrosis","volume":"12","author":"Sun","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.mtbio.2026.103390_bib154","article-title":"Softness-Aided mild hyperthermia boosts stiff nanomedicine by regulating tumor mechanics","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.mtbio.2026.103390_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.137829","article-title":"Cyclized polyacrylonitrile nanoparticles: enhanced intratumoral delivery by photocatalysis and collagen denaturation","volume":"696","author":"Xu","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2026.103390_bib156","article-title":"Dual strategy of Ca(2+) influx and collagen denaturation to remodel the extracellular matrix and amplify sonopiezoelectric therapy","volume":"37","author":"Yu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103390_bib157","doi-asserted-by":"crossref","first-page":"27957","DOI":"10.1021\/acsnano.5c10591","article-title":"Focused acoustic vortex-activated dual-stimuli nanoplatform synergizes with checkpoint blockade to enhance macrophage phagocytosis and antitumor immunity","volume":"19","author":"Li","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103390_bib158","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1039\/D1NA00474C","article-title":"Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields","volume":"4","author":"Lopez","year":"2022","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.mtbio.2026.103390_bib159","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jconrel.2024.10.061","article-title":"Spatiotemporally cascade-driven \"Lipo(micelles)\" enhance extracellular matrix penetration and remodel intercellular crosstalk in pulmonary fibrosis","volume":"376","author":"Chang","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103390_bib160","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12951-025-03951-5","article-title":"CXCR4-engineered fibroblast membrane nanovesicles for Photothermal-enhanced ferroptotic therapy through chemokine-navigated tumor homing","volume":"24","author":"Bai","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103390_bib161","article-title":"Combinatorial leaky probiotic for anticancer immunopotentiation and tumor eradication","volume":"5","author":"Liu","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.mtbio.2026.103390_bib162","doi-asserted-by":"crossref","first-page":"18643","DOI":"10.1021\/acsami.4c02363","article-title":"Study of the synergistic immunomodulatory and antifibrotic effects of dual-loaded budesonide and Serpine1 siRNA lipid-polymer nanoparticles targeting macrophage dysregulation in tendinopathy","volume":"16","author":"L\u00f3pez-Cerd\u00e1","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2026.103390_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.163837","article-title":"Ultrasound-mediated FAK-targeted nano-sapper for tumor extracellular matrix remodeling to potentiate cancer immunotherapy","volume":"515","author":"Huang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.mtbio.2026.103390_bib174","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1186\/s12951-024-02968-6","article-title":"A collagenase-decorated Cu-based nanotheranostics: remodeling extracellular matrix for optimizing cuproptosis and MRI in pancreatic ductal adenocarcinoma","volume":"22","author":"Wang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103390_bib175","article-title":"A polymeric nanovesicle delivers sulfopin and gemcitabine to remodel tumor microenvironment for enhanced chemoimmunotherapy against orthotopic pancreatic cancer, Mater","volume":"34","author":"Jiang","year":"2025","journal-title":"Today Bio"},{"key":"10.1016\/j.mtbio.2026.103390_bib176","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1186\/s12951-024-02871-0","article-title":"Losartan-based nanocomposite hydrogel overcomes chemo-immunotherapy resistance by remodeling tumor mechanical microenvironment","volume":"22","author":"Hou","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103390_bib165","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.scib.2025.02.005","article-title":"Engineered platelets-based nano-aircraft system for precise tumor chemo-immunotherapy with graded drug delivery and self-recognized tumor targeting","volume":"70","author":"Geng","year":"2025","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.mtbio.2026.103390_bib166","first-page":"287","article-title":"Synergistic therapy for pancreatic cancer by deactivating cancer-associated fibroblasts and driving T-cell migration into tumor microenvironment using nanochaperone delivery system","volume":"52","author":"Chen","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103390_bib167","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.7150\/thno.114892","article-title":"Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming","volume":"15","author":"Shen","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103390_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102447","article-title":"Bioinspired Hf-based metal-organic framework radiosensitizer for nitric oxide-assisted radio-immunotherapy","volume":"58","author":"Li","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.mtbio.2026.103390_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2025.214677","article-title":"Targeted nanotheranostics mitigates radiation-induced fibrosis to promote immune infiltration and enhance radio-chemotherapy in pancreatic ductal adenocarcinoma","volume":"182","author":"Sabu","year":"2026","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.mtbio.2026.103390_bib170","article-title":"Mitochondria energy metabolism depression as novel adjuvant to sensitize radiotherapy and inhibit radiation induced-pulmonary fibrosis","volume":"11","author":"Zhou","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.mtbio.2026.103390_bib171","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1021\/acsnano.2c10845","article-title":"Extracellular Matrix Viscosity Reprogramming by In Situ Au Bioreactor-Boosted Microwavegenetics Disables Tumor Escape in CAR-T Immunotherapy","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103390_bib177","article-title":"Heat-inducible CAR-T overcomes adverse mechanical tumor microenvironment in a 3D bioprinted glioblastoma model","volume":"26","author":"Tang","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103390_bib178","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1038\/s41467-025-57718-5","article-title":"Supramolecular polyrotaxane-based nano-theranostics enable cancer-cell stiffening for enhanced T-cell-mediated anticancer immunotherapy","volume":"16","author":"Luo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103390_bib163","article-title":"Ultrahigh enzyme loading metal-organic frameworks for deep tissue pancreatic cancer photoimmunotherapy","volume":"20","author":"Liu","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.103390_bib172","doi-asserted-by":"crossref","first-page":"40535","DOI":"10.1021\/acsami.2c08951","article-title":"Collagenase-Loaded H-TiO(2) nanoparticles enhance ultrasound imaging-guided sonodynamic therapy in a pancreatic carcinoma xenograft model via digesting stromal barriers","volume":"14","author":"Luo","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2026.103390_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121992","article-title":"Cleavable collagenase-assistant nanosonosensitizer for tumor penetration and sonodynamic therapy","volume":"293","author":"Yin","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103390_bib179","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/s43018-025-01039-5","article-title":"Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity","volume":"6","author":"Han","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.mtbio.2026.103390_bib180","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1200\/JCO.20.00590","article-title":"Randomized phase III trial of pegvorhyaluronidase alfa with nab-paclitaxel plus gemcitabine for patients with Hyaluronan-High metastatic pancreatic adenocarcinoma","volume":"38","author":"Van Cutsem","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.mtbio.2026.103390_bib181","article-title":"Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2","volume":"5","author":"Bell","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.mtbio.2026.103390_bib182","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/s12967-022-03768-y","article-title":"Biological role of matrix stiffness in tumor growth and treatment","volume":"20","author":"Deng","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mtbio.2026.103390_bib183","doi-asserted-by":"crossref","first-page":"24654","DOI":"10.1021\/acsnano.3c03305","article-title":"Pirfenidone-Loaded polymeric micelles as an effective mechanotherapeutic to potentiate immunotherapy in mouse tumor models","volume":"17","author":"Mpekris","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103390_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2026.115862","article-title":"Towards clinical translation of nanomedicines: formulation scale-up and model systems","volume":"234","author":"Kelly","year":"2026","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.103390_bib185","article-title":"A journey of challenges and victories: a bibliometric worldview of nanomedicine since the 21st century","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426006356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426006356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:52:23Z","timestamp":1787025143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426006356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":185,"alternative-id":["S2590006426006356"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103390","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanomedicine targeting ECM stiffness: restoring mechanical homeostasis for cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103390","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103390"}}