{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:46:46Z","timestamp":1788515206279,"version":"build-2803163510"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008582","name":"McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014131","name":"McGill University Health Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Quebec Health Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mtbio.2026.103395","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:00:33Z","timestamp":1782284433000},"page":"103395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Inorganic materials to prevent liquefactive necrosis and improve wound healing: A role of infection control across ischemic models"],"prefix":"10.1016","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-4362","authenticated-orcid":false,"given":"Ayden","family":"Watt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Dalisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin chandra teja","family":"Dadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1659-853X","authenticated-orcid":false,"given":"Sze Wai","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyue","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaifa","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Shash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n Eduardo N\u00fa\u00f1ez","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-6326","authenticated-orcid":false,"given":"Michael","family":"Tanzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Jaloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Vorstenbosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-0773","authenticated-orcid":false,"given":"Kevin","family":"Watters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Makhoul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Gilardino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3543-6042","authenticated-orcid":false,"given":"Jake","family":"Barralet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103395_bib1","series-title":"Statpearls, Statpearls Publishing Copyright \u00a9 2023","article-title":"Anatomy, skin (Integument)","author":"Lopez-Ojeda","year":"2023"},{"issue":"10","key":"10.1016\/j.mtbio.2026.103395_bib2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic wound healing: a review of current management and treatments","volume":"34","author":"Han","year":"2017","journal-title":"Adv. Ther."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103395_bib5","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1440-1681.2008.04934.x","article-title":"Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds","volume":"35","author":"Gordillo","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13643-016-0329-y","article-title":"Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review","volume":"5","author":"J\u00e4rbrink","year":"2016","journal-title":"Syst. Rev."},{"key":"10.1016\/j.mtbio.2026.103395_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev Cell Mol Biol"},{"key":"10.1016\/j.mtbio.2026.103395_bib9","series-title":"Necrosis. in Statpearls, Statpearls Publishing Copyright \u00a9 2025","author":"Khalid","year":"2025"},{"issue":"4","key":"10.1016\/j.mtbio.2026.103395_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cjtee.2017.06.001","article-title":"The molecular biology in wound healing & non-healing wound","volume":"20","author":"Qing","year":"2017","journal-title":"Chin. J. Traumatol. (Engl. Ed.)"},{"issue":"6","key":"10.1016\/j.mtbio.2026.103395_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1524-475X.2006.00177.x","article-title":"Guidelines for the treatment of arterial insufficiency ulcers","volume":"14","author":"Hopf","year":"2006","journal-title":"Wound Repair Regen."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103395_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/1534734609335149","article-title":"Evidence-based recommendations for the use of topical oxygen therapy in the treatment of lower extremity wounds","volume":"8","author":"Gordillo","year":"2009","journal-title":"Int. J. Low. Extrem. Wounds"},{"issue":"31","key":"10.1016\/j.mtbio.2026.103395_bib13","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1016\/j.biomaterials.2007.07.003","article-title":"Oxygen producing biomaterials for tissue regeneration","volume":"28","author":"Harrison","year":"2007","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.mtbio.2026.103395_bib14","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/wrr.12324","article-title":"Peroxide-based oxygen generating topical wound dressing for enhancing healing of dermal wounds","volume":"23","author":"Chandra","year":"2015","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.mtbio.2026.103395_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125081","article-title":"Sprayable alginate hydrogel dressings with oxygen production and exosome loading for the treatment of diabetic wounds","volume":"242","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103395_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113325","article-title":"Natural and biocompatible dressing unit based on tea carbon dots modified core-shell electrospun fiber for diabetic wound disinfection and healing","volume":"226","author":"Dong","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.mtbio.2026.103395_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtadv.2023.100458","article-title":"Electron irradiation of zein protein-loaded nano CaO2\/CD for enhancing infectious diabetic wounds with adaptive hydrophobicity-to-hydrophilicity","volume":"21","author":"Zhou","year":"2024","journal-title":"Materials. Today. Advances"},{"issue":"16","key":"10.1016\/j.mtbio.2026.103395_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303314","article-title":"Calcium peroxide-based hydrogel patch with sustainable oxygenation for diabetic wound healing","volume":"13","author":"Li","year":"2024","journal-title":"Adv. Healthcare. Mater."},{"issue":"32","key":"10.1016\/j.mtbio.2026.103395_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301984","article-title":"Hypoxic microenvironment reconstruction with synergistic biofunctional ions promotes diabetic wound healing","volume":"12","author":"Chen","year":"2023","journal-title":"Adv. Healthcare. Mater."},{"issue":"46","key":"10.1016\/j.mtbio.2026.103395_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202404538","article-title":"Oxygen-propelled dual-modular microneedles with dopamine-enhanced RNA delivery for regulating each stage of diabetic wounds","volume":"20","author":"Ran","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.103395_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.123051","article-title":"An injectable in situ-forming hydrogel with self-activating genipin-chitosan (GpCS) cross-linking and an O2\/Ca2+ self-supplying capability for wound healing and rapid hemostasis","volume":"351","author":"Lin","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.mtbio.2026.103395_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.131670","article-title":"Poly (vinyl alcohol)\/sodium alginate\/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing","volume":"268","author":"Chai","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103395_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115156","article-title":"A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for diabetic wound healing","volume":"165","author":"Ullah","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"18","key":"10.1016\/j.mtbio.2026.103395_bib24","doi-asserted-by":"crossref","DOI":"10.1021\/acsanm.4c02549","article-title":"Combination strategy of two hydrogels loaded with prussian blue nanoparticles and calcium peroxide separately for diabetic wound repair","volume":"7","author":"Chai","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.mtbio.2026.103395_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120020","article-title":"Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing","volume":"249","author":"Shiekh","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103395_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jiec.2018.09.048","article-title":"Oxygen-generating alginate hydrogels as a bioactive acellular matrix for facilitating wound healing","volume":"69","author":"Kang","year":"2019","journal-title":"J. Ind. Eng. Chem."},{"key":"10.1016\/j.mtbio.2026.103395_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213519","article-title":"Necrosis reduction efficacy of subdermal biomaterial mediated oxygen delivery in ischemic skin flaps","volume":"153","author":"Ouhaddi","year":"2023","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.mtbio.2026.103395_bib28","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.actbio.2022.04.004","article-title":"Aqueous decomposition behavior of solid peroxides: effect of pH and buffer composition on oxygen and hydrogen peroxide formation","volume":"145","author":"Rastinfard","year":"2022","journal-title":"Acta Biomater."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103395_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202000094","article-title":"Effects of oxygen and glucose on bone marrow mesenchymal stem cell culture","volume":"4","author":"Lau","year":"2020","journal-title":"Adv. Biosyst."},{"issue":"21","key":"10.1016\/j.mtbio.2026.103395_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201701338","article-title":"Preservation of blood vessels with an oxygen generating composite","volume":"7","author":"Zhang","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103395_bib31","doi-asserted-by":"crossref","unstructured":"G. McDonnell, The use of hydrogen peroxide for disinfection and sterilization applications. In Patai's Chemistry of Functional Groups, pp 1.","DOI":"10.1002\/9780470682531.pat0885"},{"issue":"8","key":"10.1016\/j.mtbio.2026.103395_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/anbr.202500045","article-title":"Comparative antimicrobial properties of sodium borate and carbonate and their perborate and percarbonate counterparts","volume":"5","author":"Watt","year":"2025","journal-title":"Advanced NanoBiomed Research"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1524-475X.2008.00436.x","article-title":"Wound healing essentials: let there be oxygen","volume":"17","author":"Sen","year":"2009","journal-title":"Wound Repair Regen."},{"issue":"7","key":"10.1016\/j.mtbio.2026.103395_bib34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.it.2019.05.001","article-title":"The healing power of neutrophils","volume":"40","author":"Phillipson","year":"2019","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103395_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3390\/jfb14040213","article-title":"In vivo assessment of the apatite-forming ability of new-generation hydraulic calcium silicate cements using a rat subcutaneous implantation model","volume":"14","author":"Edanami","year":"2023","journal-title":"J. Funct. Biomater."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103395_bib36","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.joen.2007.07.008","article-title":"Calcium phosphate phase transformation produced by the interaction of the portland cement component of white mineral trioxide aggregate with a phosphate-containing fluid","volume":"33","author":"Tay","year":"2007","journal-title":"J. Endod."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib37","article-title":"Nano-thick calcium oxide armed titanium: boosts bone cells against methicillin-resistant Staphylococcus aureus","volume":"6","author":"Cao","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103395_bib38","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1590\/1678-775720140049","article-title":"Analysis of the reaction of subcutaneous tissues in rats and the antimicrobial activity of calcium hydroxide paste used in association with different substances","volume":"23","author":"Midena","year":"2015","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.mtbio.2026.103395_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.114067","article-title":"Calcium sulfate-magnesium oxide composites for antimicrobial and pro-osteogenic bone grafting materials","volume":"254","author":"Hu","year":"2025","journal-title":"Mater. Des."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103395_bib40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1582-4934.2003.tb00216.x","article-title":"Mast cells in tissue response to dentistry materials: an adhesive resin, a calcium hydroxide and a glass ionomer cement","volume":"7","author":"Mussel","year":"2003","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mtbio.2026.103395_bib41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2298\/SARH151214012N","article-title":"A histological evaluation of bone tissue response to a sealer based on calcium hydroxide: an experimental study","volume":"145","author":"Nikolic","year":"2017","journal-title":"Srp. Arh. Celok. Lek."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103395_bib42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1034\/j.1600-0501.1997.080504.x","article-title":"The effect of a calcium hydroxide paste on wound healing and osseointegration of dental implants. A pilot study in beagle dogs","volume":"8","author":"Kohal","year":"1997","journal-title":"Clin. Oral Implants Res."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103395_bib43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-9657.1988.tb00314.x","article-title":"Solubility and biocompatibility of calcium hydroxide-containing root canal sealers","volume":"4","author":"Tronstad","year":"1988","journal-title":"Endod. Dent. Traumatol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2672.1983.tb02637.x","article-title":"The bactericidal, fungicidal and sporicidal properties of hydrogen peroxide and peracetic acid","volume":"54","author":"Baldry","year":"1983","journal-title":"J. Appl. Bacteriol."},{"issue":"4 Pt 1","key":"10.1016\/j.mtbio.2026.103395_bib45","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0016-5107(99)70055-6","article-title":"Clinical usefulness of 3% hydrogen peroxide in acute upper GI bleeding: a pilot study","volume":"49","author":"Kalloo","year":"1999","journal-title":"Gastrointest. Endosc."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103395_bib46","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.freeradbiomed.2010.07.015","article-title":"Cytotoxic potency of H2O2 in cell cultures: impact of cell concentration and exposure time","volume":"49","author":"G\u00fclden","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103395_bib47","doi-asserted-by":"crossref","DOI":"10.1097\/SAP.0000000000002919","article-title":"Standardization of the rat dorsal random pattern (McFarlane) flap model and evaluation of the pharmacological agents aiming to salvage partial flap necrosis: a systematic review and a meta-analysis","volume":"87","author":"\u00dcst\u00fcn","year":"2021","journal-title":"Ann. Plast. Surg."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-39722-1","article-title":"A new fasciocutaneous flap model identifies a critical role for endothelial notch signaling in wound healing and flap survival","volume":"13","author":"Dastagir","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2026.103395_bib49","series-title":"Gangrene. in Statpearls, Statpearls Publishing Copyright \u00a9 2025","author":"Buttolph","year":"2025"},{"issue":"9","key":"10.1016\/j.mtbio.2026.103395_bib50","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.bjps.2009.08.011","article-title":"A new design of a dorsal flap in the rat to study skin necrosis and its prevention","volume":"63","author":"Kelly","year":"2010","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103395_bib51","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.3390\/ijms23095234","article-title":"Current status of experimental animal skin flap models: ischemic preconditioning and molecular factors","volume":"23","author":"Lee","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7536","key":"10.1016\/j.mtbio.2026.103395_bib52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/bmj.332.7536.285","article-title":"Wound assessment","volume":"332","author":"Grey","year":"2006","journal-title":"Bmj"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103395_bib53","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/wrr.12996","article-title":"Animal experimental models of ischemic wounds \u2013 a review of literature","volume":"30","author":"Lovasova","year":"2022","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib54","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2020-001676","article-title":"Animal models of ischemic limb ulcers: a systematic review and meta-analysis","volume":"8","author":"Thanigaimani","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1016\/j.mtbio.2026.103395_bib55","first-page":"35","article-title":"Ischemic skin wound healing models in rats","volume":"13","author":"Blalock","year":"2001","journal-title":"Wounds"},{"key":"10.1016\/j.mtbio.2026.103395_bib56","series-title":"Statpearls, Statpearls Publishing Copyright \u00a9 2025","article-title":"Cell liquefactive necrosis","author":"Adigun","year":"2025"},{"issue":"11\u201312","key":"10.1016\/j.mtbio.2026.103395_bib57","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1007\/s00018-016-2206-1","article-title":"The interplay between regulated necrosis and bacterial infection","volume":"73","author":"Bl\u00e9riot","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"22","key":"10.1016\/j.mtbio.2026.103395_bib58","doi-asserted-by":"crossref","DOI":"10.1021\/acsami.8b01736","article-title":"Oxygen-releasing antioxidant cryogel scaffolds with sustained oxygen delivery for tissue engineering applications","volume":"10","author":"Shiekh","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib59","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/0300060514541826","article-title":"A dissolved oxygen dressing: a pilot study in an ischemic skin flap model","volume":"43","author":"Zellner","year":"2015","journal-title":"J. Int. Med. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib60","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00000637-199001000-00004","article-title":"Effects of ischemia on ulcer wound healing: a new model in the rabbit ear","volume":"24","author":"Ahn","year":"1990","journal-title":"Ann. Plast. Surg."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.wndm.2018.12.001","article-title":"Wound healing models: a systematic review of animal and non-animal models","volume":"24","author":"Sami","year":"2019","journal-title":"Wound Medicine"},{"issue":"98","key":"10.1016\/j.mtbio.2026.103395_bib62","doi-asserted-by":"crossref","DOI":"10.3791\/52637","article-title":"Demonstration of the rat ischemic skin wound model","author":"Trujillo","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.mtbio.2026.103395_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000386263","article-title":"Some aspects of the repair process in mammals","volume":"2","author":"Russell","year":"1962","journal-title":"Prog. Surg."},{"issue":"Pt 1","key":"10.1016\/j.mtbio.2026.103395_bib64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/icb.1982.5","article-title":"Wound contraction. The effects of scab formation and the nature of the wound bed","volume":"60","author":"Snowden","year":"1982","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib65","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1002\/mba2.75","article-title":"Comparison of antimicrobial properties of inorganic peroxide polymer composites","volume":"3","author":"Job","year":"2024","journal-title":"MedComm \u2013 Biomaterials and Applications"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib66","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4068\/cmj.2012.48.3.133","article-title":"Antimicrobial activity of calcium hydroxide in endodontics: a review","volume":"48","author":"Mohammadi","year":"2012","journal-title":"Chonnam Med. J."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib67","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41522-024-00569-7","article-title":"Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms","volume":"10","author":"Bankar","year":"2024","journal-title":"npj Biofilms Microbiomes"},{"issue":"12","key":"10.1016\/j.mtbio.2026.103395_bib68","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/00004770-200112000-00013","article-title":"Antimicrobial activity of several calcium hydroxide preparations in root canal dentin","volume":"27","author":"Behnen","year":"2001","journal-title":"J. Endod."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib69","doi-asserted-by":"crossref","first-page":"303","DOI":"10.14744\/eej.2021.97658","article-title":"Cytotoxicity and genotoxicity of calcium hydroxide and two antibiotic pastes on human stem cells of the apical papilla","volume":"6","author":"Jamshidi","year":"2021","journal-title":"Eur Endod J."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib70","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1038\/s41598-025-86401-4","article-title":"Calcium hydroxide nanoparticles induce cell death, genomic instability, oxidative stress and apoptotic gene dysregulation on human HepG2 cells","volume":"15","author":"Mohamed","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2026.103395_bib71","series-title":"Histology, Tooth. in Statpearls, Statpearls Publishing Copyright \u00a9 2025","author":"Farci","year":"2025"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103395_bib72","doi-asserted-by":"crossref","first-page":"788","DOI":"10.2741\/e286","article-title":"Dental pulp and dentin tissue engineering and regeneration: advancement and challenge","volume":"3","author":"Huang","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.mtbio.2026.103395_bib73","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad059","article-title":"The role of the skin microbiome in wound healing","volume":"12","author":"Yang","year":"2024","journal-title":"Burns Trauma"},{"issue":"5","key":"10.1016\/j.mtbio.2026.103395_bib74","first-page":"565","article-title":"Systematics, diagnosis and treatment of wound infections in chronic wounds: a position paper from WundDACH","volume":"23","author":"Dissemond","year":"2025","journal-title":"J. Dtsch. Dermatol. Ges."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103395_bib75","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41590-020-0721-6","article-title":"The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin","volume":"21","author":"Di Domizio","year":"2020","journal-title":"Nat. Immunol."},{"issue":"27","key":"10.1016\/j.mtbio.2026.103395_bib76","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1073\/pnas.1802165115","article-title":"Commensal pathogen competition impacts host viability","volume":"115","author":"Fast","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib77","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03300-22","article-title":"Cutaneous surgical wounds have distinct microbiomes from intact skin","volume":"11","author":"Gupta","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103395_bib78","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.chom.2017.11.001","article-title":"Coagulase-negative staphylococcal strain prevents Staphylococcus aureus colonization and skin infection by blocking quorum sensing","volume":"22","author":"Paharik","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mtbio.2026.103395_bib79","first-page":"5","article-title":"Acidic environment and wound healing: a review","volume":"27","author":"Nagoba","year":"2015","journal-title":"Wounds: a compendium of clinical research and practice"},{"issue":"9","key":"10.1016\/j.mtbio.2026.103395_bib80","first-page":"1159","article-title":"The role of oxygen in wound healing: a review of the literature","volume":"34","author":"Rodriguez","year":"2008","journal-title":"Dermatol. Surg."},{"issue":"1\u20132","key":"10.1016\/j.mtbio.2026.103395_bib81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/iep.12346","article-title":"Experimental models and methods for cutaneous wound healing assessment","volume":"101","author":"Masson-Meyers","year":"2020","journal-title":"Int. J. Exp. Pathol."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103395_bib82","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0022-4804(84)90213-0","article-title":"Wound closure: an analysis of the relative contributions of contraction and epithelialization","volume":"37","author":"Snowden","year":"1984","journal-title":"J. Surg. Res."},{"issue":"Pt 2","key":"10.1016\/j.mtbio.2026.103395_bib83","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/icb.1981.16","article-title":"Wound contraction. A quantitative interpretation","volume":"59","author":"Snowden","year":"1981","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"issue":"7","key":"10.1016\/j.mtbio.2026.103395_bib84","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41419-022-05066-3","article-title":"Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2026.103395_bib85","series-title":"Statpearls, Statpearls Publishing Copyright \u00a9 2025","article-title":"Necrosis pathology","author":"Khalid","year":"2025"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103395_bib86","article-title":"The pH of wounds during healing and infection: a descriptive literature review","volume":"25","author":"Louisa","year":"2017","journal-title":"Wound Practice and Research"},{"issue":"7","key":"10.1016\/j.mtbio.2026.103395_bib87","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/wound.2014.0538","article-title":"The effect of pH on the extracellular matrix and biofilms","volume":"4","author":"Jones","year":"2015","journal-title":"Adv. Wound Care"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib88","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.molmed.2013.11.005","article-title":"Proteases: common culprits in human skin disorders","volume":"20","author":"de Veer","year":"2014","journal-title":"Trends Mol. Med."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103395_bib89","article-title":"Protease activity as a prognostic factor for wound healing in venous leg ulcers","volume":"9","author":"Westby","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103395_bib90","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1089\/wound.2012.0370","article-title":"Proteases and delayed wound healing","volume":"2","author":"McCarty","year":"2013","journal-title":"Adv. Wound Care"},{"issue":"7","key":"10.1016\/j.mtbio.2026.103395_bib91","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1001\/archsurg.137.7.822","article-title":"A randomized, controlled trial of promogran (a Collagen\/Oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers","volume":"137","author":"Veves","year":"2002","journal-title":"Arch. Surg."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib92","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1038\/s41467-025-58175-w","article-title":"Ferroptosis spreads to neighboring cells via plasma membrane contacts","volume":"16","author":"Roeck","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103395_bib93","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.jid.2025.06.1289","article-title":"Emerging roles of ferroptosis in skin pathophysiology","volume":"145","author":"Reznik","year":"2025","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103395_bib94","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib95","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0041-1731460","article-title":"Updates in diabetic wound healing, inflammation, and scarring","volume":"35","author":"Dasari","year":"2021","journal-title":"Semin. Plast. Surg."},{"issue":"7","key":"10.1016\/j.mtbio.2026.103395_bib96","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jid.2023.11.024","article-title":"Modeling wound chronicity in vivo: the translational challenge to capture the complexity of chronic wounds","volume":"144","author":"Pignet","year":"2024","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib97","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0041-1731791","article-title":"Wound healing: a comprehensive review","volume":"35","author":"Almadani","year":"2021","journal-title":"Semin. Plast. Surg."},{"key":"10.1016\/j.mtbio.2026.103395_bib98","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1002\/mba2.75","article-title":"Comparison of antimicrobial properties of inorganic peroxide polymer composites","volume":"3","author":"Job","year":"2024","journal-title":"MedComm \u2013 Biomaterials and Applications"},{"issue":"63","key":"10.1016\/j.mtbio.2026.103395_bib99","doi-asserted-by":"crossref","DOI":"10.3791\/3341","article-title":"A simplified technique for producing an ischemic wound model","author":"Chien","year":"2012","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.mtbio.2026.103395_bib101","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1089\/scd.2021.0124","article-title":"Histology scoring system for murine cutaneous wounds","volume":"30","author":"van de Vyver","year":"2021","journal-title":"Stem Cell. Dev."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103395_bib102","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/wrr.12845","article-title":"Rapid detection of biofilm with modified alcian blue staining: In-vitro protocol improvement and validation with clinical cases","volume":"28","author":"Wu","year":"2020","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103395_bib103","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/wrr.12505","article-title":"Biofilm detection by wound blotting can predict slough development in pressure ulcers: a prospective observational study","volume":"25","author":"Nakagami","year":"2017","journal-title":"Wound Repair Regen."},{"issue":"Sup4","key":"10.1016\/j.mtbio.2026.103395_bib104","doi-asserted-by":"crossref","DOI":"10.12968\/jowc.2021.30.Sup4.S4","article-title":"Concurrent validity of biofilm detection by wound blotting on hard-to-heal wounds","volume":"30","author":"Astrada","year":"2021","journal-title":"J. Wound Care"},{"issue":"5","key":"10.1016\/j.mtbio.2026.103395_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051200","article-title":"Point-of-Care wound blotting with alcian blue grading versus fluorescence imaging for biofilm detection and predicting 90-Day healing outcomes","volume":"10","author":"Wu","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103395_bib106","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/00045632211050531","article-title":"Best practice in statistics: the use of log transformation","volume":"59","author":"West","year":"2022","journal-title":"Ann. Clin. Biochem."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642600640X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642600640X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:11:35Z","timestamp":1787026295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259000642600640X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":105,"alternative-id":["S259000642600640X"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103395","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inorganic materials to prevent liquefactive necrosis and improve wound healing: A role of infection control across ischemic models","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103395"}}