{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:30:18Z","timestamp":1787027418998,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mtbio.2026.103423","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:43:11Z","timestamp":1783752191000},"page":"103423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeted HA@Que-Mn nanozymes alleviate postherpetic neuralgia by modulating neuroinflammation"],"prefix":"10.1016","volume":"39","author":[{"given":"Yike","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2570-3792","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103423_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mtbio.2026.103423_bib2","first-page":"E1227","article-title":"Association between the risk of relapse and the type of surgical procedure for herpes zoster-related pain","volume":"24","author":"Luo","year":"2021","journal-title":"Pain Physician"},{"key":"10.1016\/j.mtbio.2026.103423_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40122-023-00561-7","article-title":"Progress in radiofrequency therapy for zoster-associated pain about parameters, modes, targets, and combined therapy: a narrative review","volume":"13","author":"Rui","year":"2024","journal-title":"Pain Ther."},{"key":"10.1016\/j.mtbio.2026.103423_bib4","article-title":"Gabapentin for chronic neuropathic pain and fibromyalgia in adults","author":"Moore","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.mtbio.2026.103423_bib5","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mtbio.2026.103423_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.mtbio.2026.103423_bib8","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a040501","article-title":"Mendelian randomization: concepts and scope","volume":"12","author":"Richmond","year":"2022","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.mtbio.2026.103423_bib9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrd2638","article-title":"Adenosine receptors: therapeutic aspects for inflammatory and immune diseases","volume":"7","author":"Hask\u00f3","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mtbio.2026.103423_bib10","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/physrev.00043.2006","article-title":"Physiology and pathophysiology of purinergic neurotransmission","volume":"87","author":"Burnstock","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mtbio.2026.103423_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.10.031","article-title":"Adenosine receptor targets for pain","volume":"338","author":"Sawynok","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.mtbio.2026.103423_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.it.2009.04.001","article-title":"A(2B) adenosine receptors in immunity and inflammation","volume":"30","author":"Hask\u00f3","year":"2009","journal-title":"Trends Immunol."},{"key":"10.1016\/j.mtbio.2026.103423_bib13","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.4103\/1673-5374.384067","article-title":"Prediction of cell-cell communication patterns of dorsal root ganglion cells: single-cell RNA sequencing data analysis","volume":"19","author":"Lian","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.mtbio.2026.103423_bib14","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1002\/glia.24593","article-title":"Adenosine A2B receptors differently modulate oligodendrogliogenesis and myelination depending on their cellular localization","volume":"72","author":"Cherchi","year":"2024","journal-title":"Glia"},{"key":"10.1016\/j.mtbio.2026.103423_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrn.2018.2","article-title":"Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential","volume":"19","author":"Inoue","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mtbio.2026.103423_bib16","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mtbio.2026.103423_bib17","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.3390\/ijms24076328","article-title":"The potential benefits of quercetin for brain health: a review of anti-inflammatory and neuroprotective mechanisms","volume":"24","author":"Chiang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103423_bib18","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.2174\/09298673113209990120","article-title":"Bioavailability of quercetin: problems and promises","volume":"20","author":"Cai","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mtbio.2026.103423_bib19","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/acs.chemrev.8b00672","article-title":"Classification, catalytic mechanisms, activity regulation, and applications","volume":"119","author":"Huang","year":"2019","journal-title":"Chem Rev"},{"key":"10.1016\/j.mtbio.2026.103423_bib20","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3390\/pharmaceutics14061122","article-title":"Transferrin-enabled blood-brain barrier crossing manganese-based nanozyme for rebalancing the reactive oxygen species level in ischemic stroke","volume":"14","author":"Zhao","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2026.103423_bib21","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.3390\/ijms26073262","article-title":"Application of density functional theory to molecular engineering of pharmaceutical formulations","volume":"26","author":"Guan","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103423_bib22","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1039\/c3cs35486e","article-title":"Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes","volume":"42","author":"Wei","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.mtbio.2026.103423_bib23","article-title":"Brain delivery of protein therapeutics by cell matrix-inspired biomimetic nanocarrier","volume":"36","author":"Huang","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.mtbio.2026.103423_bib24","doi-asserted-by":"crossref","first-page":"10971","DOI":"10.1021\/acs.nanolett.3c03222","article-title":"Intracerebral nanoparticle transport facilitated by alzheimer pathology and age","volume":"23","author":"Tracy","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.mtbio.2026.103423_bib25","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.7150\/thno.111130","article-title":"The basolateral amygdala-anterior cingulate cortex circuit contributes to postherpetic neuralgia-anxiety comorbidity","volume":"15","author":"Jiang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103423_bib26","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.spinee.2010.03.029","article-title":"Brain-derived neurotrophic factor redistribution in the dorsal root ganglia correlates with neuropathic pain inhibition after resiniferatoxin treatment","volume":"10","author":"Tender","year":"2010","journal-title":"Spine J."},{"key":"10.1016\/j.mtbio.2026.103423_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103423_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00210-007-0252-9","article-title":"Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia","volume":"377","author":"Bilkei-Gorzo","year":"2008","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.mtbio.2026.103423_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201801362","article-title":"Overcoming the blood-brain barrier: the role of nanomaterials in treating neurological diseases","volume":"30","author":"Furtado","year":"2018","journal-title":"Adv Mater"},{"key":"10.1016\/j.mtbio.2026.103423_bib30","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx consortium atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2026.103423_bib32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12951-025-03210-7","article-title":"Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks","volume":"23","author":"Tang","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.mtbio.2026.103423_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202201733","article-title":"Manganese-based nanozymes: preparation, catalytic mechanisms, and biomedical applications","volume":"11","author":"Tang","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103423_bib34","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1074\/jbc.273.9.5093","article-title":"Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency","volume":"273","author":"Blackburn","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2026.103423_bib35","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1523\/JNEUROSCI.23-07-02911.2003","article-title":"Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action","volume":"23","author":"Pan","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mtbio.2026.103423_bib36","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mtbio.2026.103423_bib37","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMcp1403062","article-title":"Clinical practice. Postherpetic neuralgia","volume":"371","author":"Johnson","year":"2014","journal-title":"N. Engl. J. Med."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642600668X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259000642600668X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:59:43Z","timestamp":1787025583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259000642600668X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"alternative-id":["S259000642600668X"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103423","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted HA@Que-Mn nanozymes alleviate postherpetic neuralgia by modulating neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103423","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103423"}}