{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:07Z","timestamp":1790337787682,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20240304057SF"],"award-info":[{"award-number":["20240304057SF"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mtbio.2026.103424","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:33:11Z","timestamp":1788017591000},"page":"103424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A microenvironment-responsive injectable hydrogel with core-shell nanoplatforms for sequential treatment of infected bone defects"],"prefix":"10.1016","volume":"40","author":[{"given":"Xiao","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7714-9733","authenticated-orcid":false,"given":"Jinghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.mtbio.2026.103424_bib1","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1021\/acsnano.4c12343","article-title":"Multienzyme-Activity Sulfur quantum dot nanozyme-mediated Cascade reactions in whole-stage symptomatic therapy of infected bone defects","volume":"19","author":"Liu","year":"2025","journal-title":"ACS Nano"},{"issue":"23","key":"10.1016\/j.mtbio.2026.103424_bib2","doi-asserted-by":"crossref","first-page":"21679","DOI":"10.1021\/acsnano.5c04595","article-title":"Cascade magnetic hyperthermia therapy for biofilm eradication and bone regeneration via dual osteoimmuno-regulation","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103424_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123642","article-title":"Multifunctional, enzyme\/pH-responsive gelatin microspheres with aptamer-targeted antibacterial and ionic-mediated dual therapy for infected bone defects","volume":"326","author":"Zhang","year":"2026","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103424_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40779-023-00454-y","article-title":"Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration","volume":"10","author":"Yu","year":"2023","journal-title":"Milit. Med. Res."},{"key":"10.1016\/j.mtbio.2026.103424_bib5","article-title":"Diatom-Inspired scaffold for infected bone defect therapy: achieving stable photothermal properties and coordinated antibacterial-osteogenic functions","author":"Li","year":"2025","journal-title":"Adv Mater"},{"key":"10.1016\/j.mtbio.2026.103424_bib6","first-page":"18","article-title":"Vancomycin-encapsulated hydrogel loaded microarc-oxidized 3D-printed porous Ti6Al4V implant for infected bone defects: reconstruction, anti-infection, and osseointegration","volume":"42","author":"Zhang","year":"2024","journal-title":"Bioact. Mater."},{"issue":"15","key":"10.1016\/j.mtbio.2026.103424_bib7","doi-asserted-by":"crossref","first-page":"14707","DOI":"10.1021\/acsnano.4c13690","article-title":"Bone morphogenetic Protein-2-Derived peptide-conjugated nanozyme-integrated photoenhanced hybrid hydrogel for cascade-regulated bone regeneration","volume":"19","author":"Chen","year":"2025","journal-title":"ACS Nano"},{"issue":"39","key":"10.1016\/j.mtbio.2026.103424_bib8","doi-asserted-by":"crossref","first-page":"35154","DOI":"10.1021\/acsnano.5c13201","article-title":"Intelligent responsive zeolitic imidazolate Framework-8@Copper oxide nanocomposite 3D-Printed scaffolds for efficient repair of infected bone defects","volume":"19","author":"Li","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103424_bib9","article-title":"Acid-Responsive bimetallic peroxide composite nanoplatform for synergistic therapy of drug-resistant bacterial infections via inducing oxidative stress and disrupting bacterial energy metabolism","author":"Wang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"11","key":"10.1016\/j.mtbio.2026.103424_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307695","article-title":"Photothermal and photocatalytic glycol chitosan and polydopamine-grafted oxygen vacancy bismuth oxyiodide (BiOI) nanoparticles for the diagnosis and targeted therapy of diabetic wounds","volume":"36","author":"Kong","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.mtbio.2026.103424_bib11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jcis.2024.04.122","article-title":"Micro-environment-triggered chemodynamic treatment for boosting bacteria elimination at low-temperature by synergistic effect of photothermal treatment and nanozyme catalysis","volume":"667","author":"Wu","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2026.103424_bib12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.actbio.2024.07.044","article-title":"Acidic biofilm microenvironment-responsive ROS generation via a protein nanoassembly with hypoxia-relieving and GSH-depleting capabilities for efficient elimination of biofilm bacteria","volume":"186","author":"Li","year":"2024","journal-title":"Acta Biomater."},{"issue":"27","key":"10.1016\/j.mtbio.2026.103424_bib13","article-title":"AuCu@CuO(2) aerogels with H(2)O(2)\/O(2) self-supplying and quadruple enzyme-like activity for MRSA-Infected diabetic wound management","volume":"12","author":"Tan","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"Pt A","key":"10.1016\/j.mtbio.2026.103424_bib14","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jcis.2024.11.040","article-title":"Engineering Robust Silver-Decorated calcium peroxide Nano-Antibacterial Platforms for chemodynamic enhanced sterilization","volume":"680","author":"Bai","year":"2025","journal-title":"J. Colloid Interface Sci."},{"issue":"50","key":"10.1016\/j.mtbio.2026.103424_bib15","doi-asserted-by":"crossref","first-page":"69055","DOI":"10.1021\/acsami.4c17388","article-title":"GSH-Depleting and H(2)O(2) self-supplying calcium peroxide-based nanoplatforms for efficient bacterial eradication via photothermal-enhanced chemodynamic therapy","volume":"16","author":"Shi","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2026.103424_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123334","article-title":"Glucose-triggered NO-evolving coating bestows orthopedic implants with enhanced anti-bacteria and angiectasis for safeguarding diabetic osseointegration","volume":"321","author":"Shi","year":"2025","journal-title":"Biomaterials"},{"issue":"24","key":"10.1016\/j.mtbio.2026.103424_bib17","doi-asserted-by":"crossref","first-page":"15845","DOI":"10.1021\/acsnano.4c02825","article-title":"CuCo2O4 nanoflowers with multiple enzyme activities for treating bacterium-infected wounds via cuproptosis-like death","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"issue":"25","key":"10.1016\/j.mtbio.2026.103424_bib18","doi-asserted-by":"crossref","first-page":"16184","DOI":"10.1021\/acsnano.4c01452","article-title":"Molybdenum disulfide-supported cuprous oxide nanocomposite for Near-Infrared-I light-responsive synergistic antibacterial therapy","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103424_bib19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1021\/acsnano.1c07893","article-title":"One-Step integration of tumor microenvironment-responsive calcium and copper peroxides nanocomposite for enhanced Chemodynamic\/Ion-Interference therapy","volume":"16","author":"Liu","year":"2022","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103424_bib20","article-title":"Dual antibody-aided mesoporous nanoreactor for H2O2 self-supplying chemodynamic therapy and checkpoint blockade immunotherapy in triple-negative breast cancer","volume":"21","author":"Chen","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"36","key":"10.1016\/j.mtbio.2026.103424_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303432","article-title":"Biofilm microenvironment-responsive self-assembly nanoreactors for all-stage biofilm associated infection through bacterial cuproptosis-like death and macrophage Re-Rousing","volume":"35","author":"Mei","year":"2023","journal-title":"Adv Mater"},{"issue":"35","key":"10.1016\/j.mtbio.2026.103424_bib22","doi-asserted-by":"crossref","first-page":"24327","DOI":"10.1021\/acsnano.4c06565","article-title":"Nanoarchitectonics of in situ antibiotic-releasing acicular nanozymes for targeting and inducing cuproptosis-like death to eliminate drug-resistant bacteria","volume":"18","author":"Hu","year":"2024","journal-title":"ACS Nano"},{"issue":"14","key":"10.1016\/j.mtbio.2026.103424_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202500601","article-title":"Defect-Rich MoO@CuO Nanosheets mediated ultrasound-enhanced cuproptosis antibacterial activity and M2 macrophage reprogramming for optimizing diabetic wound repairment","volume":"14","author":"Li","year":"2025","journal-title":"Adv. Healthcare Mater."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103424_bib24","doi-asserted-by":"crossref","first-page":"9938","DOI":"10.1021\/acsnano.2c04630","article-title":"Two-Dimensional MXene-Originated nanosonosensitizer generation for augmented and synergistic sonodynamic tumor nanotherapy","volume":"16","author":"Zhang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103424_bib25","first-page":"450","article-title":"Enhanced piezocatalytic therapy of MRSA-infected osteomyelitis using ultrasound-triggered copper nanocrystals-doped barium titanate","volume":"51","author":"Wu","year":"2025","journal-title":"Bioact. Mater."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103424_bib26","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1021\/acsnano.4c13753","article-title":"Cuproptosis-Inducing functional nanocomposites for enhanced and synergistic cancer radiotherapy","volume":"19","author":"Jiang","year":"2025","journal-title":"ACS Nano"},{"issue":"Pt 2","key":"10.1016\/j.mtbio.2026.103424_bib27","article-title":"Mesoporous polydopamine\/copper sulfide hybrid nanocomposite for highly efficient NIR-triggered bacterial inactivation","volume":"277","author":"Yan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103424_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2025.01.064","article-title":"Heterogeneous Cu2O-SnO2 doped polydopamine fenton-like nanoenzymes for synergetic photothermal-chemodynamic antibacterial application (vol 173, pg 420, 2024)","volume":"196","author":"Gao","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.mtbio.2026.103424_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120092","article-title":"Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au\/Ag nanorods","volume":"251","author":"Mei","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103424_bib30","article-title":"NIR-II responsive multifunctional scaffold enabling \u201cKill-Modulation-Build\u201d synergistic therapy for infectious bone defects","author":"Yang","year":"2025","journal-title":"Adv Sci"},{"issue":"8","key":"10.1016\/j.mtbio.2026.103424_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41565-019-0522-y","article-title":"Miniature gold nanorods for photoacoustic molecular imaging in the second near-infrared optical window (vol 14, pg 465, 2019)","volume":"14","author":"Chen","year":"2019","journal-title":"Nat. Nanotechnol."},{"issue":"51","key":"10.1016\/j.mtbio.2026.103424_bib32","doi-asserted-by":"crossref","first-page":"23522","DOI":"10.1021\/jacs.2c10323","article-title":"NIR-II photoacoustic-active DNA origami nanoantenna for early diagnosis and smart therapy of Acute Kidney injury","volume":"144","author":"Xu","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2026.103424_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123249","article-title":"Ultrasound-activated piezoelectric heterojunction drives nanozyme catalysis to induce bacterial cuproptosis-like death and promote bone vascularization and osseointegration","volume":"320","author":"Qiu","year":"2025","journal-title":"Biomaterials"},{"issue":"22","key":"10.1016\/j.mtbio.2026.103424_bib34","doi-asserted-by":"crossref","first-page":"14312","DOI":"10.1021\/acsnano.4c00137","article-title":"Sulfated chitosan-modified CuS nanocluster: a versatile nanoformulation for simultaneous antibacterial and bone regenerative therapy in periodontitis","volume":"18","author":"Chen","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103424_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121901","article-title":"Cobalt loaded electrospun poly(epsilon-caprolactone) grafts promote antibacterial activity and vascular regeneration in a diabetic rat model","volume":"291","author":"Huang","year":"2022","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103424_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12951-025-03358-2","article-title":"An injectable multifunctional nanocomposite hydrogel promotes vascularized bone regeneration by regulating macrophages","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"18","key":"10.1016\/j.mtbio.2026.103424_bib37","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.7150\/thno.102779","article-title":"Multifunctional injectable hydrogel system as a mild photothermal-assisted therapeutic platform for programmed regulation of inflammation and osteo-microenvironment for enhanced healing of diabetic bone defects in situ","volume":"14","author":"Zhu","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103424_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123423","article-title":"A new paradigm in bone tissue biomaterials: enhanced osteogenesis-angiogenic coupling by targeting H-type blood vessels","volume":"324","author":"Yang","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103424_bib39","article-title":"3D-printed intelligent photothermal conversion Nb(2)C MXene composite scaffolds facilitate the regulation of angiogenesis-osteogenesis coupling for vascularized bone regeneration","volume":"31","author":"Zhang","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"25","key":"10.1016\/j.mtbio.2026.103424_bib40","doi-asserted-by":"crossref","first-page":"22710","DOI":"10.1021\/acsnano.4c10386","article-title":"Injectable thymosin beta4-Modified hyaluronic acid hydrogel with exosomes for stem cell homing and neuronic-angiogenic-osteogenic coupled cranial repair","volume":"19","author":"Xi","year":"2025","journal-title":"ACS Nano"},{"issue":"11","key":"10.1016\/j.mtbio.2026.103424_bib41","doi-asserted-by":"crossref","first-page":"19038","DOI":"10.1021\/acsnano.2c08077","article-title":"Biomimetic yolk-shell nanocatalysts for activatable dual-modal-image-guided Triple- augmented chemodynamic therapy of cancer","volume":"16","author":"Pan","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103424_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121621","article-title":"Synthesis of multi-branched Au nanocomposites with distinct plasmon resonance in NIR-II window and controlled CRISPR-Cas9 delivery for synergistic gene-photothermal therapy","volume":"287","author":"Tao","year":"2022","journal-title":"Biomaterials"},{"issue":"15","key":"10.1016\/j.mtbio.2026.103424_bib43","article-title":"Mucous permeable nanoparticle for inducing Cuproptosis-Like death in broad-spectrum bacteria for nebulized treatment of Acute Pneumonia","volume":"12","author":"Hu","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103424_bib44","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1038\/s41467-021-26221-y","article-title":"Addressing MRSA infection and antibacterial resistance with peptoid polymers","volume":"12","author":"Xie","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103424_bib45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jconrel.2024.05.011","article-title":"A hyaluronic acid hydrogel as a mild photothermal antibacterial, antioxidant, and nitric oxide release platform for diabetic wound healing","volume":"370","author":"He","year":"2024","journal-title":"J. Contr. Release"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103424_bib46","first-page":"890","article-title":"Hybrid gelatin\/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation","volume":"6","author":"Zhou","year":"2021","journal-title":"Bioact. Mater."},{"issue":"Pt A","key":"10.1016\/j.mtbio.2026.103424_bib47","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jcis.2024.08.234","article-title":"Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal\/chemodynamic therapy","volume":"678","author":"Liu","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2026.103424_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122030","article-title":"MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy","volume":"295","author":"Liu","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103424_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.124364","article-title":"Multifunctional self-healing hemicellulose-based hydrogel for antimicrobial wound dressings and motion-responsive wearable sensing","volume":"370","author":"Shao","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"10","key":"10.1016\/j.mtbio.2026.103424_bib50","doi-asserted-by":"crossref","first-page":"15886","DOI":"10.1021\/acsami.5c00904","article-title":"Construction of a CuO@PDA nanozyme with switchable dual enzyme-mimic activities for colorimetric sensing of catechol and hydroquinone","volume":"17","author":"Zhang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"13","key":"10.1016\/j.mtbio.2026.103424_bib51","doi-asserted-by":"crossref","first-page":"12544","DOI":"10.1021\/acsnano.3c02401","article-title":"Doxorubicin-Fe(III)-Gossypol infinite coordination Polymer@PDA:CuO composite nanoparticles for cost-effective programmed photothermal-chemodynamic-coordinated dual drug chemotherapy trimodal synergistic tumor therapy","volume":"17","author":"Zhu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103424_bib52","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jcis.2024.06.147","article-title":"Disulfiram-loaded CuO2 nanocarriers for enhanced synergistic chemodynamic chemotherapy","volume":"674","author":"Hu","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.mtbio.2026.103424_bib53","article-title":"Near-infrared-triggered copper-doped carbon nitride nanocomposite inducing domino effect for synergistic tumor therapy and immune microenvironment reprogramming","volume":"34","author":"Zhang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103424_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123566","article-title":"Self-assembled copper-amino acid nanoleaves for targeted treatment of deep-seated bacterial infections via chemodynamic therapy and cuproptosis-like death","volume":"325","author":"Li","year":"2026","journal-title":"Biomaterials"},{"issue":"38","key":"10.1016\/j.mtbio.2026.103424_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202510774","article-title":"Multifunctional NIR-Triggered nanozyme-based microneedles for synergistic eradication of MRSA and enhanced wound healing","volume":"12","author":"Qian","year":"2025","journal-title":"Adv Sci"},{"issue":"15","key":"10.1016\/j.mtbio.2026.103424_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202408580","article-title":"Mucous permeable nanoparticle for inducing Cuproptosis-Like death in broad-spectrum bacteria for nebulized treatment of Acute Pneumonia","volume":"12","author":"Hu","year":"2025","journal-title":"Adv Sci"},{"issue":"44","key":"10.1016\/j.mtbio.2026.103424_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202470353","article-title":"Ultrasound-Activated probiotics vesicles coating for titanium implant infections through bacterial Cuproptosis-Like death and immunoregulation","volume":"36","author":"Li","year":"2024","journal-title":"Adv Mater"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103424_bib58","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12951-024-02320-y","article-title":"Injectable ultrasound-powered bone-adhesive nanocomposite hydrogel for electrically accelerated irregular bone defect healing","volume":"22","author":"Zhou","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103424_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122750","article-title":"Injectable Salecan\/hyaluronic acid-based hydrogels with antibacterial, rapid self-healing, pH-responsive and controllable drug release capability for infected wound repair","volume":"347","author":"Wang","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"Pt 6","key":"10.1016\/j.mtbio.2026.103424_bib60","article-title":"Anti-inflammatory dressing based on hyaluronic acid and hydroxyethyl starch for wound healing","volume":"282","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103424_bib61","article-title":"Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis","volume":"29","author":"Wu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103424_bib62","first-page":"85","article-title":"Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect","volume":"42","author":"Yang","year":"2024","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103424_bib63","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.1038\/s41467-023-42598-4","article-title":"Self-promoted electroactive biomimetic mineralized scaffolds for bacteria-infected bone regeneration","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103424_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54894-8","article-title":"Biodegradable Janus sonozyme with continuous reactive oxygen species regulation for treating infected critical-sized bone defects","volume":"15","author":"Ou","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426006691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426006691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:32:21Z","timestamp":1790335941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426006691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":64,"alternative-id":["S2590006426006691"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103424","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A microenvironment-responsive injectable hydrogel with core-shell nanoplatforms for sequential treatment of infected bone defects","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103424","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103424"}}