{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:30:54Z","timestamp":1787027454423,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["ZY2024010"],"award-info":[{"award-number":["ZY2024010"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007928","name":"Ningbo Municipal Bureau of Science and Technology","doi-asserted-by":"publisher","award":["2023J254"],"award-info":[{"award-number":["2023J254"]}],"id":[{"id":"10.13039\/501100007928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241031"],"award-info":[{"award-number":["82241031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mtbio.2026.103430","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:36:11Z","timestamp":1783035371000},"page":"103430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Orally administered biomimetic nanovesicles engineered with FGF2 orchestrate mucosal healing and microbiome remodeling in inflammatory bowel disease"],"prefix":"10.1016","volume":"39","author":[{"given":"Meilin","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3725-7834","authenticated-orcid":false,"given":"Ebrahim","family":"Abdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuyao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juqin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-3834","authenticated-orcid":false,"given":"Keqing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103430_bib1","first-page":"850","article-title":"Small molecule oral targeted therapies in ulcerative colitis, the lancet","volume":"5","author":"Shivaji","year":"2020","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103430_bib2","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/s41401-020-0497-0","article-title":"Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease","volume":"42","author":"Prados","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.mtbio.2026.103430_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2026.103430_bib4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nature Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103430_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nri.2017.10","article-title":"Neutrophils as protagonists and targets in chronic inflammation","volume":"17","author":"Soehnlein","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mtbio.2026.103430_bib6","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.immuni.2026.03.019","article-title":"Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation","volume":"59","author":"Yu","year":"2026","journal-title":"Immunity"},{"key":"10.1016\/j.mtbio.2026.103430_bib7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.mtbio.2026.103430_bib8","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1021\/acsnano.0c01018","article-title":"Nanoparticles derived from the natural antioxidant rosmarinic acid ameliorate acute inflammatory bowel disease","volume":"14","author":"Chung","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103430_bib9","first-page":"564","article-title":"Ulcerative colitis-diagnostic and therapeutic algorithms","volume":"117","author":"Kucharzik","year":"2020","journal-title":"Dtsch. \u00c4rztebl. Int."},{"key":"10.1016\/j.mtbio.2026.103430_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.semcdb.2015.10.009","article-title":"Role of fibroblast growth factors in organ regeneration and repair","volume":"53","author":"El Agha","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.mtbio.2026.103430_bib11","first-page":"209","article-title":"Susceptibility of growth factors to degradation by Helicobacter pylori protease: effect of ebrotidine and sucralfate","volume":"40","author":"Slomiany","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.mtbio.2026.103430_bib12","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.1158\/0008-5472.CAN-16-1681","article-title":"A hyaluronidase-responsive nanoparticle-based drug delivery system for targeting Colon cancer cells","volume":"76","author":"Zhang","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103430_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120432","article-title":"\u03a0 electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer","volume":"266","author":"Liang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.mtbio.2026.103430_bib14","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1016\/j.apsb.2020.11.003","article-title":"Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: opportunities and emerging strategies","volume":"11","author":"Liu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2026.103430_bib15","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103430_bib16","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.mtbio.2026.103430_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases","volume":"569","author":"Lloyd-Price","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103430_bib18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3390\/pharmaceutics17040397","article-title":"Barriers and strategies for oral peptide and protein therapeutics delivery: update on clinical advances","volume":"17","author":"Baral","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2026.103430_bib19","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/j.apsb.2026.01.031","article-title":"Targeted intestinal barrier repair via probiotic-derived engineered outer membrane vesicles: a 3A1M strategy with antioxidant, anti-inflammatory, anti-ferroptotic, and microbiome modulation effects","volume":"16","author":"Yu","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2026.103430_bib20","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.apsb.2026.01.033","article-title":"Outer membrane vesicles: versatile nanocarriers for therapeutic delivery and immune modulation","volume":"16","author":"Yang","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2026.103430_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/bit.27965","article-title":"Outer membrane vesicles (OMVs) enabled bio-applications: a critical review","volume":"119","author":"Huang","year":"2022","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.mtbio.2026.103430_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2026.103055","article-title":"An oral dual-targeting inulin-based nanomicelle for ulcerative colitis therapy via combined H2S-mediated immunomodulation with prebiotic microbiota regulation","volume":"69","author":"Xu","year":"2026","journal-title":"Nano Today"},{"key":"10.1016\/j.mtbio.2026.103430_bib23","article-title":"CO-Releasing polyoxometalates nanozyme with gut mucosal immunity and microbiota homeostasis remodeling effects for restoring intestinal barrier integrity","volume":"12","author":"Lu","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.mtbio.2026.103430_bib24","first-page":"136","article-title":"Manganese oxide nanozyme-loaded CO-releasing halloysite nanotubes for remodeling colonic immune, microbiota, and intestinal barrier homeostasis with concurrent pain relief in ulcerative colitis","volume":"56","author":"Zhang","year":"2026","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103430_bib25","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/j.apsb.2026.01.031","article-title":"Targeted intestinal barrier repair via probiotic-derived engineered outer membrane vesicles: a 3A1M strategy with antioxidant, anti-inflammatory, anti-ferroptotic, and microbiome modulation effects","volume":"16","author":"Yu","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.mtbio.2026.103430_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.micro.091208.073413","article-title":"Biological functions and biogenesis of secreted bacterial outer membrane vesicles","volume":"64","author":"Kulp","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.mtbio.2026.103430_bib27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nrmicro3525","article-title":"Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions","volume":"13","author":"Schwechheimer","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.mtbio.2026.103430_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1270158","article-title":"The potential role of gut microbiota outer membrane vesicles in colorectal cancer","volume":"14","author":"Meng","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.mtbio.2026.103430_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/wdev.176","article-title":"The fibroblast growth factor signaling pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"Wiley Interdiscip. Rev.: Dev. Biol."},{"key":"10.1016\/j.mtbio.2026.103430_bib30","first-page":"707","article-title":"Bacteroides thetaiotaomicron in the gut: molecular aspects of their interaction","volume":"39","author":"Zocco","year":"2007","journal-title":"Dig. Liver Dis., Off. J. Italian Soc. Gastroenterol. Italian Assoc. Study Liver"},{"key":"10.1016\/j.mtbio.2026.103430_bib31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1741-7007-11-61","article-title":"Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent","volume":"11","author":"Wrzosek","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.mtbio.2026.103430_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3390\/nu9060555","article-title":"Evidence of the anti-inflammatory effects of probiotics and synbiotics in intestinal chronic diseases","volume":"9","author":"Plaza-D\u00edaz","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.mtbio.2026.103430_bib33","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/gutjnl-2018-316906","article-title":"Tight junction proteins in gastrointestinal and liver disease","volume":"68","author":"Zeisel","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2026.103430_bib34","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.addr.2005.01.009","article-title":"Occludin: structure, function and regulation","volume":"57","author":"Feldman","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.103430_bib35","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/j.gastro.2021.08.047","article-title":"The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair","volume":"161","author":"Kuo","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mtbio.2026.103430_bib36","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1136\/gutjnl-2020-322260","article-title":"Mucus barrier, mucins and gut microbiota: the expected slimy partners?","volume":"69","author":"Paone","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2026.103430_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12182","article-title":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.mtbio.2026.103430_bib38","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103430_bib39","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.103430_bib40","article-title":"High-efficiency expression of TAT-bFGF fusion protein in Escherichia coli and the effect on hypertrophic scar tissue","volume":"10","author":"Jia","year":"2015","journal-title":"PLoS One"}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426006757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426006757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:18:47Z","timestamp":1787026727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426006757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":40,"alternative-id":["S2590006426006757"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103430","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orally administered biomimetic nanovesicles engineered with FGF2 orchestrate mucosal healing and microbiome remodeling in inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103430"}}