{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:47Z","timestamp":1790337827547,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301137"],"award-info":[{"award-number":["32301137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271424"],"award-info":[{"award-number":["32271424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mtbio.2026.103581","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:29:12Z","timestamp":1787066952000},"page":"103581","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Spatiotemporal ultrasound-driven piezoelectric electro-NO therapy restores neuro-vascular-immune homeostasis for radiation ulcer repair"],"prefix":"10.1016","volume":"40","author":[{"given":"Yueyue","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zesu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beini","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingliang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihua","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-8106","authenticated-orcid":false,"given":"Miao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.mtbio.2026.103581_bib1","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.7150\/thno.108309","article-title":"Recent advances in the mechanisms, current treatment status, and application of multifunctional biomaterials for radiation-induced skin injury","volume":"15","author":"Xu","year":"2025","journal-title":"Theranostics"},{"issue":"20","key":"10.1016\/j.mtbio.2026.103581_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203387","article-title":"Bio-inspired antioxidant heparin-mimetic peptide hydrogel for radiation-induced skin injury repair","volume":"12","author":"Hao","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"40","key":"10.1016\/j.mtbio.2026.103581_bib3","doi-asserted-by":"crossref","first-page":"27557","DOI":"10.1021\/acsnano.4c08508","article-title":"Co-Assembled binary polyphenol natural products for the prevention and treatment of radiation-induced skin injury","volume":"18","author":"Hu","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103581_bib4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/s12951-022-01620-5","article-title":"Multifunctional mesoporous silica-cerium oxide nanozymes facilitate miR129 delivery for high-quality healing of radiation-induced skin injury","volume":"20","author":"Zhou","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"19","key":"10.1016\/j.mtbio.2026.103581_bib5","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.7150\/thno.27385","article-title":"Prostaglandin E(2) hydrogel improves cutaneous wound healing via M2 macrophages polarization","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.mtbio.2026.103581_bib6","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1152\/physrev.00026.2005","article-title":"Neuronal control of skin function: the skin as a neuroimmunoendocrine organ","volume":"86","author":"Roosterman","year":"2006","journal-title":"Physiol. Rev."},{"issue":"7048","key":"10.1016\/j.mtbio.2026.103581_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nature03875","article-title":"Common mechanisms of nerve and blood vessel wiring","volume":"436","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mtbio.2026.103581_bib8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(02)00757-2","article-title":"Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin","volume":"109","author":"Mukouyama","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.103581_bib9","first-page":"64","article-title":"Anisotropic structure of nanofiber hydrogel accelerates diabetic wound healing via triadic synergy of immune-angiogenic-neurogenic microenvironments","volume":"47","author":"Kim","year":"2025","journal-title":"Bioact. Mater."},{"issue":"32","key":"10.1016\/j.mtbio.2026.103581_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado7538","article-title":"Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure","volume":"10","author":"Kaveti","year":"2024","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103581_bib11","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/jid.2010.96","article-title":"Effects of physiological electric fields on migration of human dermal fibroblasts","volume":"130","author":"Guo","year":"2010","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103581_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001384","article-title":"Conductive materials for healing wounds: their incorporation in electroactive wound dressings, characterization, and perspectives","volume":"10","author":"Korupalli","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103581_bib13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mattod.2025.02.003","article-title":"An ultrasound-responsive hydrogel with piezoelectric-enhanced electrokinetic effect accelerates neurovascular regeneration for diabetic wound healing","volume":"84","author":"Wang","year":"2025","journal-title":"Mater. Today"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103581_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41551-022-00965-4","article-title":"Deep brain stimulation by blood-brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound","volume":"7","author":"Kim","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2026.103581_bib15","article-title":"An ultrasound\u2010responsive hydrogel for diabetic wound electrotherapy based on interfacial ion\/electron transfer","author":"Wang","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2026.103581_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.156183","article-title":"Spatiotemporal piezoelectric microcapsules for programmable sonodynamic sterilization and wound healing","volume":"499","author":"Huang","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103581_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202109175","article-title":"Compositionally graded KNN-based multilayer composite with excellent piezoelectric temperature stability","volume":"34","author":"Zheng","year":"2022","journal-title":"Adv. Mater."},{"issue":"10","key":"10.1016\/j.mtbio.2026.103581_bib18","doi-asserted-by":"crossref","first-page":"16513","DOI":"10.1021\/acsnano.2c05818","article-title":"Wirelessly powered electrical-stimulation based on biodegradable 3D piezoelectric scaffolds promotes the spinal cord injury repair","volume":"16","author":"Chen","year":"2022","journal-title":"ACS Nano"},{"issue":"22","key":"10.1016\/j.mtbio.2026.103581_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adv2385","article-title":"Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN)","volume":"11","author":"Wang","year":"2025","journal-title":"Sci. Adv."},{"issue":"33","key":"10.1016\/j.mtbio.2026.103581_bib20","article-title":"In situ forming of nitric oxide and electric stimulus for nerve therapy by wireless chargeable gold yarn-dynamos","volume":"10","author":"Chiang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"22","key":"10.1016\/j.mtbio.2026.103581_bib21","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1021\/acsnano.3c04556","article-title":"Exudate absorbing and antimicrobial hydrogel integrated with multifunctional curcumin-loaded magnesium polyphenol network for facilitating burn wound healing","volume":"17","author":"Gong","year":"2023","journal-title":"ACS Nano"},{"issue":"27","key":"10.1016\/j.mtbio.2026.103581_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn7006","article-title":"ECM-Mimetic immunomodulatory hydrogel for methicillin-resistant staphylococcus aureus-infected chronic skin wound healing","volume":"8","author":"Liu","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103581_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201801651","article-title":"The collagen suprafamily: from biosynthesis to advanced biomaterial development","volume":"31","author":"Sorushanova","year":"2019","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103581_bib24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.biomac.4c01211","article-title":"Self-cross-linked collagen sponge from the Alosa sapidissima scale for hemostasis and wound healing applications","volume":"26","author":"Li","year":"2025","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.mtbio.2026.103581_bib25","article-title":"Biodegradable piezoelectric implant for wirelessly delivering electrical stimulation to the heart under ultrasound stress","author":"Zhao","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"10","key":"10.1016\/j.mtbio.2026.103581_bib26","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/s41419-022-05281-y","article-title":"Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK\/SIRT7\/HMGB1 regulatory axis","volume":"13","author":"Jin","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103581_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/1523-1747.ep12479347","article-title":"Radiobiology of the skin: review of some effects on epidermis and hair","volume":"77","author":"Malkinson","year":"1981","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mtbio.2026.103581_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113734","article-title":"In vivo delivery of antioxidant enzymes with multi-functionalized lipid nanoparticles for sepsis therapy","volume":"382","author":"Koide","year":"2025","journal-title":"J. Contr. Release"},{"issue":"9","key":"10.1016\/j.mtbio.2026.103581_bib29","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.7150\/thno.31884","article-title":"Synechococcus elongatus PCC7942 secretes extracellular vesicles to accelerate cutaneous wound healing by promoting angiogenesis","volume":"9","author":"Yin","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103581_bib30","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1038\/s41467-025-60858-3","article-title":"Microenvironment-feedback regulated hydrogels as living wound healing materials","volume":"16","author":"Cheng","year":"2025","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103581_bib31","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1161\/CIRCRESAHA.120.315935","article-title":"CD31 as a therapeutic target in atherosclerosis","volume":"126","author":"Caligiuri","year":"2020","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103581_bib32","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1073\/pnas.041359198","article-title":"Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability","volume":"98","author":"Fukumura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.mtbio.2026.103581_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170706","article-title":"GLUT3 promotes macrophage signaling and function via RAS-Mediated endocytosis in atopic dermatitis and wound healing","volume":"133","author":"Yu","year":"2023","journal-title":"J. Clin. Investig."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103581_bib34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ccr.2013.09.014","article-title":"Low-dose irradiation programs macrophage differentiation to an iNOS+\/M1 phenotype that orchestrates effective T cell immunotherapy","volume":"24","author":"Klug","year":"2013","journal-title":"Cancer Cell"},{"issue":"12","key":"10.1016\/j.mtbio.2026.103581_bib35","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.addr.2003.08.008","article-title":"Recombinant collagen and gelatin for drug delivery","volume":"55","author":"Olsen","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103581_bib36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s42114-026-01617-w","article-title":"Gut-to-brain nanoantenna-mediated in situ wireless charging activation across the brain barrier and neural regeneration","volume":"9","author":"Pan","year":"2026","journal-title":"Adv. Compos. Hybrid Mater."},{"issue":"32","key":"10.1016\/j.mtbio.2026.103581_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202500650","article-title":"In situ magnetoelectric generation of miRNA sponges and wireless electric stimulus by conductive granular scaffolds for nerve regeneration","volume":"37","author":"Pan","year":"2025","journal-title":"Adv. Mater."},{"issue":"28","key":"10.1016\/j.mtbio.2026.103581_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202504786","article-title":"Wireless in situ catalytic electron signaling-mediated transcriptomic reprogramming for neuron regeneration via adaptable antennas","volume":"12","author":"Iao","year":"2025","journal-title":"Adv. Sci."},{"issue":"25","key":"10.1016\/j.mtbio.2026.103581_bib39","article-title":"Sustained release of nitric oxide-mediated angiogenesis and nerve repair by mussel-inspired adaptable microreservoirs for brain traumatic injury therapy","volume":"13","author":"Liu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103581_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101935","article-title":"In situ magnetoelectric generation of nitric oxide and electric stimulus for nerve therapy by wireless chargeable molybdenum carbide octahedrons","volume":"51","author":"Chan","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.mtbio.2026.103581_bib41","first-page":"213","article-title":"Dual-layer microneedles with NO\/O(2) releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation","volume":"46","author":"Liu","year":"2025","journal-title":"Bioact. Mater."},{"issue":"23","key":"10.1016\/j.mtbio.2026.103581_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba4376","article-title":"Human interleukin-4-treated regulatory macrophages promote epithelial wound healing and reduce colitis in a mouse model","volume":"6","author":"Jayme","year":"2020","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103581_bib43","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1021\/acsnano.5c16768","article-title":"A sonopiezoelectric Z-Scheme nanoplatform synergizing trace Ag(+) for eradicating methicillin-resistant staphylococcus aureus-Induced pneumonia","volume":"20","author":"Xu","year":"2026","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103581_bib44","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41467-024-44968-y","article-title":"Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing","volume":"15","author":"Pranantyo","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426008264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426008264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:42:00Z","timestamp":1790336520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426008264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"alternative-id":["S2590006426008264"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103581","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatiotemporal ultrasound-driven piezoelectric electro-NO therapy restores neuro-vascular-immune homeostasis for radiation ulcer repair","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103581","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103581"}}