{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:12Z","timestamp":1790337792289,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473152"],"award-info":[{"award-number":["52473152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mtbio.2026.103641","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:49:10Z","timestamp":1788418150000},"page":"103641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Biohybrid nanovesicle-mediated targeted delivery of HSP90 inhibitor for enhanced sorafenib therapy of hepatocellular carcinoma after radiofrequency ablation"],"prefix":"10.1016","volume":"40","author":[{"given":"Angfeng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoming","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6584-4111","authenticated-orcid":false,"given":"Qiao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103641_bib1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jhep.2024.10.031","article-title":"Liver cancer in 2021: Global Burden of Disease study","volume":"82","author":"Tan","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103641_bib2","doi-asserted-by":"crossref","first-page":"S228","DOI":"10.3350\/cmh.2024.0824","article-title":"Hepatocellular carcinoma: updates on epidemiology, surveillance, diagnosis and treatment","volume":"31","author":"Hwang","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"issue":"Suppl 1","key":"10.1016\/j.mtbio.2026.103641_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/hep.31288","article-title":"Epidemiology of hepatocellular carcinoma","volume":"73","author":"McGlynn","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.mtbio.2026.103641_bib4","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.mtbio.2026.103641_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.216048","article-title":"Human liver cancer organoids: biological applications, current challenges, and prospects in hepatoma therapy","volume":"555","author":"Chen","year":"2023","journal-title":"Cancer Lett."},{"issue":"Suppl 1","key":"10.1016\/j.mtbio.2026.103641_bib6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.31325","article-title":"Surgical treatments of hepatobiliary cancers","volume":"73","author":"Gunasekaran","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.mtbio.2026.103641_bib7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41423-020-00572-w","article-title":"Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells","volume":"18","author":"Ruf","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.mtbio.2026.103641_bib8","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1097\/JS9.0000000000001950","article-title":"Clinical guidelines for early hepatocellular carcinoma treatment options: a systematic review and bibliometric analysis","volume":"110","author":"Wu","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.mtbio.2026.103641_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.746","article-title":"Radiofrequency ablation: mechanisms and clinical applications","volume":"5","author":"Wu","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.mtbio.2026.103641_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41571-021-00573-2","article-title":"Immunotherapies for hepatocellular carcinoma","volume":"19","author":"Llovet","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.mtbio.2026.103641_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","article-title":"The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects","volume":"5","author":"Tang","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.103641_bib12","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/HEP.0000000000000237","article-title":"Mechanisms of drug resistance in HCC","volume":"79","author":"Ladd","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.mtbio.2026.103641_bib13","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1038\/s41388-018-0169-4","article-title":"Stress-induced phosphoprotein 1 mediates hepatocellular carcinoma metastasis after insufficient radiofrequency ablation","volume":"37","author":"Su","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.mtbio.2026.103641_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1090324","article-title":"Glycosylation-related molecular subtypes and risk score of hepatocellular carcinoma: novel insights to clinical decision-making","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103641_bib15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41420-024-02010-6","article-title":"Ubiquitin specific peptidase 3: an emerging deubiquitinase that regulates physiology and diseases","volume":"10","author":"Wang","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mtbio.2026.103641_bib16","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00535-022-01895-3","article-title":"Sorafenib as adjuvant therapy following radiofrequency ablation for recurrent hepatocellular carcinoma within Milan criteria: a multicenter analysis","volume":"57","author":"Zhou","year":"2022","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.mtbio.2026.103641_bib17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.semcancer.2018.11.006","article-title":"Therapy resistance mediated by cancer stem cells","volume":"53","author":"Steinbichler","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.mtbio.2026.103641_bib18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrclinonc.2015.61","article-title":"Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update","volume":"12","author":"Takebe","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.mtbio.2026.103641_bib19","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41571-019-0293-2","article-title":"Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update","volume":"17","author":"Clara","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.mtbio.2026.103641_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.addr.2008.08.007","article-title":"Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice","volume":"61","author":"Vlaming","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.103641_bib21","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1038\/s41467-020-18954-z","article-title":"Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells","volume":"11","author":"Valle","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103641_bib22","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41580-023-00640-9","article-title":"Structural and functional complexity of HSP90 in cellular homeostasis and disease","volume":"24","author":"Chiosis","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103641_bib23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.canlet.2014.10.035","article-title":"The inhibitor of differentiation isoform Id1b, generated by alternative splicing, maintains cell quiescence and confers self-renewal and cancer stem cell-like properties","volume":"356","author":"Manrique","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mtbio.2026.103641_bib24","first-page":"816","article-title":"Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer","volume":"20","author":"Fu","year":"2023","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103641_bib25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41580-023-00640-9","article-title":"Structural and functional complexity of HSP90 in cellular homeostasis and disease","volume":"24","author":"Chiosis","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103641_bib26","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1158\/0008-5472.CAN-15-2630","article-title":"Acidosis acts through HSP90 in a PHD\/VHL-Independent manner to promote HIF function and stem cell maintenance in Glioma","volume":"76","author":"Filatova","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103641_bib27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/s12883-022-02924-7","article-title":"HSP90 facilitates stemness and enhances glycolysis in glioma cells","volume":"22","author":"Kang","year":"2022","journal-title":"BMC Neurol."},{"key":"10.1016\/j.mtbio.2026.103641_bib28","article-title":"Hsp90 promotes gastric cancer cell metastasis and stemness by regulating the regional distribution of glycolysis-related metabolic enzymes in the cytoplasm","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.103641_bib29","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.biopha.2018.03.102","article-title":"Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: overview and current state of the art","volume":"102","author":"Mellatyar","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2026.103641_bib30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tranon.2016.01.002","article-title":"Preclinical data on efficacy of 10 drug-radiation combinations: evaluations, concerns, and recommendations","volume":"9","author":"Stone","year":"2016","journal-title":"Transl. Oncol."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103641_bib31","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1158\/0008-5472.CAN-13-1641","article-title":"VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation","volume":"74","author":"Fantozzi","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103641_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1615\/CritRevOncog.2016016976","article-title":"Resistance to cell death and its modulation in cancer stem cells","volume":"21","author":"Safa","year":"2016","journal-title":"Crit. Rev. Oncog."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103641_bib33","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/nprot.2007.405","article-title":"Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry","volume":"2","author":"Troiano","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mtbio.2026.103641_bib34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41392-023-01536-y","article-title":"Nanomedicine in cancer therapy","volume":"8","author":"Fan","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.103641_bib35","article-title":"Milk-derived exosomes as functional nanocarriers in wound healing: mechanisms, applications, and future directions","volume":"32","author":"Ruan","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103641_bib36","first-page":"138","article-title":"Oral TNF-\u03b1 siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease","volume":"34","author":"Han","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103641_bib37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13046-024-03061-4","article-title":"PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1\/miR-195-5p axis-dependent manner in hepatocellular carcinoma","volume":"43","author":"Li","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103641_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/adfm.202213134","article-title":"A NIR-II AIEgen-Based supramolecular nanodot for peroxynitrite-potentiated mild-temperature photothermal therapy of hepatocellular carcinoma","volume":"33","author":"Hu","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.mtbio.2026.103641_bib39","article-title":"A pH-Sensitive nanosized covalent-organic polymer for enhanced tumor photodynamic immunotherapy by hypoxia relief and STAT3 inhibition","volume":"12","author":"Lei","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.103641_bib40","doi-asserted-by":"crossref","first-page":"6082","DOI":"10.1039\/D4BM01190B","article-title":"Simultaneous inhibition of heat shock proteins and autophagy enhances radiofrequency ablation of hepatocellular carcinoma","volume":"12","author":"Zhao","year":"2024","journal-title":"Biomater. Sci."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426008860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426008860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:28:49Z","timestamp":1790335729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426008860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"alternative-id":["S2590006426008860"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103641","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biohybrid nanovesicle-mediated targeted delivery of HSP90 inhibitor for enhanced sorafenib therapy of hepatocellular carcinoma after radiofrequency ablation","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103641","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103641"}}