{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:40Z","timestamp":1790337820578,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SBF009 \\\\1019"],"award-info":[{"award-number":["SBF009 \\\\1019"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RGS\\\\R1\\\\231342"],"award-info":[{"award-number":["RGS\\\\R1\\\\231342"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["ICAE\\\\R1\\\\261019"],"award-info":[{"award-number":["ICAE\\\\R1\\\\261019"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP \/Y001486\/1"],"award-info":[{"award-number":["EP \/Y001486\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mtbio.2026.103653","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:46:35Z","timestamp":1788849995000},"page":"103653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Electrospun core\u2013shell nanofibres embedding drug nanocrystals for long-acting mucosal delivery"],"prefix":"10.1016","volume":"40","author":[{"given":"Gaia","family":"Zucca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Vigani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Valentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Lopez-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Sangalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Sandri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-8972","authenticated-orcid":false,"given":"Alejandro J.","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103653_bib1","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.3390\/molecules26082229","article-title":"Engineering polymeric nanosystems against oral diseases","volume":"26","author":"Mercadante","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.mtbio.2026.103653_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ajodo.2016.11.010","article-title":"A new definition for oral health developed by the FDI world dental Federation opens the door to a universal definition of oral health","volume":"151","author":"Glick","year":"2017","journal-title":"Am. J. Orthod. Dentofacial Orthop."},{"key":"10.1016\/j.mtbio.2026.103653_bib3","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.mtbio.2026.103653_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/CAD.0b013e3283462086","article-title":"Oral mucositis","volume":"22","author":"Sonis","year":"2011","journal-title":"Anti Cancer Drugs"},{"key":"10.1016\/j.mtbio.2026.103653_bib5","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3390\/curroncol30010074","article-title":"Interventions for the prevention of oral mucositis in patients receiving cancer treatment: evidence from randomised controlled trials","volume":"30","author":"Colella","year":"2023","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.mtbio.2026.103653_bib6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13046-020-01715-7","article-title":"Oral mucositis: the hidden side of cancer therapy","volume":"39","author":"Pulito","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103653_bib7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.oraloncology.2010.03.012","article-title":"Oral mucositis","volume":"46","author":"Raber-Durlacher","year":"2010","journal-title":"Oral Oncol."},{"key":"10.1016\/j.mtbio.2026.103653_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1517\/17425247.5.5.531","article-title":"Current status and the future of buccal drug delivery systems","volume":"5","author":"Pather","year":"2008","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.mtbio.2026.103653_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2011.01.027","article-title":"Advances in oral transmucosal drug delivery","volume":"153","author":"Patel","year":"2011","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103653_bib10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3390\/pharmaceutics17081025","article-title":"Micro and nano drug delivery systems for the treatment of oral mucositis: a review","volume":"17","author":"Maia","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.mtbio.2026.103653_bib11","doi-asserted-by":"crossref","first-page":"e377","DOI":"10.1016\/j.clinthera.2021.10.016","article-title":"Applications of novel and nanostructured drug delivery systems for the treatment of oral cavity diseases","volume":"43","author":"Hosseinpour-Moghadam","year":"2021","journal-title":"Clin. Ther."},{"key":"10.1016\/j.mtbio.2026.103653_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jconrel.2022.03.012","article-title":"Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes","volume":"345","author":"McGuckin","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103653_bib13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.drudis.2018.01.016","article-title":"Pharmaceutical nanocrystals: production by wet milling and applications","volume":"23","author":"Malamatari","year":"2018","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.mtbio.2026.103653_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2011.01.007","article-title":"State of the art of nanocrystals\u2013special features, production, nanotoxicology aspects and intracellular delivery","volume":"78","author":"M\u00fcller","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.mtbio.2026.103653_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123585","article-title":"Curcumin nanocrystals-in-nanofibres as a promising platform for the management of periodontal disease","volume":"648","author":"Zhang","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2026.103653_bib16","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1002\/jbm.a.37257","article-title":"Fabrication of multifunctional mucoadhesive buccal patch for drug delivery applications","volume":"109","author":"Rohani Shirvan","year":"2021","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.mtbio.2026.103653_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/15583720802022257","article-title":"Co\u2010axial electrospinning for nanofiber structures: preparation and applications","volume":"48","author":"Moghe","year":"2008","journal-title":"Polym. Rev."},{"key":"10.1016\/j.mtbio.2026.103653_bib18","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1080\/03639045.2022.2053985","article-title":"Nanocrystals based mucosal delivery system: research advances","volume":"47","author":"Liu","year":"2021","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.mtbio.2026.103653_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.114216","article-title":"Super-fast production of drug nanocrystals: dual asymmetric centrifugation-enabled media milling applied to high throughput formulation screening","author":"Lopez-Vidal","year":"2025","journal-title":"Mater. Des."},{"key":"10.1016\/j.mtbio.2026.103653_bib20","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1021\/acs.molpharmaceut.7b00291","article-title":"Hydrophobically modified polymer\/\u03b1-cyclodextrin thermoresponsive hydrogels for use in ocular drug delivery","volume":"14","author":"Iohara","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.mtbio.2026.103653_bib21","series-title":"Pharmaceutical Dissolution Testing","author":"Dressman","year":"2005"},{"key":"10.1016\/j.mtbio.2026.103653_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1208\/s12249-016-0496-0","article-title":"Design and in vitro\/in vivo evaluation of ultra-thin mucoadhesive buccal film containing fluticasone propionate","volume":"18","author":"Ammar","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.mtbio.2026.103653_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126142","article-title":"Sub-150 nm drug nanocrystals produced using a milligram-scale media mill","author":"Sangalli","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2026.103653_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/colloids7010015","article-title":"Dynamic light scattering: a powerful tool for in situ nanoparticle sizing","volume":"7","author":"Jia","year":"2023","journal-title":"Colloids and Interfaces"},{"key":"10.1016\/j.mtbio.2026.103653_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114466","article-title":"Biological and intracellular fates of drug nanocrystals through different delivery routes: recent development enabled by bioimaging and PK modeling","volume":"188","author":"Lv","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.mtbio.2026.103653_bib26","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1248\/bpb.29.1060","article-title":"Poloxamer 188 and propylene glycol-based rectal suppository enhances anticancer effect of 5-fluorouracil in mice","volume":"29","author":"Paek","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.mtbio.2026.103653_bib27","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s13205-019-1835-0","article-title":"Improved antioxidant, antimicrobial and anticancer activity of naringenin on conjugation with pectin","volume":"9","author":"Mundlia","year":"2019","journal-title":"3 Biotech"},{"key":"10.1016\/j.mtbio.2026.103653_bib28","doi-asserted-by":"crossref","first-page":"33672","DOI":"10.1039\/C4RA04920A","article-title":"Preparation and in vitro release of buccal tablets of naringenin-loaded MPEG-PCL nanoparticles","volume":"4","author":"Wang","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.mtbio.2026.103653_bib29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3390\/molecules27030741","article-title":"Preparation of naringenin nanosuspension and its antitussive and expectorant effects","volume":"27","author":"Dong","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.mtbio.2026.103653_bib30","first-page":"5733","article-title":"Effect of particle size on solubility, dissolution rate, and oral bioavailability: evaluation using coenzyme Q10 as naked nanocrystals","author":"Sun","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2026.103653_bib31","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1021\/ja02086a003","article-title":"The rate of solution of solid substances in their own solutions","volume":"19","author":"Noyes","year":"1897","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mtbio.2026.103653_bib32","article-title":"Electrospinning and nanofiber technology: fundamentals, innovations, and applications","volume":"37","author":"Cho","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.mtbio.2026.103653_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.elstat.2022.103770","article-title":"Taylor cone height as a tool to understand properties of electrospun PVDF nanofibers","volume":"120","author":"Singh","year":"2022","journal-title":"J. Electrost."},{"key":"10.1016\/j.mtbio.2026.103653_bib34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jconrel.2021.03.033","article-title":"Electrospinning for drug delivery applications: a review","volume":"334","author":"Luraghi","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.mtbio.2026.103653_bib35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ijpharm.2018.12.026","article-title":"Controlled dual drug release by coaxial electrospun fibers\u2013impact of the core fluid on drug encapsulation and release","volume":"556","author":"Wang","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.mtbio.2026.103653_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2025.114033","article-title":"Polycaprolactone (PCL): the biodegradable polyester shaping the future of materials\u2013a review on synthesis, properties, biodegradation, applications and future perspectives","author":"Ntrivala","year":"2025","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.mtbio.2026.103653_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76971-w","article-title":"Sustainable drug release from polycaprolactone coated chitin-lignin gel fibrous scaffolds","volume":"10","author":"Abdullah","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2026.103653_bib38","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1007\/s13346-024-01559-0","article-title":"Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery systems","volume":"14","author":"Rossier","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.mtbio.2026.103653_bib39","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2217\/nnm-2017-0381","article-title":"Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals","volume":"13","author":"Zhou","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.mtbio.2026.103653_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/ph12010032","article-title":"Development and characterization of chitosan microparticles-in-films for buccal delivery of bioactive peptides","volume":"12","author":"Batista","year":"2019","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.mtbio.2026.103653_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-026-40193-3","article-title":"Preclinical efficacy and safety evaluation of a topical mesenchymal stem cell derived conditioned media gel for oral mucositis management","volume":"16","author":"Mathen","year":"2026","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mtbio.2026.103653_bib42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3390\/md17030153","article-title":"Development of a mucoadhesive and an in situ gelling formulation based on \u03ba-Carrageenan for application on oral mucosa and esophagus walls. II. loading of a bioactive hydroalcoholic extract","volume":"17","author":"Vigani","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.mtbio.2026.103653_bib43","series-title":"Biocompatibility of Dental Materials","author":"Schmalz","year":"2009"},{"key":"10.1016\/j.mtbio.2026.103653_bib44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc1318","article-title":"The pathobiology of mucositis","volume":"4","author":"Sonis","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mtbio.2026.103653_bib45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/CCO.0000000000000180","article-title":"Mucositis: pathobiology and management","volume":"27","author":"Villa","year":"2015","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.mtbio.2026.103653_bib46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/ph12010011","article-title":"The therapeutic potential of naringenin: a review of clinical trials","volume":"12","author":"Salehi","year":"2019","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.mtbio.2026.103653_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140024","article-title":"Development of a nasal spray based on cyclodextrin\/hydrophobically-modified hydroxypropyl-methyl cellulose for the prevention of viral respiratory infections","volume":"299","author":"Zucca","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.mtbio.2026.103653_bib48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3390\/polym10030254","article-title":"Assessing mucoadhesion in polymer gels: the effect of method type and instrument variables","volume":"10","author":"Bassi da Silva","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.mtbio.2026.103653_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fmedt.2021.687681","article-title":"Low acyl gellan as an excipient to improve the sprayability and mucoadhesion of iota carrageenan in a nasal spray to prevent infection with SARS-CoV-2","volume":"3","author":"Robinson","year":"2021","journal-title":"Frontiers in Medical Technology"},{"key":"10.1016\/j.mtbio.2026.103653_bib50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/ma19010033","article-title":"Why does mucoadhesion matter? Mucoadhesive drug delivery systems with antifungal activity in the local treatment of oral cavity candidiasis","volume":"19","author":"Olechno","year":"2025","journal-title":"Materials"},{"key":"10.1016\/j.mtbio.2026.103653_bib51","article-title":"Development and characterization of alginate-derived bioadhesive films incorporated with anti-infective lectins for application in the treatment of oral candidiasis","volume":"90","author":"Baz\u00e1n","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426008987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426008987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:29:07Z","timestamp":1790335747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426008987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":51,"alternative-id":["S2590006426008987"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103653","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrospun core\u2013shell nanofibres embedding drug nanocrystals for long-acting mucosal delivery","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103653"}}