{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T22:46:57Z","timestamp":1793486817210,"version":"4.5.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD101130"],"award-info":[{"award-number":["R01HD101130"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD11458"],"award-info":[{"award-number":["R21HD11458"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CMMI-2130192"],"award-info":[{"award-number":["CMMI-2130192"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CMMI-2022421"],"award-info":[{"award-number":["CMMI-2022421"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET-1943798"],"award-info":[{"award-number":["CBET-1943798"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mtbio.2026.103667","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:55:33Z","timestamp":1789120533000},"page":"103667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes"],"prefix":"10.1016","volume":"40","author":[{"given":"Chenyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0604-9078","authenticated-orcid":false,"given":"Nhu Y.","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6498-7228","authenticated-orcid":false,"given":"Fred J.","family":"Donelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Moradi Nasab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-8201","authenticated-orcid":false,"given":"Huaxiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-0457","authenticated-orcid":false,"given":"Patrick T.","family":"Mather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-3144","authenticated-orcid":false,"given":"Xinrui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3355-5953","authenticated-orcid":false,"given":"James H.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-105X","authenticated-orcid":false,"given":"Zhen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/physrev.2000.80.2.853","article-title":"Regulation of contraction in striated muscle","volume":"80","author":"Gordon","year":"2000","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s12551-021-00840-7","article-title":"Cardiac sarcomere mechanics in health and disease","volume":"13","author":"Crocini","year":"2021","journal-title":"Biophys. Rev."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103667_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1083\/jcb.201101100","article-title":"Cellular mechanisms of cardiomyopathy","volume":"194","author":"Harvey","year":"2011","journal-title":"JCB (J. Cell Biol.)"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13287-022-02905-0","article-title":"Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib5","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3390\/jcm10051149","article-title":"Genetic cardiomyopathies: the lesson learned from hiPSCs","volume":"10","author":"My","year":"2021","journal-title":"JCM"},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib6","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.stemcr.2018.10.006","article-title":"Isogenic pairs of hiPSC-CMs with hypertrophic Cardiomyopathy\/LVNC-Associated ACTC1 E99K Mutation Unveil differential functional deficits","volume":"11","author":"Smith","year":"2018","journal-title":"Stem Cell Rep."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103667_bib7","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/01.RES.86.8.846","article-title":"Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium","volume":"86","author":"Heling","year":"2000","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbamem.2013.07.011","article-title":"The physiological role of cardiac cytoskeleton and its alterations in heart failure","volume":"1838","author":"Sequeira","year":"2014","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jbiomech.2009.09.014","article-title":"Mechanobiology of cardiomyocyte development","volume":"43","author":"Jacot","year":"2010","journal-title":"J. Biomech."},{"issue":"23","key":"10.1016\/j.mtbio.2026.103667_bib10","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.cub.2013.10.057","article-title":"Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating","volume":"23","author":"Majkut","year":"2013","journal-title":"Curr. Biol."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103667_bib11","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10237-012-0419-2","article-title":"The contribution of cellular mechanotransduction to cardiomyocyte form and function","volume":"11","author":"Sheehy","year":"2012","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103667_bib12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10237-021-01421-z","article-title":"Precision medicine in human heart modeling: perspectives, challenges, and opportunities","volume":"20","author":"Peirlinck","year":"2021","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103667_bib13","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/j.2040-4603.2015.tb00659.x","article-title":"Biomechanics of cardiac function","volume":"5","author":"Voorhees","year":"2015","journal-title":"Compr. Physiol."},{"issue":"41","key":"10.1016\/j.mtbio.2026.103667_bib14","doi-asserted-by":"crossref","first-page":"12705","DOI":"10.1073\/pnas.1508073112","article-title":"Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness","volume":"112","author":"Ribeiro","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6251","key":"10.1016\/j.mtbio.2026.103667_bib15","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1126\/science.aaa5458","article-title":"HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy","volume":"349","author":"Hinson","year":"2015","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.mtbio.2026.103667_bib16","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/s41551-018-0280-4","article-title":"Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload","volume":"2","author":"Ma","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.mtbio.2026.103667_bib17","doi-asserted-by":"crossref","DOI":"10.1101\/2025.10.02.680018","article-title":"A micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant \u03b1B crystallin","author":"Kargar Gaz Kooh","year":"2025","journal-title":"Bioengineering"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib18","doi-asserted-by":"crossref","DOI":"10.1063\/5.0160677","article-title":"Engineered tissue geometry and Plakophilin-2 regulate electrophysiology of human iPSC-derived cardiomyocytes","volume":"8","author":"Simmons","year":"2024","journal-title":"APL Bioeng."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib19","doi-asserted-by":"crossref","DOI":"10.1063\/5.0141269","article-title":"Dynamic mechanobiology of cardiac cells and tissues: current status and future perspective","volume":"4","author":"Wang","year":"2023","journal-title":"Biophys. Rev."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103667_bib20","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.biomaterials.2010.12.006","article-title":"Dynamic cell behavior on shape memory polymer substrates","volume":"32","author":"Davis","year":"2011","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/adhm.201200105","article-title":"Stem cell response to spatially and temporally displayed and reversible surface topography","volume":"2","author":"Guvendiren","year":"2013","journal-title":"Adv. Healthcare Mater."},{"issue":"19","key":"10.1016\/j.mtbio.2026.103667_bib22","doi-asserted-by":"crossref","first-page":"21450","DOI":"10.1021\/acsami.0c03464","article-title":"Progressive myofibril reorganization of human cardiomyocytes on a dynamic nanotopographic substrate","volume":"12","author":"Sun","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.mtbio.2026.103667_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1049523","article-title":"Cooperation between myofibril growth and costamere maturation in human cardiomyocytes","volume":"10","author":"Shi","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103667_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s12195-025-00880-z","article-title":"Disrupted sarcomere reorganization of cardiomyopathy-prone human iPSC-Derived cardiomyocytes on a dynamic mechanical substrate","volume":"18","author":"Mai","year":"2025","journal-title":"Cell. Mol. Bioeng."},{"issue":"7","key":"10.1016\/j.mtbio.2026.103667_bib25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11626-009-9182-9","article-title":"Control of myocyte remodeling in vitro with engineered substrates","volume":"45","author":"Geisse","year":"2009","journal-title":"In Vitro CellDevBiol-Animal"},{"issue":"10","key":"10.1016\/j.mtbio.2026.103667_bib26","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1096\/fj.02-0038com","article-title":"Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces","volume":"16","author":"Parker","year":"2002","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103667_bib27","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1161\/CIRCRESAHA.108.182469","article-title":"Myofibrillar architecture in engineered cardiac myocytes","volume":"103","author":"Parker","year":"2008","journal-title":"Circ. Res."},{"issue":"18","key":"10.1016\/j.mtbio.2026.103667_bib28","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1039\/c3sm00024a","article-title":"In vitro wrinkle formation via shape memory dynamically aligns adherent cells","volume":"9","author":"Yang","year":"2013","journal-title":"Soft Matter"},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3390\/polym16050609","article-title":"Tuning the topography of dynamic 3D scaffolds through functional protein wrinkled coatings","volume":"16","author":"Oguntade","year":"2024","journal-title":"Polymers"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1001088","article-title":"Self-organization of muscle cell structure and function","volume":"7","author":"Grosberg","year":"2011","journal-title":"PLoS Comput. Biol."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103667_bib31","doi-asserted-by":"crossref","first-page":"H1525","DOI":"10.1152\/ajpheart.00799.2013","article-title":"Matrix elasticity regulates the optimal cardiac myocyte shape for contractility","volume":"306","author":"McCain","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib32","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ae573e","article-title":"Integrating traction force microscopy and finite element analysis to assess hiPSC-CM mechanics on micropatterned substrates","volume":"18","author":"Jannati","year":"2026","journal-title":"Biofabrication"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54665-2","article-title":"Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue","volume":"9","author":"Dutsch","year":"2019","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.mtbio.2026.103667_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.94623","article-title":"A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress","volume":"2","author":"Judge","year":"2017","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103667_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1007676","article-title":"Striated myocyte structural integrity: automated analysis of sarcomeric z-discs","volume":"16","author":"Morris","year":"2020","journal-title":"PLoS Comput. Biol."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib36","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1089\/ten.tec.2014.0283","article-title":"Automated video-based analysis of contractility and calcium flux in human-induced pluripotent stem cell-derived cardiomyocytes cultured over different spatial scales","volume":"21","author":"Huebsch","year":"2015","journal-title":"Tissue Eng. C Methods"},{"issue":"8","key":"10.1016\/j.mtbio.2026.103667_bib37","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/bit.26709","article-title":"Quantitatively characterizing drug\u2010induced arrhythmic contractile motions of human stem cell\u2010derived cardiomyocytes","volume":"115","author":"Hoang","year":"2018","journal-title":"Biotechnol. Bioeng."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41378-022-00383-1","article-title":"A biosensing system using a multiparameter nonlinear dynamic analysis of cardiomyocyte beating for drug-induced arrhythmia recognition","volume":"8","author":"Wang","year":"2022","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.mtbio.2026.103667_bib39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.yjmcc.2014.09.010","article-title":"Image-based evaluation of contraction\u2013relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: correlation and complementarity with extracellular electrophysiology","volume":"77","author":"Hayakawa","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib40","doi-asserted-by":"crossref","first-page":"H499","DOI":"10.1152\/ajpheart.00595.2001","article-title":"Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat","volume":"282","author":"Janssen","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib41","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1038\/s41467-021-23272-z","article-title":"Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover","volume":"12","author":"Martin","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib42","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jacbts.2017.09.009","article-title":"The multifunctional protein BAG3","volume":"3","author":"Myers","year":"2018","journal-title":"JACC, Basic Transl. Sci."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103667_bib43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajhg.2011.01.016","article-title":"Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy","volume":"88","author":"Norton","year":"2011","journal-title":"Am. J. Hum. Genet."},{"issue":"12","key":"10.1016\/j.mtbio.2026.103667_bib44","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/jamacardio.2024.3547","article-title":"Bidirectional risk modulator and modifier variant of dilated and hypertrophic cardiomyopathy in BAG3","volume":"9","author":"Park","year":"2024","journal-title":"JAMA Cardiol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/ana.21553","article-title":"Mutation in BAG3 causes severe dominant childhood muscular dystrophy","volume":"65","author":"Selcen","year":"2009","journal-title":"Ann. Neurol."},{"issue":"22","key":"10.1016\/j.mtbio.2026.103667_bib46","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128799","article-title":"Investigation of a dilated cardiomyopathy\u2013associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes","volume":"4","author":"McDermott-Roe","year":"2019","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib47","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.gene.2015.09.008","article-title":"Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology","volume":"573","author":"Carrier","year":"2015","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib48","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133782","article-title":"Effects of MYBPC3 loss-of-function mutations preceding hypertrophic cardiomyopathy","volume":"5","author":"Helms","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.mtbio.2026.103667_bib49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.yjmcc.2020.10.003","article-title":"Targeting the population for gene therapy with MYBPC3","volume":"150","author":"Carrier","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"14","key":"10.1016\/j.mtbio.2026.103667_bib50","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCULATIONAHA.117.033200","article-title":"Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the sarcomeric human cardiomyopathy registry (SHaRe)","volume":"138","author":"Ho","year":"2018","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/CIRCGENETICS.108.821314","article-title":"Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy","volume":"2","author":"Kaski","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"issue":"4","key":"10.1016\/j.mtbio.2026.103667_bib52","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/heartjnl-2014-306387","article-title":"Novel genotype\u2013phenotype associations demonstrated by high-throughput sequencing in patients with hypertrophic cardiomyopathy","volume":"101","author":"Lopes","year":"2015","journal-title":"Heart"},{"issue":"9","key":"10.1016\/j.mtbio.2026.103667_bib53","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/CIRCRESAHA.109.211888","article-title":"Regulation of cardiomyocyte polyploidy and multinucleation by CyclinG1","volume":"106","author":"Liu","year":"2010","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1139\/cjpp-2019-0566","article-title":"Mechanisms for the transition from physiological to pathological cardiac hypertrophy","volume":"98","author":"Oldfield","year":"2020","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103667_bib55","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1021\/acsbiomaterials.8b01256","article-title":"Substrate stiffness, cell anisotropy, and cell\u2013cell contact contribute to enhanced structural and calcium handling properties of human embryonic stem cell-derived cardiomyocytes","volume":"5","author":"Rodriguez","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"3","key":"10.1016\/j.mtbio.2026.103667_bib56","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/HCO.0b013e328337ba52","article-title":"The genetics of dilated cardiomyopathy","volume":"25","author":"Dellefave","year":"2010","journal-title":"Curr. Opin. Cardiol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib57","article-title":"Dynamic myofibrillar remodeling in live cardiomyocytes under static stretch","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103667_bib58","doi-asserted-by":"crossref","first-page":"H757","DOI":"10.1152\/ajpheart.00290.2017","article-title":"Mitochondrial function in engineered cardiac tissues is regulated by extracellular matrix elasticity and tissue alignment","volume":"313","author":"Lyra-Leite","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/srep19614","article-title":"Breaking sarcomeres by in vitro exercise","volume":"6","author":"Orfanos","year":"2016","journal-title":"Sci. Rep."},{"issue":"6565","key":"10.1016\/j.mtbio.2026.103667_bib60","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1126\/science.abe5620","article-title":"Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction","volume":"374","author":"Roman","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.mtbio.2026.103667_bib61","first-page":"367","article-title":"Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography","volume":"10","author":"Shi","year":"2022","journal-title":"Bioact. Mater."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103667_bib62","doi-asserted-by":"crossref","first-page":"H2291","DOI":"10.1152\/ajpheart.00749.2005","article-title":"Costameres, focal adhesions, and cardiomyocyte mechanotransduction","volume":"289","author":"Samarel","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib63","doi-asserted-by":"crossref","DOI":"10.1063\/5.0320788","article-title":"Cardiac mechanotransduction from development to disease","volume":"10","author":"Kim","year":"2026","journal-title":"APL Bioeng."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103667_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbm.2024.100085","article-title":"YAP\/TAZ as mechanobiological signaling pathway in cardiovascular physiological regulation and pathogenesis","volume":"2","author":"Islam","year":"2024","journal-title":"Mechanobiol. Med"},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib65","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/cimb47050297","article-title":"The mechanical role of YAP\/TAZ in the development of diabetic cardiomyopathy","volume":"47","author":"Shen","year":"2025","journal-title":"Curr Issues Mol Biol."},{"issue":"10","key":"10.1016\/j.mtbio.2026.103667_bib66","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/CIRCRESAHA.110.225649","article-title":"BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress","volume":"107","author":"Hishiya","year":"2010","journal-title":"Circ. Res."},{"issue":"18","key":"10.1016\/j.mtbio.2026.103667_bib67","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1016\/j.cub.2024.07.088","article-title":"Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic","volume":"34","author":"Ottensmeyer","year":"2024","journal-title":"Curr. Biol."},{"issue":"24","key":"10.1016\/j.mtbio.2026.103667_bib68","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029938","article-title":"Dysregulated autophagy and sarcomere dysfunction in patients with heart failure with co\u2010occurrence of P63A and P380S BAG3 variants","volume":"12","author":"Martin","year":"2023","journal-title":"J. Am. Heart Assoc"},{"key":"10.1016\/j.mtbio.2026.103667_bib69","doi-asserted-by":"crossref","DOI":"10.1177\/20417314251371296","article-title":"A patient-specific engineered tissue model of BAG3-mediated cardiomyopathy","volume":"16","author":"Morsink","year":"2025","journal-title":"J. Tissue Eng."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103667_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180064","article-title":"MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy","volume":"12","author":"McNamara","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.mtbio.2026.103667_bib71","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/CIRCRESAHA.122.321951","article-title":"iPSC-Based modeling of variable clinical presentation in hypertrophic cardiomyopathy","volume":"133","author":"Escrib\u00e1","year":"2023","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103667_bib72","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1161\/CIRCULATIONAHA.118.034624","article-title":"A premature termination codon mutation in MYBPC3 causes hypertrophic cardiomyopathy via chronic activation of nonsense-mediated decay","volume":"139","author":"Seeger","year":"2019","journal-title":"Circulation"},{"issue":"603","key":"10.1016\/j.mtbio.2026.103667_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd1817","article-title":"Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype","volume":"13","author":"Bliley","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib74","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.3390\/ijms24054909","article-title":"Cardiomyocyte apoptosis is associated with contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopathy","volume":"24","author":"Loiben","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103667_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109954","article-title":"Substrate mechanics unveil early structural and functional pathology in iPSC micro-tissue models of hypertrophic cardiomyopathy","volume":"27","author":"Guo","year":"2024","journal-title":"iScience"},{"issue":"5","key":"10.1016\/j.mtbio.2026.103667_bib76","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cub.2013.01.064","article-title":"Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy","volume":"23","author":"Ulbricht","year":"2013","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib77","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/CIRCRESAHA.116.300561","article-title":"Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium","volume":"116","author":"Moss","year":"2015","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103667_bib78","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1161\/CIRCRESAHA.119.315862","article-title":"Cardiomyocyte maturation: new phase in development","volume":"126","author":"Guo","year":"2020","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103667_bib79","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41569-019-0331-x","article-title":"Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine","volume":"17","author":"Karbassi","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.mtbio.2026.103667_bib80","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.actbio.2024.10.029","article-title":"Developing a soft micropatterned substrate to enhance maturation of human induced pluripotent stem cell-derived cardiomyocytes","volume":"190","author":"Maaref","year":"2024","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103667_bib81","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.113.001878","article-title":"Pathological ventricular remodeling: mechanisms: part 1 of 2","volume":"128","author":"Burchfield","year":"2013","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.mtbio.2026.103667_bib82","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1161\/CIRCRESAHA.109.214429","article-title":"Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein Connexin43","volume":"106","author":"Salameh","year":"2010","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103667_bib83","doi-asserted-by":"crossref","DOI":"10.1063\/5.0025378","article-title":"Stimuli-responsive biomaterials for cardiac tissue engineering and dynamic mechanobiology","volume":"5","author":"Shi","year":"2021","journal-title":"APL Bioeng."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426009129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426009129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:44:15Z","timestamp":1790336655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426009129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":83,"alternative-id":["S2590006426009129"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103667","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103667","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103667"}}