{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:39:03Z","timestamp":1793367543317,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374486"],"award-info":[{"award-number":["82374486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.mtbio.2026.103708","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:22:28Z","timestamp":1790148148000},"page":"103708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Electroacupuncture synergizes with anti-ferroptosis bioelectrical niche remodeling to promote spinal cord regeneration"],"prefix":"10.1016","volume":"41","author":[{"given":"Yihui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YunGang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9903-0362","authenticated-orcid":false,"given":"Zhouguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103708_bib1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0140-6736(02)07603-1","article-title":"Spinal-cord injury","volume":"359","author":"McDonald","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.mtbio.2026.103708_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1474-4422(18)30415-0","article-title":"Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mtbio.2026.103708_bib3","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1093\/neuros\/nyw080","article-title":"Traumatic spinal cord injury-repair and regeneration","volume":"80","author":"Ahuja","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.mtbio.2026.103708_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.631500","article-title":"Revascularization after traumatic Spinal Cord injury","volume":"12","author":"Yao","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mtbio.2026.103708_bib5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4103\/1673-5374.350187","article-title":"Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.mtbio.2026.103708_bib6","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.4103\/NRR.NRR-D-24-00112","article-title":"Pyroptosis, ferroptosis, and autophagy in spinal cord injury: regulatory mechanisms and therapeutic targets","volume":"20","author":"Zheng","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.mtbio.2026.103708_bib7","doi-asserted-by":"crossref","first-page":"G192","DOI":"10.1152\/ajpgi.00254.2016","article-title":"Anti-inflammatory effects and mechanisms of vagal nerve stimulation combined with electroacupuncture in a rodent model of TNBS-induced colitis","volume":"313","author":"Jin","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mtbio.2026.103708_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/692795","article-title":"Effect and potential mechanism of electroacupuncture Add-On treatment in patients with Parkinson's Disease","volume":"2015","author":"Wang","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.mtbio.2026.103708_bib9","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1007\/s11064-022-03634-9","article-title":"Electroacupuncture promotes autophagy by regulating the AKT\/mTOR signaling pathway in temporal Lobe Epilepsy","volume":"47","author":"Gao","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mtbio.2026.103708_bib10","article-title":"Cell-Free extracts from human fat tissue with a Hyaluronan-Based Hydrogel attenuate inflammation in a spinal cord injury model through M2 Microglia\/Microphage polarization","volume":"18","author":"Xu","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.mtbio.2026.103708_bib11","article-title":"Electroacupuncture for spinal cord injury: a systematic review and meta-analysis of randomised controlled trials","volume":"2022","author":"Tan","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.mtbio.2026.103708_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18240","article-title":"Electroacupuncture suppresses neuronal ferroptosis to relieve chronic neuropathic pain","volume":"28","author":"Xue","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mtbio.2026.103708_bib13","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.2147\/NDT.S183436","article-title":"The effect of different frequencies of electroacupuncture on BDNF and NGF expression in the hippocampal CA3 area of the ischemic hemisphere in cerebral ischemic rats","volume":"14","author":"Duan","year":"2018","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.mtbio.2026.103708_bib14","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2015.09.020","article-title":"Antioxidant role for lipid droplets in a stem cell niche of drosophila","volume":"163","author":"Bailey","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.103708_bib15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00604-025-07203-z","article-title":"A neuraminidase-based electrochemical biosensor for high-throughput screening of antiviral compounds in traditional Chinese medicine","volume":"192","author":"Zhou","year":"2025","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.mtbio.2026.103708_bib16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/cns.13813","article-title":"Electro-acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: a summary of current laboratory findings and a review of literature","volume":"28","author":"Zeng","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.mtbio.2026.103708_bib17","doi-asserted-by":"crossref","first-page":"510","DOI":"10.7150\/thno.89008","article-title":"Exosomes derived from CD271(+)CD56(+) bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon regeneration after spinal cord injury","volume":"14","author":"Sun","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103708_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado9120","article-title":"Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays","volume":"10","author":"Tan","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.103708_bib19","article-title":"HAda: Hyper-Adaptive parameter-efficient learning for multi-view ConvNets","author":"Wang","year":"2024","journal-title":"IEEE Trans. Image Process."},{"key":"10.1016\/j.mtbio.2026.103708_bib20","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.7150\/thno.29400","article-title":"Mitochondrial transfer from bone marrow mesenchymal stem cells to motor neurons in spinal cord injury rats via gap junction","volume":"9","author":"Li","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103708_bib21","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.1021\/acsnano.2c03991","article-title":"DNA Origami as a nanomedicine for targeted rheumatoid Arthritis therapy through reactive oxygen species and nitric oxide scavenging","volume":"16","author":"Ma","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.mtbio.2026.103708_bib22","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/s41556-025-01722-w","article-title":"A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis","volume":"27","author":"Zhang","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103708_bib23","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2026.103708_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mtbio.2026.103708_bib25","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.7150\/ijbs.102859","article-title":"Mechanism of ferroptosis and its role in disease development","volume":"21","author":"Ye","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mtbio.2026.103708_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.brainresbull.2020.08.016","article-title":"Anti-inflammatory and immunomodulatory effects of baicalin in cerebrovascular and neurological disorders","volume":"164","author":"Li","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mtbio.2026.103708_bib27","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-024-04395-9","article-title":"Baicalin improves isoproterenol-induced cardiac remodeling by regulating the Nrf2-dependent signaling pathway","volume":"24","author":"Qian","year":"2024","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.mtbio.2026.103708_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.sjpain.2012.11.001","article-title":"Transient receptor potential ankyrin 1 (TRPA1) ion channel in the pathophysiology of peripheral diabetic neuropathy","volume":"4","author":"Koivisto","year":"2013","journal-title":"Scand J Pain"},{"key":"10.1016\/j.mtbio.2026.103708_bib29","doi-asserted-by":"crossref","first-page":"12818","DOI":"10.1074\/jbc.M113.450072","article-title":"Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine","volume":"288","author":"Than","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mtbio.2026.103708_bib30","article-title":"ROS-Scavenging hydrogels synergize with neural stem cells to enhance spinal cord Injury repair via regulating microenvironment and facilitating nerve regeneration","volume":"12","author":"Liu","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.mtbio.2026.103708_bib31","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.2147\/IJN.S436111","article-title":"Advances in conductive hydrogel for Spinal Cord Injury Repair and regeneration","volume":"18","author":"Qin","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.mtbio.2026.103708_bib32","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ac1d3c","article-title":"Research advances of biomaterials-based microenvironment-regulation therapies for repair and regeneration of spinal cord injury","volume":"16","author":"Li","year":"2021","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.mtbio.2026.103708_bib33","first-page":"274","article-title":"A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis","volume":"22","author":"Ying","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103708_bib34","article-title":"Timed sulfonylurea modulation improves locomotor and sensory dysfunction following spinal cord injury","volume":"15","author":"Xu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mtbio.2026.103708_bib35","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41593-018-0209-y","article-title":"DeepLabCut: markerless pose estimation of user-defined body parts with deep learning","volume":"21","author":"Mathis","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mtbio.2026.103708_bib36","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/d41586-024-01474-x","article-title":"DeepLabCut: the motion-tracking tool that went viral","volume":"629","author":"Madhusoodanan","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103708_bib37","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/brain\/awad392","article-title":"Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances","volume":"147","author":"Hosseini","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.mtbio.2026.103708_bib38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1177\/0963689718755778","article-title":"Microenvironment imbalance of spinal cord injury","volume":"27","author":"Fan","year":"2018","journal-title":"Cell Transplant."},{"key":"10.1016\/j.mtbio.2026.103708_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114682","article-title":"The acute spinal cord injury microenvironment and its impact on the homing of mesenchymal stem cells","volume":"373","author":"Liu","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mtbio.2026.103708_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1692346","article-title":"Mechanism analysis and intervention strategies of the inflammatory microenvironment in traumatic spinal cord injury","volume":"16","author":"Gu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2026.103708_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.redox.2015.12.011","article-title":"Cellular and subcellular oxidative stress parameters following severe spinal cord injury","volume":"8","author":"Visavadiya","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.mtbio.2026.103708_bib42","article-title":"GPX4: the hub of lipid oxidation, ferroptosis, disease and treatment","volume":"1878","author":"Liu","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.mtbio.2026.103708_bib43","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103708_bib44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103708_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116512","article-title":"GPX4, ferroptosis, and diseases","volume":"174","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mtbio.2026.103708_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the crossroads of lipid homeostasis and ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.mtbio.2026.103708_bib47","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0891-5849(02)01184-X","article-title":"Spinal cord injury increases iron levels: catalytic production of hydroxyl radicals","volume":"34","author":"Liu","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mtbio.2026.103708_bib48","article-title":"Mechanisms and regulations of ferroptosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mtbio.2026.103708_bib49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pharmthera.2011.10.006","article-title":"Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases","volume":"133","author":"Zheng","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mtbio.2026.103708_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.70067","article-title":"Ferroptosis in spinal cord injury: research progress and novel insights","volume":"126","author":"Li","year":"2025","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mtbio.2026.103708_bib51","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426009531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426009531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:01:29Z","timestamp":1793365289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426009531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":51,"alternative-id":["S2590006426009531"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103708","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electroacupuncture synergizes with anti-ferroptosis bioelectrical niche remodeling to promote spinal cord regeneration","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103708"}}