{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:34:36Z","timestamp":1793453676272,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.mtbio.2026.103719","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:30:34Z","timestamp":1790699434000},"page":"103719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A zinc organic metal skeleton vaccine for lung cancer treatment can stimulate strong innate and adaptive anti-tumor immunity"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-3710","authenticated-orcid":false,"given":"Xuejian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shitao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mtbio.2026.103719_bib1","article-title":"Hypoxic exosomal circPLEKHM1-Mediated crosstalk between tumor cells and macrophages drives lung cancer metastasis","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.103719_bib2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41392-025-02460-z","article-title":"Ablation plus immunotherapy versus immunotherapy alone in patients of advanced NSCLC who develop oligo-residual disease after anti-PD-1\/L1 therapy (BOOSTER): a randomized phase 2 trial","volume":"10","author":"Yang","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.mtbio.2026.103719_bib3","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jtho.2022.06.011","article-title":"Tumor cells modulate macrophage phenotype in a novel in vitro Co-Culture model of the NSCLC tumor microenvironment","volume":"17","author":"Park","year":"2022","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.mtbio.2026.103719_bib4","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/s41401-022-01047-6","article-title":"AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage","volume":"44","author":"Pei","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.mtbio.2026.103719_bib5","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1016\/j.cell.2025.03.018","article-title":"A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancer","volume":"188","author":"Liu","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.103719_bib6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41591-023-02758-x","article-title":"Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial","volume":"30","author":"Verschoor","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2026.103719_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009032","article-title":"PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF-caspase 8-GSDMD\/E axis in ovarian cancer","volume":"12","author":"Xia","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.mtbio.2026.103719_bib8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1186\/s12951-025-03672-9","article-title":"Ultrasound molecular imaging of M2 macrophages for early detection of chronic rejection in heart transplantation","volume":"23","author":"Xu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103719_bib9","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-025-02243-5","article-title":"M2pep-modified liposomal nanoparticles delivering siITGB4 induce apoptosis and inhibit NSCLC metastasis via macrophage reprogramming","volume":"31","author":"Huang","year":"2026","journal-title":"Apoptosis"},{"key":"10.1016\/j.mtbio.2026.103719_bib10","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1021\/acsabm.0c00368","article-title":"Targeted imaging of CD206 expressing tumor-associated M2-like macrophages using mannose-conjugated antibiofouling magnetic iron oxide nanoparticles","volume":"3","author":"Li","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.mtbio.2026.103719_bib11","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.2147\/DDDT.S531190","article-title":"Cinobufagin inhibits invasion and migration of non-small cell lung cancer via regulating glucose metabolism reprogramming in tumor-associated macrophages","volume":"19","author":"Sun","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.mtbio.2026.103719_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413416","article-title":"CLDN6: from traditional barrier function to emerging roles in cancers","volume":"22","author":"Qu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103719_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3892\/ijmm.2024.5424","article-title":"Claudin 1, 4, 6 and 18 isoform 2 as targets for the treatment of cancer","volume":"54","author":"Katoh","year":"2024","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mtbio.2026.103719_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009563","article-title":"SAIL66, a next generation CLDN6-targeting T-cell engager, demonstrates potent antitumor efficacy through dual binding to CD3\/CD137","volume":"12","author":"Kamikawa","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.mtbio.2026.103719_bib15","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1158\/1078-0432.CCR-22-2981","article-title":"Preclinical efficacy of the antibody-drug conjugate CLDN6-23-ADC for the treatment of CLDN6-Positive solid tumors","volume":"29","author":"McDermott","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103719_bib16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s11658-024-00629-y","article-title":"CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation","volume":"29","author":"Jin","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.mtbio.2026.103719_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2026.108276","article-title":"CLDN6 in cancer: biology, clinical significance, and emerging therapeutic strategies","volume":"230","author":"Yang","year":"2026","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mtbio.2026.103719_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13046-023-02644-x","article-title":"CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy","volume":"42","author":"Dong","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103719_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/pjp.2022.117171","article-title":"Claudin 6 is associated with a short survival and a short recurrent free interval in non-small cell lung carcinoma","volume":"73","author":"Soini","year":"2022","journal-title":"Pol. J. Pathol."},{"key":"10.1016\/j.mtbio.2026.103719_bib20","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.7150\/ijbs.116340","article-title":"CLDN6 induces chemoresistance through protective autophagy in breast cancer","volume":"21","author":"Qu","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mtbio.2026.103719_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.115142","article-title":"A zinc-glycyrrhizic acid hydrogel alleviates atopic dermatitis by targeting the TLR4\/NLRP12-driven PANoptosis axis","volume":"397","author":"Wang","year":"2026","journal-title":"J Control Release"},{"key":"10.1016\/j.mtbio.2026.103719_bib22","article-title":"Zinc-organometallic framework vaccine controlled-release Zn(2+) regulates tumor extracellular matrix degradation potentiate efficacy of immunotherapy","volume":"10","author":"Ding","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.103719_bib23","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1186\/s12951-025-03870-5","article-title":"A novel biomimetic nanoplatform amplifies ferroptosis for specific cGAS-STING pathway activation to enhance hepatocellular carcinoma chemo-immunotherapy","volume":"23","author":"Peng","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103719_bib24","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41419-023-06044-z","article-title":"ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mtbio.2026.103719_bib25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/gutjnl-2024-333492","article-title":"Induction of macrophage efferocytosis in pancreatic cancer via PI3K\u03b3 inhibition and radiotherapy promotes tumour control","volume":"74","author":"Russell","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.mtbio.2026.103719_bib26","doi-asserted-by":"crossref","first-page":"9580","DOI":"10.7150\/thno.118014","article-title":"Macrophage-TREM2 promotes cardiac repair by restricting the infiltration of CD8(+) T cells via CXCL16-CXCR6 axis after myocardial infarction","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.mtbio.2026.103719_bib27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13046-024-03163-z","article-title":"Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation","volume":"43","author":"Yuan","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mtbio.2026.103719_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2024.107078","article-title":"Oral squamous cell carcinomas drive monocytes into immunosuppressive CD25(+)CD163(+)CD206(+) macrophages","volume":"159","author":"Pelaez-Prestel","year":"2024","journal-title":"Oral Oncol."},{"key":"10.1016\/j.mtbio.2026.103719_bib29","article-title":"ZnS@BSA nanoclusters potentiate efficacy of cancer immunotherapy","volume":"33","author":"Cen","year":"2021","journal-title":"Adv Mater"},{"key":"10.1016\/j.mtbio.2026.103719_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/asia.202200685","article-title":"Pseudocapacitive features of freestanding nickel-zinc organometallic nanostructure for high-energy density coin-cell asymmetric supercapacitors","volume":"17","author":"Zeng","year":"2022","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.mtbio.2026.103719_bib31","doi-asserted-by":"crossref","DOI":"10.2147\/IJN.S604563","article-title":"Key tumor responsive ZIF-8 nanocarriers for effective anti-cancer therapeutics","volume":"21","author":"He","year":"2026","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.mtbio.2026.103719_bib32","article-title":"Controlled releasing melatonin nanoparticles promote restoration of nucleus pulposus cell homeostasis for alleviating intervertebral disc degeneration","volume":"33","author":"Yang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103719_bib33","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1038\/s41467-023-37727-y","article-title":"Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer","volume":"14","author":"Palakurthi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103719_bib34","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41590-023-01604-z","article-title":"CXCR6 orchestrates brain CD8(+) T cell residency and limits mouse alzheimer's disease pathology","volume":"24","author":"Su","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mtbio.2026.103719_bib35","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1016\/j.cell.2021.07.015","article-title":"CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment","volume":"184","author":"Di Pilato","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.mtbio.2026.103719_bib36","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/s41586-024-08261-8","article-title":"Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers","volume":"637","author":"Steffin","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.mtbio.2026.103719_bib37","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.jhep.2025.06.037","article-title":"B cells drive CCR5(+)CD4(+) tissue-resident memory T-cell cytotoxicity via IL-15R\u03b1-IL-15 signaling in primary biliary cholangitis","volume":"83","author":"Pu","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mtbio.2026.103719_bib38","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1038\/s41591-023-02612-0","article-title":"CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial","volume":"29","author":"Mackensen","year":"2023","journal-title":"Nat. Med."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426009646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426009646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:02:50Z","timestamp":1793451770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426009646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":38,"alternative-id":["S2590006426009646"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103719","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A zinc organic metal skeleton vaccine for lung cancer treatment can stimulate strong innate and adaptive anti-tumor immunity","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103719"}}