{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:34:09Z","timestamp":1793453649842,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012753"],"award-info":[{"award-number":["2025A1515012753"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401888"],"award-info":[{"award-number":["82401888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571457"],"award-info":[{"award-number":["82571457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201427"],"award-info":[{"award-number":["82201427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571691"],"award-info":[{"award-number":["82571691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Materials Today Bio"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.mtbio.2026.103743","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:31:56Z","timestamp":1791588716000},"page":"103743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["AICAR-induced energy supply and paracrine activity of endothelial cells accelerate chronic diabetic wound healing by promoting angiogenesis and modulating macrophage reprogramming"],"prefix":"10.1016","volume":"41","author":[{"given":"Hengxian","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengshi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzhi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4874-8048","authenticated-orcid":false,"given":"Xin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.mtbio.2026.103743_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","article-title":"Genetics of diabetes mellitus and diabetes complications","volume":"16","author":"Cole","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.mtbio.2026.103743_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"9498","key":"10.1016\/j.mtbio.2026.103743_bib3","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0140-6736(05)67698-2","article-title":"The global burden of diabetic foot disease","volume":"366","author":"Boulton","year":"2005","journal-title":"Lancet"},{"issue":"14","key":"10.1016\/j.mtbio.2026.103743_bib4","article-title":"Targeting grancalcin accelerates wound healing by improving angiogenesis in diabetes","volume":"11","author":"Xiang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.103743_bib5","article-title":"Microenvironment self-adaptive multifunctional hydrogels elicit immunomodulation mediated wound healing","volume":"35","author":"Fang","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12951-025-03451-6","article-title":"Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism","volume":"23","author":"Gao","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.mtbio.2026.103743_bib7","first-page":"283","article-title":"Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body","volume":"11","author":"Chen","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103743_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.121998","article-title":"Bioactive glass-elicited stem cell-derived extracellular vesicles regulate M2 macrophage polarization and angiogenesis to improve tendon regeneration and functional recovery","volume":"294","author":"Xu","year":"2023","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.mtbio.2026.103743_bib9","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.apsb.2020.12.014","article-title":"Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses","volume":"11","author":"Hu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"8","key":"10.1016\/j.mtbio.2026.103743_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.658","article-title":"Macrophage plasticity: signaling pathways, tissue repair, and regeneration","volume":"5","author":"Yan","year":"2024","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib11","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41467-024-45101-9","article-title":"Programmed microalgae-gel promotes chronic wound healing in diabetes","volume":"15","author":"Kang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103743_bib12","first-page":"302","article-title":"Netrin-1 co-cross-linked hydrogel accelerates diabetic wound healing in situ by modulating macrophage heterogeneity and promoting angiogenesis","volume":"39","author":"Shu","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103743_bib13","article-title":"2A-biohydrogels accelerate diabetic wound healing by promoting M2 macrophage polarization and functionalized mitochondrial transfer to endothelial cells","volume":"514","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.mtbio.2026.103743_bib14","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.cmet.2024.05.005","article-title":"The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair","volume":"36","author":"Cai","year":"2024","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib15","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/s41467-021-23482-5","article-title":"Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing","volume":"12","author":"Atcha","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib16","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1038\/s41467-022-30467-5","article-title":"Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury","volume":"13","author":"Francos-Quijorna","year":"2022","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.mtbio.2026.103743_bib17","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIRCULATIONAHA.119.044484","article-title":"gp130 controls cardiomyocyte proliferation and heart regeneration","volume":"142","author":"Li","year":"2020","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.mtbio.2026.103743_bib18","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1039\/D2BM01338J","article-title":"Cellular energy supply for promoting vascular remodeling of small-diameter vascular grafts: a preliminary study of a new strategy for vascular graft development","volume":"11","author":"Su","year":"2023","journal-title":"Biomater. Sci."},{"issue":"13","key":"10.1016\/j.mtbio.2026.103743_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay7608","article-title":"Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state","volume":"6","author":"Liu","year":"2020","journal-title":"Sci. Adv."},{"issue":"15","key":"10.1016\/j.mtbio.2026.103743_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307176","article-title":"Supramolecular hydrogel with ultra-rapid cell-mediated network adaptation for enhancing cellular metabolic energetics and tissue regeneration","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"issue":"42","key":"10.1016\/j.mtbio.2026.103743_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adp7872","article-title":"Bioenergetic-active exosomes for cartilage regeneration and homeostasis maintenance","volume":"10","author":"Liu","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mtbio.2026.103743_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mattod.2024.12.008","article-title":"A highly versatile bioenergetic-active scaffold system for customized orthopedic applications","volume":"82","author":"Zhang","year":"2025","journal-title":"Mater. Today"},{"issue":"6382","key":"10.1016\/j.mtbio.2026.103743_bib23","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.aar5557","article-title":"Targeting angiogenic metabolism in disease","volume":"359","author":"Li","year":"2018","journal-title":"Science"},{"issue":"35","key":"10.1016\/j.mtbio.2026.103743_bib24","article-title":"Gasdermin D mediated mitochondrial metabolism orchestrate neurogenesis through LDHA during embryonic development","volume":"11","author":"Ma","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103743_bib25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2021.01.014","article-title":"Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells","volume":"33","author":"Kosaisawe","year":"2021","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103743_bib26","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.ymthe.2023.02.013","article-title":"Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading","volume":"31","author":"Radler","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.mtbio.2026.103743_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105490","article-title":"The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics","volume":"166","author":"Xiong","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"30","key":"10.1016\/j.mtbio.2026.103743_bib28","article-title":"Adipose-derived mesenchymal stem cell-derived exosomes biopotentiated extracellular matrix hydrogels accelerate diabetic wound healing and skin regeneration","volume":"10","author":"Song","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.mtbio.2026.103743_bib29","article-title":"Exosome-loaded tannic acid-thioctic acid hydrogel enhances wound healing in coagulation disorders","volume":"31","author":"Tu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.mtbio.2026.103743_bib30","first-page":"157","article-title":"Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization","volume":"33","author":"Cheng","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.mtbio.2026.103743_bib31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","article-title":"Exosomes","volume":"88","author":"Pegtel","year":"2019","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12951-023-02006-x","article-title":"Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood-brain-barrier penetration and tumor microenvironment modulation","volume":"21","author":"Kim","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"48","key":"10.1016\/j.mtbio.2026.103743_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202105749","article-title":"Engineering bacteria-activated multifunctionalized hydrogel for promoting diabetic wound healing","volume":"31","author":"Lu","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"7986","key":"10.1016\/j.mtbio.2026.103743_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-023-06537-z","article-title":"The power and potential of mitochondria transfer","volume":"623","author":"Borcherding","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41392-020-00440-z","article-title":"Intercellular mitochondrial transfer as a means of tissue revitalization","volume":"6","author":"Liu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103743_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103743_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mtbio.2026.103743_bib38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.34133\/research.0433","article-title":"Mitophagy promotes hair regeneration by activating glutathione metabolism","volume":"7","author":"Wang","year":"2024","journal-title":"Research"},{"issue":"11","key":"10.1016\/j.mtbio.2026.103743_bib39","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1016\/j.cell.2024.04.037","article-title":"Mitochondria at the crossroads of health and disease","volume":"187","author":"Suomalainen","year":"2024","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.mtbio.2026.103743_bib40","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.cmet.2021.10.004","article-title":"Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing","volume":"33","author":"Willenborg","year":"2021","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103743_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/INMD.20240062","article-title":"Effects of reactive oxygen species and antioxidant strategies on wound healing in diabetes","volume":"3","author":"Yu","year":"2025","journal-title":"Interdiscip. Med."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103743_bib42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Pena","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"13","key":"10.1016\/j.mtbio.2026.103743_bib43","article-title":"All-natural immunomodulatory bioadhesive hydrogel promotes angiogenesis and diabetic wound healing by regulating macrophage heterogeneity","volume":"10","author":"Fu","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib44","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1186\/s12951-024-02893-8","article-title":"Lactobacillus rhamnosus GG-derived extracellular vesicles promote wound healing via miR-21-5p-mediated re-epithelization and angiogenesis","volume":"22","author":"Wang","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"18","key":"10.1016\/j.mtbio.2026.103743_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202211602","article-title":"Young exosome bio-nanoparticles restore aging-impaired tendon stem\/progenitor cell function and reparative capacity","volume":"35","author":"Jin","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib46","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41392-021-00779-x","article-title":"Roles and mechanisms of exosomal non-coding RNAs in human health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"15","key":"10.1016\/j.mtbio.2026.103743_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl0372","article-title":"Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle","volume":"10","author":"Zhuang","year":"2024","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103743_bib48","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.7150\/ijbs.92897","article-title":"Exosomes: the emerging mechanisms and potential clinical applications in dermatology","volume":"20","author":"Yu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103743_bib49","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/s41591-022-01926-9","article-title":"Anti-inflammatory clearance of amyloid-beta by a chimeric Gas6 fusion protein","volume":"28","author":"Jung","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.mtbio.2026.103743_bib50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jare.2024.04.020","article-title":"Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury","volume":"70","author":"Lu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.mtbio.2026.103743_bib51","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9690832","article-title":"Selective increment of synovial soluble TYRO3 correlates with disease severity and joint inflammation in patients with rheumatoid arthritis","volume":"2020","author":"Vullings","year":"2020","journal-title":"J. Immunol. Res."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib52","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","article-title":"A network of macrophages supports mitochondrial homeostasis in the heart","volume":"183","author":"Nicolas-Avila","year":"2020","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.mtbio.2026.103743_bib53","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s42255-023-00736-8","article-title":"PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages","volume":"5","author":"Schilperoort","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.mtbio.2026.103743_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107893","article-title":"Resolving inflammation by TAM receptor activation","volume":"227","author":"Vago","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.mtbio.2026.103743_bib55","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1681\/ASN.2017030234","article-title":"Protein S protects against podocyte injury in diabetic nephropathy","volume":"29","author":"Zhong","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"11","key":"10.1016\/j.mtbio.2026.103743_bib56","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41423-022-00919-5","article-title":"Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair","volume":"19","author":"Audu","year":"2022","journal-title":"Cell. Mol. Immunol."},{"issue":"8","key":"10.1016\/j.mtbio.2026.103743_bib57","article-title":"Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing","volume":"4","author":"Lv","year":"2023","journal-title":"Cell Rep. Med."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib58","doi-asserted-by":"crossref","first-page":"7658","DOI":"10.1038\/s41467-023-43067-8","article-title":"Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mtbio.2026.103743_bib59","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jare.2025.04.038","article-title":"OTUD1 delays wound healing by regulating endothelial function and angiogenesis in diabetic mice","volume":"80","author":"Zhang","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.mtbio.2026.103743_bib60","first-page":"409","article-title":"Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles: symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus","volume":"27","author":"Deng","year":"2023","journal-title":"Bioact. Mater."},{"issue":"9","key":"10.1016\/j.mtbio.2026.103743_bib61","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1016\/j.ymthe.2022.07.016","article-title":"Macrophages as a therapeutic target to promote diabetic wound healing","volume":"30","author":"Sharifiaghdam","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.mtbio.2026.103743_bib62","doi-asserted-by":"crossref","DOI":"10.1177\/20417314241265202","article-title":"Immunomodulation in diabetic wounds healing: the intersection of macrophage reprogramming and immunotherapeutic hydrogels","volume":"15","author":"Sun","year":"2024","journal-title":"J. Tissue Eng."},{"issue":"4","key":"10.1016\/j.mtbio.2026.103743_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/INMD.20230019","article-title":"Small extracellular vesicles: yields, functionalization and applications in diabetic wound management","volume":"1","author":"Liu","year":"2023","journal-title":"Interdiscip. Med."},{"key":"10.1016\/j.mtbio.2026.103743_bib64","unstructured":"M.A.-O. Tkach, J.A.-O. Kowal, C.A.-O. Th\u00e9ry, Why the need and how to approach the functional diversity of extracellular vesicles, Philos. Trans. R. Soc. Lond. B Biol. Sci. (1471-2970 (Electronic))."},{"issue":"2","key":"10.1016\/j.mtbio.2026.103743_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.mtbio.2026.103743_bib66","first-page":"10","article-title":"Current research status and progress of laser therapy in wound healing","volume":"13","author":"Liu","year":"2026","journal-title":"PLAST AESTHET RES"},{"key":"10.1016\/j.mtbio.2026.103743_bib67","first-page":"19","article-title":"Role of mechanical forces and skin tension in scar pathophysiology","volume":"13","author":"Sheckley","year":"2026","journal-title":"PLAST AESTHET RES"},{"issue":"8","key":"10.1016\/j.mtbio.2026.103743_bib68","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1089\/wound.2020.1254","article-title":"Limited treatment options for diabetic wounds: barriers to clinical translation despite therapeutic success in murine models","volume":"10","author":"Barakat","year":"2021","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.mtbio.2026.103743_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1640935","article-title":"Comprehensive review of macrophage models: primary cells and immortalized lines across species","volume":"16","author":"Ding","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.mtbio.2026.103743_bib70","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s44385-025-00053-7","article-title":"Don't judge an implant by its cover: how the foreign body response and fibrotic capsule might be harnessed for good","volume":"3","author":"Dickenson","year":"2026","journal-title":"NPJ Biomed Innov"},{"issue":"4","key":"10.1016\/j.mtbio.2026.103743_bib71","doi-asserted-by":"crossref","DOI":"10.1002\/INMD.20240117","article-title":"Applications of bioactive herbal extracts in dressing materials for skin wound repair: ingredients, mechanisms and innovations","volume":"3","author":"Yang","year":"2025","journal-title":"Interdiscip. Med."}],"container-title":["Materials Today Bio"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426009889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590006426009889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:02:45Z","timestamp":1793451765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590006426009889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":71,"alternative-id":["S2590006426009889"],"URL":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103743","relation":{},"ISSN":["2590-0064"],"issn-type":[{"value":"2590-0064","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AICAR-induced energy supply and paracrine activity of endothelial cells accelerate chronic diabetic wound healing by promoting angiogenesis and modulating macrophage reprogramming","name":"articletitle","label":"Article Title"},{"value":"Materials Today Bio","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mtbio.2026.103743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103743"}}