{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:56:02Z","timestamp":1790693762201,"version":"4.1.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["T32 AI074491"],"award-info":[{"award-number":["T32 AI074491"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["AI119004"],"award-info":[{"award-number":["AI119004"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["AI156901"],"award-info":[{"award-number":["AI156901"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.mucimm.2023.04.002","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T20:36:08Z","timestamp":1682195768000},"page":"357-372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-2387","authenticated-orcid":false,"given":"Katherine","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uryan","family":"Isik Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-409X","authenticated-orcid":false,"given":"Mindy M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy K.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Dell'Aringa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-0876","authenticated-orcid":false,"given":"Hans","family":"Dooms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max A.","family":"Seibold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Scott-Browne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lee Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mucimm.2023.04.002_b0005","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1221064","article-title":"New paradigms in type 2 immunity","volume":"337","author":"Pulendran","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.mucimm.2023.04.002_b0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cyto.2015.05.008","article-title":"The differential expression of IL-4 and IL-13 and its impact on type-2 immunity","volume":"75","author":"Bao","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.mucimm.2023.04.002_b0020","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.0903505","article-title":"Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)","volume":"185","author":"Yusuf","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0025","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1084\/jem.20090303","article-title":"T follicular helper cells differentiate from Th2 cells in response to helminth antigens","volume":"206","author":"Glatman Zaretsky","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1715","article-title":"Cytokine-secreting follicular T cells shape the antibody repertoire","volume":"10","author":"Reinhardt","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0035","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.20090313","article-title":"IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells","volume":"206","author":"King","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0040","doi-asserted-by":"crossref","first-page":"eaaw6433","DOI":"10.1126\/science.aaw6433","article-title":"Identification of a T follicular helper cell subset that drives anaphylactic IgE","volume":"365","author":"Gowthaman","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.mucimm.2023.04.002_b0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/imr.12208","article-title":"Transcriptional and epigenetic networks of helper T and innate lymphoid cells","volume":"261","author":"Shih","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.mucimm.2023.04.002_b0050","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4049\/jimmunol.173.1.68","article-title":"T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1\/Th2 effector cells that provide help for B cells","volume":"173","author":"Chtanova","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/ni.2182","article-title":"Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity","volume":"13","author":"Liang","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0065","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80439-2","article-title":"Stat6 is required for mediating responses to IL-4 and for development of Th2 cells","volume":"4","author":"Kaplan","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0070","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/380630a0","article-title":"Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene","volume":"380","author":"Shimoda","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2023.04.002_b0075","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/380627a0","article-title":"Essential role of Stat6 in IL-4 signalling","volume":"380","author":"Takeda","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2023.04.002_b0080","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","article-title":"The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells","volume":"89","author":"Zheng","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mucimm.2023.04.002_b0085","doi-asserted-by":"crossref","first-page":"21597","DOI":"10.1074\/jbc.272.34.21597","article-title":"Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene","volume":"272","author":"Zhang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mucimm.2023.04.002_b0090","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1073\/pnas.0400339101","article-title":"Interleukin 2 plays a central role in Th2 differentiation","volume":"101","author":"Cote-Sierra","year":"2004","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.mucimm.2023.04.002_b0095","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S1074-7613(03)00292-9","article-title":"Stat5 activation plays a critical role in Th2 differentiation","volume":"19","author":"Zhu","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0100","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/ni1128","article-title":"Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses","volume":"5","author":"Zhu","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0105","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.4049\/jimmunol.167.8.4414","article-title":"The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3","volume":"167","author":"Kishikawa","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0110","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1073\/pnas.1217158110","article-title":"Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells","volume":"110","author":"Klein Wolterink","year":"2013","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.mucimm.2023.04.002_b0115","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2012.08.015","article-title":"The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells","volume":"37","author":"Mj\u00f6sberg","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0120","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.immuni.2012.06.020","article-title":"The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells","volume":"37","author":"Hoyler","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0125","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/mi.2015.78","article-title":"Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation","volume":"9","author":"O'Brien","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0130","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1074-7613(00)80073-4","article-title":"The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines","volume":"10","author":"Kim","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0135","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)81299-4","article-title":"The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4","volume":"85","author":"Ho","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.mucimm.2023.04.002_b0140","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4049\/jimmunol.1700141","article-title":"T Follicular helper cell-derived IL-4 is required for IgE production during intestinal helminth infection","volume":"199","author":"Meli","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0145","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.immuni.2015.11.004","article-title":"Interleukin-2-dependent allergen-specific tissue-resident memory cells drive asthma","volume":"44","author":"Hondowicz","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0150","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3389\/fimmu.2017.00480","article-title":"The transcription factor c-Maf promotes the differentiation of follicular helper T cells","volume":"8","author":"Andris","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0155","doi-asserted-by":"crossref","first-page":"7997","DOI":"10.1038\/ncomms8997","article-title":"BATF is important for IL-4 expression in T follicular helper cells","volume":"6","author":"Sahoo","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mucimm.2023.04.002_b0160","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.4049\/jimmunol.1103246","article-title":"Bcl6 and maf cooperate to instruct human follicular helper CD4 T cell differentiation","volume":"188","author":"Kroenke","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0165","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ni.2037","article-title":"The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells","volume":"12","author":"Ise","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0170","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1084\/jem.188.10.1859","article-title":"c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms","volume":"188","author":"Ho","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0175","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41590-018-0083-5","article-title":"c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells","volume":"19","author":"Gabry\u0161ov\u00e1","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0180","doi-asserted-by":"crossref","first-page":"e1009602","DOI":"10.1371\/journal.ppat.1009602","article-title":"Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4+ T cell repertoire","volume":"17","author":"Brown","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.mucimm.2023.04.002_b0185","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1084\/jem.187.5.787","article-title":"Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells","volume":"187","author":"Xu","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0190","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1073\/pnas.95.12.6930","article-title":"T1\/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function","volume":"95","author":"L\u00f6hning","year":"1998","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.mucimm.2023.04.002_b0195","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1084\/jem.20162069","article-title":"PPARgamma in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation","volume":"214","author":"Nobs","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0200","doi-asserted-by":"crossref","first-page":"eaal5196","DOI":"10.1126\/sciimmunol.aal5196","article-title":"PPAR-gamma promotes type 2 immune responses in allergy and nematode infection","volume":"2","author":"Chen","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0205","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/imr.12561","article-title":"Spectrum of T-lymphocyte activities regulating allergic lung inflammation","volume":"278","author":"Gelfand","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.mucimm.2023.04.002_b0210","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature12910","article-title":"Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development","volume":"507","author":"Liu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2023.04.002_b0215","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.mucimm.2023.04.002_b0220","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1084\/jem.193.12.1373","article-title":"Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells","volume":"193","author":"Kim","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0225","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1084\/jem.192.11.1553","article-title":"CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function","volume":"192","author":"Schaerli","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0230","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.192.11.1545","article-title":"Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production","volume":"192","author":"Breitfeld","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0235","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ni.3461","article-title":"Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation","volume":"17","author":"Shaw","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0240","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1084\/jem.20110308","article-title":"T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse","volume":"208","author":"Moran","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0245","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/mi.2013.67","article-title":"Lung niches for the generation and maintenance of tissue-resident memory T cells","volume":"7","author":"Turner","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0250","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.immuni.2012.09.020","article-title":"Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets","volume":"38","author":"Sathaliyawala","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0255","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.immuni.2014.09.015","article-title":"miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation","volume":"41","author":"Hu","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0260","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jaci.2018.03.012","article-title":"Eleven loci with new reproducible genetic associations with allergic disease risk","volume":"143","author":"Ferreira","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0265","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/ni.3026","article-title":"A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production","volume":"15","author":"Simpson","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0270","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ni.1690","article-title":"The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells","volume":"10","author":"Bauquet","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0275","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4049\/jimmunol.0904023","article-title":"In vivo regulation of Bcl6 and T follicular helper cell development","volume":"185","author":"Poholek","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0280","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","article-title":"Bcl6 mediates the development of T follicular helper cells","volume":"325","author":"Nurieva","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.mucimm.2023.04.002_b0285","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2005.09.006","article-title":"A two-step process for cytokine production revealed by IL-4 dual-reporter mice","volume":"23","author":"Mohrs","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0290","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1074-7613(01)00186-8","article-title":"Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter","volume":"15","author":"Mohrs","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0295","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mucimm.2023.04.002_b0300","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/emboj\/18.2.420","article-title":"Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.mucimm.2023.04.002_b0305","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.immuni.2017.09.001","article-title":"The IRF4 gene regulatory module functions as a read-write integrator to dynamically coordinate T helper cell fate","volume":"47","author":"Krishnamoorthy","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0310","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2009.10.008","article-title":"Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors","volume":"31","author":"Kwon","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0315","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.4049\/jimmunol.1501841","article-title":"Cutting edge: NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection","volume":"196","author":"Martinez","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0320","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.immuni.2011.12.014","article-title":"Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V","volume":"36","author":"Vijayanand","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0325","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/ni.3226","article-title":"LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6","volume":"16","author":"Choi","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0330","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni.3229","article-title":"The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection","volume":"16","author":"Xu","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0335","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.celrep.2015.08.049","article-title":"TCF1 is required for the T follicular helper cell response to viral infection","volume":"12","author":"Wu","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.mucimm.2023.04.002_b0340","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.4049\/jimmunol.154.12.6397","article-title":"The proximal promoter of the IL-4 gene is composed of multiple essential regulatory sites that bind at least two distinct factors","volume":"154","author":"Hodge","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0345","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1126\/science.1214314","article-title":"The transcription factor c-Maf controls touch receptor development and function","volume":"335","author":"Wende","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.mucimm.2023.04.002_b0350","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1084\/jem.189.10.1565","article-title":"Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses","volume":"189","author":"McKenzie","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0355","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.4049\/jimmunol.154.9.4675","article-title":"IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice","volume":"154","author":"Urban","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0360","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0960-9822(98)70256-8","article-title":"Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses","volume":"8","author":"Barner","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0365","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/s41586-022-05395-5","article-title":"Non-redundant functions of group 2 innate lymphoid cells","volume":"611","author":"Jarick","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2023.04.002_b0370","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41586-022-05297-6","article-title":"Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces","volume":"611","author":"Tsou","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2023.04.002_b0375","doi-asserted-by":"crossref","first-page":"11234","DOI":"10.1074\/jbc.M111.324046","article-title":"STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function","volume":"287","author":"Nurieva","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mucimm.2023.04.002_b0380","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1084\/jem.20111174","article-title":"STAT5 is a potent negative regulator of TFH cell differentiation","volume":"209","author":"Johnston","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0385","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.immuni.2011.09.009","article-title":"Opposing signals from the bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells","volume":"35","author":"Pepper","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0390","article-title":"Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells","volume":"361, eaao2933","author":"DiToro","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.mucimm.2023.04.002_b0395","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1084\/jem.190.8.1123","article-title":"In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines","volume":"190","author":"Ansel","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0400","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1182\/blood.V84.3.830.bloodjournal843830","article-title":"Expression of the G-protein\u2013coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells","volume":"84","author":"F\u00f6rster","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.mucimm.2023.04.002_b0405","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.4049\/jimmunol.1601371","article-title":"BATF modulates the Th2 locus control region and regulates CD4+ T cell fate during antihelminth immunity","volume":"197","author":"Bao","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0410","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2731","article-title":"Innate and adaptive immune responses in asthma","volume":"18","author":"Holgate","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0415","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/ni.1892","article-title":"The many paths to asthma: phenotype shaped by innate and adaptive immunity","volume":"11","author":"Kim","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0420","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1073\/pnas.0308697100","article-title":"GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells","volume":"101","author":"Pai","year":"2004","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.mucimm.2023.04.002_b0425","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.4049\/jimmunol.161.8.3817","article-title":"Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3","volume":"161","author":"Zhang","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0430","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1084\/jem.20051304","article-title":"Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment","volume":"202","author":"Yamane","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0435","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.4049\/jimmunol.174.6.3734","article-title":"Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation","volume":"174","author":"Takatori","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0440","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1074-7613(00)80142-9","article-title":"Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells","volume":"11","author":"Kurata","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0445","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1074-7613(00)80156-9","article-title":"Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment","volume":"12","author":"Ouyang","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0450","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.4049\/jimmunol.174.5.2720","article-title":"IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation","volume":"174","author":"Yang","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0455","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1182\/blood.V97.8.2358","article-title":"Stat5a regulates T helper cell differentiation by several distinct mechanisms","volume":"97","author":"Kagami","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.mucimm.2023.04.002_b0460","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.immuni.2012.02.002","article-title":"The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells","volume":"36","author":"Harada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0465","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41385-018-0012-9","article-title":"Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate","volume":"11","author":"Dell'Aringa","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0470","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.4049\/jimmunol.1300643","article-title":"Notch signaling regulates follicular helper T cell differentiation","volume":"191","author":"Auderset","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0475","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.immuni.2006.04.009","article-title":"The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells","volume":"24","author":"Tanaka","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0480","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1084\/jem.20091548","article-title":"BATF coordinates multiple aspects of B and T cell function required for normal antibody responses","volume":"207","author":"Betz","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mucimm.2023.04.002_b0485","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature10279","article-title":"A critical role for TCF-1 in T-lineage specification and differentiation","volume":"476","author":"Weber","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2023.04.002_b0490","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/1074-7613(95)90028-4","article-title":"Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene","volume":"2","author":"Rooney","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0495","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1182\/blood-2004-10-4074","article-title":"Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice","volume":"106","author":"Tanaka","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.mucimm.2023.04.002_b0500","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1074-7613(00)80477-X","article-title":"IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis","volume":"8","author":"Urban","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0505","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0960-9822(98)70134-4","article-title":"A distinct role for interleukin-13 in Th2-cell-mediated immune responses","volume":"8","author":"McKenzie","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0510","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Gr\u00fcnig","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mucimm.2023.04.002_b0515","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.4049\/jimmunol.160.7.3453","article-title":"A critical role for IL-13 in resistance to intestinal nematode infection","volume":"160","author":"Bancroft","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.04.002_b0520","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1074-7613(00)80625-1","article-title":"Impaired development of Th2 cells in IL-13-deficient mice","volume":"9","author":"McKenzie","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2023.04.002_b0525","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1101\/gad.11.2.179","article-title":"Stat5a is mandatory for adult mammary gland development and lactogenesis","volume":"11","author":"Liu","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.mucimm.2023.04.002_b0530","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0092-8674(94)90140-6","article-title":"A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development","volume":"77","author":"Sawada","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.mucimm.2023.04.002_b0535","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1084\/jem.20052448","article-title":"Type 2 immunity is controlled by IL-4\/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system","volume":"203","author":"Voehringer","year":"2006","journal-title":"J. Exp. Med."}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021923000284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021923000284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:30:45Z","timestamp":1761831045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021923000284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":107,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S1933021923000284"],"URL":"https:\/\/doi.org\/10.1016\/j.mucimm.2023.04.002","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mucimm.2023.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of Society for Mucosal Immunology.","name":"copyright","label":"Copyright"}]}}