{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:56:18Z","timestamp":1791618978148,"version":"4.3.4"},"reference-count":68,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014707","name":"Society for the Study of Theology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015766","name":"Danone Nutricia Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015766","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023703","name":"Topsector Agri & Food","doi-asserted-by":"publisher","award":["16495"],"award-info":[{"award-number":["16495"]}],"id":[{"id":"10.13039\/501100023703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007772","name":"Nutricia Research BV","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.mucimm.2023.06.001","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T13:59:50Z","timestamp":1686405590000},"page":"567-577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mast cells disrupt the function of the esophageal epithelial barrier"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1366-6034","authenticated-orcid":false,"given":"Mirelle T.A.","family":"Kleuskens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-0650","authenticated-orcid":false,"given":"Marie K.","family":"Bek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youmna","family":"Al Halabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-6404","authenticated-orcid":false,"given":"Bart R.J.","family":"Blokhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara A.P.","family":"Diks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Haasnoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-9182","authenticated-orcid":false,"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-2062","authenticated-orcid":false,"given":"Albert J.","family":"Bredenoord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty C.A.M.","family":"van Esch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-7960","authenticated-orcid":false,"given":"Frank A.","family":"Redegeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mucimm.2023.06.001_b0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41577-021-00538-7","article-title":"Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?","volume":"21","author":"Akdis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0010","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.cgh.2017.06.035","article-title":"The esophageal epithelial barrier in health and disease","volume":"16","author":"Blevins","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0015","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1056\/NEJMra1502863","article-title":"Eosinophilic esophagitis","volume":"373","author":"Furuta","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mucimm.2023.06.001_b0020","doi-asserted-by":"crossref","first-page":"G641","DOI":"10.1152\/ajpgi.00386.2013","article-title":"IL-4 induces columnar-like differentiation of esophageal squamous epithelium through JAK\/PI3K pathway: possible role in pathogenesis of Barrett's esophagus","volume":"306","author":"Shan","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0025","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/mi.2013.90","article-title":"Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis","volume":"7","author":"Sherrill","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0030","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.4049\/jimmunol.0903069","article-title":"Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis","volume":"184","author":"Blanchard","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0035","doi-asserted-by":"crossref","first-page":"eaaz7773","DOI":"10.1126\/scitranslmed.aaz7773","article-title":"Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis","volume":"12","author":"Azouz","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mucimm.2023.06.001_b0040","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.cgh.2014.12.032","article-title":"Endoscopic mucosal impedance measurements correlate with eosinophilia and dilation of intercellular spaces in patients with eosinophilic esophagitis","volume":"13","author":"Katzka","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0045","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaci.2010.08.050","article-title":"Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction","volume":"126","author":"Aceves","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0050","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/his.13653","article-title":"Eosinophilic oesophagitis: relevance of mast cell infiltration","volume":"73","author":"Strasser","year":"2018","journal-title":"Histopathology"},{"key":"10.1016\/j.mucimm.2023.06.001_b0055","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1016\/j.jaci.2022.02.025","article-title":"Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission","volume":"149","author":"Ben-Baruch Morgenstern","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0060","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jaci.2010.04.009","article-title":"Involvement of mast cells in eosinophilic esophagitis","volume":"126","author":"Abonia","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0065","doi-asserted-by":"crossref","first-page":"224","DOI":"10.14309\/ajg.0000000000000474","article-title":"Mast cell infiltration is associated with persistent symptoms and endoscopic abnormalities despite resolution of eosinophilia in pediatric eosinophilic esophagitis","volume":"115","author":"Bolton","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0070","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1067\/mai.2001.119917","article-title":"Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response","volume":"108","author":"Straumann","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0075","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jaci.2014.05.013","article-title":"Food allergy: a practice parameter update-2014","volume":"134","author":"Sampson","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0080","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1365-2559.2012.4303.x","article-title":"Atopic and non-atopic eosinophilic oesophagitis are distinguished by immunoglobulin E-bearing intraepithelial mast cells","volume":"61","author":"Mulder","year":"2012","journal-title":"Histopathology"},{"key":"10.1016\/j.mucimm.2023.06.001_b0085","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1038\/sj.jid.5700461","article-title":"A characteristic subset of psoriasis-associated genes is induced by oncostatin-M in reconstituted epidermis","volume":"126","author":"Gazel","year":"2006","journal-title":"J, Invest. Dermatol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0090","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaci.2015.01.043","article-title":"Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease","volume":"136","author":"Pothoven","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0095","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.4049\/jimmunol.178.7.4615","article-title":"Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation","volume":"178","author":"Boniface","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0100","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.4049\/jimmunol.0903476","article-title":"A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent","volume":"186","author":"Fritz","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0105","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1097\/01.mlg.0000187819.89889.4a","article-title":"Upregulation of oncostatin M in allergic rhinitis","volume":"115","author":"Kang","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mucimm.2023.06.001_b0110","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3109\/01902140902906412","article-title":"Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction","volume":"35","author":"Simpson","year":"2009","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.mucimm.2023.06.001_b0115","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/gene.2014.27","article-title":"Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing","volume":"15","author":"Sherrill","year":"2014","journal-title":"Genes Immun."},{"key":"10.1016\/j.mucimm.2023.06.001_b0120","doi-asserted-by":"crossref","first-page":"e159093","DOI":"10.1172\/jci.insight.159093","article-title":"Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation","volume":"7","author":"Rochman","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.mucimm.2023.06.001_b0125","doi-asserted-by":"crossref","first-page":"e86355","DOI":"10.1172\/jci.insight.86355","article-title":"Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment","volume":"1","author":"Davis","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.mucimm.2023.06.001_b0130","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/all.15260","article-title":"Mast cell-pain connection in eosinophilic esophagitis","volume":"77","author":"Zhang","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.mucimm.2023.06.001_b0135","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jaci.2017.08.039","article-title":"Histamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis","volume":"141","author":"Steelant","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0140","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1136\/gutjnl-2013-305690","article-title":"Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism","volume":"63","author":"Vanuytsel","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.mucimm.2023.06.001_b0145","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/all.13666","article-title":"Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells","volume":"74","author":"Zhou","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.mucimm.2023.06.001_b0150","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/all.14132","article-title":"Nasal epithelial barrier dysfunction increases sensitization and mast cell degranulation in the absence of allergic inflammation","volume":"75","author":"Kortekaas Krohn","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.mucimm.2023.06.001_b0155","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.3390\/jcm11144246","article-title":"Esophageal mucosal permeability as a surrogate measure of cure in eosinophilic esophagitis","volume":"11","author":"Chen","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mucimm.2023.06.001_b0160","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ajg.2017.107","article-title":"Esophageal and small intestinal mucosal integrity in eosinophilic esophagitis and response to an elemental diet","volume":"112","author":"Warners","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0165","doi-asserted-by":"crossref","first-page":"eaap9736","DOI":"10.1126\/scitranslmed.aap9736","article-title":"The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses","volume":"10","author":"Azouz","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mucimm.2023.06.001_b0170","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/apt.13676","article-title":"Allergy tests do not predict food triggers in adult patients with eosinophilic oesophagitis. A comprehensive prospective study using five modalities","volume":"44","author":"Philpott","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.mucimm.2023.06.001_b0175","doi-asserted-by":"crossref","first-page":"e0113483","DOI":"10.1371\/journal.pone.0113483","article-title":"A pilot study of omalizumab in eosinophilic esophagitis","volume":"10","author":"Loizou","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mucimm.2023.06.001_b0180","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1189\/jlb.1106653","article-title":"Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice","volume":"81","author":"Mishra","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0185","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nm.3281","article-title":"Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis","volume":"19","author":"Noti","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.mucimm.2023.06.001_b0190","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/gut.2009.178020","article-title":"Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis","volume":"59","author":"Vicario","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.mucimm.2023.06.001_b0195","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41586-020-03118-2","article-title":"Local immune response to food antigens drives meal-induced abdominal pain","volume":"590","author":"Aguilera-Lizarraga","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2023.06.001_b0200","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/j.1398-9995.2008.01695.x","article-title":"Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response","volume":"63","author":"Rond\u00f3n","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.mucimm.2023.06.001_b0205","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/all.12846","article-title":"Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity","volume":"71","author":"Simon","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.mucimm.2023.06.001_b0210","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1053\/j.gastro.2014.05.036","article-title":"Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE","volume":"147","author":"Clayton","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mucimm.2023.06.001_b0215","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1053\/j.gastro.2014.09.048","article-title":"IgG and EoE: too soon for a paradigm shift away from IgE","volume":"148","author":"Philpott","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mucimm.2023.06.001_b0220","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2015.07.017","article-title":"Non-IgE mediated mast cell activation","volume":"778","author":"Yu","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0225","unstructured":"EOS Network. Paterson, C. Lirentelimab met histologic co-primary endpoints but missed symptomatic co-primary endpoints in both ENIGMA and KRYPTOS studies. Available at: https:\/\/www.eosnetwork.org\/news\/lirentelimab-studies-meet-histologic-endpoints-but-miss-symptomatic-endpoints (2021) [Date accessed: 22 March 2023]."},{"key":"10.1016\/j.mucimm.2023.06.001_b0230","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.anai.2018.03.006","article-title":"A randomized, double-blinded, placebo-controlled study of the use of viscous oral cromolyn sodium for the treatment of eosinophilic esophagitis","volume":"120","author":"Lieberman","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0235","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1341367","article-title":"The barrier hypothesis and oncostatin M: restoration of epithelial barrier function as a novel therapeutic strategy for the treatment of type 2 inflammatory disease","volume":"5","author":"Pothoven","year":"2017","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.mucimm.2023.06.001_b0240","doi-asserted-by":"crossref","first-page":"32635","DOI":"10.1074\/jbc.271.51.32635","article-title":"Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation","volume":"271","author":"Mosley","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mucimm.2023.06.001_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107158","article-title":"Oncostatin M: A mysterious cytokine in cancers","volume":"90","author":"Masjedi","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0250","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.jaci.2016.10.039","article-title":"Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease","volume":"139","author":"Pothoven","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0255","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.4049\/jimmunol.139.9.2977","article-title":"Purification and characterization of cytostatic lymphokines produced by activated human T lymphocytes. Synergistic antiproliferative activity of transforming growth factor beta 1, interferon-gamma, and oncostatin M for human melanoma cells","volume":"139","author":"Brown","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0260","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/cyto.2002.1023","article-title":"Oncostatin M production by human dendritic cells in response to bacterial products","volume":"17","author":"Suda","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.mucimm.2023.06.001_b0265","doi-asserted-by":"crossref","first-page":"eabf8188","DOI":"10.1126\/scitranslmed.abf8188","article-title":"Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma","volume":"14","author":"Headland","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mucimm.2023.06.001_b0270","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/s41385-021-00400-y","article-title":"Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes","volume":"14","author":"Dunn","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0275","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.jaci.2018.08.044","article-title":"GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation","volume":"143","author":"Nobs","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0280","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.jaci.2020.12.638","article-title":"GM-CSF instigates a dendritic cell-T-cell inflammatory circuit that drives chronic asthma development","volume":"147","author":"Nobs","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0285","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.jaci.2013.02.042","article-title":"Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis","volume":"131","author":"Otani","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0290","doi-asserted-by":"crossref","first-page":"e0114831","DOI":"10.1371\/journal.pone.0114831","article-title":"Altered esophageal histamine receptor expression in eosinophilic esophagitis (EoE): implications on disease pathogenesis","volume":"10","author":"Merves","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mucimm.2023.06.001_b0295","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jaci.2016.09.049","article-title":"IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level","volume":"140","author":"Joulia","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mucimm.2023.06.001_b0300","doi-asserted-by":"crossref","first-page":"e0127755","DOI":"10.1371\/journal.pone.0127755","article-title":"In vitro model for studying esophageal epithelial differentiation and allergic inflammatory responses identifies keratin involvement in eosinophilic esophagitis","volume":"10","author":"Kc","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mucimm.2023.06.001_b0305","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nprot.2011.437","article-title":"Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture","volume":"7","author":"Kalabis","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mucimm.2023.06.001_b0310","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1101\/gad.1544507","article-title":"The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation","volume":"21","author":"Okawa","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.mucimm.2023.06.001_b0315","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1038\/sj.onc.1210025","article-title":"AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture","volume":"26","author":"Oyama","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.mucimm.2023.06.001_b0320","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1172\/JCI85538","article-title":"Different activation signals induce distinct mast cell degranulation strategies","volume":"126","author":"Gaudenzio","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mucimm.2023.06.001_b0325","doi-asserted-by":"crossref","first-page":"e1504729","DOI":"10.1080\/2162402X.2018.1504729","article-title":"Human mast cells promote colon cancer growth via bidirectional crosstalk: studies in 2D and 3D co-culture models","volume":"7","author":"Yu","year":"2018","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.mucimm.2023.06.001_b0330","doi-asserted-by":"crossref","DOI":"10.1111\/all.15694","article-title":"In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis","author":"Haasnoot","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.mucimm.2023.06.001_b0335","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/all.15069","article-title":"Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function","volume":"77","author":"Kleuskens","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.mucimm.2023.06.001_b0340","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2017.151","article-title":"Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data","volume":"4","author":"Fernandez","year":"2017","journal-title":"Sci. Data"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021923000454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021923000454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:33:05Z","timestamp":1761831185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021923000454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1933021923000454"],"URL":"https:\/\/doi.org\/10.1016\/j.mucimm.2023.06.001","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast cells disrupt the function of the esophageal epithelial barrier","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mucimm.2023.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of Society for Mucosal Immunology.","name":"copyright","label":"Copyright"}]}}