{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:43:41Z","timestamp":1791474221592,"version":"4.3.4"},"reference-count":154,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.mucimm.2025.05.002","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T18:39:48Z","timestamp":1747247988000},"page":"782-792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Parasite and host immune factors that impact the development of a mucosal vaccine for Cryptosporidium"],"prefix":"10.1016","volume":"18","author":[{"given":"Maria","family":"Merolle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Striepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.mucimm.2025.05.002_b0005","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S1286-4579(02)01630-1","article-title":"Cryptosporidiosis: epidemiology and impact","volume":"4","author":"Dillingham","year":"2002","journal-title":"Microbes Infect"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0010","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/BF01303222","article-title":"Cryptosporidiosis in a patient receiving immunosuppressive therapy. Possible activation of latent infection","volume":"31","author":"Holley","year":"1986","journal-title":"Dig Dis Sci"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3949\/ccjm.88a.20016","article-title":"Cryptosporidiosis in an immunosuppressed patient with persistent diarrhea","volume":"88","author":"Bahdi","year":"2021","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.mucimm.2025.05.002_b0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1051\/parasite\/2020025","article-title":"Cryptosporidiosis in HIV-positive patients and related risk factors: a systematic review and meta-analysis","volume":"27","author":"Ahmadpour","year":"2020","journal-title":"Parasite"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0025","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0016-5085(76)80503-3","article-title":"Acute enterocolitis in a human being infected with the protozoan Cryptosporidium","volume":"70","author":"Nime","year":"1976","journal-title":"Gastroenterology"},{"issue":"21","key":"10.1016\/j.mucimm.2025.05.002_b0030","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1056\/NEJM198305263082102","article-title":"Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission","volume":"308","author":"Current","year":"1983","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJM199407213310304","article-title":"A massive outbreak in Milwaukee of cryptosporidium infection transmitted through the public water supply","volume":"331","author":"Mac Kenzie","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mucimm.2025.05.002_b0040","article-title":"Immunity to Cryptosporidium: insights into principles of enteric responses to infection","author":"Pardy","year":"2023","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0045","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.chom.2022.11.013","article-title":"Multiple introductions and recombination events underlie the emergence of a hyper-transmissible Cryptosporidium hominis subtype in the USA","volume":"31","author":"Huang","year":"2023","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0050","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1086\/506565","article-title":"Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response","volume":"43","author":"Kirkpatrick","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0055","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.molmed.2012.04.007","article-title":"Environmental enteropathy: critical implications of a poorly understood condition","volume":"18","author":"Korpe","year":"2012","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.mucimm.2025.05.002_b0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12916-014-0187-1","article-title":"Environmental enteropathy and malnutrition: do we know enough to intervene?","volume":"12","author":"Petri","year":"2014","journal-title":"BMC Med"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0065","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrmicro2053","article-title":"Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea","volume":"7","author":"Viswanathan","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0070","doi-asserted-by":"crossref","first-page":"e568","DOI":"10.1016\/S2214-109X(19)30076-2","volume":"7","author":"Kotloff","year":"2019","journal-title":"Lancet Glob Health"},{"issue":"12","key":"10.1016\/j.mucimm.2025.05.002_b0075","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.chom.2023.11.008","article-title":"Dietary environmental factors shape the immune defense against Cryptosporidium infection","volume":"31","author":"Maradana","year":"2023","journal-title":"Cell Host Microbe"},{"issue":"7","key":"10.1016\/j.mucimm.2025.05.002_b0080","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1016\/S2214-109X(18)30283-3","article-title":"Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study","volume":"6","author":"Khalil","year":"2018","journal-title":"Lancet Glob Health"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0085","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.4161\/hv.28485","article-title":"Prospects for immunotherapy and vaccines against Cryptosporidium","volume":"10","author":"Mead","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.mucimm.2025.05.002_b0090","doi-asserted-by":"crossref","unstructured":"Sow SO, Muhsen K, Nasrin D, Blackwelder WC, Wu Y, Farag TH, et al. The burden of cryptosporidium diarrheal disease among children < 24 months of age in moderate\/high mortality regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS). PLoS Negl Trop Dis. 2016. 10(5):e0004729. doi: 10.1371\/journal.pntd.0004729. PubMed PMID: 27219054; PubMed Central PMCID: PMC4878811. Epub 20160524.","DOI":"10.1371\/journal.pntd.0004729"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009445","article-title":"Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition","volume":"17","author":"Kabir","year":"2021","journal-title":"PLoS Pathog"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4269\/ajtmh.20-0657","article-title":"Delayed time to cryptosporidiosis in bangladeshi children is associated with greater Fecal IgA against two sporozoite-expressed antigens","volume":"104","author":"Steiner","year":"2021","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0105","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1086\/515377","article-title":"The antibody response to 27-, 17-, and 15-kDa Cryptosporidium antigens following experimental infection in humans","volume":"178","author":"Moss","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.mucimm.2025.05.002_b0110","doi-asserted-by":"crossref","unstructured":"Gilchrist CA, Campo JJ, Pablo JV, Ma JZ, Teng A, Oberai A, et al. Specific Cryptosporidium antigens associate with reinfection immunity and protection from cryptosporidiosis. J Clin Invest. 133(16) 2023. Doi: 10.1172\/JCI166814 PubMed PMID: 37347553; PubMed Central PMCID: PMC10425216 Epub 20230815.","DOI":"10.1172\/JCI166814"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4269\/ajtmh.1999.60.157","article-title":"Infectivity of Cryptosporidium parvum in healthy adults with pre-existing anti-C. parvum serum immunoglobulin G","volume":"60","author":"Chappell","year":"1999","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0120","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/IAI.66.2.441-443.1998","article-title":"Susceptibility and serologic response of healthy adults to reinfection with Cryptosporidium parvum","volume":"66","author":"Okhuysen","year":"1998","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.mucimm.2025.05.002_b0125","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1128\/iai.58.7.2237-2240.1990","article-title":"Resistance of calves to Cryptosporidium parvum: effects of age and previous exposure","volume":"58","author":"Harp","year":"1990","journal-title":"Infect Immun"},{"issue":"47","key":"10.1016\/j.mucimm.2025.05.002_b0130","doi-asserted-by":"crossref","first-page":"34111","DOI":"10.1074\/jbc.M113.515544","article-title":"Elongation factor-1alpha is a novel protein associated with host cell invasion and a potential protective antigen of Cryptosporidium parvum","volume":"288","author":"Matsubayashi","year":"2013","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0135","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0140","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41385-021-00450-2","article-title":"STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8","volume":"15","author":"Stolzer","year":"2022","journal-title":"Mucosal Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0145","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.chom.2016.03.003","article-title":"Intrinsic defense mechanisms of the intestinal epithelium","volume":"19","author":"Ramanan","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mucimm.2025.05.002_b0150","doi-asserted-by":"crossref","unstructured":"Sateriale A, Gullicksrud JA, Engiles JB, McLeod BI, Kugler EM, Henao-Mejia J, et al. The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6. Proc Natl Acad Sci U S A. 118(2) 2021. Doi: 10.1073\/pnas.2007807118. PubMed PMID: 33372132; PubMed Central PMCID: PMC7812745.","DOI":"10.1073\/pnas.2007807118"},{"issue":"11","key":"10.1016\/j.mucimm.2025.05.002_b0155","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.immuni.2021.08.014","article-title":"Cognate recognition of microbial antigens defines constricted CD4(+) T cell receptor repertoires in the inflamed colon","volume":"54","author":"Muschaweck","year":"2021","journal-title":"Immunity"},{"issue":"6101","key":"10.1016\/j.mucimm.2025.05.002_b0160","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1220961","article-title":"Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses","volume":"337","author":"Hand","year":"2012","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.mucimm.2025.05.002_b0165","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1084\/jem.20070602","article-title":"Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid","volume":"204","author":"Sun","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.mucimm.2025.05.002_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103114","article-title":"The gut ecosystem and immune tolerance","volume":"141","author":"Shao","year":"2023","journal-title":"J Autoimmun"},{"key":"10.1016\/j.mucimm.2025.05.002_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.716499","article-title":"Intestinal regulatory T cells as specialized tissue-restricted immune cells in intestinal immune homeostasis and disease","volume":"12","author":"Jacobse","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0180","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis","volume":"75","author":"Kuhn","year":"1993","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0185","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/mi.2015.49","article-title":"Regulatory immune cells in regulation of intestinal inflammatory response to microbiota","volume":"8","author":"Sun","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.mucimm.2025.05.002_b0190","doi-asserted-by":"crossref","unstructured":"Canesso MCC, Castro TBR, Nakandakari-Higa S, Lockhart A, Luehr J, Bortolatto J, et al. Identification of antigen-presenting cell-T cell interactions driving immune responses to food. Science. 2024:eado5088. doi: 10.1126\/science.ado5088. PubMed PMID: 39700315. Epub 20241219.","DOI":"10.1126\/science.ado5088"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0195","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1128\/iai.43.3.856-859.1984","article-title":"Persistent Cryptosporidium infection in congenitally athymic (nude) mice","volume":"43","author":"Heine","year":"1984","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0200","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1128\/iai.61.9.3928-3932.1993","article-title":"Requirements for CD4+ cells and gamma interferon in resolution of established Cryptosporidium parvum infection in mice","volume":"61","author":"Chen","year":"1993","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.mucimm.2025.05.002_b0205","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1128\/iai.61.8.3548-3551.1993","article-title":"Gamma interferon functions in resistance to Cryptosporidium parvum infection in severe combined immunodeficient mice","volume":"61","author":"Chen","year":"1993","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0210","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.exppara.2006.07.001","article-title":"Cryptosporidium parvum: the contribution of Th1-inducing pathways to the resolution of infection in mice","volume":"115","author":"Ehigiator","year":"2007","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.mucimm.2025.05.002_b0215","doi-asserted-by":"crossref","unstructured":"Sateriale A, Slapeta J, Baptista R, Engiles JB, Gullicksrud JA, Herbert GT, et al. A genetically tractable, natural mouse model of cryptosporidiosis offers insights into host protective immunity. Cell Host Microbe. 2019;26(1):135-46 e5. doi: 10.1016\/j.chom.2019.05.006. PubMed PMID: 31231045; PubMed Central PMCID: PMC6617386. Epub 20190620.","DOI":"10.1016\/j.chom.2019.05.006"},{"key":"10.1016\/j.mucimm.2025.05.002_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.mucimm.2024.03.003","article-title":"Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8(+) T cell responses","author":"Haskins","year":"2024","journal-title":"Mucosal Immunol"},{"issue":"7","key":"10.1016\/j.mucimm.2025.05.002_b0225","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20232067","article-title":"Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium","volume":"221","author":"Cohn","year":"2024","journal-title":"J Exp Med"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0230","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/mi.2016.59","article-title":"The human intestinal B-cell response","volume":"9","author":"Spencer","year":"2016","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.mucimm.2025.05.002_b0235","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.791095","article-title":"IgA plasma cells are long-lived residents of gut and bone marrow that express isotype- and tissue-specific gene expression patterns","volume":"12","author":"Wilmore","year":"2021","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.mucimm.2025.05.002_b0240","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/ni.3213","article-title":"Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota","volume":"16","author":"Lindner","year":"2015","journal-title":"Nat Immunol"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0245","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.4049\/jimmunol.0901838","article-title":"Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits","volume":"183","author":"Boullier","year":"2009","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0250","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1084\/jem.182.3.769","article-title":"Monoclonal immunoglobulin A antibody directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis","volume":"182","author":"Phalipon","year":"1995","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0255","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41577-020-00479-7","article-title":"A guide to vaccinology: from basic principles to new developments","volume":"21","author":"Pollard","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0260","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4269\/ajtmh.2012.11-0273","article-title":"Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh","volume":"86","author":"Borad","year":"2012","journal-title":"Am J Trop Med Hyg"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0265","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1128\/IAI.66.9.4469-4473.1998","article-title":"Role of immunoglobulin A monoclonal antibodies against P23 in controlling murine Cryptosporidium parvum infection","volume":"66","author":"Enriquez","year":"1998","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0270","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3347\/kjp.1993.31.3.223","article-title":"Passive transfer of immunity against Cryptosporidium infection in neonatal mice using monoclonal antibodies","volume":"31","author":"Cho","year":"1993","journal-title":"Korean J Parasitol"},{"issue":"10","key":"10.1016\/j.mucimm.2025.05.002_b0275","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00275-23","article-title":"Identification of the glycopeptide epitope recognized by a protective Cryptosporidium monoclonal antibody","volume":"91","author":"Bhalchandra","year":"2023","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetvac.2024.100054","article-title":"The first commercially approved efficacious cryptosporidium vaccine protecting New-Born calves from severe diarrhea","volume":"3","author":"Timmermans","year":"2024","journal-title":"Veterinary Vaccine"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0285","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/gut.31.6.714","article-title":"Protracted enteric cryptosporidial infection in selective immunoglobulin A and saccharomyces opsonin deficiencies","volume":"31","author":"Jacyna","year":"1990","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0290","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11926-021-01037-3","article-title":"Long-term safety of rituximab (risks of viral and opportunistic infections)","volume":"23","author":"Varley","year":"2021","journal-title":"Curr Rheumatol Rep"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0295","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ckj\/sfx038","article-title":"Infectious complications of rituximab therapy in renal disease","volume":"10","author":"Nixon","year":"2017","journal-title":"Clin Kidney J"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0300","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1645\/0022-3395(2003)089[0391:CPIIGB]2.0.CO;2","article-title":"Cryptosporidium parvum infection in gene-targeted B cell-deficient mice","volume":"89","author":"Chen","year":"2003","journal-title":"J Parasitol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0305","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11041056","article-title":"Dendritic cells and cryptosporidium: from recognition to restriction","volume":"11","author":"Saraav","year":"2023","journal-title":"Microorganisms"},{"issue":"12","key":"10.1016\/j.mucimm.2025.05.002_b0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003801","article-title":"Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice","volume":"9","author":"Lantier","year":"2013","journal-title":"PLoS Pathog"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0315","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/2049-632X.12078","article-title":"Interaction of Cryptosporidium parvum with mouse dendritic cells leads to their activation and parasite transportation to mesenteric lymph nodes","volume":"70","author":"Perez-Cordon","year":"2014","journal-title":"Pathog Dis"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0320","first-page":"437","article-title":"Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S","volume":"205","author":"Hapfelmeier","year":"2008","journal-title":"Typhimurium colitis J Exp Med"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0325","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nri2335","article-title":"Dendritic cells in intestinal immune regulation","volume":"8","author":"Coombes","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"10.1016\/j.mucimm.2025.05.002_b0330","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1084\/jem.20051100","article-title":"Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing","volume":"202","author":"Johansson-Lindbom","year":"2005","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0335","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/mi.2012.53","article-title":"Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells","volume":"6","author":"Cerovic","year":"2013","journal-title":"Mucosal Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0340","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.immuni.2004.08.011","article-title":"Retinoic acid imprints gut-homing specificity on T cells","volume":"21","author":"Iwata","year":"2004","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0345","first-page":"97","article-title":"Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue","volume":"151","author":"Briskin","year":"1997","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0350","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.immuni.2016.02.008","article-title":"IRF8 transcription-factor-dependent classical dendritic cells are essential for intestinal T cell homeostasis","volume":"44","author":"Luda","year":"2016","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0355","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/mi.2014.40","article-title":"Lymph-borne CD8alpha+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells","volume":"8","author":"Cerovic","year":"2015","journal-title":"Mucosal Immunol"},{"issue":"11","key":"10.1016\/j.mucimm.2025.05.002_b0360","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/j.immuni.2021.10.002","article-title":"Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections","volume":"54","author":"Russler-Germain","year":"2021","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011820","article-title":"Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-gamma on parasite restriction","volume":"20","author":"Pardy","year":"2024","journal-title":"PLoS Pathog"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0370","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/imm.13270","article-title":"Why do intestinal epithelial cells express MHC class II?","volume":"162","author":"Heuberger","year":"2021","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0375","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.mucimm.2023.05.001","article-title":"MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses","volume":"17","author":"Heuberger","year":"2024","journal-title":"Mucosal Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0380","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4269\/ajtmh.2010.09-0590","article-title":"Human CD8(+) T cells clear Cryptosporidium parvum from infected intestinal epithelial cells","volume":"82","author":"Pantenburg","year":"2010","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0385","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1645\/0022-3395(2003)089[0270:ROMIIL]2.0.CO;2","article-title":"Role of murine intestinal intraepithelial lymphocytes and lamina propria lymphocytes against primary and challenge infections with Cryptosporidium parvum","volume":"89","author":"Guk","year":"2003","journal-title":"J Parasitol"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0390","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.4049\/jimmunol.147.3.1014","article-title":"Cryptosporidium infection in an adult mouse model. Independent roles for IFN-gamma and CD4+ T lymphocytes in protective immunity","volume":"147","author":"Ungar","year":"1991","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0395","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/mi.2014.17","article-title":"Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium","volume":"7","author":"Wang","year":"2014","journal-title":"Mucosal Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0400","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nm.2628","article-title":"An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection","volume":"18","author":"Chen","year":"2012","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0405","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.immuni.2014.03.007","article-title":"Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function","volume":"40","author":"Sheridan","year":"2014","journal-title":"Immunity"},{"issue":"8\u20139","key":"10.1016\/j.mucimm.2025.05.002_b0410","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.micinf.2013.04.009","article-title":"CD4(+) effector and memory cell populations protect against Cryptosporidium parvum infection","volume":"15","author":"McNair","year":"2013","journal-title":"Microbes Infect"},{"issue":"10","key":"10.1016\/j.mucimm.2025.05.002_b0415","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/eji.202149759","article-title":"Intestinal CD8(+) tissue-resident memory T cells: From generation to function","volume":"52","author":"Cheng","year":"2022","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.mucimm.2025.05.002_b0420","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.3389\/fimmu.2019.01595","article-title":"Striking a balance-cellular and molecular drivers of memory T cell development and responses to chronic stimulation","volume":"10","author":"Hope","year":"2019","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.mucimm.2025.05.002_b0425","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.immuni.2023.06.005","article-title":"Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts","volume":"56","author":"Evrard","year":"2023","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0430","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.immuni.2018.02.010","article-title":"Understanding subset diversity in T cell memory","volume":"48","author":"Jameson","year":"2018","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0435","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/ni.2038","article-title":"Origins of CD4(+) effector and central memory T cells","volume":"12","author":"Pepper","year":"2011","journal-title":"Nat Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0440","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/s41590-023-01510-4","article-title":"CD4(+) T cell memory","volume":"24","author":"Kunzli","year":"2023","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0445","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/imm.12929","article-title":"The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination","volume":"154","author":"Gray","year":"2018","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/j.mucimm.2025.05.002_b0450","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250060","article-title":"Tissue-resident memory T (T(RM)) cells: Front-line workers of the immune system","volume":"53","author":"Osman","year":"2023","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.mucimm.2025.05.002_b0455","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1039194","article-title":"Tissue resident memory T cells- A new benchmark for the induction of vaccine-induced mucosal immunity","volume":"13","author":"Hassert","year":"2022","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0460","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1084\/jem.20090858","article-title":"Dynamic T cell migration program provides resident memory within intestinal epithelium","volume":"207","author":"Masopust","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.mucimm.2025.05.002_b0465","unstructured":"Reina-Campos M, Monell A, Ferry A, Luna V, Cheung KP, Galletti G, et al. Functional diversity of memory CD8 T cells is spatiotemporally imprinted. bioRxiv. 2024. doi: 10.1101\/2024.03.20.585130. PubMed PMID: 38585842; PubMed Central PMCID: PMC10996520. Epub 20240325."},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0470","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1084\/jem.20181365","article-title":"CD4(+) resident memory T cells dominate immunosurveillance and orchestrate local recall responses","volume":"216","author":"Beura","year":"2019","journal-title":"J Exp Med"},{"issue":"10","key":"10.1016\/j.mucimm.2025.05.002_b0475","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.4049\/jimmunol.1200402","article-title":"Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues","volume":"188","author":"Casey","year":"2012","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0480","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.celrep.2017.03.031","article-title":"Local inflammatory cues regulate differentiation and persistence of CD8(+) tissue-resident memory T cells","volume":"19","author":"Bergsbaken","year":"2017","journal-title":"Cell Rep"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0485","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41590-021-01004-1","article-title":"Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity","volume":"22","author":"Christo","year":"2021","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0490","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210923","article-title":"Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation","volume":"220","author":"Qiu","year":"2023","journal-title":"J Exp Med"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0495","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.mucimm.2024.04.004","article-title":"MAdCAM-1 co-stimulation combined with retinoic acid and TGF-beta induces blood CD8(+) T cells to adopt a gut CD101(+) T(RM) phenotype","volume":"17","author":"Girard","year":"2024","journal-title":"Mucosal Immunol"},{"issue":"6462","key":"10.1016\/j.mucimm.2025.05.002_b0500","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav5728","article-title":"Migratory DCs activate TGF-beta to precondition naive CD8(+) T cells for tissue-resident memory fate","volume":"366","author":"Mani","year":"2019","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111963","article-title":"The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8(+) T cell differentiation and function","volume":"42","author":"Dean","year":"2023","journal-title":"Cell Rep"},{"issue":"77","key":"10.1016\/j.mucimm.2025.05.002_b0510","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abl9925","article-title":"CD103 fate mapping reveals that intestinal CD103(-) tissue-resident memory T cells are the primary responders to secondary infection","volume":"7","author":"Fung","year":"2022","journal-title":"Sci Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0515","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12967-020-02263-6","article-title":"Oral typhoid vaccine Ty21a elicits antigen-specific resident memory CD4(+) T cells in the human terminal ileum lamina propria and epithelial compartments","volume":"18","author":"Booth","year":"2020","journal-title":"J Transl Med"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0520","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.immuni.2005.03.005","article-title":"Dendritic cells maximize the memory CD8 T cell response to infection","volume":"22","author":"Zammit","year":"2005","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.mucimm.2025.05.002_b0525","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.14202\/vetworld.2022.2772-2784","article-title":"Evaluation of a vaccine candidate isolated from Cryptosporidium parvum oocyst in mice","volume":"15","author":"Aboelsoued","year":"2022","journal-title":"Vet World"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0530","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02666-22","article-title":"Structural analyses of a dominant cryptosporidium parvum epitope presented by H-2K(b) offer new options to combat cryptosporidiosis","volume":"14","author":"Wang","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.mucimm.2025.05.002_b0535","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giac010","article-title":"Fully resolved assembly of Cryptosporidium parvum","volume":"11","author":"Menon","year":"2022","journal-title":"GigaScience"},{"issue":"7012","key":"10.1016\/j.mucimm.2025.05.002_b0540","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/nature02977","article-title":"The genome of Cryptosporidium hominis","volume":"431","author":"Xu","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2025.05.002_b0545","unstructured":"Dumaine JE, Striepen B, University of Pennsylvania. Department of Cell and Molecular Biology. Cryptosporidium parvum exports proteins to the epithelial host cell. 1 online resource (271 pages) p."},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0550","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.chom.2023.03.001","article-title":"Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell","volume":"31","author":"Guerin","year":"2023","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0555","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-023-01557-7","article-title":"Vaccine adjuvants: mechanisms and platforms","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"13","key":"10.1016\/j.mucimm.2025.05.002_b0560","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.178216","article-title":"IL-10 inhibition during immunization improves vaccine-induced protection against Staphylococcus aureus infection","volume":"9","author":"Kelly","year":"2024","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.mucimm.2025.05.002_b0565","article-title":"Using adjuvants to drive t cell responses for next-generation infectious disease vaccines","volume":"9","author":"Rapaka","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.mucimm.2025.05.002_b0570","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.coph.2018.03.015","article-title":"ADP-ribosylating enterotoxins as vaccine adjuvants","volume":"41","author":"Lycke","year":"2018","journal-title":"Curr Opin Pharmacol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0575","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/mi.2017.70","article-title":"Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4(+) T cells following parenteral immunization","volume":"11","author":"Frederick","year":"2018","journal-title":"Mucosal Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2025.05.002_b0580","first-page":"338","article-title":"Cholera toxin acts as a potent adjuvant for the induction of cytotoxic T-lymphocyte responses with non-replicating antigens","volume":"81","author":"Bowen","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.mucimm.2025.05.002_b0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102398","article-title":"Recent advances in enterotoxin vaccine adjuvants","volume":"85","author":"Crothers","year":"2023","journal-title":"Curr Opin Immunol"},{"issue":"6572","key":"10.1016\/j.mucimm.2025.05.002_b0590","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm0829","article-title":"mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern","volume":"374","author":"Goel","year":"2021","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.mucimm.2025.05.002_b0595","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.172510","article-title":"Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine","volume":"8","author":"Kingstad-Bakke","year":"2023","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0600","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s41467-023-37559-w","article-title":"Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection","volume":"14","author":"Pieren","year":"2023","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0605","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s13346-021-00908-7","article-title":"Current approaches in lipid-based nanocarriers for oral drug delivery","volume":"11","author":"Plaza-Oliver","year":"2021","journal-title":"Drug Deliv Transl Res"},{"issue":"757","key":"10.1016\/j.mucimm.2025.05.002_b0610","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adm8451","article-title":"Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70","volume":"16","author":"Brook","year":"2024","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0615","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03537-20","article-title":"Prime-pull immunization with a bivalent M-protein and Spy-CEP peptide vaccine adjuvanted with CAF(R)01 liposomes induces both mucosal and peripheral protection from covR\/S mutant streptococcus pyogenes","volume":"12","author":"Ozberk","year":"2021","journal-title":"MBio"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0620","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.4049\/jimmunol.2200297","article-title":"Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits sustained mucosal immunity that prevents SARS-CoV-2 infection and pathology","volume":"210","author":"Shamseldin","year":"2023","journal-title":"J Immunol"},{"key":"10.1016\/j.mucimm.2025.05.002_b0625","doi-asserted-by":"crossref","unstructured":"Mao T, Israelow B, Pena-Hernandez MA, Suberi A, Zhou L, Luyten S, et al. Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses. Science. 2022;378(6622):eabo2523. Epub 20221doi: 10.1126\/science.abo2523. PubMed PMID: 36302057; PubMed Central PMCID: PMC9798903.","DOI":"10.1126\/science.abo2523"},{"key":"10.1016\/j.mucimm.2025.05.002_b0630","doi-asserted-by":"crossref","unstructured":"Shin H, Iwasaki A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature. 2012;491(7424):463-7. Epub 20121017. doi: 10.1038\/nature11522. PubMed PMID: 23075848; PubMed Central PMCID: PMC3499630.","DOI":"10.1038\/nature11522"},{"key":"10.1016\/j.mucimm.2025.05.002_b0635","doi-asserted-by":"crossref","unstructured":"Lavelle EC, Ward RW. Mucosal vaccines - fortifying the frontiers. Nat Rev Immunol. 2022;22(4):236-50. Epub 20210726. doi: 10.1038\/s41577-021-00583-2. PubMed PMID: 34312520; PubMed Central PMCID: PMC8312369.","DOI":"10.1038\/s41577-021-00583-2"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0640","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/cei.13285","article-title":"Mucosal vaccines and technology","volume":"196","author":"Miquel-Clopes","year":"2019","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0645","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1128\/CVI.00089-09","article-title":"Oral immunization with attenuated Salmonella enterica serovar Typhimurium encoding Cryptosporidium parvum Cp23 and Cp40 antigens induces a specific immune response in mice","volume":"16","author":"Benitez","year":"2009","journal-title":"Clin Vaccine Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.05.002_b0650","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1645\/GE-3333RN","article-title":"Protection of calves against cryptosporiosis by oral inoculation with gamma-irradiated Cryptosporidium parvum oocysts","volume":"90","author":"Jenkins","year":"2004","journal-title":"J Parasitol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0655","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1080\/14760584.2023.2245890","article-title":"Sporozoite immunization: innovative translational science to support the fight against malaria","volume":"22","author":"Richie","year":"2023","journal-title":"Expert Rev Vaccines"},{"issue":"8","key":"10.1016\/j.mucimm.2025.05.002_b0660","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/14760584.2017.1341835","article-title":"Genetically attenuated malaria parasites as vaccines","volume":"16","author":"Vaughan","year":"2017","journal-title":"Expert Rev Vaccines"},{"issue":"544","key":"10.1016\/j.mucimm.2025.05.002_b0665","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz5629","article-title":"A double-blind, placebo-controlled phase 1\/2a trial of the genetically attenuated malaria vaccine PfSPZ-GA1","volume":"12","author":"Roestenberg","year":"2020","journal-title":"Sci Transl Med"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0670","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s44321-024-00057-7","article-title":"A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion","volume":"16","author":"Goswami","year":"2024","journal-title":"EMBO Mol Med"},{"issue":"6874","key":"10.1016\/j.mucimm.2025.05.002_b0675","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/415926a","article-title":"De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii","volume":"415","author":"Fox","year":"2002","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.mucimm.2025.05.002_b0680","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1128\/IAI.00024-09","article-title":"Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii","volume":"77","author":"Jordan","year":"2009","journal-title":"Infect Immun"},{"issue":"75","key":"10.1016\/j.mucimm.2025.05.002_b0685","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abq7432","article-title":"cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory","volume":"7","author":"Christian","year":"2022","journal-title":"Sci Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0690","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2313210120","article-title":"Genetic crosses within and between species of Cryptosporidium","volume":"121","author":"Shaw","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8015","key":"10.1016\/j.mucimm.2025.05.002_b0695","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-024-07466-1","article-title":"Transcriptional control of the Cryptosporidium life cycle","volume":"630","author":"Walzer","year":"2024","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.mucimm.2025.05.002_b0700","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105017","article-title":"The immune system in children with malnutrition\u2013a systematic review","volume":"9","author":"Rytter","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.mucimm.2025.05.002_b0705","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.it.2016.04.003","article-title":"Immune dysfunction as a cause and consequence of malnutrition","volume":"37","author":"Bourke","year":"2016","journal-title":"Trends Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0710","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/eji.201646423","article-title":"Nutritional effects on T-cell immunometabolism","volume":"47","author":"Cohen","year":"2017","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.05.002_b0715","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4049\/jimmunol.1004027","article-title":"Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells","volume":"188","author":"Iyer","year":"2012","journal-title":"J Immunol"},{"issue":"8","key":"10.1016\/j.mucimm.2025.05.002_b0720","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.immuni.2021.07.005","article-title":"Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy","volume":"54","author":"Bhattacharjee","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2025.05.002_b0725","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1741-7007-8-129","article-title":"Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine","volume":"8","author":"Levine","year":"2010","journal-title":"BMC Biol"},{"issue":"25","key":"10.1016\/j.mucimm.2025.05.002_b0730","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1016\/j.vaccine.2022.04.032","article-title":"Association of anti-rotavirus IgA seroconversion with growth, environmental enteric dysfunction and enteropathogens in rural pakistani infants","volume":"40","author":"Ahmed","year":"2022","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.mucimm.2025.05.002_b0735","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S1473-3099(14)71060-6","article-title":"Effectiveness of a monovalent rotavirus vaccine in infants in Malawi after programmatic roll-out: an observational and case-control study","volume":"15","author":"Bar-Zeev","year":"2015","journal-title":"Lancet Infect Dis"},{"issue":"14","key":"10.1016\/j.mucimm.2025.05.002_b0740","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1056\/NEJM199610033351404","article-title":"Rotavirus infection in infants as protection against subsequent infections","volume":"335","author":"Velazquez","year":"1996","journal-title":"N Engl J Med"},{"issue":"5802","key":"10.1016\/j.mucimm.2025.05.002_b0745","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1126\/science.1130388","article-title":"New strategies for the elimination of polio from India","volume":"314","author":"Grassly","year":"2006","journal-title":"Science"},{"issue":"Suppl 2","key":"10.1016\/j.mucimm.2025.05.002_b0750","doi-asserted-by":"crossref","first-page":"B157","DOI":"10.1016\/j.vaccine.2012.10.113","article-title":"Strategies to advance vaccine technologies for resource-poor settings","volume":"31","author":"Kristensen","year":"2013","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.mucimm.2025.05.002_b0755","article-title":"Vaccine technologies and platforms for infectious diseases: current progress, challenges, and opportunities","volume":"9","author":"Ghattas","year":"2021","journal-title":"Vaccines (Basel)"},{"issue":"2","key":"10.1016\/j.mucimm.2025.05.002_b0760","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1017\/jme.2023.85","article-title":"The coalition for epidemic preparedness innovations (CEPI) and the partnerships of equitable vaccine access","volume":"51","author":"Halabi","year":"2023","journal-title":"J Law Med Ethics"},{"issue":"37","key":"10.1016\/j.mucimm.2025.05.002_b0765","doi-asserted-by":"crossref","first-page":"14017","DOI":"10.1073\/pnas.0805452105","article-title":"Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria","volume":"105","author":"Schmidt","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"10.1016\/j.mucimm.2025.05.002_b0770","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1158\/1078-0432.CCR-11-0503","article-title":"Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice","volume":"17","author":"Klebanoff","year":"2011","journal-title":"Clin Cancer Res"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021925000492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021925000492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:13:48Z","timestamp":1786652028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021925000492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":154,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1933021925000492"],"URL":"https:\/\/doi.org\/10.1016\/j.mucimm.2025.05.002","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parasite and host immune factors that impact the development of a mucosal vaccine for Cryptosporidium","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mucimm.2025.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Society for Mucosal Immunology.","name":"copyright","label":"Copyright"}]}}