{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:27:34Z","timestamp":1787084854134,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2021-NR056438"],"award-info":[{"award-number":["RS-2021-NR056438"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-NR077244"],"award-info":[{"award-number":["RS-2023-NR077244"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00439735"],"award-info":[{"award-number":["RS-2024-00439735"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.mucimm.2025.06.006","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T19:45:07Z","timestamp":1749843907000},"page":"1058-1071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Placental inflammation-driven T cell memory formation promotes allergic responses in offspring via endogenous glucocorticoids"],"prefix":"10.1016","volume":"18","author":[{"given":"Myoung Seung","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Hyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongwoo","family":"La","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3977-1510","authenticated-orcid":false,"given":"Heung Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.mucimm.2025.06.006_b0005","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1056\/NEJMra054308","article-title":"The asthma epidemic","volume":"355","author":"Eder","year":"2006","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.mucimm.2025.06.006_b0010","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jaci.2023.11.918","article-title":"Feast for thought: a comprehensive review of food allergy 2021-2023","volume":"153","author":"Bartha","year":"2024","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.06.006_b0015","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1542\/peds.2014-0439","article-title":"Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma","volume":"134","author":"Forno","year":"2014","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.mucimm.2025.06.006_b0020","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S2213-2600(13)70145-0","article-title":"Prenatal and childhood infections: implications for the development and treatment of childhood asthma","volume":"1","author":"Fuchs","year":"2013","journal-title":"Lancet Respir Med"},{"issue":"8","key":"10.1016\/j.mucimm.2025.06.006_b0025","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1111\/all.14234","article-title":"Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner","volume":"75","author":"Alhasan","year":"2020","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.mucimm.2025.06.006_b0030","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1164\/rccm.200202-158OC","article-title":"The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands General Practice Database","volume":"166","author":"McKeever","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"35","key":"10.1016\/j.mucimm.2025.06.006_b0035","doi-asserted-by":"crossref","first-page":"e4671","DOI":"10.1097\/MD.0000000000004671","article-title":"Meta-analysis of antenatal infection and risk of asthma and eczema","volume":"95","author":"Zhu","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.mucimm.2025.06.006_b0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1398-9995.2003.00338.x","article-title":"Infectious and uterus related complications during pregnancy and development of atopic and nonatopic asthma in children","volume":"59","author":"Calvani","year":"2004","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.mucimm.2025.06.006_b0045","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/ije\/28.4.723","article-title":"Maternal infections in pregnancy and the development of asthma among offspring","volume":"28","author":"Xu","year":"1999","journal-title":"Int J Epidemiol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.06.006_b0050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/acr.23251","article-title":"Risk of allergic conditions in children born to women with systemic lupus erythematosus","volume":"70","author":"Couture","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"2","key":"10.1016\/j.mucimm.2025.06.006_b0055","doi-asserted-by":"crossref","DOI":"10.1111\/pai.13728","article-title":"Maternal autoimmune disease and risk of hospitalization for autoimmune disease, allergy, and cancer in offspring","volume":"33","author":"Zhao","year":"2022","journal-title":"Pediatr Allergy Immunol"},{"issue":"16","key":"10.1016\/j.mucimm.2025.06.006_b0060","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1017\/S0950268818002455","article-title":"Maternal infection during pregnancy and type 1 diabetes mellitus in offspring: a systematic review and meta-analysis","volume":"146","author":"Yue","year":"2018","journal-title":"Epidemiol Infect"},{"issue":"6276","key":"10.1016\/j.mucimm.2025.06.006_b0065","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aad0314","article-title":"The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Science"},{"issue":"31","key":"10.1016\/j.mucimm.2025.06.006_b0070","doi-asserted-by":"crossref","first-page":"12776","DOI":"10.1073\/pnas.1202556109","article-title":"Modeling an autism risk factor in mice leads to permanent immune dysregulation","volume":"109","author":"Hsiao","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.mucimm.2025.06.006_b0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.immuni.2021.11.005","article-title":"Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4(+) T cells","volume":"55","author":"Kim","year":"2022","journal-title":"Immunity"},{"issue":"6558","key":"10.1016\/j.mucimm.2025.06.006_b0080","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf3002","article-title":"Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring","volume":"373","author":"Lim","year":"2021","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.mucimm.2025.06.006_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111677","article-title":"Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity","volume":"41","author":"Lopez","year":"2022","journal-title":"Cell Rep"},{"issue":"7","key":"10.1016\/j.mucimm.2025.06.006_b0090","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1182\/blood.V95.7.2284","article-title":"Expansion of hematopoietic stem cells in the developing liver of a mouse embryo","volume":"95","author":"Ema","year":"2000","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.mucimm.2025.06.006_b0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0925-4773(99)00325-1","article-title":"The molecular basis of lung morphogenesis","volume":"92","author":"Warburton","year":"2000","journal-title":"Mech Dev"},{"issue":"7","key":"10.1016\/j.mucimm.2025.06.006_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114365","article-title":"Prenatal inflammation remodels lung immunity and function by programming ILC2 hyperactivation","volume":"43","author":"Lopez","year":"2024","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.mucimm.2025.06.006_b0105","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.immuni.2012.10.016","article-title":"Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen","volume":"38","author":"Plantinga","year":"2013","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.mucimm.2025.06.006_b0110","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.immuni.2015.11.004","article-title":"Interleukin-2-dependent allergen-specific tissue-resident memory cells drive asthma","volume":"44","author":"Hondowicz","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.mucimm.2025.06.006_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2023.105656","article-title":"Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2","volume":"216","author":"Jung","year":"2023","journal-title":"Antiviral Res"},{"issue":"12","key":"10.1016\/j.mucimm.2025.06.006_b0120","doi-asserted-by":"crossref","first-page":"8299","DOI":"10.4049\/jimmunol.180.12.8299","article-title":"The central memory CD4+ T cell population generated during leishmania major infection requires IL-12 to produce IFN-\u03b31","volume":"180","author":"Pakpour","year":"2008","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2025.06.006_b0125","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S1074-7613(02)00322-9","article-title":"Activated T cell death in vivo mediated by proapoptotic Bcl-2 family member bim","volume":"16","author":"Hildeman","year":"2002","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.mucimm.2025.06.006_b0130","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0092-8674(91)90362-3","article-title":"bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship","volume":"67","author":"Strasser","year":"1991","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.mucimm.2025.06.006_b0135","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1074-7613(01)00191-1","article-title":"OX40 promotes bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells","volume":"15","author":"Rogers","year":"2001","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.mucimm.2025.06.006_b0140","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.immuni.2023.03.002","article-title":"Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection","volume":"56","author":"Sikder","year":"2023","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.mucimm.2025.06.006_b0145","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1038\/s41467-023-43903-x","article-title":"Maternal antibiotic exposure enhances ILC2 activation in neonates via downregulation of IFN1 signaling","volume":"14","author":"Xu","year":"2023","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.mucimm.2025.06.006_b0150","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1016\/j.ajpath.2011.02.042","article-title":"Placental TNF-alpha signaling in illness-induced complications of pregnancy","volume":"178","author":"Carpentier","year":"2011","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.06.006_b0155","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41423-020-0412-0","article-title":"Neutrophil chemoattractant receptors in health and disease: double-edged swords","volume":"17","author":"Metzemaekers","year":"2020","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.06.006_b0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0303-7207(01)00624-4","article-title":"The fetal placental hypothalamic\u2013pituitary\u2013adrenal (HPA) axis, parturition and post natal health","volume":"185","author":"Challis","year":"2001","journal-title":"Mol Cell Endocrinol"},{"issue":"6602","key":"10.1016\/j.mucimm.2025.06.006_b0165","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/383726a0","article-title":"Functional interactions between Stat5 and the glucocorticoid receptor","volume":"383","author":"St\u00f6cklin","year":"1996","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mucimm.2025.06.006_b0170","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3324\/haematol.2021.280405","article-title":"STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment","volume":"108","author":"Van der Zwet","year":"2023","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.mucimm.2025.06.006_b0175","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1128\/MCB.17.10.5952","article-title":"Antagonism between Nur77 and glucocorticoid receptor for control of transcription","volume":"17","author":"Philips","year":"1997","journal-title":"Mol Cell Biol"},{"issue":"8","key":"10.1016\/j.mucimm.2025.06.006_b0180","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.4049\/jimmunol.1900559","article-title":"Glucocorticoids oppose thymocyte negative selection by inhibiting helios and nur77","volume":"203","author":"Mittelstadt","year":"2019","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2025.06.006_b0185","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1081-1206(10)60270-0","article-title":"Effects of endogenous glucocorticoids on allergic inflammation and TH1\/TH2 balance in airway allergic disease","volume":"103","author":"Zhang","year":"2009","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2025.06.006_b0190","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/cells9030531","article-title":"Memory CD4+ T cells in immunity and autoimmune diseases","volume":"9","author":"Raphael","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mucimm.2025.06.006_b0195","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-immunol-042617-053352","article-title":"Signaling and function of interleukin-2 in T lymphocytes","volume":"36","author":"Ross","year":"2018","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.06.006_b0200","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/ni.3706","article-title":"Epigenetic landscapes reveal transcription factors that regulate CD8(+) T cell differentiation","volume":"18","author":"Yu","year":"2017","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.06.006_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.02.018","article-title":"Long-term programming of CD8 T cell immunity by perinatal exposure to glucocorticoids","volume":"180","author":"Hong","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mucimm.2025.06.006_b0210","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/pai.12344","article-title":"Maternal preeclampsia and childhood asthma in the offspring","volume":"26","author":"Liu","year":"2015","journal-title":"Pediatr Allergy Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.06.006_b0215","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/cen.13092","article-title":"Evidence for central hypercortisolism and elevated blood pressure in adolescent offspring of mothers with pre-eclampsia","volume":"85","author":"Henley","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"10.1016\/j.mucimm.2025.06.006_b0220","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1365-2265.1997.1230939.x","article-title":"Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure","volume":"46","author":"Benediktsson","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"10.1016\/j.mucimm.2025.06.006_b0225","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1080\/15548627.2019.1596493","article-title":"Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells","volume":"15","author":"Oh","year":"2019","journal-title":"Autophagy"},{"issue":"17","key":"10.1016\/j.mucimm.2025.06.006_b0230","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.mucimm.2025.06.006_b0235","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"3","key":"10.1016\/j.mucimm.2025.06.006_b0240","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.06.006_b0245","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/ni.3706","article-title":"Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation","volume":"18","author":"Yu","year":"2017","journal-title":"Nat Immunol"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021925000662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021925000662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:49:51Z","timestamp":1787082591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021925000662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1933021925000662"],"URL":"https:\/\/doi.org\/10.1016\/j.mucimm.2025.06.006","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placental inflammation-driven T cell memory formation promotes allergic responses in offspring via endogenous glucocorticoids","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mucimm.2025.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Society for Mucosal Immunology.","name":"copyright","label":"Copyright"}]}}