{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:37:51Z","timestamp":1790411871747,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 AI120526"],"award-info":[{"award-number":["R01 AI120526"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["R01 AI155444"],"award-info":[{"award-number":["R01 AI155444"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mucimm.2025.09.002","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:47:46Z","timestamp":1758602866000},"page":"1341-1352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rhinovirus C15 infection induces airway epithelial cell remodeling and robust inflammatory responses: Potential implications for airway obstruction in children"],"prefix":"10.1016","volume":"18","author":[{"given":"Yiran","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Kreger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex L.","family":"Sliwicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Eberhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiuhyang","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Czapla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Kelley","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi R.","family":"Flori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Horani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Brody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-5593","authenticated-orcid":false,"given":"Marc B.","family":"Hershenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mucimm.2025.09.002_b0005","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bmj.310.6989.1225","article-title":"Community study of role of viral infections in exacerbations of asthma in 9-11 year old children","volume":"310","author":"Johnston","year":"1995","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.mucimm.2025.09.002_b0010","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaci.2004.09.025","article-title":"The September epidemic of asthma exacerbations in children: a search for etiology","volume":"115","author":"Johnston","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.09.002_b0015","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jaci.2004.04.006","article-title":"Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing","volume":"114","author":"Heymann","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.09.002_b0020","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2222.2005.02244.x","article-title":"Persistence of rhinovirus RNA after asthma exacerbation in children","volume":"35","author":"Kling","year":"2005","journal-title":"Clin Exp Allergy"},{"issue":"2","key":"10.1016\/j.mucimm.2025.09.002_b0025","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jaci.2006.08.041","article-title":"Prevalence of viral respiratory tract infections in children with asthma","volume":"119","author":"Khetsuriani","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"10.1016\/j.mucimm.2025.09.002_b0030","doi-asserted-by":"crossref","first-page":"e966","DOI":"10.1371\/journal.pone.0000966","article-title":"A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.mucimm.2025.09.002_b0035","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1086\/524312","article-title":"A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany","volume":"196","author":"Renwick","year":"2007","journal-title":"J Infect Dis"},{"issue":"11","key":"10.1016\/j.mucimm.2025.09.002_b0040","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.3201\/eid1411.080386","article-title":"Novel human rhinoviruses and exacerbation of asthma in children","volume":"14","author":"Khetsuriani","year":"2008","journal-title":"Emerging Infect Dis J"},{"issue":"1","key":"10.1016\/j.mucimm.2025.09.002_b0045","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2008.10.007","article-title":"A novel group of rhinoviruses is associated with asthma hospitalizations","volume":"123","author":"Miller","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.09.002_b0050","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jcv.2009.04.016","article-title":"Clinical severity and molecular typing of human rhinovirus C strains during a fall outbreak affecting hospitalized patients","volume":"45","author":"Piralla","year":"2009","journal-title":"J Clin Virol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.09.002_b0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jcv.2009.06.007","article-title":"Human rhinovirus C associated with wheezing in hospitalised children in the Middle East","volume":"46","author":"Miller","year":"2009","journal-title":"J Clin Virol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.09.002_b0060","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jcv.2010.07.013","article-title":"Human rhinovirus C infections mirror those of human rhinovirus a in children with community-acquired pneumonia","volume":"49","author":"Xiang","year":"2010","journal-title":"J Clin Virol"},{"issue":"8","key":"10.1016\/j.mucimm.2025.09.002_b0065","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/INF.0b013e3181d7a708","article-title":"Role of rhinovirus C respiratory infections in sick and healthy children in Spain","volume":"29","author":"Calvo","year":"2010","journal-title":"Pediatr Infect Dis J"},{"issue":"5","key":"10.1016\/j.mucimm.2025.09.002_b0070","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1183\/09031936.00092410","article-title":"Association between human rhinovirus C and severity of acute asthma in children","volume":"37","author":"Bizzintino","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.mucimm.2025.09.002_b0075","doi-asserted-by":"crossref","unstructured":"Lee W-M, Robert F. Lemanske J, Evans MD, Vang F, Pappas T, Gangnon R et al. Human rhinovirus species and season of infection determine illness severity. Am J Respir Crit Care Med 2012; 186(9): 886-891.","DOI":"10.1164\/rccm.201202-0330OC"},{"issue":"11","key":"10.1016\/j.mucimm.2025.09.002_b0080","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1164\/rccm.201303-0498OC","article-title":"Human rhinovirus species c infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions","volume":"188","author":"Cox","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.mucimm.2025.09.002_b0085","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/irv.12346","article-title":"Detection and characterization of respiratory viruses causing acute respiratory illness and asthma exacerbation in children during three different seasons (2011\u20132014) in Mexico City","volume":"9","author":"Moreno-Valencia","year":"2015","journal-title":"Influenza Other Respir Viruses"},{"issue":"1","key":"10.1016\/j.mucimm.2025.09.002_b0090","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jmv.24300","article-title":"Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil","volume":"88","author":"Fawkner-Corbett","year":"2016","journal-title":"J Med Virol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.09.002_b0095","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00207-2018","article-title":"Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions","volume":"52","author":"Cox","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.mucimm.2025.09.002_b0100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/ng.2830","article-title":"A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations","volume":"46","author":"B\u00f8nnelykke","year":"2013","journal-title":"Nat Genetics"},{"issue":"5","key":"10.1016\/j.mucimm.2025.09.002_b0105","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1164\/rccm.201705-1021OC","article-title":"Cadherin-related family member 3 genetics and rhinovirus C respiratory illnesses","volume":"197","author":"B\u00f8nnelykke","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"17","key":"10.1016\/j.mucimm.2025.09.002_b0110","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1073\/pnas.1421178112","article-title":"Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication","volume":"112","author":"Bochkov","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.mucimm.2025.09.002_b0115","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/jamapediatrics.2019.0384","article-title":"Association of rhinovirus C bronchiolitis and immunoglobulin E sensitization during infancy with development of recurrent wheeze","volume":"173","author":"Hasegawa","year":"2019","journal-title":"JAMA Pediatr"},{"issue":"7","key":"10.1016\/j.mucimm.2025.09.002_b0120","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1111\/all.13723","article-title":"Association of type 2 cytokines in severe rhinovirus bronchiolitis during infancy with risk of developing asthma: a multicenter prospective study","volume":"74","author":"Hasegawa","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.mucimm.2025.09.002_b0125","series-title":"Rhinoviruses: Methods and Protocols","first-page":"63","article-title":"Propagation of rhinovirus-C strains in human airway epithelial cells differentiated at air-liquid interface","author":"Ashraf","year":"2015"},{"issue":"6","key":"10.1016\/j.mucimm.2025.09.002_b0130","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1016\/j.jaci.2017.07.018","article-title":"Propagation of respiratory viruses in human airway epithelia reveals persistent virus-specific signatures","volume":"141","author":"Essaidi-Laziosi","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.mucimm.2025.09.002_b0135","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.virol.2016.09.025","article-title":"Mutations in VP1 and 3A proteins improve binding and replication of rhinovirus C15 in HeLa-E8 cells","volume":"499","author":"Bochkov","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.mucimm.2025.09.002_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2023.107372","article-title":"Dysfunctional mucociliary clearance in asthma and airway remodeling - New insights into an old topic","volume":"218","author":"Jesenak","year":"2023","journal-title":"Respir Med"},{"issue":"2","key":"10.1016\/j.mucimm.2025.09.002_b0145","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1164\/ajrccm.163.2.2004039","article-title":"Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression","volume":"163","author":"Ordo\u00f1ez","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1016\/j.mucimm.2025.09.002_b0150","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1111\/all.15280","article-title":"Transcriptomics of rhinovirus persistence reveals sustained expression of RIG-I and interferon-stimulated genes in nasal epithelial cells in vitro","volume":"77","author":"Ong","year":"2022","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.mucimm.2025.09.002_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118286","article-title":"Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus","volume":"10","author":"Bai","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.mucimm.2025.09.002_b0160","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1165\/rcmb.2008-0223OC","article-title":"Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway","volume":"40","author":"Zhu","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.mucimm.2025.09.002_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.649520","article-title":"Rhinovirus C infection induces type 2 innate lymphoid cell expansion and eosinophilic airway inflammation","volume":"12","author":"Rajput","year":"2021","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2025.09.002_b0170","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1183\/09031936.00026910","article-title":"Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-\u03baB and EGFR pathways","volume":"36","author":"Hewson","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.mucimm.2025.09.002_b0175","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4939-1571-2_6","article-title":"Propagation of rhinovirus-C strains in human airway epithelial cells differentiated at air-liquid interface","volume":"1221","author":"Ashraf","year":"2015","journal-title":"Methods Mol Biol"},{"issue":"12","key":"10.1016\/j.mucimm.2025.09.002_b0180","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/ng.263","article-title":"Foxj1 transcription factors are master regulators of the motile ciliogenic program","volume":"40","author":"Yu","year":"2008","journal-title":"Nat Genetics"},{"issue":"9","key":"10.1016\/j.mucimm.2025.09.002_b0185","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/BC20100035","article-title":"Transcriptional control of genes involved in ciliogenesis: a first step in making cilia","volume":"102","author":"Thomas","year":"2010","journal-title":"Biol Cell"},{"issue":"6","key":"10.1016\/j.mucimm.2025.09.002_b0190","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1165\/rcmb.2009-0328OC","article-title":"Temporal relationship between primary and motile ciliogenesis in airway epithelial cells","volume":"43","author":"Jain","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"10.1016\/j.mucimm.2025.09.002_b0195","first-page":"2914","article-title":"SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production","volume":"119","author":"Chen","year":"2009","journal-title":"J Clin Invest"},{"issue":"13","key":"10.1016\/j.mucimm.2025.09.002_b0200","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1242\/dev.034884","article-title":"Notch signaling controls the balance of ciliated and secretory cell fates in developing airways","volume":"136","author":"Tsao","year":"2009","journal-title":"Development"},{"issue":"7580","key":"10.1016\/j.mucimm.2025.09.002_b0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nature15715","article-title":"Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung","volume":"528","author":"Lafkas","year":"2015","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.mucimm.2025.09.002_b0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048037","article-title":"Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine","volume":"7","author":"Mata","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.mucimm.2025.09.002_b0215","doi-asserted-by":"crossref","first-page":"11493","DOI":"10.1038\/s41598-019-48013-7","article-title":"Characterization of cellular transcriptomic signatures induced by different respiratory viruses in human reconstituted airway epithelia","volume":"9","author":"Nicolas de Lamballerie","year":"2019","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.mucimm.2025.09.002_b0220","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00095-21","article-title":"CX3CR1 engagement by respiratory syncytial virus leads to induction of nucleolin and dysregulation of cilia-related genes","volume":"95","author":"Anderson","year":"2021","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.mucimm.2025.09.002_b0225","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1172\/JCI72948","article-title":"RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction","volume":"124","author":"Liesman","year":"2014","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.mucimm.2025.09.002_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107872","article-title":"Single-cell and population transcriptomics reveal pan-epithelial remodeling in type 2-high asthma","volume":"32","author":"Jackson","year":"2020","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.mucimm.2025.09.002_b0235","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1165\/rcmb.2009-0304OC","article-title":"Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium","volume":"44","author":"Turner","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"10.1016\/j.mucimm.2025.09.002_b0240","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.resp.2005.11.006","article-title":"Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells","volume":"154","author":"Inoue","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"issue":"3","key":"10.1016\/j.mucimm.2025.09.002_b0245","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1164\/rccm.201306-1181OC","article-title":"Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity","volume":"189","author":"Chen","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.mucimm.2025.09.002_b0250","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jaci.2014.04.020","article-title":"Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells","volume":"134","author":"Hong","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2025.09.002_b0255","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.166136","article-title":"Tuft cells are required for a rhinovirus-induced asthma phenotype in immature mice","volume":"9","author":"Li","year":"2024","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.mucimm.2025.09.002_b0260","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.jaci.2020.11.002","article-title":"Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma","volume":"147","author":"Raita","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2025.09.002_b0265","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12931-016-0483-8","article-title":"The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL)","volume":"18","author":"Shukla","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.mucimm.2025.09.002_b0270","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.691957","article-title":"ICAM-1 and ICAM-2 are differentially expressed and up-regulated on inflamed pulmonary epithelium, but neither ICAM-2 nor LFA-1: ICAM-1 are required for neutrophil migration into the airways in vivo","volume":"12","author":"Chong","year":"2021","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2025.09.002_b0275","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1165\/rcmb.2018-0220OC","article-title":"CDHR3 asthma-risk genotype affects susceptibility of airway epithelium to rhinovirus c infections","volume":"61","author":"Basnet","year":"2019","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"44","key":"10.1016\/j.mucimm.2025.09.002_b0280","doi-asserted-by":"crossref","first-page":"36952","DOI":"10.1074\/jbc.M502449200","article-title":"Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression","volume":"280","author":"Newcomb","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mucimm.2025.09.002_b0285","series-title":"Molecular identification and quantification of human rhinoviruses in respiratory samples","first-page":"25","author":"Lee","year":"2015"},{"issue":"7","key":"10.1016\/j.mucimm.2025.09.002_b0290","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1128\/IAI.72.7.4188-4199.2004","article-title":"Responses of well-differentiated airway epithelial cell cultures from healthy donors and patients with cystic fibrosis to Burkholderia cenocepacia infection","volume":"72","author":"Sajjan","year":"2004","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.mucimm.2025.09.002_b0295","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1164\/rccm.200801-136OC","article-title":"Rhinovirus disrupts the barrier function of polarized airway epithelial cells","volume":"178","author":"Sajjan","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.mucimm.2025.09.002_b0300","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mucimm.2025.09.002_b0305","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"10.1016\/j.mucimm.2025.09.002_b0310","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/s41591-023-02327-2","article-title":"An integrated cell atlas of the lung in health and disease","volume":"29","author":"Sikkema","year":"2023","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.mucimm.2025.09.002_b0315","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.mucimm.2025.09.002_b0320","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15349","article-title":"Quantifying cilia beat frequency using high-speed video microscopy: Assessing frame rate requirements when imaging different ciliated tissues","volume":"10","author":"Scopulovic","year":"2022","journal-title":"Physiol Rep"},{"issue":"7","key":"10.1016\/j.mucimm.2025.09.002_b0325","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1096\/fj.10-179549","article-title":"Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching","volume":"25","author":"Derichs","year":"2011","journal-title":"FASEB J"},{"issue":"11","key":"10.1016\/j.mucimm.2025.09.002_b0330","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1164\/rccm.201812-2366OC","article-title":"Elevated levels of type 2 respiratory innate lymphoid cells in human infants with severe RSV bronchiolitis","volume":"200","author":"Vu","year":"2019","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021925000923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021925000923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T08:01:20Z","timestamp":1780214480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021925000923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1933021925000923"],"URL":"https:\/\/doi.org\/10.1016\/j.mucimm.2025.09.002","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhinovirus C15 infection induces airway epithelial cell remodeling and robust inflammatory responses: Potential implications for airway obstruction in children","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mucimm.2025.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Society for Mucosal Immunology.","name":"copyright","label":"Copyright"}]}}