{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:49:32Z","timestamp":1782114572242,"version":"3.54.5"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK123712"],"award-info":[{"award-number":["R01 DK123712"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006512","name":"School of Medicine, Duke University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007924","name":"University of Louisville","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.mucimm.2026.01.013","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:17:37Z","timestamp":1770225457000},"page":"1922-1936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["EPICERTIN, an engineered variant of cholera toxin B subunit, promotes survival and a pro-remodeling macrophage phenotype for mucosal healing in colitis"],"prefix":"10.1016","volume":"19","author":[{"given":"Noel","family":"Verjan Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy Fernando","family":"Cifuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela A.","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yeon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juw Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Galandiuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-3004","authenticated-orcid":false,"given":"Nobuyuki","family":"Matoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7351","key":"10.1016\/j.mucimm.2026.01.013_b0005","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal homeostasis and its breakdown in inflammatory bowel disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2026.01.013_b0010","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.3389\/fimmu.2019.02825","article-title":"ER Stress and the UPR in Shaping Intestinal Tissue Homeostasis and Immunity","volume":"10","author":"Coleman","year":"2019","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.mucimm.2026.01.013_b0015","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.cgh.2024.01.026","article-title":"Biomarkers for Personalizing IBD Therapy: The Quest Continues","volume":"22","author":"Atreya","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.mucimm.2026.01.013_b0020","article-title":"IBD: From conventional immunosuppression to biological therapy","author":"Sokic-Milutinovic","year":"2023","journal-title":"Dig Dis"},{"issue":"7","key":"10.1016\/j.mucimm.2026.01.013_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11072066","article-title":"The Unfolded Protein Response and Its Implications for Novel Therapeutic Strategies in Inflammatory Bowel Disease","volume":"11","author":"Verjan Garcia","year":"2023","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.mucimm.2026.01.013_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/jpm14050505","article-title":"Histologic Disease Persists beyond Mucosal Healing and Could Predict Reactivation in Ulcerative Colitis","volume":"14","author":"Laterza","year":"2024","journal-title":"J Pers Med"},{"key":"10.1016\/j.mucimm.2026.01.013_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.896591","article-title":"The Role of Tissue-Resident Macrophages in the Development and Treatment of Inflammatory Bowel Disease","volume":"10","author":"Ma","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.mucimm.2026.01.013_b0040","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41590-020-00849-2","article-title":"Does tissue imprinting restrict macrophage plasticity?","volume":"22","author":"Guilliams","year":"2021","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2026.01.013_b0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.imbio.2016.07.013","article-title":"Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages","volume":"222","author":"Marelli","year":"2017","journal-title":"Immunobiology"},{"issue":"2","key":"10.1016\/j.mucimm.2026.01.013_b0050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.imlet.2004.11.009","article-title":"Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA","volume":"97","author":"Holmgren","year":"2005","journal-title":"Immunol Lett"},{"issue":"15","key":"10.1016\/j.mucimm.2026.01.013_b0055","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0264-410X(02)00734-X","article-title":"Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells","volume":"21","author":"Jang","year":"2003","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.mucimm.2026.01.013_b0060","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/vaccines3030579","article-title":"Cholera Toxin Subunit B as Adjuvant\u2013An Accelerator in Protective Immunity and a Break in Autoimmunity","volume":"3","author":"Stratmann","year":"2015","journal-title":"Vaccines (Basel)"},{"issue":"43","key":"10.1016\/j.mucimm.2026.01.013_b0065","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1016\/j.vaccine.2009.07.071","article-title":"Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity","volume":"27","author":"Yuki","year":"2009","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.mucimm.2026.01.013_b0070","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0167-5699(98)01397-8","article-title":"Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic","volume":"20","author":"Williams","year":"1999","journal-title":"Immunol Today"},{"issue":"6","key":"10.1016\/j.mucimm.2026.01.013_b0075","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1080\/21645515.2018.1504155","article-title":"Oral cholera vaccines and their impact on the global burden of disease","volume":"15","author":"Wierzba","year":"2019","journal-title":"Hum Vaccin Immunother"},{"issue":"5","key":"10.1016\/j.mucimm.2026.01.013_b0080","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.4049\/jimmunol.166.5.3522","article-title":"Oral administration of recombinant cholera toxin subunit B inhibits IL-12-mediated murine experimental (trinitrobenzene sulfonic acid) colitis","volume":"166","author":"Boirivant","year":"2001","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.01.013_b0085","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2036.2009.04185.x","article-title":"Clinical trial: the safety and short-term efficacy of recombinant cholera toxin B subunit in the treatment of active Crohn's disease","volume":"31","author":"Stal","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.mucimm.2026.01.013_b0090","doi-asserted-by":"crossref","first-page":"e2046","DOI":"10.1371\/journal.pntd.0002046","article-title":"Rapid and scalable plant-based production of a cholera toxin B subunit variant to aid in mass vaccination against cholera outbreaks","volume":"7","author":"Hamorsky","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"10.1016\/j.mucimm.2026.01.013_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11120678","article-title":"Repeated Oral Administration of a KDEL-tagged Recombinant Cholera Toxin B Subunit Effectively Mitigates DSS Colitis Despite a Robust Immunogenic Response","volume":"11","author":"Royal","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.mucimm.2026.01.013_b0100","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3390\/toxins2030310","article-title":"Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum","volume":"2","author":"Wernick","year":"2010","journal-title":"Toxins (Basel)"},{"issue":"12","key":"10.1016\/j.mucimm.2026.01.013_b0105","doi-asserted-by":"crossref","first-page":"13527","DOI":"10.1096\/fj.201901255R","article-title":"A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repair via an unfolded protein response","volume":"33","author":"Royal","year":"2019","journal-title":"FASEB J"},{"issue":"4","key":"10.1016\/j.mucimm.2026.01.013_b0110","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/mi.2016.95","article-title":"Oral administration of a recombinant cholera toxin B subunit promotes mucosal healing in the colon","volume":"10","author":"Baldauf","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"11","key":"10.1016\/j.mucimm.2026.01.013_b0115","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.stem.2023.09.015","article-title":"TGFB1 induces fetal reprogramming and enhances intestinal regeneration","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.mucimm.2026.01.013_b0120","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgad050","article-title":"Boosting UPR transcriptional activator XBP1 accelerates acute wound healing","volume":"2","author":"Wang","year":"2023","journal-title":"PNAS Nexus"},{"issue":"1","key":"10.1016\/j.mucimm.2026.01.013_b0125","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1038\/s41598-023-30834-2","article-title":"Characterization and utility of two monoclonal antibodies to cholera toxin B subunit","volume":"13","author":"Verjan Garcia","year":"2023","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.mucimm.2026.01.013_b0130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1189\/jlb.3RU0316-144R","article-title":"Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage","volume":"100","author":"Ushach","year":"2016","journal-title":"J Leukoc Biol"},{"issue":"5","key":"10.1016\/j.mucimm.2026.01.013_b0135","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","article-title":"XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease","volume":"134","author":"Kaser","year":"2008","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.mucimm.2026.01.013_b0140","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1042\/BST0391081","article-title":"Intestinal secretory cell ER stress and inflammation","volume":"39","author":"McGuckin","year":"2011","journal-title":"Biochem Soc Trans"},{"issue":"4","key":"10.1016\/j.mucimm.2026.01.013_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13040576","article-title":"Spray-Dried Formulation of Epicertin, a Recombinant Cholera Toxin B Subunit Variant That Induces Mucosal Healing","volume":"13","author":"Reeves","year":"2021","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.mucimm.2026.01.013_b0150","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1124\/jpet.121.000904","article-title":"Pharmacokinetics and Safety Studies in Rodent Models Support Development of EPICERTIN as a Novel Topical Wound-Healing Biologic for Ulcerative Colitis","volume":"380","author":"Tuse","year":"2022","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.mucimm.2026.01.013_b0155","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.imlet.2021.02.001","article-title":"Dynamic role of macrophage CX3CR1 expression in inflammatory bowel disease","volume":"232","author":"Li","year":"2021","journal-title":"Immunol Lett"},{"issue":"8","key":"10.1016\/j.mucimm.2026.01.013_b0160","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.celrep.2015.07.040","article-title":"Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses","volume":"12","author":"Panea","year":"2015","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.mucimm.2026.01.013_b0165","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1084\/jem.20101387","article-title":"Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon","volume":"209","author":"Rivollier","year":"2012","journal-title":"J Exp Med"},{"issue":"6","key":"10.1016\/j.mucimm.2026.01.013_b0170","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1128\/IAI.00581-06","article-title":"Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells","volume":"75","author":"Schnitzler","year":"2007","journal-title":"Infect Immun"},{"issue":"15","key":"10.1016\/j.mucimm.2026.01.013_b0175","doi-asserted-by":"crossref","first-page":"8536","DOI":"10.1073\/pnas.161273098","article-title":"A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity","volume":"98","author":"Aman","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.mucimm.2026.01.013_b0180","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.4049\/jimmunol.148.7.1999","article-title":"Cyclic AMP-independent effects of cholera toxin on B cell activation. II. Binding of ganglioside GM1 induces B cell activation","volume":"148","author":"Francis","year":"1992","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2026.01.013_b0185","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1365-2567.1997.00291.x","article-title":"Modulation of B-cell activation by the B subunit of Escherichia coli enterotoxin: receptor interaction up-regulates MHC class II, B7, CD40, CD25 and ICAM-1","volume":"91","author":"Nashar","year":"1997","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.mucimm.2026.01.013_b0190","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/gutjnl-2018-317726","article-title":"Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction","volume":"69","author":"Tulkens","year":"2020","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.mucimm.2026.01.013_b0195","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2249.2009.03981.x","article-title":"Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease","volume":"157","author":"Baumgart","year":"2009","journal-title":"Clin Exp Immunol"},{"issue":"13","key":"10.1016\/j.mucimm.2026.01.013_b0200","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v31.i13.104671","article-title":"Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn's disease","volume":"31","author":"Zheng","year":"2025","journal-title":"World J Gastroenterol"},{"issue":"4","key":"10.1016\/j.mucimm.2026.01.013_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106498","article-title":"ER stress modulates the immune regulatory ability in gut M2 cells of patients with ulcerative colitis","volume":"26","author":"Feng","year":"2023","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.mucimm.2026.01.013_b0210","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"10.1016\/j.mucimm.2026.01.013_b0215","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/1521-4141(200206)32:6<1737::AID-IMMU1737>3.0.CO;2-J","article-title":"CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation","volume":"32","author":"Salmond","year":"2002","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2026.01.013_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113981","article-title":"A stress sensor, IRE1alpha, is required for bacterial-exotoxin-induced interleukin-1beta production in tissue-resident macrophages","volume":"43","author":"Sasaki","year":"2024","journal-title":"Cell Rep"},{"issue":"10","key":"10.1016\/j.mucimm.2026.01.013_b0225","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/intimm\/dxz004","article-title":"Cholera toxin B induces interleukin-1beta production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome","volume":"31","author":"Orimo","year":"2019","journal-title":"Int Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2026.01.013_b0230","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni.1857","article-title":"TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages","volume":"11","author":"Martinon","year":"2010","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2026.01.013_b0235","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2019.06.017","article-title":"Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR","volume":"178","author":"Mogilenko","year":"2019","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.mucimm.2026.01.013_b0240","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41590-019-0336-y","article-title":"Inflammatory macrophage dependence on NAD(+) salvage is a consequence of reactive oxygen species-mediated DNA damage","volume":"20","author":"Cameron","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.mucimm.2026.01.013_b0245","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.734229","article-title":"Reactive Oxygen Species in Macrophages: Sources and Targets","volume":"12","author":"Canton","year":"2021","journal-title":"Front Immunol"},{"issue":"6151","key":"10.1016\/j.mucimm.2026.01.013_b0250","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1240248","article-title":"Noncanonical inflammasome activation by intracellular LPS independent of TLR4","volume":"341","author":"Kayagaki","year":"2013","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.mucimm.2026.01.013_b0255","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ydbio.2016.09.021","article-title":"The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster","volume":"420","author":"Zhang","year":"2016","journal-title":"Dev Biol"},{"key":"10.1016\/j.mucimm.2026.01.013_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109698","article-title":"ATF4 knockdown in macrophage impairs glycolysis and mediates immune tolerance by targeting HK2 and HIF-1alpha ubiquitination in sepsis","volume":"254","author":"Liu","year":"2023","journal-title":"Clin Immunol"},{"key":"10.1016\/j.mucimm.2026.01.013_b0265","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1471-2164-14-92","article-title":"Combined ChIP-Seq and transcriptome analysis identifies AP-1\/JunD as a primary regulator of oxidative stress and IL-1beta synthesis in macrophages","volume":"14","author":"Hull","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.mucimm.2026.01.013_b0270","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1430486","article-title":"New insight into the CNC-bZIP member, NFE2L3, in human diseases","volume":"12","author":"Xiong","year":"2024","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.mucimm.2026.01.013_b0275","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41590-021-01110-0","article-title":"Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation","volume":"23","author":"Zhou","year":"2022","journal-title":"Nat Immunol"},{"issue":"7","key":"10.1016\/j.mucimm.2026.01.013_b0280","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.4049\/jimmunol.164.7.3476","article-title":"Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression","volume":"164","author":"Nomura","year":"2000","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2026.01.013_b0285","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.3892\/mmr.2015.4340","article-title":"Quercetin protects RAW264.7 macrophages from glucosamine-induced apoptosis and lipid accumulation via the endoplasmic reticulum stress pathway","volume":"12","author":"Cai","year":"2015","journal-title":"Mol Med Rep"},{"issue":"7339","key":"10.1016\/j.mucimm.2026.01.013_b0290","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature09837","article-title":"Initial genome sequencing and analysis of multiple myeloma","volume":"471","author":"Chapman","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2026.01.013_b0295","doi-asserted-by":"crossref","unstructured":"Akins EA, Wilkins D, Aghi MK, Kumar S. An engineered glioblastoma model yields novel macrophage-secreted drivers of invasion. bioRxiv 2023.","DOI":"10.1101\/2023.11.18.567683"},{"issue":"1","key":"10.1016\/j.mucimm.2026.01.013_b0300","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1038\/cddis.2011.132","article-title":"ER stress activates the NLRP3 inflammasome via an UPR-independent pathway","volume":"3","author":"Menu","year":"2012","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.mucimm.2026.01.013_b0305","doi-asserted-by":"crossref","first-page":"e1080","DOI":"10.1038\/cddis.2014.16","article-title":"Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein","volume":"5","author":"Abbas","year":"2014","journal-title":"Cell Death Dis"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021926000139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021926000139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:25:57Z","timestamp":1782113157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021926000139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1933021926000139"],"URL":"https:\/\/doi.org\/10.1016\/j.mucimm.2026.01.013","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EPICERTIN, an engineered variant of cholera toxin B subunit, promotes survival and a pro-remodeling macrophage phenotype for mucosal healing in colitis","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mucimm.2026.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Society for Mucosal Immunology.","name":"copyright","label":"Copyright"}]}}